Artificial intelligence (AI) and digital engineering have become prevalent in business, industry, government, and academia. However, the workforce still has a lot to learn on how to leverage them. This handbook presents the preparatory and operational foundations for the efficacy, applicability, risk, and how to take advantage of these tools and techniques. "Handbook of Mathematical and Digital Engineering Foundations for Artificial Intelligence: A Systems Methodology" provides a guide for using digital engineering platforms for advancing AI applications. The book discusses an interface of education and research in the pursuit of AI developments and highlights the facilitation of advanced education through AI and digital engineering systems. It presents an integration of soft and hard skills in developing and using AI and offers a rigorous systems approach to understanding and using AI. This handbook will be the go-to resource for practitioners and students on applying systems methodology to the body of knowledge of understanding, embracing, and using digital engineering tools and techniques.