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This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
The kidney plays a vital role in certain endocrine functions.
Abnormalities caused by toxic chemicals or other interventions can
have profound effects on these functions and consequently, on total
functions. Toxicology of the Kidney, Third Edition is updated to
reflect the latest research in this field and focuses on the
correlation between anatomy, biochemistry, and physiology of the
kidney. The text explains how these factors are related to concepts
of clinical nephrotoxicity and renal failure in humans, and how
animal models can be used to understand the mechanisms of human
renal disease. In addition to updating many of the key elements of
previous editions, such as in vitro models for studying renal
function and toxicity and classic nephrotoxicants, it also
incorporates cutting edge information on newly emerging areas of
renal research. These include mechanisms of cell injury, signaling
pathways, biomarkers of renal disease and the interface between
basic renal science and clinical outcomes. This book includes
current reviews of unpublished and recently published information
which allows it to serve as a concise compendium of many key topics
that will continue to play a central role in our understanding and
treatment of nephrotoxicity for decades to come.
A compendium of proven experimental approaches and strategies for
studying the bioactivation, detoxification, tissue distribution,
and elimination of xenobiotics in the metabolism and/or transport
of various chemicals. The authors address several of the major drug
metabolizing systems, including the cytochrome P450 family,
flavin-containing monooxygenases, glutathione, S-transferase,
glucuronidation, N-acetylation, and sulfotransferases. Additional
chapters present novel approaches to the study of: signaling
pathways in the regulation of drug metabolism enzymes, how the
modulation of thiols and other low molecular-weight cofactors can
alter drug metabolism, and how modulation of drug metabolism
pathways can influence antiviral therapy.
This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
A compendium of proven experimental approaches and strategies for
studying the bioactivation, detoxification, tissue distribution,
and elimination of xenobiotics in the metabolism and/or transport
of various chemicals. The authors address several of the major drug
metabolizing systems, including the cytochrome P450 family,
flavin-containing monooxygenases, glutathione, S-transferase,
glucuronidation, N-acetylation, and sulfotransferases. Additional
chapters present novel approaches to the study of: signaling
pathways in the regulation of drug metabolism enzymes, how the
modulation of thiols and other low molecular-weight cofactors can
alter drug metabolism, and how modulation of drug metabolism
pathways can influence antiviral therapy.
The kidney plays a vital role in certain endocrine functions.
Abnormalities caused by toxic chemicals or other interventions can
have profound effects on these functions and consequently, on total
functions. Toxicology of the Kidney, Third Edition is updated to
reflect the latest research in this field and focuses on the
correlation between anatomy, biochemistry, and physiology of the
kidney. The text explains how these factors are related to concepts
of clinical nephrotoxicity and renal failure in humans, and how
animal models can be used to understand the mechanisms of human
renal disease. In addition to updating many of the key elements of
previous editions, such as in vitro models for studying renal
function and toxicity and classic nephrotoxicants, it also
incorporates cutting edge information on newly emerging areas of
renal research. These include mechanisms of cell injury, signaling
pathways, biomarkers of renal disease and the interface between
basic renal science and clinical outcomes. This book includes
current reviews of unpublished and recently published information
which allows it to serve as a concise compendium of many key topics
that will continue to play a central role in our understanding and
treatment of nephrotoxicity for decades to come.
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