Electron paramagnetic resonance (EPR) applications remain highly significant in modern analytical science and this volume compiles critical coverage of developments in the recent literature. The topics covered in this volume describe contrasting types of EPR application, including rapid scan EPR, using the EPR toolkit to investigate the structural dynamics of membrane proteins and pulse dipolar EPR spectroscopy for investigating biomolecular binding events. An additional chapter reviewing the PARACAT collaboration from the EU has also been included. Providing a snapshot of the area by a handpicked group of researchers at the cutting-edge of the field, this book is a useful addition to any library supporting this research.

Electron Paramagnetic Resonance (EPR) highlights major developments in this area, with results being set into the context of earlier work and presented as a set of critical yet coherent overviews. The topics covered describe contrasting types of application, ranging from biological areas such as EPR studies of free-radical reactions in biology and medically-related systems, to experimental developments and applications involving EPR imaging, the use of very high fields, and time-resolved methods. Critical and up-to-the-minute reviews of advances involving the design of spin-traps, advances in spin-labelling, paramagnetic centres on solid surfaces, exchange-coupled oligomers, metalloproteins and radicals in flavoenzymes are also included. As EPR continues to find new applications in virtually all areas of modern science, including physics, chemistry, biology and materials science, this series caters not only for experts in the field, but also those wishing to gain a general overview of EPR applications in a given area.

Immunobiology is the premier text for immunology at the advanced undergraduate, graduate and medical school levels. Beginning students appreciate the book's clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope. Every chapter is reviewed with experts to ensure accuracy, authority, currency and depth. The Tenth Edition is supported by InQuizitive, Norton's award-winning, easy-to-use adaptive learning tool that helps students learn immunological terms and apply them conceptually.

This is an introduction to and critique of Einstein's views on space, time and gravity. Einstein's views are rejected as ideology rather than science. His claim that time and space can dilate, expand or contract, resulted from his belief that this would resolve the Galileo/Maxwell dilemma and from his misunderstanding of the hypothesis that the speed of light cannot be increased or added to. His explanation of gravity as the bending of space is rejected and an alternative model of gravity is provided.

Brands are among the most valuable assets of most of today's corporations. Brand names are the lingua franca of commerce. Branding is all about brands in both the packaged goods and the services industries - how to develop them, how to protect them, how to use them effectively. It combines the practical experience of marketing executives, trade mark lawyers, designers, advertising agents and others. It provides an international perspective on branding and is the first, authoritative book written on this increasingly important subject.

The Highway Horror Film argues that 'Highway Horror' is a hither-to overlooked sub-genre of the American horror movie. In these films, the American landscape is by its very accessibility rendered terrifyingly hostile, and encounters with other travellers almost always have sinister outcomes.

"It Came From the 1950s" is an eclectic, witty and insightful collection of essays predicated on the hypothesis that popular cultural documents provide unique insights into the concerns, anxieties and desires of their times. The essays explore the emergence of "Hammer Horror" and the company's groundbreaking 1958 adaptation of "Dracula"; the work of popular authors such as Shirley Jackson and Robert Bloch, and the effect that 50s food advertisements had upon the poetry of Sylvia Plath; the place of special effects in the decade's science fiction films; and 1950s Anglo-American relations as refracted through the prism of the 1957 film "Night of the Demon."

This is the first Open Access book introducing more than 20 of Japan's leading innovative entrepreneurs from the 17th century to the present. The author outlines the innovative business models created by entrepreneurs including SoftBank's Masayoshi Son, Fast Retailing (Uniqlo)'s Yanai Tadashi, Honda's Soichiro Honda, Sony's Akio Morita, Panasonic's Konosuke Matsushita, and Toyota's Kiichiro Toyoda, as well as their predecessors including Takatoshi Mitsui of Mitsui Zaibatsu, Shibusawa Eiichi of Daiichi Bank. While introducing the innovators, the author also raises three broader questions: 1. Why did Japan industrialize earlier than any other country outside Europe and the United States? 2. Why was Japan able to realize unsurpassed economic growth between the 1910s and the 1980s? 3. Why has Japan's economy stagnated for more than 30 years since the 1990s? Drawing upon analytical concepts including Schumpeter's breakthrough innovation, Kirzner's incremental innovation, and Christensen's disruptive innovation, the author contends that Japan's successes were based on unique and systematic breakthrough innovation and an accumulation of incremental innovation, while it later fell victim to a combination of breakthrough innovation from advanced countries and disruptive innovation by developing nations.

