Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.

In Interop , technology experts John Palfrey and Urs Gasser explore the immense importance of interoperability,the standardization and integration of technology,and show how this simple principle will hold the key to our success in the coming decades and beyond. The practice of standardization has been facilitating innovation and economic growth for centuries. The standardization of the railroad gauge revolutionized the flow of commodities, the standardization of money revolutionized debt markets and simplified trade, and the standardization of credit networks has allowed for the purchase of goods using money deposited in a bank half a world away. These advancements did not eradicate the different systems they affected instead, each system has been transformed so that it can interoperate with systems all over the world, while still preserving local diversity. As Palfrey and Gasser show, interoperability is a critical aspect of any successful system,and now it is more important than ever. Today we are confronted with challenges that affect us on a global scale: the financial crisis, the quest for sustainable energy, and the need to reform health care systems and improve global disaster response systems. The successful flow of information across systems is crucial if we are to solve these problems, but we must also learn to manage the vast degree of interconnection inherent in each system involved. Interoperability offers a number of solutions to these global challenges, but Palfrey and Gasser also consider its potential negative effects, especially with respect to privacy, security, and co-dependence of states indeed, interoperability has already sparked debates about document data formats, digital music, and how to create successful yet safe cloud computing. Interop demonstrates that, in order to get the most out of interoperability while minimizing its risks, we will need to fundamentally revisit our understanding of how it works, and how it can allow for improvements in each of its constituent parts. In Interop , Palfrey and Gasser argue that there needs to be a nuanced, stable theory of interoperability,one that still generates efficiencies, but which also ensures a sustainable mode of interconnection. Pointing the way forward for the new information economy, Interop provides valuable insights into how technological integration and innovation can flourish in the twenty-first century.

Dieses Buch bietet eine eingehende rechtliche und politische Analyse der Vereinbarkeit des westfälischen Staatsmodells mit der Globalisierung und der digitalen Revolution. Es untersucht das Konzept der Demokratie in einer globalisierten Welt, erörtert die Legitimität der wirtschaftlichen Integration in den globalen Markt und präsentiert drei Fallstudien (aus Brasilien, Taiwan und Spanien) über die Auswirkungen sozialer Medien auf Wahlen. Darüber hinaus werden neue Perspektiven zu den Auswirkungen der Digitalisierung auf nationale Grenzen und auf die Rolle von Bürgerinnen und Bürgern und Expertinnen und Experten bei der Gestaltung der Globalisierung aufgezeigt. Ein abschließendes Kapitel befasst sich mit der Frage, inwieweit die aus den Analysen der oben genannten Aspekte gewonnenen Erkenntnisse bei den Bemühungen um eine Überwindung der aktuellen globalen Gesundheits- und Wirtschaftskrise berücksichtigt werden müssen.

This book offers in-depth legal and political analysis concerning the compatibility of the Westphalian state model with globalization and the digital revolution. It explores the concept of democracy in a globalized world, discusses the legitimacy of economic integration in the global market, and presents three case studies (from Brazil, Taiwan and Spain) on the impact of social media on elections. It further entails novel perspectives on the impact of digitalization on national borders, and the role of citizens and experts in the shaping of globalization. A final chapter addresses the extent to which insights gained from the analysis of the abovementioned aspects will need to be considered in efforts to recover from the current global health and economic crisis.

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. Content Level Research

The defining moments of 2001, the terrorist attacks of September 11 against the UnitedStatesofAmerica, markedaturningpointininternational lawandrelations. Bytheirscaleandaudaciousness, overnighttheyhelpedtopropeltheissueofint- national terrorism to the top of the international security agenda and particularly that of the USA, with consequences for many branches of international law, including the jus ad bellum, the jus in bello, international law relating to terrorism, international human rights law and international criminal law, that were just beginning to be felt as the year closed. The September 11 attacks were immediately characterised by the United States 3 as an act of war, an armed attack on such ascale asto constitute an armed conflict. Its immediate response was to declare a so-called 'Global War on Terrorism'. Avowedly acting in self-defense, on 7 October the US launched armed attacks against Afghanistan, notbecause Afghanistan wasconsidered tobelegally resp- sible for the September 11 attacks but for harbouring and refusing to surrender members of Al Qaeda, including its leader, Osama Bin Laden, and refusing to dismantle terrorist training camps. Although the main target of the attacks was Al Qaeda, the armed conflict that ensued was an international armed conflict between the US and its allies and the state of Afghanistan, notwithstanding that the US never recognised the Taleban as the government of Afghanistan.

