Protocols for Enhancing Function of Fetal Islets in vitro and following Transplantation (A. Hayek, G.M. Beattie). Expression of Two Nonallelic Reg Genes in the Developing Human Pancreas: Effects in vitro of Nicotinamide and Maternal Growth Factors (B. Formby et al.). Preparation of Fetal Islets for Transplantation: Importance of Growth Factors (D.A. Hullet et al.). Studies of Fetal Porcine Isletlike Cell Clusters-A Tissue Source for Xenotransplantation in Insulindependent Diabetes Mellitus? (S. Sandler). Basic Biology of Pig Fetal Pancreas and Its Use as an Allograft (B.E. Tuch et al.). Combined Transplantation of Adult and Fetal Islets for Improvement of Graft Function (Y. Mullen). Studies on Pretreatment of Human Fetal Islet in Vitro and Clinical Islet Transplantation in China (Y.F. Hu et al.). The Use of Human Fetal Islet Tissue for Adjunctive Treatment in Insulindependent Diabetic Patients: The Case for 'Partial Success' (L. JovanovicPeterson et al.). Longterm Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary (G. Farkas). Fetal Islet Transplantation and Pregnancy (C.M. Peterson et al.). Encapsulated Human Islet Transplant Trials in Type I Diabetic Patients (P. SoonShiong). 4 additional articles. Index.

Provides a systematic comparison of legal scholars' views and governments' practice regarding the occasions for, criteria for, and effects of recognition. It traces the evolution from the 19th century practice basing recognition mainly on effective rule to more frequent use of additional criteria in the interwar and early Cold War, to the reassertion of the primacy of effective rule since 1970 and places it in the context of contemporaneous changes in world politics.

No other area of biology has grown as fast and become as relevant over the last decade as virology. It is with no little amount of amaze ment, that the more we learn about fundamental biological questions and mechanisms of diseases, the more obvious it becomes that viruses perme ate all facets of our lives. While on one hand viruses are known to cause acute and chronic, mild and fatal, focal and generalized diseases, on the other hand, they are used as tools for gaining an understanding of the structure and function of higher organisms, and as vehicles for carrying protective or curative therapies. The wide scope of approaches to different biological and medical virological questions was well rep resented by the speakers that participated in this year's Symposium. While the epidemic by the human immunodeficiency virus type 1 continues to spread without hope for much relief in sight, intriguing questions and answers in the area of diagnostics, clinical manifestations and therapeutical approaches to viral infections are unveiled daily. Let us hope, that with the increasing awareness by our society of the role played by viruses, not only as causative agents of diseases, but also as models for better understanding basic biological principles, more efforts and resources are placed into their study. Luis M. de la Maza Irvine, California Ellena M."

Language educators are increasingly taking advantage of developments in technology to explore the use of computer games. This book investigates this phenomenon and examines the relationship between technological innovation and development in the field of computer-assisted language learning. Exploring relevant theories and rationales, the discussion provides one of the first critical analyses of both early and contemporary research, including a recent case study conducted in Japan. This book supplies a comprehensive and accessible overview, meeting the needs of language educators, researchers, and students.

What are the skills necessary for effective leadership? How can we learn to lead toward a better tomorrow? For six decades, the captains of Star Trek have demonstrated the potential for enlightened leaders to leverage reason and compassion in the service of others. Grounded in science yet focused on practical application, this work uses case studies from more than 40 episodes and films to explore how Captains Archer, Burnham, Pike, Kirk, Picard, Sisko, and Janeway relied upon the basic leadership skills of communication, patience, and relationship to navigate the most challenging of events.Written for both professionals and curious readers alike, this work navigates how leaders can leverage reason and compassion to create organizational cultures in which everyone has a place at the table. Whether you are a professional or a student of business, academics, schools or government, Star Trek is more relevant than ever before to the leaders of today to boldly go.

Changing Trends of Diagnostic Virology in a Tertiary Care Medical Center.- Evaluation of Electron Microscopic Information Available from Clinical Samples.- Detection of Viral Sequences in Formalin Fixed, Paraffin Embedded Tissues from HIV-1 Infected Patients Using the PCR.- Detection of Viral Nucleic Acids by Q? Replicase Amplification.- Determinants of Measles Mortality: Host or Transmission Factors?.- The International Epidemiology of HIV-1 Infections.- Human Herpesvirus 6: An Update.- Papillomaviruses and Human Cancer.- Detection and Elimination of Blood-Borne Viruses Transmitted by Transfusion.- Programmed Antigenic Stimulation - A New Approach to Influenza Vaccination.- Lessons from Varicella Vaccine.- Antisense Oligonucleotides as Anti-Viral Agents: New Drugs for a New Age.- Abstracts.- Contributors.- Author Index.

