During recent years, an increasing amount of academic research has focused on older people with a particular emphasis on settings, places and spaces. This book provides a comprehensive review of research and the policy area of 'ageing and place'. An insightful book on an important topic, Andrews and Phillips have together edited a valuable information and reference source for those with interests in the spatial dimensions of ageing in the twenty-first century. Ranging from macro-scale perspectives on the distribution of older populations on national scales, to the meaning of specific local places and settings to older individuals, on the micro-scale, the book spans an entire range of research traditions and international perspectives.

The Asia-Pacific region is now clearly witnessing the rapid ageing of many of its nations, to the extent that it will soon be the region with, relatively, the largest number of older persons. This book focuses on the challenges that this demographic trend poses to economies and societies in the region, and the policies that have evolved to date to meet new demands. It looks forward over the coming decades to consider how societies and economies will deal with ageing and the necessary structural and behavioural changes that this will entail.

eBook available with sample pages: EB:0203463080

First published in 2011. Routledge is an imprint of Taylor & Francis, an informa company.

During recent years, an increasing amount of academic research has focused on older people with a particular emphasis on settings, places and spaces. This book provides a comprehensive review of research and the policy area of 'ageing and place'.

An insightful book on an important topic, Andrews and Phillips have together edited a valuable information and reference source for those with interests in the spatial dimensions of ageing in the twenty-first century. Ranging from macro-scale perspectives on the distribution of older populations on national scales, to the meaning of specific local places and settings to older individuals, on the micro-scale, the book spans an entire range of research traditions and international perspectives.

Global Health continues to provide readers with a comprehensive, up-to-date and thought-provoking outline and understanding of the constantly evolving global health landscape. In this new edition the authors have maintained the successful structure and organisation of the previous edition to examine and explain recent health changes and consider likely future patterns. New or expanded topics covered include: emerging and re-emerging infectious disease threats increasing awareness of, and interest in, antimicrobial resistance and superbugs terrorism, global conflict and health the new UN 2030 Agenda for Sustainable Development the drive for Universal Health Coverage (UHC) the use of information technology in global health substance abuse palliative and end-of-life-care ethical issues in global health. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with discussion questions posed for readers at the end of each chapter. Readers will also be able to take advantage of the new website that was designed to complement this book. Global Health is essential reading for students and researchers of global health, public health and development studies.

This book explores the circulation of anger and hostility in contemporary American culture with particular attention to the fantasy of refusal, a dream of rejecting all the structures of the contemporary political and economic system. Framing the question of public sentiment through the lens of rhetorical studies, this book traces the circulation of symbols that craft public feelings in contemporary popular cinema. Analyzing popular twenty-first century films as invitations to a particular way of feeling, the book delves into the way popular sentiments are circulated and intensified. The book examines dystopian films (The Purge, The Cabin in the Woods), science fiction (Snowpiercer), and superhero narratives (the Marvel Cinematic Universe and Joker). Across these varied films, an affective economy that emphasizes grief, betrayal, refusal, and an underlying rage at the seeming hopelessness of contemporary culture is uncovered. These examinations are framed in terms of ongoing political protests ranging from Occupy Wall Street, the Tea Party, Black Lives Matter, and the 6th January 2021 invasion of the US Capitol Building.

Ferber is a fourth-generation French patissiere whose speciality is her unusual, delicious jams and jellies, which have gained an international following among chefs and other gourmands. This book, a best-seller in France, presents dozens of recipes, organised by season, for preserves from Black Cherry with Pinot Noir to Greengage and Mirabelle Plum with Mint; a number of them include chocolate, not a standard addition. Few of the recipes include headnotes, although translator's notes identify the more exotic ingredients; instructions are on the brief side. However, any jam maker will find Ferber's book fascinating. Recommended for all canning and preserving collections.

