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Statistics in Clinical and Observational Vaccine Studies (Paperback, 2nd ed. 2020)
Loot Price: R2,765
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Statistics in Clinical and Observational Vaccine Studies (Paperback, 2nd ed. 2020)
Series: Springer Series in Pharmaceutical Statistics
Expected to ship within 10 - 15 working days
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This book offers an overview of the statistical methods used in
clinical and observational vaccine studies. Pursuing a practical
rather than theoretical approach, it presents a range of real-world
examples with SAS codes, making the application of the methods
straightforward. This revised edition has been significantly
expanded to reflect the current interest in this area. It opens
with two introductory chapters on the immunology of vaccines to
provide readers with the necessary background knowledge. It then
continues with an in-depth exploration of the analysis of
immunogenicity data. Discussed are, amongst others, maximum
likelihood estimation for censored antibody titers, ANCOVA for
antibody values, analysis of data of equivalence, and
non-inferiority immunogenicity studies. Other topics covered
include fitting protection curves to data from vaccine efficacy
studies, and the analysis of vaccine safety data. In addition, the
book features four new chapters on vaccine field studies: an
introductory one, one on randomized vaccine efficacy studies, one
on observational vaccine effectiveness studies, and one on the
meta-analysis of vaccine efficacy studies. The book offers useful
insights for statisticians and epidemiologists working in the
pharmaceutical industry or at vaccines institutes, as well as
graduate students interested in pharmaceutical statistics.
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