This book examines the fundamental question of how legislators and other rule-makers should handle remembering and forgetting information (especially personally identifiable information) in the digital age. It encompasses such topics as privacy, data protection, individual and collective memory, and the right to be forgotten when considering data storage, processing and deletion. The authors argue in support of maintaining the new digital default, that (personally identifiable) information should be remembered rather than forgotten. The book offers guidelines for legislators as well as private and public organizations on how to make decisions on remembering and forgetting personally identifiable information in the digital age. It draws on three main perspectives: law, based on a comprehensive analysis of Swiss law that serves as an example; technology, specifically search engines, internet archives, social media and the mobile internet; and an interdisciplinary perspective with contributions from various disciplines such as philosophy, anthropology, sociology, psychology, and economics, amongst others.. Thanks to this multifaceted approach, readers will benefit from a holistic view of the informational phenomenon of "remembering and forgetting". This book will appeal to lawyers, philosophers, sociologists, historians, economists, anthropologists, and psychologists among many others. Such wide appeal is due to its rich and interdisciplinary approach to the challenges for individuals and society at large with regard to remembering and forgetting in the digital age.

Naturalism is the reigning creed in analytic philosophy. Naturalists claim that natural science provides a complete account of all forms of existence. According to the naturalistic credo there are no aspects of human existence which transcend methods and explanations of science. Our concepts of the self, the mind, subjectivity, human freedom or responsibility is to be defined in terms of established sciences. The aim of the present volume is to draw the balance of naturalism s success so far. Unlike other volumes it does not contain a collection of papers which unanimously reject naturalism. Naturalists and anti-naturalists alike unfold their positions discussing the success or failure of naturalistic approaches. "How successful is naturalism? shows where the lines of agreement and disagreement between naturalists and their critics are to be located in contemporary philosophical discussion. With contributions of Rudder Lynne Baker, Johannes Brandl, Helmut Fink, Ulrich Frey, Georg Gasser & Matthias Stefan, Peter S.M. Hacker, Winfried Loffler, Nancey Murphy, Josef Quitterer, Michael Rea, Thomas Sukopp, Konrad Talmont-Kaminski and Gerd Vollmer."

Modern mathematical logic would not exist without the analytical tools first developed by George Boole in The Mathematical Analysis of Logic and The Laws of Thought. The influence of the Boolean school on the development of logic, always recognised but long underestimated, has recently become a major research topic. This collection is the first anthology of works on Boole. It contains two works published in 1865, the year of Boole's death, but never reprinted, as well as several classic studies of recent decades and ten original contributions appearing here for the first time. From the programme of the English Algebraic School to Boole's use of operator methods, from the problem of interpretability to that of psychologism, a full range of issues is covered. The Boole Anthology is indispensable to Boole studies and will remain so for years to come.

Distributed AI is the branch of AI concerned with how to coordinate behavior among a collection of semi-autonomous problem-solving agents: how they can coordinate their knowledge, goals and plans to act together, to solve joint problems, or to make individually or globally rational decisions in the face of uncertainty and multiple, conflicting perspectives. Distributed, coordinated systems of problem solvers are rapidly becoming practical partners in critical human problem-solving environments, and DAI is a rapidly developing field of both application and research, experiencing explosive growth around the world. This book presents a collection of articles surveying several major recent developments in DAI. The book focuses on issues that arise in building practical DAI systems in real-world settings, and covers work undertaken in a number of major research and development projects in the U.S. and in Europe. It provides a synthesis of recent thinking, both theoretical and applied, on major problems of DAI in the 1990s.

