This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).

An outgrow of an earlier workshop held by the community of European Solar Radio Astronomers (CESRA), this topical volume collects reviews on the current multiwavelength findings and perspectives from the space missions RHESSI, TRACE and SOTTO. The aspects of solar physics dealt with are particle acceleration during flares, large-scale disturbances, and coronal plasma physics.

Why sex matters

Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases.

The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes.

The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology.

The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.

Accounting for more than 40% of all heart failure problems, diastolic heart failure is a complex and often difficult diagnosis with rapidly evolving diagnostic management protocols. Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction, 2nd Edition, brings you up to date and equips you to successfully diagnose and manage even the most challenging incidences of diastolic heart failure and their comorbidities. It incorporates the latest guidelines for the diagnostic evaluation of the patient with suspected or known diastolic dysfunction, provides a comprehensive review of clinical conditions associated with heart failure with preserved ejection fraction, and describes the complementary role of imaging modalities and novel therapeutic approaches. Keeps you current with recent extensive changes in the understanding of the mechanisms of diastolic heart failure with preserved ejection fraction (HFpEF) that have resulted in dramatic changes in treatment guidelines. Covers the latest molecular, genetic, and cellular mechanisms behind diastolic heart failure as a basis for the latest clinical approaches, diagnosis, and treatment of common and uncommon pathological conditions such as hypertensive heart disease, cardiomyopathies, arterial and valvular diseases, pericardial diseases, congenital heart disease, diabetes mellitus, and metabolic syndrome. Features 50 video cases, new key summary points, new multiple-choice review questions, and six new chapters: Evaluation of Diastolic Function by Radionuclide Techniques; Diastology Stress Test; ASE/EACVI Diastolic Guidelines; Valve Disease; Perioperative Assessment of Diastolic Dysfunction; and Pulmonary Hypertension. Reviews new techniques and indices for assessing diastolic function, such as 3D echo, strain rate imaging, late gadolinium enhancement and T1-mapping by CMR, and novel nuclear scintigraphic methods - as well as the traditional indices of LV filling, LA function, and tissue Doppler indices. Covers emerging topics such as the role of neurohormones, global and regional systolic function of the left ventricle, chronotopic incompetence and pacing, aging, perioperative assessment, and more. Presents information in a quick-retrieval format, covering Epidemiology, Pathophysiology, Diagnostic Evaluation, Differential Diagnosis, Treatment, and Future Directions. Helps you learn efficiently and prepare for self-assessment with key summaries and multiple-choice questions and answers for each chapter. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Death before Sentencing provides a comprehensive description of America's 3,000 plus county and local jails being ignored by the media, politicians, and even criminal justice reformers. Jails have largely escaped scrutiny for deaths in their facilities for several reasons. First, the nation's jails are local affairs. Even repeat jail deaths warrant no more than limited local coverage at most. Jails are mostly run by sheriffs, often the most powerful and largely untouchable political figure in a local community. Third, the families of deceased jail inmates do not usually have the resources to sue or socioeconomic clout to be heard demanding jail accountability for loved ones' deaths. And lastly, many understood jail deaths as occurring from "natural causes," the verdict medical examiners and coroners erroneously employ to allow those responsible for the deaths to escape any accountability. This book constitutes the most complete investigation of the deadly side of jails, describing the daily deaths of detainees, including those from suicides, drug and alcohol withdrawal, forced restraint and brutality, as well as medical malpractice. Andrew R. Klein with Jessica L. Klein show how the failure of jail oversight by state correctional officials, state and county prosecutors, state police as well as sheriffs, medical examiners, and coroners allows for the secrecy surrounding and the cover up of jail deaths. Through a growing number of wrongful death lawsuits and the increasing role of the media in uncovering the truth about deadly jails, communities, led by the grieving families, are working to hold jailers and their medical providers accountable. This book concludes with hopeful signs of reforms being initiated by the U.S. Justice Department under President Biden, state legislatures, successful lawsuits, and reformers as well as suggests the major institutional reforms required to stop the daily deaths in America's jails.

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves - such as bisphosphonates, antiresorptives and anabolic agents - within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Departing from the traditional German school of music theorists, Michael Klein injects a unique French critical theory perspective into the framework of music and meaning. Using primarily Lacanian notions of the symptom, that unnamable jouissance located in the unconscious, and the registers of subjectivity (the Imaginary, the Symbolic Order, and the Real), Klein explores how we understand music as both an artistic form created by "the subject" and an artistic expression of a culture that imposes its history on this modern subject. By creatively navigating from critical theory to music, film, fiction, and back to music, Klein distills the kinds of meaning that we have been missing when we perform, listen to, think about, and write about music without the insights of Lacan and others into formulations of modern subjectivity.

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves - such as bisphosphonates, antiresorptives and anabolic agents - within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.

