Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets, such as the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms. Other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, as well as describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV, and respiratory viruses. The book also outlines potential new avenues for research. RNA Interference and Viruses is essential reading for researchers involved in RNAi or antiviral research and is a recommended text for all virology laboratories.

This edited volume advances our understanding of urban activism beyond the social movement theorization dominated by thesis of political opportunity structure and resource mobilization, as well as by research based on experience from the global north. Covering a diversity of urban actions from a broad range of countries in both hemispheres as well as the global north and global south, this unique collection notably focuses on non-institutionalised or localised urban actions that have the potential to bring about radical structural transformation of the urban system and also addresses actions in authoritarian regimes that are too sensitive to call themselves "movement". It addresses localized issues cut off from international movements such as collective consumption issues, like clean water, basic shelter, actions against displacement or proper venues for street vendors, and argues that the integration of the actions in cities in the global south with the specificity of their local social and political environment is as pivotal as their connection with global movement networks or international NGOs. A key read for researchers and policy makers cutting across the fields of urban sociology, political science, public policy, geography, regional studies and housing studies, this text provides an interdisciplinary and international perspective on 21st century urban activism in the global north and south.

This edited volume advances our understanding of urban activism beyond the social movement theorization dominated by thesis of political opportunity structure and resource mobilization, as well as by research based on experience from the global north. Covering a diversity of urban actions from a broad range of countries in both hemispheres as well as the global north and global south, this unique collection notably focuses on non-institutionalised or localised urban actions that have the potential to bring about radical structural transformation of the urban system and also addresses actions in authoritarian regimes that are too sensitive to call themselves "movement". It addresses localized issues cut off from international movements such as collective consumption issues, like clean water, basic shelter, actions against displacement or proper venues for street vendors, and argues that the integration of the actions in cities in the global south with the specificity of their local social and political environment is as pivotal as their connection with global movement networks or international NGOs. A key read for researchers and policy makers cutting across the fields of urban sociology, political science, public policy, geography, regional studies and housing studies, this text provides an interdisciplinary and international perspective on 21st century urban activism in the global north and south.