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Showing 1 - 6 of 6 matches in All Departments

Toxicology of Metals, Volume I (Hardcover): Louis W. Chang Toxicology of Metals, Volume I (Hardcover)
Louis W. Chang; Contributions by Stephen Bondy, Max Costa, Bruce A. Fowler, Sam Kacew, …
R9,972 Discovery Miles 99 720 Ships in 12 - 17 working days

This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.

Toxicology of the Kidney (Hardcover, 3rd edition): Joan B. Tarloff, Lawrence H. Lash Toxicology of the Kidney (Hardcover, 3rd edition)
Joan B. Tarloff, Lawrence H. Lash; Ferdinand Rodriguez, Ferdinand Cohen, Christopher K. Ober, …
R5,483 Discovery Miles 54 830 Ships in 12 - 17 working days

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

Drug Metabolism and Transport - Molecular Methods and Mechanisms (Paperback, Softcover reprint of hardcover 1st ed. 2005):... Drug Metabolism and Transport - Molecular Methods and Mechanisms (Paperback, Softcover reprint of hardcover 1st ed. 2005)
Lawrence H. Lash
R4,513 Discovery Miles 45 130 Ships in 10 - 15 working days

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Toxicology of Metals, Volume I (Paperback): Louis W. Chang Toxicology of Metals, Volume I (Paperback)
Louis W. Chang; Contributions by Stephen Bondy, Max Costa, Bruce A. Fowler, Sam Kacew, …
R2,094 Discovery Miles 20 940 Ships in 12 - 17 working days

This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.

Drug Metabolism and Transport - Molecular Methods and Mechanisms (Hardcover, 2005 ed.): Lawrence H. Lash Drug Metabolism and Transport - Molecular Methods and Mechanisms (Hardcover, 2005 ed.)
Lawrence H. Lash
R4,545 Discovery Miles 45 450 Ships in 10 - 15 working days

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Toxicology of the Kidney (Paperback, 3rd edition): Joan B. Tarloff, Lawrence H. Lash Toxicology of the Kidney (Paperback, 3rd edition)
Joan B. Tarloff, Lawrence H. Lash; Ferdinand Rodriguez, Ferdinand Cohen, Christopher K. Ober, …
R2,090 Discovery Miles 20 900 Ships in 12 - 17 working days

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

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