Leaving Atlantis is a suite of poems that explores the unstable territory between public and private. They are addressed to the great Barbadian novelist and thinker, George Lamming, the silent but speaking partner in a relationship of love that comes between two writers when "your flag is flying at half-mast". The suite works at multiple levels, as a record of the negotiation of feelings, permissions, exclusions and treaties between two persons who have to confront the reality of long lives that have accumulated "memories I cannot share", and not least that the poet is a woman of deep religious faith, and the man a lifelong Marxist and non-believer. What the poems also deal with in a moving but resolutely unsentimental way is the fact that the age of one of the partners makes the temporal finiteness of the relationship a matter of acute awareness. What is the poet to think when she sees the man throwing out and putting his papers in order? "Clearing out?" The poems also meditate on the ironies of a relationship with a man who has both been public property as a writer and a leader of the struggle for Caribbean sovereignty, but also an intensely private person, habituated to a life of movement and temporariness. Quite literally, Leaving Atlantis references the moment when the writer is forced to leave, with a rude absence of notice, the hotel at Bathsheba on the Atlantic coast of Barbados, his refuge for many years. Is the relationship and provision of a home a "Coming Home", the arrival at a place of rest after the turbulence of a life of struggle, or does it threaten a loss of autonomy after a life of privacy and independence? What of sovereignty now when "I am your dotage, your vulnerable/ season"? More than a portrait, fascinating and intimate as it is, of a public man; more than an exploration of the writing of the man for clues about what he might be thinking (and an acceptance of the ultimate mystery and unknowability of the intimate other), this is a suite of poems about the miracle of love, and how it may come at any time.

Cytochromes P450 (CYPs) comprise a large superfamily of proteins that are of central importance in the detoxification or activation of a tremendous number of natural and synthetic hydrophobic xenobiotics, including many therapeutic drugs, chemical carcinogens and environmental pollutants. CYPs are important in mediating interactions between an organism and its chemical environment and in the regulation of physiological processes. Cytochrome P450 Protocols, Third Edition focuses on high-throughput methods for the simultaneous analysis of multiple CYPs, substrates or ligands. Although the emphasis is on CYPs of mammalian origin, it reflects an increasing interest in CYPs of bacterial species. Also included are chapters on cytochrome P450 reductase (the redox partner of CYPs) and the flavin-containing monooxygenases (FMOs), and metabolomic and lipidomic approaches for identification of endogenous substrates of CYPs ('de-orphanizing' CYP substrates). Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cytochrome P450 Protocols, Third Edition provides a wide range of techniques accessible to researchers in fields as diverse as biochemistry, molecular biology, pharmacology, toxicology, environmental biology and genetics.

Biz Jets: Technology and Market Structure in the Corporate Jet Aircraft Industry traces the development of business jet aircraft from the mid-1950s through early 1993. It begins with a discussion of the technological and market opportunities existing in the period prior to the introduction of the Lockheed JetStar and the North American Sabreliner. The subsequent appearances of other biz jets -- the Learjets, HS-125s, Jet Commanders, Falcons, Gulfstreams, Citations, Challengers, Mitsubishis and derivative aircraft are treated in considerable detail. Biz Jets also covers 'planes involved in many unsuccessful attempts to enter the industry from 1955 through 1993. The study shows that while the industry has been quite concentrated throughout its history, the positions of the leading firms have always been contestable. Indeed, leaders at one point in time have often been displaced by others who succeeded in marshalling technological and market opportunities to their advantage. Manufacturers have had to undertake continuous efforts to improve the price-performance characteristics of their aircraft to gain and hold their market shares. Rivalries in the effective use of the stream of new technologies have brought forth new aircraft with both better performance and lower operating costs. At the same time, however, participation in the market has been extremely risky. Only a few companies have been able to earn profits. Entries, exits and mergers have altered the structure of the industry, but it remained decidedly unstable at least through 1992.

Fifteen years have passed since I was working at a dam site super vising grouting work. That was not the first time that I had to car ry out engineering geological investigations for several similar projects, which always included testing programmes to find out the permeability of the rock, and often I was in charge of grouting work. It thus attracted my attention when this particular grouting programme did not run as intended: most of the grout holes took only very little grout It could not be the aim of the invested work simply to drill holes and fill them again without bringing about any further improvement. Fortunately, I had the chance to be en gaged in many other grouting programmes in the following years and used all these examples to analyse as thoroughly as possible the permeability of the rocks being treated in view of their grout ability. The more I studied, the stronger my conviction grew that our rules which had decided the grouting of rock for many de cades should be developed further, and therefore I occupied my self with contributing some ideas for a new basis to investigation and judgment of permeability of rock and for a more adequate application of this technology."

