A vibrant and enchanting debut novel about an orphan girl who discovers a magical circus, perfect for fans of Kelly Barnhill and Rebecca Stead! Maddy Adriana knows that magic is real. All her life, her heart has pulled her towards things too perfect to be ordinary. One day, that tug leads her to a magical street circus, hidden in plain sight among the canals and boardwalks of Venice Beach. For the first time in Maddy's life, she finally feels like she belongs. But the circus is in grave danger. Maddy will need to confront the frightening side of magic, as well as her own deepest fears, if she's to have any hope of saving the place she dreams of calling home. This unforgettable debut shows readers the magic of following your heart and finding where you belong.

This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. * Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. * Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Major advances in instrumentation and technology have made high-performance liquid chromatography (HPLC) a pervasive tool in virtually all areas of chemical and biomedical research today. Despite HPLC's enormous growth, technical problems still bedevil most users at least occasionally. Based on their immensely successful short courses, Dolan and Snyder's landmark new book --Troubleshooting LC Systems--now makes available to every practicing chromatographer the authors' wealth of expertise from years of hands-on troubleshooting of real-world LC problems--problems that routinely cause crises and unproductive downtime in nearly every lab. Believing that successful troubleshooting requires an understanding of the basics, Dolan and Snyder open by setting forth all the fundamental principles of LC operation, then move on to a microscopic description of all the elements of LC devices, to lay out their optimal preventive maintenance routines, and ultimately to offer an unprecedentedly thorough treatment of each and every facet of troubleshooting.Displaying a special tutorial mastery--honed to a fineness during their ongoing teaching and consulting activities, and a well-received feature column in LC Magazine--the book's chapters cover: automation and robotics * approaches to troubleshooting * reactions of samples * basic separation techniques * valves, tubing, syringes * band broadening and tailing * preventive maintenance * column packing and flushing * individual LC modules * troubleshooting principles * reagents and buffering * specific problems in separation * ghost and vacancy peaks * quantitation and calibration * pumps, seals, and pistons * gradient elution problems * column composition * concentration and blockages * sample cleanup * temperature and mixing effects * detectors and recorders * column packing and flushing. In short, Dolan and Snyder's eminently practical new guide to Troubleshooting LC Systems is an essential laboratory handbook--one that empowers expert and novice chromatographer alike to solve every sort of practical laboratory problem on a day-to-day basis. No one using an LC system should be without it

Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non- enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed "biological reactive intermediates. " The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. De\aforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

This classic work has helped shape the field of international relations and especially influenced scholars interested in how foreign policy is made. At a time when conventional wisdom and traditional approaches are being questioned, and when there is increased interest in the importance of process, the insights of Snyder, Bruck and Sapin have continuing and increased relevance. Prescient in its focus on the effects on foreign policy of individuals and their preconceptions, organizations and their procedures, and cultures and their values, Foreign Policy Decision-Making is of continued relevance for anyone seeking to understand the ways foreign policy is made. Their seminal framework is here complemented by two new chapters examining its influence on generations of scholars, the current state of the field, and areas for future research.

Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non- enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed "biological reactive intermediates. " The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. De\aforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. * Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. * Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

The easy way to take charge of your adrenal health Despite their small size, the adrenal glands play an important role in the body, producing numerous hormones that impact our development and growth, affect our ability to deal with stress, and help to regulate kidney function. In Adrenal Fatigue For Dummies, you'll find clear self-evaluations and treatment guidelines that will empower you to take charge of your adrenal health through nutrition, vitamins, herbs, bioidentical adrenal hormone supplementation, and self-care practices. Adrenal fatigue is in essence a "tired out" adrenal gland that is not able to support the body the way that it should. The effects can be far-reaching and affect the quality of one's daily life. It can affect the immune system, cause inflammation, decrease sex drive, and inhibit the ability to get up in the morning. But now there's hope! * The 4-1-1 on the structure and function of the adrenal gland * Linking inflammation and adrenal fatigue * Connecting food allergy and adrenal issues * How to test for adrenal fatigue * Information on eating patterns for all-day energy and improved concentration * Dealing with other medical conditions and adrenal fatigue * Relaxation tips to reduce stress Adrenal Fatigue For Dummies helps those suffering from this debilitating illness reclaim their lives by addressing the delicate balance among the adrenal glands which can make the day-to-day difference between feeling awful and feeling good.