Designing satellite structures poses an ongoing challenge as the interaction between analysis, experimental testing, and manufacturing phases is underdeveloped. "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing "explains the theoretical and practical knowledge needed to perform design of satellite structures. By layering detailed practical discussions with fully developed examples, "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing" provides the missing link between theory and implementation.

Computational examples cover all the major aspects of advanced analysis; including modal analysis, harmonic analysis, mechanical and thermal fatigue analysis using finite element method. Test cases are included to support explanations an a range of different manufacturing simulation techniques are described from riveting to shot peening to material cutting. Mechanical design of a satellites structures are covered in three steps: analysis step under design loads, experimental testing to verify design, and manufacturing.

Stress engineers, lecturers, researchers and students will find "Finite Element Analysis for Satellite Structures: Applications to Their Design, Manufacture & Testing "a key guide on with practical instruction on applying manufacturing simulations to improve their design and reduce project cost, how to prepare static and dynamic test specifications, and how to use finite element method to investigate in more details any component that may fail during testing. "

How society can shape individual actions in times of uncertainty When we make decisions, our thinking is informed by societal norms, “guardrails� guiding our decisions, like the laws and rules that govern us. But what are good guardrails in today’s world of overwhelming information flows and increasingly powerful technologies, such as artificial intelligence? Based on the latest insights from the cognitive sciences, economics, and public policy, Guardrails offers a novel approach to shaping decisions by embracing human agency in its social context. In this visionary book, Urs Gasser and Viktor Mayer-Schönberger show how the quick embrace of technological solutions can lead to results we don’t always want and explain how society itself can provide guardrails more suited to the digital age, ones that empower individual choice while accounting for the social good, encourage flexibility in the face of changing circumstances, and ultimately help us to make better decisions as we tackle the most daunting problems of our times, such as global injustice and climate change. Whether we change jobs, buy a house, or quit smoking, thousands of decisions large and small shape our daily lives. Decisions drive our economies, seal the fate of democracies, create war or peace, and affect the well-being of our planet. Guardrails challenges the notion that technology should step in where our own decision making fails, laying out a surprisingly human-centered set of principles that can create new spaces for better decisions and a more equitable and prosperous society.

Haemonchus Contortus and Haemonchosis - Past, Present and Future Trends, the latest in the Advances in Parasitology series first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. The 2014 impact factor is 6.226.

What happens to us when we die? According to Christian faith, we will rise again bodily from the dead. This claim raises a series of philosophical and theological conundrums: is it rational to hope for life after death in bodily form? Will it truly be we who are raised again or will it be post-mortem duplicates of us? How can personal identity be secured? What is God's role in resurrection and everlasting life? In response to these conundrums, this book presents the first ever joint work of leading philosophers and theologians on life after death. This is an impressive demonstration of interdisciplinary cooperation between philosophy and theology. Various models are offered which depict what resurrection into an incorruptible post-mortem body might look like. Therefore this book is an indispensable resource for anyone interested in the doctrine of bodily resurrection - be they philosophers, theologians, scholars in religious studies, or believers interested in examining their faith.

This volume, - explores this immediate need to rethink the axis of postcolonial cultural productions, to fashion tools to disarticulate Eurocentrism, to recognise Europe as more diverse, plural and fluid space; - analyses of literary texts from East-Central Europe and beyond, this volume sheds light on alternative literary cartographies; - covers a wide spatial and temporal terrain in postcolonial European cultural productions, it will be of great interest to scholars and researchers of literature and literary criticism, cultural studies, post-colonial studies, Global South studies and European studies.

This volume, - explores this immediate need to rethink the axis of postcolonial cultural productions, to fashion tools to disarticulate Eurocentrism, to recognise Europe as more diverse, plural and fluid space; - analyses of literary texts from East-Central Europe and beyond, this volume sheds light on alternative literary cartographies; - covers a wide spatial and temporal terrain in postcolonial European cultural productions, it will be of great interest to scholars and researchers of literature and literary criticism, cultural studies, post-colonial studies, Global South studies and European studies.