Demand for water in agricultural, municipal, industrial, and environmental uses is growing. More frequent and severe extreme weather conditions now exacerbate water shortages in many locations and existing infrastructure to store and release water rarely has the capacity to both prevent floods during wet periods and meet demand during drought periods. Competition among sectors adds pressure not only on water infrastructure, but also on management policies and allocation institutions. This book of contributed chapters assesses the performance of existing infrastructure, institutions and policies under different climate variability scenarios. It also provides suggestions for minimizing conflict over scarce water resources. More flexible water-allocation institutions and management policies, and better tools for decision-making under uncertainty will be required to maximize society's net benefit from less reliable water resources. The chapters show how incentives for individuals to conserve water, and policies for helping vulnerable populations prepare for and recover from extreme events, will also need to be improved. This book was originally published as a special issue of the Journal of Natural Resources Policy Research.

Techniques for the Couple Therapist features many of the most prominent psychotherapists today, presenting their most effective couple therapy interventions. This book provides clinicians with a user-friendly quick reference with an array of techniques that can be quickly read and immediately used in session. The book includes over 50 chapters by experts in the field on the fundamental principles and techniques for effective couple therapy. Many of the techniques focus on common couple therapy processes such as enactments, communication, and reframing. Others focus on specific presenting problems, such as trauma, sexual issues, infidelity, intimate partner violence, and high conflict. Students, beginning therapists, and seasoned clinicians will find this pragmatic resource invaluable in their work with couples.

Techniques for the Couple Therapist features many of the most prominent psychotherapists today, presenting their most effective couple therapy interventions. This book provides clinicians with a user-friendly quick reference with an array of techniques that can be quickly read and immediately used in session. The book includes over 50 chapters by experts in the field on the fundamental principles and techniques for effective couple therapy. Many of the techniques focus on common couple therapy processes such as enactments, communication, and reframing. Others focus on specific presenting problems, such as trauma, sexual issues, infidelity, intimate partner violence, and high conflict. Students, beginning therapists, and seasoned clinicians will find this pragmatic resource invaluable in their work with couples.

Over the past years, the changing nature of pharmacy practice has caused many to realize that the practice must not only be managed, but also led. Leadership and Management in Pharmacy Practice discusses a variety of leadership and managerial issues facing pharmacists now and in the future. This second edition has been reorganized by placing leadership chapters up front, followed by management chapters, thus emphasizing the need for leadership first. The book is written by contributors from within and outside pharmacy practice-a reflection of the complexity of management in pharmacy settings. It offers a real-world approach to everyday issues in pharmacy leadership and management, written by authors who have faced these issues themselves. The book includes case studies which are thought provoking and promote critical thinking as well as problem solving-skills critical for effective pharmacy leaders or managers. References are also made throughout the text to changes occurring to the profession both internally and externally. Much of the material discussed applies to all settings of pharmacy practice: community, hospital, industry, ambulatory care, and long-term care. This book provides pharmacy students and new pharmacy leaders and managers a broad overview of the complexities and intricacies inherent in managing and leading the profession. It is a valuable resource for students in the professional years of their pharmacy curricula and those promoted recently into pharmacy leadership or management positions.

Foundations of Astrophysics provides a contemporary and complete introduction to astrophysics for astronomy and physics majors. With a logical presentation and conceptual and quantitative end-of-chapter problems, the material is accessible to introductory astrophysics students taking a two-semester survey course. Starting with the motions of the solar system and a discussion of the interaction of matter and light, the authors explore the physical nature of objects in the solar system, and the exciting new field of exoplanets. The second half of their text covers stellar, galactic, and extragalactic astronomy, followed by a brief discussion of cosmology. This is a reissue of the original 2010 edition, which has established itself as one of the market-leading astrophysics texts, well known for its clarity and simplicity. It has introduced thousands of physical science students to the breadth of astronomy, and helped prepare them for more advanced studies.

The second edition of this popular formulary contains the entire spectrum of confectionery and chocolate products. New formulas as well as formulas for low-calorie candy have been added to reflect consumers' changing preferences. Additional chapters deal with Hazard Analysis Critical Control Point (HACCP), U.S. Labeling Laws, Storage and Color Addition. Formulas are presented in a clear and precise manner, including the ingredients for their manufacture and the step-by-step procedure.