In autumn 2002, the Ernst Schering Research Foundation Workshop sponsored the 45th in its series of conferences devoted to emerging areas in basic and applied biomedical research. These conferences bring together a critical mass of top scientists working in an impor- tant area in an intimate setting that fosters the free exchange of knowledge and ideas. In this spirit, Workshop 45 assembled leaders in the field of chemokines - hemotactic cytokines that coordinate leukocyte trafficking - amid the scenic vineyards and wineries of Napa Valley, to discuss the latest concepts of how these molecules regulate the immune response and disease. Chemokines were se- lected as a conference topic because they have revitalized the study of leukocyte trafficking and are widely considered to be potential new targets for drug development, in diseases ranging from acute in- flammation and autoimmunity to HIV and cancer. Discovered in the 1980s, the chemokine superfamily currently has 43 human members, making it the largest subset of cytokines. Mem- bers are defined by conserved sequences and a common three-di- mensional fold, and can be divided into two major functional groups - homeostatic and inflammatory - depending on whether they are produced constitutively, and thereby control basal lymphocyte traf- ficking, or whether they must be induced, for example by pathogens or injury, and thereby control deployment of effector leukocytes in emergencies.

A revealing collection from the intellectual titan whose work shaped the modern world. As an economist and public intellectual, Gary S. Becker was a giant. The recipient of a Nobel Prize, a John Bates Clark Medal, and a Presidential Medal of Freedom, Becker is widely regarded as the greatest microeconomist in history. After forty years at the University of Chicago, Becker left a slew of unpublished writings that used an economic approach to human behavior, analyzing such topics as preference formation, rational indoctrination, income inequality, drugs and addiction, and the economics of family. These papers unveil the process and personality—direct, critical, curious—that made him a beloved figure in his field and beyond. The Economic Approach examines these extant works as a capstone to the Becker oeuvre—not because the works are perfect, but because they offer an illuminating, instructive glimpse into the machinations of an economist who wasn’t motivated by publications. Here, and throughout his works, an inquisitive spirit remains remarkable and forever resonant.

The Routledge Handbook of Contemporary English Pronunciation provides a comprehensive survey of this field covering both theoretical and practical perspectives on pronunciation. In 35 chapters contributed by leading scholars from around the world, this Handbook examines: linguistic and historical background of sound systems and theoretical issues linked to sound changes; pronunciation acquisition and factors related to speech production; pronunciation research and applications to second language pronunciation; the link between pronunciation and other language skills including perception and other socio-cultural factors; pronunciation and its relation to World Englishes. The Routledge Handbook of Contemporary English Pronunciation will be essential reading for anyone with an interest in pronunciation.

This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers - clinicians, pathologists, laboratorians, and other inquisitive minds - independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto- oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, repla

A comprehensive introduction to the syncretic religions developed in the Caribbean region Creolization-the coming together of diverse beliefs and practices to form new beliefs and practices-is one of the most significant phenomena in Caribbean religious history. Brought together in the crucible of the sugar plantation, Caribbean peoples drew on the variants of Christianity brought by European colonizers, as well as on African religious and healing traditions and the remnants of Amerindian practices, to fashion new systems of belief. Creole Religions of the Caribbean offers a comprehensive introduction to the syncretic religions that have developed in the region. From Vodou, Santeria, Regla de Palo, the Abakua Secret Society, and Obeah to Quimbois and Espiritismo, the volume traces the historical-cultural origins of the major Creole religions, as well as the newer traditions such as Pocomania and Rastafarianism. This second edition updates the scholarship on the religions themselves and also expands the regional considerations of the Diaspora to the U. S. Latino community who are influenced by Creole spiritual practices. Fernandez Olmos and Paravisini-Gebert also take into account the increased significance of material culture-art, music, literature-and healing practices influenced by Creole religions.