Alles für die Prüfung im Studienfach Urologie Dieses Lehrbuch bietet Ihnen übersichtlich und kompakt einen vollständigen Überblick über alle prüfungsrelevanten Inhalte der Urologie. Durch das neue Autorenteam steht Ihnen jetzt noch mehr geballtes Expertenwissen zur Verfügung. Das Buch leitet Sie leicht verständlich und GK-und NKLM-orientiert durch das gesamte Basiswissen der Urologievon den Grundlagen bis hin zu den wichtigsten Krankheitsbildern. Profitieren Sie von der langjährigen Erfahrung der Dozenten, die sorgfältig das Wesentliche für Sie ausgewählt und aufbereitet hat. Der Inhalt Das bewährte didaktische Konzept  ermöglicht ein effizientes Lernen: ·         Prüfungsteil – Für eine optimale Vorbereitung auf MC-Fragen und Fallstudien ·         Kernaussagen – Bringen das Wichtigste auf den Punkt ·         Fallbeispiele – Stellen einen anschaulichen Bezug zur Praxis her Keine Zeit zu lernen? Superkompakt und durchstrukturiert bekommen Sie hier einen schnellen Überblick für die Prüfung. Ein hilfreicher Begleiter für Ihr Studium oder die Praxis von Anomalien bis Zystitis. Ihr Lernprozess wird durch eine Extra-Sektion mit MC-Fragen und Fallquiz noch beschleunigt. Die Autoren Professor Dr. med. Thomas Gasser war langjähriger Chefarzt der Urologischen Universitätsklinik Basel-Liestal, Dekan und ordentlicher Professor für Urologie an der Universität Basel. Prof. Dr. med. Dr. rer. nat. Daniel Eberli ist Klinikdirektor Klinik für Urologie, Universitätsspital Zürich Professor Dr. med. Christian Thomas ist Direktor der Klinik und Poliklinik für Urologie, Universitätsklinikum Carl Gustav Carus Dresden

WTO law sets the global minimum standards for trade regulation, while allowing some regulatory flexibility for developing countries. The exact scope of regulatory flexibility is often unclear and, at times, flexibility may be counterproductive to sustainable economic growth in developing countries. Undisputedly, developing countries would have some flexibility with respect to tailoring preferential services trade agreements to their individual economic needs and circumstances, but empirical data from over 280 preferential services trade agreements worldwide shows that this flexibility is rarely used. This volume clarifies the regulatory scope of flexibility for preferential services trade agreements between developing countries by linking the legal interpretation of WTO law with evidence from research in economics and political sciences. The book suggests that the current regulatory framework leaves room for meaningful flexibility for developing countries, and encourages policymakers and scholars to take these flexibilities into consideration in their design and study of trade policies.

This volume provides an overview of the main yeast production platforms currently used and future yeast cell factories for recombinant protein production. Chapters detail approaches of genetic and metabolic engineering, co-factor containing proteins and virus-like particles, glycoproteins, and post-translational modifications of proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Recombinant Protein Production in Yeast: Methods and Protocols aims to provide state of the art background and methods for protein producing yeast platforms, as well as case studies for special applications.

The goal of the present study was to identify, describe and account for bilingual (Russian-Hebrew) varieties spoken in the Russian immigrant community in Israel. In order to achieve this complex goal, an interdisciplinary approach was chosen based on a combination of linguistic, psychological and sociological disciplines. The analysis of bilingual data has shown that there were three main types of bilingual varieties in use. The varieties were distinguished on the basis of the dominant patterns of language mixing (showing the evidence of a general shift from insertional to alternational CS) as well as of the directionality of CS. The three main speech styles were partly related to their speakers' generational memberships. However, the differences in speech styles were not so much the function of generational affiliations, as of the actual linguistic behavior in the immigrants' social lives. The variations within generational cohorts were better accounted for in terms of these speakers' identities, attitudes and habitual language choices.