Demand for water in agricultural, municipal, industrial, and environmental uses is growing. More frequent and severe extreme weather conditions now exacerbate water shortages in many locations and existing infrastructure to store and release water rarely has the capacity to both prevent floods during wet periods "and "meet demand during drought periods. Competition among sectors adds pressure not only on water infrastructure, but also on management policies and allocation institutions.

This book of contributed chapters assesses the performance of existing infrastructure, institutions and policies under different climate variability scenarios. It also provides suggestions for minimizing conflict over scarce water resources. More flexible water-allocation institutions and management policies, and better tools for decision-making under uncertainty will be required to maximize society s net benefit from less reliable water resources. The chapters show how incentives for individuals to conserve water, and policies for helping vulnerable populations prepare for and recover from extreme events, will also need to be improved.

This book was originally published as a special issue of the "Journal of Natural Resources Policy Research.""

In this witty and provocative study of sex and marriage manuals, M.E. Melody and Linda M. Peterson reveal that permissiveness, prohibition, and, tellingly, persuasion and enforcement-from sermons and hellfire to mutilation and electroshock-have informed popular sex education over the past hundred and twenty years.

From the late Victorian obsession with masturbation and hygiene, to the "if it feels good, do it" ethos of "The Joy of Sex," America's disposition to sex has evolved from a general squeamishness to a veritable cult of mutual orgasm. But despite the recent emphasis on "voluptuous pleasure," the basic power dynamic underlying the discourse on sex has been remarkably resistant to change. The authors reveal that, even as sexual behavior changed during periods of upheaval, the prescriptive literature on sex has remained traditional at its core, promoting sex within marriage for the purpose of reproduction.

A cross-generational account of the major constructions of masculinity and femininity from 1880 to the present day, Teaching America About Sex serves up a lucid and entertaining reading of the twentieth century's vexed relationship with sex.

This book traces women's influence on maternity policy in Norway from 1880-1940. Maternity policies, including maternity leave, midwifery services and public assistance for mothers, were some of the first welfare policies enacted in Norway. Feminists, midwives, and working women participated in their creation and helped transform maternity policies from a restriction to a benefit. Situating Norway within the larger European context, the book contributes to discussions of Scandinavian welfare state development and further untangles the relationship between social policy and gender equality. The study of poor, rural women alongside urban middle-class feminists is rooted in an inclusive archival source base that speaks to the interplay between local and national welfare officials and recipients, the development and implementation of laws in diverse settings, the divergent effects maternity policies had on women, and women's varied response.

The study of AGN is one of the most dynamic areas of contemporary astronomy, involving one-fifth of all research astronomers. This textbook provides a systematic review of the observed properties of AGN across the entire electromagnetic spectrum, examines the underlying physics, and shows how the brightest AGN--quasars--can be used to probe the farthest reaches of the Universe. This timely textbook is a clear, comprehensive and self-contained introduction to active galactic nuclei (AGN)--for advanced undergraduates and graduate students in astronomy and physics.

Karl Z. Morgan was a physicist at the Manhattan Project and Oak Ridge National Laboratory, where he was director of health physics from the late 1940s until his retirement in 1972. He collaborated with leading trial lawyer Ken M. Peterson to write this extraordinary memoir about the dawn of the nuclear age and the moral dilemmas associated with nuclear energy.

A deeply humane and religious scientist, Morgan regards his own role, in meeting the challenges presented by the "angry genie" of nuclear energy, with the same unblinking eye he focuses on government, the military, and the nuclear industry. He tells harrowing tales of radiation accidents and near-disasters, and shows the actual and potential consequences of the clumsiness, recklessness, and carelessness of fallible human beings.