Horror and Gothic in all of their various forms have penetrated the cultural mainstream in a manner unseen since the last horror boom in mid/late 1970s; even people who would never before have entertained an interest in such dark genres are now happily settling down to watch zombie- and serial killer-related TV shows after the family dinner. This unique collection of 54 short biographical essays, by scholars and experts, brings together a vast array of figures who have played a role in the ever-expanding world of Gothic and Horror. However, you won't find the usual suspects here. Names such as Bram Stoker, Vincent Price, and Stephen King are notably absent. Such titans of terror have received and continue to receive prominent attention in all manner of publications. This collection, instead, focuses on those underrated or overlooked people whom our contributors persuasively argue are deserving of acknowledgement or reappraisal. Stimulatingly eclectic, the essays muse and enthuse on figures as diverse as American singer-songwriter, Tom Waits; British occultist and author, Dion Fortune; American author and scriptwriter, Charles Beaumont; Gallo-Roman historian and Bishop, Gregory of Tours; British gothic novelist and playwright, Francis Lathom; Japanese video game designer, Shinji Mikami; English stage and film actor, Skelton Knaggs; 19th-century Irish novelist, Charlotte Riddell; and Russian-born American experimental filmmaker, Maya Deren. Informative and entertaining, these essays expand, enrich (and, at times, challenge) the boundaries of what we actually define as Gothic and Horror. They celebrate the wide variety of talented individuals whose participation in Gothic and Horror's ongoing evolution has been unjustly overlooked...until now.

The Tempest: Critical Essays traces the history of Shakespeare's controversial late romance from its early reception (and adaptation) in the seventeenth and eighteenth centuries to the present. The volume reprints influential criticism, and it also offers eight originalessays which study The Tempest from a variety of contemporary perspectives, including cultural materialism, feminism, deconstruction, performance theory, and postcolonial studies. Unlike recent anthologies about The Tempest which reprint contemporary articles along with a few new essays, this volume contains a mixture of old and new materials pertaining to the play's use in the theater and in literary history.

Shirley Jackson was one of America's most prominent female writers of the 1950s. Between 1948 and 1965 she published one best-selling story collection, six novels, two popular volumes of her family chronicles and many stories, which ranged from fairly conventional tales for the women's magazine market to the ambiguous, allusive, delicately sinister and more obviously literary stories that were closest to Jackson's heart and destined to end up in the more highbrow end of the market. Most critical discussions of Jackson tend to focus on ""The Lottery"" and The Haunting of Hill House. An author of such accomplishment - and one so fully engaged with the pressures and preoccupations of postwar America - merits fuller discussion. To that end, this collection of essays widens the scope of Jackson scholarship with new writing on such works as The Road through the Wall and We Have Always Lived in the Castle, and topics ranging from Jackson's domestic fiction to ethics, cosmology, and eschatology. The book also makes newly available some of the most significant Jackson scholarship published in the last two decades.