What happens to us when we die? According to Christian faith, we will rise again bodily from the dead. This claim raises a series of philosophical and theological conundrums: is it rational to hope for life after death in bodily form? Will it truly be we who are raised again or will it be post-mortem duplicates of us? How can personal identity be secured? What is God's role in resurrection and everlasting life? In response to these conundrums, this book presents the first ever joint work of leading philosophers and theologians on life after death. This is an impressive demonstration of interdisciplinary cooperation between philosophy and theology. Various models are offered which depict what resurrection into an incorruptible post-mortem body might look like. Therefore this book is an indispensable resource for anyone interested in the doctrine of bodily resurrection - be they philosophers, theologians, scholars in religious studies, or believers interested in examining their faith.

This book is the first to directly address the question of how to bridge what has been termed the "great divide" between the approaches of systems developers and those of social scientists to computer supported cooperative work--a question that has been vigorously debated in the systems development literature. Traditionally, developers have been trained in formal methods and oriented to engineering and formal theoretical problems; many social scientists in the CSCW field come from humanistic traditions in which results are reported in a narrative mode. In spite of their differences in style, the two groups have been cooperating more and more in the last decade, as the "people problems" associated with computing become increasingly evident to everyone.
The authors have been encouraged to examine, rigorously and in depth, the theoretical basis of CSCW. With contributions from field leaders in the United Kingdom, France, Scandinavia, Mexico, and the United States, this volume offers an exciting overview of the cutting edge of research and theory. It constitutes a solid foundation for the rapidly coalescing field of social informatics.
Divided into three parts, this volume covers social theory, design theory, and the sociotechnical system with respect to CSCW. The first set of chapters looks at ways of rethinking basic social categories with the development of distributed collaborative computing technology--concepts of the group, technology, information, user, and text. The next section concentrates more on the lessons that can be learned at the design stage given that one wants to build a CSCW system incorporating these insights--what kind of work does one need to do and how is understanding of design affected? The final part looks at the integration of social and technical in the operation of working sociotechnical systems. Collectively the contributors make the argument that the social and technical are irremediably linked in practice and so the "great divide" not only should be a thing of the past, it should never have existed in the first place.

This book is the first to directly address the question of how to bridge what has been termed the "great divide" between the approaches of systems developers and those of social scientists to computer supported cooperative work--a question that has been vigorously debated in the systems development literature. Traditionally, developers have been trained in formal methods and oriented to engineering and formal theoretical problems; many social scientists in the CSCW field come from humanistic traditions in which results are reported in a narrative mode. In spite of their differences in style, the two groups have been cooperating more and more in the last decade, as the "people problems" associated with computing become increasingly evident to everyone. The authors have been encouraged to examine, rigorously and in depth, the theoretical basis of CSCW. With contributions from field leaders in the United Kingdom, France, Scandinavia, Mexico, and the United States, this volume offers an exciting overview of the cutting edge of research and theory. It constitutes a solid foundation for the rapidly coalescing field of social informatics. Divided into three parts, this volume covers social theory, design theory, and the sociotechnical system with respect to CSCW. The first set of chapters looks at ways of rethinking basic social categories with the development of distributed collaborative computing technology--concepts of the group, technology, information, user, and text. The next section concentrates more on the lessons that can be learned at the design stage given that one wants to build a CSCW system incorporating these insights--what kind of work does one need to do and how is understanding of design affected? The final part looks at the integration of social and technical in the operation of working sociotechnical systems. Collectively the contributors make the argument that the social and technical are irremediably linked in practice and so the "great divide" not only should be a thing of the past, it should never have existed in the first place.

This book offers in-depth legal and political analysis concerning the compatibility of the Westphalian state model with globalization and the digital revolution. It explores the concept of democracy in a globalized world, discusses the legitimacy of economic integration in the global market, and presents three case studies (from Brazil, Taiwan and Spain) on the impact of social media on elections. It further entails novel perspectives on the impact of digitalization on national borders, and the role of citizens and experts in the shaping of globalization. A final chapter addresses the extent to which insights gained from the analysis of the abovementioned aspects will need to be considered in efforts to recover from the current global health and economic crisis.