The book contains courses taught to a public of Ph. D. students, post-docs and con?rmed researchers in all ?elds of heliospheric plasma physics. It aims at identifying physical issues which are common to two di?erent ?elds of astr- omy: solar and magnetospheric physics. Emphasis is given to basic processes of transport and conversion of energy: magnetic reconnection is discussed in detail from the viewpoints of MHD and kinetic physics. Processes of charged particle acceleration are reviewed and confronted with recent observations. The subject is introduced by a summary of MHD and the basic structures and parameters of the solar atmosphere, terrestrial ionosphere and mag- tosphere are reviewed. The book combines a pedagogic and comprehensive presentation of physical issues and raises fully open questions, with the c- plementary and sometimes con?icting views of geophysicists and solar phy- cists. The book's focus, while basic, opens new avenues. Observatory of Meudon, France Ludwig Klein IAS, Orsay, France Jean-Claude Vial OCA, France Jean-Pierre Rozelot August 2000 The Editors Preface Following the great success of the ?rst two CNRS Summer Schools on Solar Astrophysics held in Oleron (May 1996 and May 1997 - two schools devoted to the highlights of solar physics), I came to the conclusion that the initiative should be continued."

This volume is the second in the series of final reports on the work of the Kavousi Project and the first volume on the cleaning (1982-1984) and excavations (1987-1992) at the mountain sites located above the modern village of Kavousi in eastern Crete. These sites, Vronda and the Kastro, shed light on the Early Iron Age, the transitional period in Cretan history known popularly as the Dark Ages, thereby elucidating the way of life of the people who lived in the area of Kavousi during that period and how their culture changed over time. Kavousi IIA is devoted to the excavation of material from the Late Minoan IIIC settlement at Vronda, particulary the houses on the summit of the Vronda ridge (Buildings A-B, C-D, J-K, and Q), along with earlier (Building P) and later (Building R) structures around them.

An outgrow of an earlier workshop held by the community of European Solar Radio Astronomers (CESRA), this topical volume collects reviews on the current multiwavelength findings and perspectives from the space missions RHESSI, TRACE and SOTTO. The aspects of solar physics dealt with are particle acceleration during flares, large-scale disturbances, and coronal plasma physics.

The second edition of this text catches the specialty of anesthesia at what will probably prove to be the apex of its influence and recognition amongst the specialties of medicine. The scientific basis of the specialty is becoming increasingly well delineated. Anesthesiologists have established themselves in local, regional, and national forums as spokespersons not only for the specialty, but also for medicine in general. And the specialty at last may be emerging from the stereotype of a faceless, inarticulate, shy and retiring figure, whose outstanding characteristic was the cloying odor of diethel ether! Technology has moved into the specialty on seven league boots. Just as an example, the basic design of the anesthesia machine was stable between the early 1950s and certainly the late 1970s. Suddenly, in the blink of an eye, our anesthesia machines are becoming intelligent, are utilizing heads-up displays, and are becoming more and more capable of writing the anesthesia record. Monitoring standards for anesthesia have burgeoned to the point that almost every aspect of the specialty is impinged upon by some rule and some "thou will or thou will not. " The importation and creation of terminology is exploding. In fact, one of the problems in updating this book was deciding when to stop. The author hopes that the goal of creating a snapshot in time through definitions of commonly used words and phrases has been achieved.

Whatever the number, domestic violence victims remain far too many for a preventable crime. More and more victims of intimate partner violence are reaching out to police, prosecutors and judges only to be sorely disappointed, even betrayed. While laws and programs have multiplied over the last few decades to address domestic violence, the country is getting safer for almost everyone except for women who have, or have had, abusive male intimate partners. Andrew R. Klein and Jessica L. Klein look at the criminal justice response to domestic violence across America today, ranging from police to prosecutors and courtrooms across the nation. Abetting Batterers reveals the troubling pattern of inattention and incompetence that compromises the safety of women and encourages their male abusers to continue their abuse and violence. Although criminal justice system agencies vary among cities, towns and counties within the same state they all too often relegate domestic violence to the backburners of the system, dismissing victims and ignoring even the most serious and chronic abusers. The variation reveals the real problem in preventing intimate partner violence lies in these agencies’ commitment and will, rather than their ability to do the job. The authors unveil what is working in regard to protecting victims of domestic violence and holding their abusers accountable, and they suggest strategies for ensuring that what is being done right can be replicated and become the law and practice across the nation. The wide variation in how intimate partner violence is handled by similar jurisdictions demonstrates the real problem in preventing it lies in these agencies’ commitment, rather than ability to do the job. This book proves to be invaluable in understanding what is and is not being done in the reality of domestic violence in America.