Growth of immobilized cells can be viewed as an alternative to growth of free cells in many instances. In others, immobilization confers a precision of control over the process not possible in free growth. Immobilization of cells can sometimes be considered to be a lower cost alternative to immobilization of enzymes. In this volume, immobilization procedures based on mechanical means and bonding of various types are examined, with detailed application examples. These applications include microorganisms, plant and animal cells, sub-cellular organelles and multiple enzyme systems. Particular attention is devoted to enzyme properties in immobilized cells and the properties of the carrier. The volume should provide the reader with a comprehensive overview of the subject, together with copious references. As well as serving as a research monograph, it could be used to provide reference material for a graduate course. Special thanks are due Mrs. JENNIFER KERBY for her dedicated work in the preparation of the manuscript, and IT-CHIN HSIEH for bibliographical assistance. COLIN R. PHILLIPS Toronto, July 1988 YIU C. POON v Table of Contents 1 Introduction. 1 References . 9 2 Methods of Cell Immobilization 11 2.1 Mechanical Immobilization . 11 2.1.1 Mycelial Pellet and Mat 11 2.1.2 Encapsulation .. 48 2.1.3 Dialysis Culture. . . 49 2.1.4 Entrapment. .... 50 2.2 Covalent Attachment 61 2.3 Ionic Attachment 62 2.3.1 Flocculation 62 2.3.2 Adsorption . 64 References . 66 3 Special Problems and Extended Applications . 75 3.1 Special Problems and Techniques .

For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.

For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.

For many years, Terri LeClercq's "Legal Writing" column in the Texas Bar Journal helped polish the prose of lawyers and law students, judges and clerks, paralegals, writing instructors, and legal secretaries. This book collects all the advice she has given in her columns into one authoritative guide for expert legal writing. LeClercq covers everything a legal writer needs to know, from the mechanics of grammar and punctuation to the finer points of style, organization, and clarity of meaning. With her practical, readable, and often humorous advice, those who prepare legal documents can rid their prose of mind-numbing "legalese" and write with the clarity and precision that characterize the very best legal writing.

Biz Jets: Technology and Market Structure in the Corporate Jet Aircraft Industry traces the development of business jet aircraft from the mid-1950s through early 1993. It begins with a discussion of the technological and market opportunities existing in the period prior to the introduction of the Lockheed JetStar and the North American Sabreliner. The subsequent appearances of other biz jets -- the Learjets, HS-125s, Jet Commanders, Falcons, Gulfstreams, Citations, Challengers, Mitsubishis and derivative aircraft are treated in considerable detail. Biz Jets also covers 'planes involved in many unsuccessful attempts to enter the industry from 1955 through 1993. The study shows that while the industry has been quite concentrated throughout its history, the positions of the leading firms have always been contestable. Indeed, leaders at one point in time have often been displaced by others who succeeded in marshalling technological and market opportunities to their advantage. Manufacturers have had to undertake continuous efforts to improve the price-performance characteristics of their aircraft to gain and hold their market shares. Rivalries in the effective use of the stream of new technologies have brought forth new aircraft with both better performance and lower operating costs. At the same time, however, participation in the market has been extremely risky. Only a few companies have been able to earn profits. Entries, exits and mergers have altered the structure of the industry, but it remained decidedly unstable at least through 1992.

Develop and harness a powerful, sustainable word-of-mouth movement

How did the 360-year-old scissor company, Fiskars, double its profit in key markets just by realizing its customers had already formed a community of avid scrapbookers? How is Best Buy planning to dominate the musical instruments market? By understanding the Brains on Fire model of tapping movements and stepping away from the old-school marketing "campaign" mentality.

Brains on Fire offers original, practical and actionable steps for creating a word-of-mouth movement for corporations, products, services, and organizations. It takes you step-by-step through the necessary actions needed to start your own authentic movement.Develop and harness a powerful, sustainable, word-of-mouth movementDescribes 10 lessons to master and create a powerful, sustainable movementThe Brains on Fire blog is often ranked in the top 100 of AdAge's Power 150 Marketing Blogs

Global Health continues to provide readers with a comprehensive, up-to-date and thought-provoking outline and understanding of the constantly evolving global health landscape. In this new edition the authors have maintained the successful structure and organisation of the previous edition to examine and explain recent health changes and consider likely future patterns. New or expanded topics covered include: emerging and re-emerging infectious disease threats increasing awareness of, and interest in, antimicrobial resistance and superbugs terrorism, global conflict and health the new UN 2030 Agenda for Sustainable Development the drive for Universal Health Coverage (UHC) the use of information technology in global health substance abuse palliative and end-of-life-care ethical issues in global health. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with discussion questions posed for readers at the end of each chapter. Readers will also be able to take advantage of the new website that was designed to complement this book. Global Health is essential reading for students and researchers of global health, public health and development studies.