A vibrant and enchanting debut novel about an orphan girl who discovers a magical circus, perfect for fans of Kelly Barnhill and Rebecca Stead! Maddy Adriana knows that magic is real. All her life, her heart has pulled her towards things too perfect to be ordinary. One day, that tug leads her to a magical street circus, hidden in plain sight among the canals and boardwalks of Venice Beach. For the first time in Maddy's life, she finally feels like she belongs. But the circus is in grave danger. Maddy will need to confront the frightening side of magic, as well as her own deepest fears, if she's to have any hope of saving the place she dreams of calling home. This unforgettable debut shows readers the magic of following your heart and finding where you belong.

"Larvatus prodeo," announced Rene Descartes at the beginning of the seventeenth century: "I come forward, masked." Deliberately disguising or silencing their most intimate thoughts and emotions, many early modern Europeans besides Descartes-princes, courtiers, aristocrats and commoners alike-chose to practice the shadowy art of dissimulation. For men and women who could not risk revealing their inner lives to those around them, this art of incommunicativity was crucial, both personally and politically. Many writers and intellectuals sought to explain, expose, justify, or condemn the emergence of this new culture of secrecy, and from Naples to the Netherlands controversy swirled for two centuries around the powers and limits of dissimulation, whether in affairs of state or affairs of the heart. This beautifully written work crisscrosses Europe, with a special focus on Italy, to explore attitudes toward the art of dissimulation in the sixteenth and seventeenth centuries. Discussing many canonical and lesser-known works, Jon R. Snyder examines the treatment of dissimulation in early modern treatises and writings on the court, civility, moral philosophy, political theory, and in the visual arts.

While White parents raising Black children has become increasingly salient in the last 20?30 years, the experience of those who grow up in these cross?racial families is much more complicated. Indeed, much of the adoption studies literature has privileged White parent voices, further silencing crossracially raised Black?identified children. "Is That Your Mom?" challenges the dominant narrative that love trumps race (and racism) in family dynamics, and reasserts the need for critical voices of those most impacted by being cross?racially raised: the very people who face extreme racism that is both similar to, and uniquely different from, that faced by people of color more broadly. "Is That Your Mom?" centers the voices of Cross Racially Raised individuals of the African Diaspora to illustrate that racial socialization is a process in which individuals have agency in their racial development. In this book, Cross Racially Raised adults, both those who were adopted and those who were raised in cross?racial birth families, share their stories regarding experiences with racism in the following three ways: (1) encounters with racism within and beyond educational settings, (2) perceptions of parents or guardians' efforts toward racial socialization, and (3) strategies used to navigate racially hostile environments (which sometimes are the families themselves). The voices of the individuals in this book illuminate a deeper conceptual understanding of how racial socialization practices are linked with one's ability to cope with racism and ways of addressing racism, particularly among those families that contradict monoracial assumptions of racial socialization processes. The book concludes with a discussion of how schools, educators, and parents can help Cross Racially Raised children and youth develop skills necessary to cope and remain resilient in the face of racism, particularly if the immediate family is not offering those supports.

While White parents raising Black children has become increasingly salient in the last 20?30 years, the experience of those who grow up in these cross?racial families is much more complicated. Indeed, much of the adoption studies literature has privileged White parent voices, further silencing crossracially raised Black?identified children. "Is That Your Mom?" challenges the dominant narrative that love trumps race (and racism) in family dynamics, and reasserts the need for critical voices of those most impacted by being cross?racially raised: the very people who face extreme racism that is both similar to, and uniquely different from, that faced by people of color more broadly. "Is That Your Mom?" centers the voices of Cross Racially Raised individuals of the African Diaspora to illustrate that racial socialization is a process in which individuals have agency in their racial development. In this book, Cross Racially Raised adults, both those who were adopted and those who were raised in cross?racial birth families, share their stories regarding experiences with racism in the following three ways: (1) encounters with racism within and beyond educational settings, (2) perceptions of parents or guardians' efforts toward racial socialization, and (3) strategies used to navigate racially hostile environments (which sometimes are the families themselves). The voices of the individuals in this book illuminate a deeper conceptual understanding of how racial socialization practices are linked with one's ability to cope with racism and ways of addressing racism, particularly among those families that contradict monoracial assumptions of racial socialization processes. The book concludes with a discussion of how schools, educators, and parents can help Cross Racially Raised children and youth develop skills necessary to cope and remain resilient in the face of racism, particularly if the immediate family is not offering those supports.