Pregnancy after prenatal or infant loss can be a lonely and frightening time, but through stories of both pain and healing, the authors show how to navigate the exciting but choppy waters of a subsequent pregnancy. The loss of a pregnancy or newborn infant changes the meaning of pregnancy, birth, and parenting forever. Increased parental fear and anxiety, and continuing grief for the deceased baby, can impact subsequent pregnancies in unexpected ways. Parents who are unsupported in pregnancy after loss are may be more at risk of experiencing anxiety, depression, Post-Traumatic Stress Disorder, and difficulty in attaching to a new baby. Different Baby Different Story explores the range of emotions, thoughts, and physical experiences of parents who have gone on to subsequent pregnancies. Including stories from mothers, fathers, other children, and extended family members, this poignant and moving work will help readers through their own feelings and give voice to those who may have felt unheard or unsupported in the past. With practical advice on self-advocacy, the book helps expectant parents gain insights as to how others learned to work with health care professionals, mental health professionals, and their own families and friends and coworkers. For expectant mothers, their partners, their families and their friends, this work supports the range of experiences and encourages readers on a path to healing.

Contents:
General Editor's Introduction, Acknowledgments, Part I. The Tempest and the Critical Legacy Interpreting The Tempest: A History of Its Readings Part II. The Tempest and the Critics Preface to The Tempest or the Enchanted Island Patrick Murphy, Comment on Caliban John Dryden, The Adventurer, Number 83 Joseph Wharton, The Transcript of Lecture 9 Samuel Taylor Coleridge, Notes on The Tempest Colerdige, The Tempest William Hazlitt, Tempest W.J. Birch, The Monster Caliban Daniel Wilson, Shakespeare's Last Plays Edward Dowden, Shakespeare's Tempest as Originally Produced at Court Ernest Law, The Tempest Don Cameron Allen, Romance, Farewell!: The Tempest M.C. Bradbrook, The Day of The Tempest John Bender, The Miranda Trap: Sexism and Racism in Shakespeare's Tempest Lorie Jerrell Leininger, Propsero's Wife Stephen Orgel, "Remember/First to Posses His Books:" The Appropriation of The Tempest, 1700-1800, Michael Dobson, Local Tempest: Shakespeare and the Work of the Early Modern Playhouse Douglas Bruster, Revisiting The Tempest, Fantasy an History in The Tempest Richard Wheeler, Part III. Performances of The Tempest The Tempest at Covent-Garden Hazlitt, Shakespeare Illuminated: Charles Kean's 1857 Production of The Tempest Mary Nillan, The Tempest at the Turn of the Century: Cross Currents in Production Nilan, Peter Brook's Tempest Margaret Croyden, The Tempest (National Theater at Old Vic's on 5 March 1974) Peter Ansorage, Prospero or the Director: Giorgio Strehler's The Tempest Jan Kott, A Brave New Tempest Lois Potter, The Tempest in Bali David E. R. George, Tampering with The Tempest Virginia Mason Vaughn & Alden T. Vaughn, Shakespeare at the Guthrie: The Tempest Through a Glass Darly Randall Louis Anderson, Tempest in a Smokepot Robert Brustein, Part IV. New Essays on The Tempest Listening for the Playwright's Voice, 4.1.139-5.1.32 Robert Hapgood, Alien Habitats in The Tempest Geraldo U de Sousa, Peopling, Profiting, and Pleasure in The Tempest Barbara Ann Sebeck, Print History of The Tempest in Early America, 1623-1787 Christopher Felker, "Their Senses I'll Restore": Montaigne and The Tempest Reconsidered Alan De Gooyer, Drama's "Inward Pinches": The Tempest James Stephans, Modernist Revisions of The Tempest: Auden, Woolf, Tippett Edward O'Shea, The Tempest as Political Allegory Claudia Harris

The Routledge Handbook of Contemporary English Pronunciation provides a comprehensive survey of this field covering both theoretical and practical perspectives on pronunciation. In 35 chapters contributed by leading scholars from around the world, this Handbook examines: linguistic and historical background of sound systems and theoretical issues linked to sound changes; pronunciation acquisition and factors related to speech production; pronunciation research and applications to second language pronunciation; the link between pronunciation and other language skills including perception and other socio-cultural factors; pronunciation and its relation to World Englishes. The Routledge Handbook of Contemporary English Pronunciation will be essential reading for anyone with an interest in pronunciation.