Respected leader in Critical Care Medicine, Phillip Dellinger has complied a top-notch range of articles on the subject of Sepsis. Topics include: "The History of Sepsis," "Molecular Biology of Sepsis," "Sepsis Induced Tissue Hypoperfusion," "Hemodynamic Monitoring in Sepsis," "Performance Improvement in Sepsis," and more

Horror is one of the most enduringly popular genres in cinema. The term "horror film" was coined in 1931 between the premiere of Dracula and the release of Frankenstein, but monsters, ghosts, demons, and supernatural and horrific themes have been popular with American audiences since the emergence of novelty kinematographic attractions in the late 1890s. A Place of Darkness illuminates the prehistory of the horror genre by tracing the way horrific elements and stories were portrayed in films prior to the introduction of the term "horror film." Using a rhetorical approach that examines not only early films but also the promotional materials for them and critical responses to them, Kendall R. Phillips argues that the portrayal of horrific elements was enmeshed in broader social tensions around the emergence of American identity and, in turn, American cinema. He shows how early cinema linked monsters, ghosts, witches, and magicians with Old World superstitions and beliefs, in contrast to an American way of thinking that was pragmatic, reasonable, scientific, and progressive. Throughout the teens and twenties, Phillips finds, supernatural elements were almost always explained away as some hysterical mistake, humorous prank, or nefarious plot. The Great Depression of the 1930s, however, constituted a substantial upheaval in the system of American certainty and opened a space for the reemergence of Old World gothic within American popular discourse in the form of the horror genre, which has terrified and thrilled fans ever since.

Papers cover topics including: physical modelling facilities; experimental advances; seismic experimental advances; education; soil behaviour; offshore systems; cold regions; geoenvironment; dynamics; earthquake effects; and strategies for disaster reduction.

Cytochromes P450 (CYPs) comprise a large superfamily of proteins that are of central importance in the detoxification or activation of a tremendous number of natural and synthetic hydrophobic xenobiotics, including many therapeutic drugs, chemical carcinogens and environmental pollutants. CYPs are important in mediating interactions between an organism and its chemical environment and in the regulation of physiological processes. Cytochrome P450 Protocols, Third Edition focuses on high-throughput methods for the simultaneous analysis of multiple CYPs, substrates or ligands. Although the emphasis is on CYPs of mammalian origin, it reflects an increasing interest in CYPs of bacterial species. Also included are chapters on cytochrome P450 reductase (the redox partner of CYPs) and the flavin-containing monooxygenases (FMOs), and metabolomic and lipidomic approaches for identification of endogenous substrates of CYPs ('de-orphanizing' CYP substrates). Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cytochrome P450 Protocols, Third Edition provides a wide range of techniques accessible to researchers in fields as diverse as biochemistry, molecular biology, pharmacology, toxicology, environmental biology and genetics.

This is an authoritative account of the history and philosophy of the Islamic faith, shown in more than 300 photographs and fine-art illustrations. This is an insightful and accessible study of Islamic faith and Muslim life. It examines the essential principles of Islamic belief such as one God, the attributes of Allah, divine will, free will, the day of judgement, and heaven and hell. It includes a fascinating overview of the spiritual aspects of Islam, as well as its wider influence on social institutions, such as marriage, the family, businesses, courts and government. It describes the distinguishing features of the Sunni, Shia and Sufi denominations. It is stunningly illustrated with over 300 colour photographs, including magnificent fine-art paintings. Islam is a powerful force today, with Muslims representing around a quarter of the global population, some 1.4 billion people. It is one of the world's younger faiths, yet in its 1400-year history its impact has been astonishing and immense. The purpose of this book is to provide a refreshing and detailed guide to and insight into the beliefs and religious practices of the Islamic faith. The volume begins by exploring the theological beliefs and the ritual worship practices of Islam, such as the six articles of belief and the five pillars of faith. The life of a Muslim is then described, from the social interaction between people to the rules of dress for men and women. The final chapter reviews the unity and division amongst the worldwide Muslim community. Each chapter also includes special themed spreads, highlighting particular issues, people and places of importance to Islam. Lavishly illustrated with over 300 photographs and fine-art paintings, this superb book offers a factual account of Islamic beliefs and rituals, and provides a greater understanding of Islam and its teachings.