This book constitutes the refereed proceedings of the 6th International Conference on Big Data analytics, BDA 2018, held in Warangal, India, in December 2018. The 29 papers presented in this volume were carefully reviewed and selected from 93 submissions. The papers are organized in topical sections named: big data analytics: vision and perspectives; financial data analytics and data streams; web and social media data; big data systems and frameworks; predictive analytics in healthcare and agricultural domains; and machine learning and pattern mining.

Cancer is a disease characterized by reduction or loss of effectiveness in normal cellular control mechanism which regulates multiplication. A normal cell turns into a cancer cell because of one or more mutations in its DNA, which can be acquired or inherited. In the body, every cell type has its own unmatched signature, referred to as biomarkers, they are useful in the diagnosis, monitoring and in predicting the disease progression. It is found that the mediators of inflammation are important constituents of the local environment of tumors. In some types of cancer, inflammatory conditions are present before a malignant change develops. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment which promotes the tumor development. In some cases, use of NSAIDs is associated with lower risks for esophageal, gastric and colon cancers as well as other solid tumors. Chronic intake of NSAIDs may reduce carcinogenesis by inhibiting production of PGs, cytokines and angiogenic factors. Moreover, the ability of these NSAIDs drugs to prevent cancer is thought to be due, in part, to COX inhibition.

Poor ocular bioavailability of drugs (> 1%) from conventional eye drops (i.e. solution, suspension and ointments) is mainly due to the precorneal loss factor. Ocular efficacy is closely related to ocular drug bioavailability, which may be enhanced by increasing corneal drug penetration and prolonging precorneal drug residence time. Sparfloxacin and levofloxacin are newer generation hydrophobic fluoroquinolones. Poorly water soluble drugs are difficult to develop as conventional ocular drug delivery system. Nanotechnology can be used to formulate poorly water soluble drugs as nanosuspension which can be further incorporated in to matrix of hydrogel. This combination thus offers the opportunity to address many of the formulation related issues with such drugs. A variety of ocular drug delivery systems, such as hydrogels, microparticles, nanoparticles, microemulsion, liposomes and collagen shields have been designed and investigated for improved ocular bioavailability. Amongst them, hydrogels and polymeric nanoparticles are the most interesting approaches to achieve local sustained delivery system. In the present work various hydrogel based systems are developed and evaluated.