Why sex matters
Among human and nonhuman animals, the prevalence and intensity
of infection typically is higher in males than females and may
reflect differences in exposure as well as susceptibility to
pathogens. Elevated immunity among females is a double-edged sword
in which it is beneficial against infectious diseases but is
detrimental in terms of increased development of autoimmune
diseases.
The present book critically reviews the evolutionary origin and
the functional mechanisms responsible for sexual dimorphism in
response to infection. It emphasizes the value of examining
responses in both males and females to improve our understanding
about host-pathogen interactions in both sexes.
The contributors are experts in their specific disciplines which
range from microbiology and immunology to genetics, pathology, and
evolutionary biology.
The book aims at bringing insight to the treatment and
management of infectious diseases; it delineates areas where
knowledge is lacking and highlights future avenues of research.
General
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