Be ready to prescribe and administer drugs safely and effectively, with the fully updated Pharmacotherapeutics for Advanced Practice, 5th Edition. Anchored in pharmacology and the principles of therapeutics, and written by experts in the field, this is your road map to effective drug therapies. Learn to correctly identify a disorder, review the drugs used to treat it, and select the optimal therapy. With expert direction on more than 50 common disorders, this is the ideal resource for advanced practice clinicians and students learning pharmacotherapeutics, and a go-to reference for experienced clinicians. Learn best practices for selecting the safest, most effective drug therapies . . . NEW section on pain management, addressing Opioid Use Disorder (OUD) and use of cannabis NEW and updated content on complementary and alternative medicine (CAM) therapies, pharmacogenomics, liver disorders and substance use disorders Easy-to-follow, evidence-based algorithms and drug tables Content organized by drug class, with quick-scan access to generic and trade names, and dosages Explains pharmacology and patient management topics - easy-to-remember, clearly worded definitions and descriptions of common presentations Offers the foundation of drug therapeutics, including: The prescribing process from pregnancy through elderly ages Avoiding medication errors Pharmacokinetics, pharmacodynamics, drug interactions and adverse events Principles of antimicrobial therapy Pharmacogenomics Chapters organized by body system or disorder for quick-reference: Dermatitis - Bacterial, fungal, and viral infections of the skin Ophthalmic disorders, otitis media and otitis externa Hypertension, hyperlipidemia, myocardial Infarction, heart failure, arrhythmias Respiratory infections, asthma, chronic obstructive pulmonary disease Gastric, functional and inflammatory bowel disorders Liver diseases Urinary tract infection, prostatic disorders and erectile dysfunction, overactive bladder, sexually transmitted infections Osteoarthritis and gout, osteoporosis, rheumatoid arthritis Headaches, seizure disorders, Alzheimer's disease, Parkinson's disease Major depressive disorder, bipolar disorders, anxiety disorders Chapter features include: Brief overview - Pathophysiology of each disorder and relevant classes of drugs Monitoring Patient Response section - What to monitor and when Patient Education section - Includes information on CAM for each disorder Drug Overview Tables - List drug uses, mechanisms of action, adverse effects, drug interactions, contraindications, and monitoring parameters Algorithms - Visual cues on how to approach treatment Case Study and Questions - Provided for each disorder Instructor Resources - Case study answers, additional case studies, multiple choice questions, power points, acronyms list

This book traces women's influence on maternity policy in Norway from 1880-1940. Maternity policies, including maternity leave, midwifery services and public assistance for mothers, were some of the first welfare policies enacted in Norway. Feminists, midwives, and working women participated in their creation and helped transform maternity policies from a restriction to a benefit. Situating Norway within the larger European context, the book contributes to discussions of Scandinavian welfare state development and further untangles the relationship between social policy and gender equality. The study of poor, rural women alongside urban middle-class feminists is rooted in an inclusive archival source base that speaks to the interplay between local and national welfare officials and recipients, the development and implementation of laws in diverse settings, the divergent effects maternity policies had on women, and women's varied response.

A comprehensive and accessible overview for language educators, researchers, and students, this book examines the relationship between technological innovation and development in the field of computer-assisted language learning, exploring relevant theories and providing practical evidence about the use of computer games in language learning.

Diabetic nephropathy is a tragic illness. Its often insidious onset in the insulin dependent (type I) diabetic, typically a young adult, heralds the last act in the course of a disease that will increasingly become the dominant preoccupation in the patient's shortened life. For most type II diabetics, the beginning of clinical renal insufficiency is but a phase in a continuous deterioration that affects the integrity ofjob, marriage, and family. The nephropathic diabetic is hypertensive, has worsening retinopathy, and more often than not, is also plagued by peripheral vascular insufficiency, heart disease, gastrointestinal malfunction, and deepening depression. Until the 1980's, few type I diabetics who became uremic (because ofdiabetic nephropathy) lived for more than two years. Hardly any attained true rehabilitation. This dismal prognosis is changing substantially for the better. Research in diabetes has resulted in striking advances at both ends of the type I diabetic's natural history. In one exciting clinical trial now underway in London, Ontario, halfofchildhood diabetics treated with cyclosporine within six weeks of onset evince"permanent" disappearanceofhyperglycemia and the need for insulin. At the otherendofthe natural historyofdiabetes for the nephropathic patientwith worsening eye disease (renal-retinal syndrome), who receives a kidney transplant, patient and graft survival, two years after cadaveric kidney transplantation in type I diabetics is now equal to that of the nondiabetic."

No other area of biology has grown as fast and become as relevant over the last decade as virology. It is with no little amount of amaze ment, that the more we learn about fundamental biological questions and mechanisms of diseases, the more obvious it becomes that viruses perme ate all facets of our lives. While on one hand viruses are known to cause acute and chronic, mild and fatal, focal and generalized diseases, on the other hand, they are used as tools for gaining an understanding of the structure and function of higher organisms, and as vehicles for carrying protective or curative therapies. The wide scope of approaches to different biological and medical virological questions was well rep resented by the speakers that participated in this year's Symposium. While the epidemic by the human immunodeficiency virus type 1 continues to spread without hope for much relief in sight, intriguing questions and answers in the area of diagnostics, clinical manifestations and therapeutical approaches to viral infections are unveiled daily. Let us hope, that with the increasing awareness by our society of the role played by viruses, not only as causative agents of diseases, but also as models for better understanding basic biological principles, more efforts and resources are placed into their study. Luis M. de la Maza Irvine, California Ellena M."

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.