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The complement system plays a major role in the host's defence
against infections and in immune complex diseases. Although it is
known to consist of a number of serum and membrane proteins that
interact through a cascade, there is still a poor understanding of
the exact nature of the components and their complex interaction.
Many of the biological consequences of complement activation also
await elucidation. This fully revised edition of "Complement in
Health and Disease" provides an up-to-date account of how the
system works and its effects on the host. Key topics covered
include the history, phylogeny and evolution of the system;
genetics and biochemistry; deficiency states and infection; immune
complex diseases; complement and angioedema; anaphylatoxins; and
diseases of the nervous system. The book is valuable both for those
wanting an introduction to this complex area of immunology as well
as those requiring a more detailed update on developments in
specific topics.
Since the first edition of Complement in Health and Disease was
published in 1986, significant advances have been made. The cDNAs
for all of the components and some of the receptors have been
cloned and sequenced. The chromosomal localization and the
structural organization of a number of these genes have now been
determined. These advances are now facilitating research into the
structure of the complement proteins, the nature of the complement
deficiency syndromes, the regulation of complement gene expression
and the role of complement in different diseases. This edition
contains contributions from both basic and clinical scientists in a
format which we hope will appeal to both immunologists and
physicians who wish to know more about this fascinating and
important host defence system. The introductory chapter by John
Weiler presents a historical background to research on the
complement system and describes the biochemical events occurring
during activation of the system. In Chapter 2 Alastair Dodds and
Tony Day discuss the phylogeny and evolution of the complement
system. The techniques of protein chemistry and molecular biology
have provided powerful insights into the modular structure of
complement proteins and the evolution of the complement system. The
structure and organisation of the complement genes is described in
Chapter 3 by Ken Reid and Duncan Campbell. This chapter describes
the modular structure of the complement proteins and some of the
mutations which are responsible for deficiencies of individual
components.
Die vorliegende EinfUhrung in die Grundziige der Elektrotechnik
entstand aus der Vorlesung, welche die beiden Autoren seit 1973
gemeinsam an der Abtei- lung fUr Maschineningenieurwesen der
Eidgenossischen Technischen Hoch- schule Ziirich halten. Der enge
zeitliche Rahmen von lediglich zwei Wochen- stunden, je im 4. und
5. Semester, verbunden mit der Verpflichtung, dem Ma- schinenbauer
ein geniigendes Riistzeug fUr den Verkehr mit dem Elektroinge-
nieur und fUr die selbstandige LOsung einfacherer
elektrotechnischer Proble- me mitzugeben, waren wegleitend bei der
Stoffauswahl. Der Kurs hat als erste Pramisse eine geniigende
Kenntnis der allgemeinen Physik, der Mechanik und der
Ingenieurmathematik, so daB auf grundlegen- de physikalische
Phanomene und mathematische Methoden nicht mehr ein- gegangen
werden muB. Ein weiteres Auswahlkriterium entstand aus der
Oberzeugung der Autoren, den Horem in erster Linie praktisch
anwendbare Kenntnisse zu vermitteln, die auch den Einstieg in
weiterflihrende Literatur gestatten. Zugleich soli damit auch die
unterschwellig haufig vorhandene Angst vor der Elektrotechnik
abgebaut werden. Die ersten beiden Buchteile, "Grundlagen" und
"Energietechnik", entspre- chen in etwa der klassischen
Elektrotechnik. 1m Teil "Energietechnik" werden aber bereits die
heute iiblichen Verfahren der Leistungselektronik gleichbe-
rechtigt mit den klassischen Methoden behandelt. Altere Verfahren,
welche in neuen Anlagen nicht mehr zum Zuge kommen, wurden
grundsatzlich im Sin- ne einer Entlastung weggelassen.
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