|
Showing 1 - 3 of
3 matches in All Departments
This book offers an overview of the statistical methods used in
clinical and observational vaccine studies. Pursuing a practical
rather than theoretical approach, it presents a range of real-world
examples with SAS codes, making the application of the methods
straightforward. This revised edition has been significantly
expanded to reflect the current interest in this area. It opens
with two introductory chapters on the immunology of vaccines to
provide readers with the necessary background knowledge. It then
continues with an in-depth exploration of the analysis of
immunogenicity data. Discussed are, amongst others, maximum
likelihood estimation for censored antibody titers, ANCOVA for
antibody values, analysis of data of equivalence, and
non-inferiority immunogenicity studies. Other topics covered
include fitting protection curves to data from vaccine efficacy
studies, and the analysis of vaccine safety data. In addition, the
book features four new chapters on vaccine field studies: an
introductory one, one on randomized vaccine efficacy studies, one
on observational vaccine effectiveness studies, and one on the
meta-analysis of vaccine efficacy studies. The book offers useful
insights for statisticians and epidemiologists working in the
pharmaceutical industry or at vaccines institutes, as well as
graduate students interested in pharmaceutical statistics.
This monograph offers well-founded training and expertise on the
statistical analysis of data from clinical vaccine trials, i.e.,
immunogenicity and vaccine field efficacy studies. The book's scope
is practical rather than theoretical. It opens with two
introductory chapters on the immunology of vaccines to provide
readers with the necessary background knowledge. It then continues
with an in-depth exploration of the statistical methodology. Many
real-life examples and SAS codes are presented, making application
of the methods straightforward. Topics discussed include maximum
likelihood estimation for censored antibody titers, ANCOVA for
antibody values, analysis of equivalence and non-inferiority
immunogenicity trial data, analysis of data from vaccine field
efficacy trials (including data from studies with recurrent
infection data), fitting protection curves to data of challenge or
field efficacy studies, and the analysis of vaccine safety data.
This book offers an overview of the statistical methods used in
clinical and observational vaccine studies. Pursuing a practical
rather than theoretical approach, it presents a range of real-world
examples with SAS codes, making the application of the methods
straightforward. This revised edition has been significantly
expanded to reflect the current interest in this area. It opens
with two introductory chapters on the immunology of vaccines to
provide readers with the necessary background knowledge. It then
continues with an in-depth exploration of the analysis of
immunogenicity data. Discussed are, amongst others, maximum
likelihood estimation for censored antibody titers, ANCOVA for
antibody values, analysis of data of equivalence, and
non-inferiority immunogenicity studies. Other topics covered
include fitting protection curves to data from vaccine efficacy
studies, and the analysis of vaccine safety data. In addition, the
book features four new chapters on vaccine field studies: an
introductory one, one on randomized vaccine efficacy studies, one
on observational vaccine effectiveness studies, and one on the
meta-analysis of vaccine efficacy studies. The book offers useful
insights for statisticians and epidemiologists working in the
pharmaceutical industry or at vaccines institutes, as well as
graduate students interested in pharmaceutical statistics.
|
You may like...
It: Chapter 1
Bill Skarsgård
Blu-ray disc
R111
Discovery Miles 1 110
Tenet
John David Washington, Robert Pattinson, …
DVD
R53
Discovery Miles 530
|