Examines some of the varied African literary responses to politics and social justice and injustice under colonialism/neocolonialism. In 1965, Chinua Achebe, in his classic essay "The Novelist as Teacher", declared that the "African past - with all its imperfections - was not one long night of savagery from which the early Europeans acting on God's behalf, delivered them." That assertion included a still reverberating sentiment shared by many of the first generation of African writers that it is possible to reclaim that distorted past creatively in order to show and understand "where andwhen the rain started beating Africa". Many genres and forms of literary and cultural production have recalled and recorded and reconfigured that past - many projecting a new confident African future defined by self-determination. The spectrum of that complex engagement, which encompasses critical issues in politics and social justice, provides the basis of this volume, which concludes with tributes to the life and works of Kofi Awoonor. Articles on: Binyavanga Wainaina + Ben Okri & Nationhood + J.M. Coetzee & the Philosophy of Justice + Isidore Okpewho & "Manhood" + Ngugi's Matigari & the Postcolonial Nation + Politics & Women in Irene Salami's MoreThan Dancing + Ayi Kwei Armah's The Resolutionaries Ernest Emenyonu is Professor of Africana Studies at the University of Michigan-Flint, USA; the editorial board is composed of scholars from US, UK and African universities Nigeria: HEBN

This book provides an overview of the underlying sex-based and hormone-based differences in immunity, wound healing and pharmacokinetics, while also exploring how pregnancy affects immunity. The second part of the book shows, for the first time in a single volume, the growing number of infectious diseases for which sex and gender differences are noted, identifies common as well as distinct mechanisms mediating these differences and illustrates how responses to treatments might differ between the sexes. The awareness that males and females differ in their response to specific pathogens as well as to treatments for infectious diseases may yield sex-specific personalized treatments. This book will be of interest to basic scientists and clinicians in the fields of microbiology, immunology and pharmacology. Individuals working in academia, government and industry will also benefit from the information presented.

In the United States at the height of the Cold War, roughly between the end of World War II and the early 1980s, a new project of redefining rationality commanded the attention of sharp minds, powerful politicians, wealthy foundations, and top military brass. Its home was the human sciences—psychology, sociology, political science, and economics, among others—and its participants enlisted in an intellectual campaign to figure out what rationality should mean and how it could be deployed. How Reason Almost Lost Its Mind brings to life the people—Herbert Simon, Oskar Morgenstern, Herman Kahn, Anatol Rapoport, Thomas Schelling, and many others—and places, including the RAND Corporation, the Center for Advanced Study in the Behavioral Sciences, the Cowles Commission for Research and Economics, and the Council on Foreign Relations, that played a key role in putting forth a \u201cCold War rationality.\u201d Decision makers harnessed this picture of rationality—optimizing, formal, algorithmic, and mechanical—in their quest to understand phenomena as diverse as economic transactions, biological evolution, political elections, international relations, and military strategy. The authors chronicle and illuminate what it meant to be rational in the age of nuclear brinkmanship.

This work documents the history of techniques that statisticians have used to manipulate economic, meteorological, biological and physical data taken from observations recorded over time. The manipulation tools include per cent change, index numbers, moving averages and 'first differences', i.e., subtracting one observation from the previous value. Professor Klein argues that nineteenth-century business journals, such as The Economist, were as important to the development of time series analysis as Latin treatises on probability theory. While examining the roots of mathematical statistics in commercial practice, she traces changes in analytical forms from table to graph to equation. Klein cautions that we risk measurement without history in unduly mechanistic blending of stationary probability theory with the practical dynamics of commercial traders. This history is accessible to students with a basic knowledge of statistics as well as financial analysts, statisticians and historians of economic thought and science.

This book presents evidence that infection is cyclical with the seasons, and that this phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms by which immune systems are bolstered to counteract seasonally-recurrent stressors, such as extreme temperature reductions and food shortages. Stress, infectious diseases, autoimmune diseases, and human cancers are examined, and the role of hormones such as melatonin and glucocorticoids is considered. The book begins with an overview of seasonality, biological rhythms and photoperiodism, and basic immunology, and then discusses seasonal fluctuations in disease prevalence, immune function, and energetics and endocrinology as they relate to immune function. The clinical significance of this issue is also addressed, as such seasonal changes may play an important role in the development and treatment of infections. This first monograph to examine seasonal immune function from an interdisciplinary perspective will serve practitioners as well as advanced undergraduates and graduate students in biology, immunology, human and veterinary medicine, neuroscience, endocrinology, and zoology.

This volume presents evidence that infection is cyclical with the seasons, and that this phenomenon is mirrored in cycles of immune function. The authors identify the mechanisms by which immune systems are bolstered to counteract seasonally-recurrent stressors, such as extreme temperature reductions and food shortages. Stress, infectious diseases, autoimmune diseases, and human cancers are examined, and the role of hormones such as melatonin and glucocorticoids are considered. This is the first monograph to examine seasonal immune function from an interdisciplinary perspective.