The antipsychotic drugs are being used mainly for treatment of schizophrenia. Schizophrenia is a mental disorder characterized by a breakdown of typical emotional responses. Modified drug delivery systems (MDDS) of antipsychotics offer advantages over conventional formulations in provison of convenience, side effects and efficacy. Extended Release tablet of Antipsychotic drug were prepared using varying ratios of drug and polymers were selected for the study. After fixing the ratio of drug and polymer to control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material. The effect of polymer concentration and channelizer concentration were studied. Drug release was observed upto 24 hrs.

In the winter of 1951, a storyteller arrives at the home of nine-year-old Ronan O'Mara in the Irish countryside. The last practitioner of an honored, centuries-old tradition, the Seanchai enthralls his assembled audience for three evenings running with narratives of foolish kings and fabled saints, of enduring accomplishments and selfless acts -- until he is banished from the household for blasphemy and moves on. But these three incomparable nights have changed young Ronan forever, setting him on the course he will follow for years to come -- as he persues the elusive, itinerant story teller ... and the magical tales that are no less than the glorious saga of his tenacious, troubled, and extraordinary isle.

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate. . In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drug compounds. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self microemulsifying drug delivery systems (SMEDDS).

The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn's diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co

The aim of the study was to develop and evaluate enteric coated matrix tablet of Aceclofenac for colonic delivery by exploiting prolonged release characteristics of HPMC K4M with pH dependent solubility property of a Eudragit S100. Extended release matrix tablet were prepared by direct compression of hydrophilic polymer HPMC and other ingredients. The pH dependent release was achieved by coating matrix tablet with Eudragit S100, soluble at pH 7. All the formulations of 32 factorial design (A1- A9) were evaluated for the physicochemical parameters and subjected to in vitro drug release in 0.1 N HCl for two hour, three hour in pH 5.2 Phosphate buffer then in pH 7.4 phosphate buffer up to 17 hrs. Multiple regression analysis, two way ANOVA followed by Tukey test were performed. Polynomial equations and response surface plots were generated for all dependent variables. It was observed that both the factors had significant effect on dependable variables (Q6, Q12, Q17 and n, k). The formulation A5 was most likely to provide targeting of aceclofenac in the colon owing to its minimal release of the drug in the first 5 hr and give release up to 17hr with 62.21 similarity factor."