These volumes present the results of two studies undertaken for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities. The aim was to review available data concerning the metabolism of a selection of toxic chemi cals in man and to develop mathematical models representing this meta bolism. Volume 1 is the report from the first study and presents re views of the data for each of the substances and proposes models for their metabolic behaviour. Volume 2 is the report of the second study and contains a review of new data relevant to the development of meta bolic models for each substance. The modelling of uptake and retention by the two major routes of uptake (the respiratory system and the gas trointestinal tract) is also reviewed. The implementation of the models in a computer code is described and results are presented illus trating organ concentrations and rates of excretion for typical regimes of exposure. vi 1 Foreword This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Models for the Metabolism of Chemical Carcinogens in Man." vii 2 Summary This report includes results of a review of the metabolism of selected actual and potential human carcinogens and proposals for pharmacokinetic models to represent that metabolism."

This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Dynamics of Selected Toxic Materials in Man." vii 2 Summary This report presents results from the second phase of a study on the metabolism of selected actual and potential human carcin ogens. In the first phase of this work a comprehensive review of literature relating to the metabolism of these materials was under taken and pharmacokinetic models were proposed to represent that meta bolism. It was suggested that these models, and the reviews on which they were based, would provide information relevant to the development of monitoring programmes and in the interpretation of dose-response data. In the second phase of the study, attention has been concen trated on the implementation of the models proposed for the various substances reviewed, i.e. arsenic, beryllium, cadmium, lead, nickel, chromium, asbestos, benzene, vinyl chloride monomer, benzidine and its congeners, carbon tetrachloride and methyl iodide. However, this programme has been supplemented by an on-going review of the relevant literature on these substances and a detailed analysis of the applica bili ty of the pharmacokinetic models used for the organs of intake, i.e. the lung and gastrointestinal tract."

Radionuclide distribution and transport in terrestrial and aquatic ecosystems is Volume 5 of a critical review of data (Prepared for the Commission of the European Communities) in 1984.