Editors hope that Regenerative Biology of the Spine and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it can be held in hand and provide a broad survey of leading edge science. At the same time its chapters can be digitally acquired for those established in the field to refine particular knowledge interests or gaps. Most importantly, we ask the reader, whomever that may be, to peruse without prejudice as countless more chapters will have been written before total spinal regeneration is achieved.

In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the frontiers of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries.

In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology.

In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise."

A fascinating dive into the purpose and potential of dreams Dreaming is one of the most deeply misunderstood functions of the human brain. Yet recent science reveals that our very survival as a species has depended on it. This Is Why You Dream explores the landscape of our subconscious, showing why humans have retained the ability to dream across millennia and how we can now harness its wondrous powers in both our sleeping and waking lives. Dreaming fortifies our ability to regulate emotions. It processes and stores memories, amplifies creativity, and promotes learning. Dreams can even forecast future mental and physical ailments. Dreams can also be put to use. Tracing recent cutting-edge dream research and brain science, dual-trained neuroscientist and neurosurgeon Dr. Rahul Jandial shows how to use lucid dreaming to practice real-life skills, how to rewrite nightmares, what our dreams reveal about our deepest desires, and how to monitor dreams for signs of Parkinson's and Alzheimer's.  In the tradition of James Nestor's Breath and Matthew Walker's Why We Sleep, This Is Why You Dream opens the door to one of our oldest and most vital functions, and unlocks its potential to impact and radically improve our lives.

THE SUNDAY TIMES BESTSELLER *As heard on Chris Evans' Virgin Radio* 'You're amazing I could talk to you (Rahul) all day' Chris Evans 'This is a gripping new book' The Times World-leading neuroscientist and neurosurgeon Dr Rahul Jandial draws on his years of work with patients suffering from the most extreme cases of brain damage, disorders and illnesses to reveal what they can tell us about the science of the mind. From a languages teacher who has to choose whether to lose her ability to speak Spanish or English after brain surgery, to a former TV exec, now homeless, who discovers that his life-altering despondency is the result of a tumour, to a fainting teen who learns that deep breathing can mean the difference between life or death, these stories uncover the secret workings of the brain. Blending cutting-edge research and beautiful storytelling, Life Lessons from a Brain Surgeon is a vital resource on the best ways to boost your memory, control stress and emotions, minimize pain, unleash your creativity, raise smart kids and reduce the risk of Alzheimer's. This is a deeply practical and readable book, which will take you on an expedition through the anatomy of the most fascinating - and mysterious - of organs. Rahul's new book Life on a Knife's Edge is out now.

Editors hope that Regenerative Biology of the Spine and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it can be held in hand and provide a broad survey of leading edge science. At the same time its chapters can be digitally acquired for those established in the field to refine particular knowledge interests or gaps. Most importantly, we ask the reader, whomever that may be, to peruse without prejudice as countless more chapters will have been written before total spinal regeneration is achieved.

In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the frontiers of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries.

In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology.

In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise."

Get step-by-step, expert guidance on fundamental procedures in neurosurgery - both in print and on video. Core Techniques in Operative Neurosurgery, 2nd Edition, provides the tools needed to hone existing surgical skills and learn new techniques, helping you minimize risk and achieve optimal outcomes for every procedure. Led by Dr. Rahul Jandial, this concise reference offers quick access to the expertise and experience of the world's leading authorities in the field of neurosurgery. Presents consistent, easy-to-follow chapters that cover the indications and contraindications, pitfalls, tips and tricks from the experts, and more for each procedure. Covers minimally invasive spine techniques such as Thoracic Corpectomy and Minimally Invasive Direct Lateral Transpsoas Interbody Fusion. Includes new chapters on Microvascular Decompression and Brachial Plexus Injury Nerve Grafting and Transfers. Features procedural videos that summarize the key steps in neurosurgery. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

'It's a brilliant book... There are lessons in every paragraph... Get it now.' Chris Evans 'Wonderous and wild. I loved this book' James Nestor, bestselling author of Breath 'Moving, raw and unflinching' Julia Samuel, bestselling author of This Too Shall Pass 'Incredible storytelling' Dr Rangan Chatterjee, bestselling author of Feel Better in 5 ____________________________________________________________________________ How do you carry on when things go deadly wrong? When Dr Rahul Jandial operated on Karina, an eleven-year-old girl whose spinal cord was splitting in two, he had to make an impossible decision. He followed his head over his gut and Karina was left permanently paralysed, altering both patient and surgeon's lives for ever. This decision would haunt Rahul for decades, a constant reminder of the fine line between saving and damaging a life. As one of the world's leading brain surgeons, Rahul is the last hope for patients with extreme forms of cancer. In treating them, he has observed humanity at its most raw and most robust. He has journeyed to unimaginable extremes with them, guiding them through the darkest moments of their lives. Life on a Knife's Edge is Rahul's poetic and beautifully written account of the resilience, courage and belief he has witnessed in his patients, and the lessons about human nature he has learned from them. It is about the impossible choices he has to make, and the fateful consequences he is forced to live with. From challenging the ethics of surgical practices, to helping a patient with locked-in syndrome communicate her dying wish to her family, Rahul shares his extraordinary experiences, revealing the depths of a surgeon's psyche that is continuously pushed to its limits.

Whether you're a patient or loved one of someone suffering from a head or brain injury, this book offers help. The only text available to provide both the doctor's and patient's views, 100 Questions & Answers About Head and Brain Injuries offers practical and thorough medical information from which patients can gain insight into their injury and understand the variety of treatment options that exist. Written by an expert neurosurgeon, with commentary from actual patients, this is an invaluable resource for anyone struggling with the medical, physical, and emotional turmoil of a head or brain injury.

Empower Yourself! Whether you're a newly diagnosed patient, a survivor, or loved one of someone suffering from a spine disorder, this book offers help. The only text available to provide both the doctor's and patient's views, 100 Questions & Answers About Spine Disorders, provides practical, authoritative answers to 100 of the most common questions asked. Written with commentary from actual patients, this is an invaluable resource for anyone struggling with the medical, physical, and emotional turmoil of this disease. This book includes sections on: The healthy spine Spine tumors Spinal cord tumors Spine trauma and fractures Spine degenerative disease (disc herniation and canal narrowing) Scoliosis Spine surgery Spine surgery-minimally invasive Spine infections Pediatric spine diseases Pediatric scoliosis Pediatric spine surgery Non-surgical spine procedures (injections) Spine rehabilitation exercises

Best Evidence for Spine Surgery provides representative cases that help you determine the optimal surgical interventions for your patients. Drs. Rahul Jandial and Steven R. Garfin, and a balanced team of preeminent neurosurgeons and orthopaedists, address the trend toward a more collaborative approach between spine and orthopaedic surgery. This easy-to-read, evidence-based resource also features "Tips from the masters" for a quick review of important elements of diagnosis and treatment and online access at www.expertconsult.com with the fully searchable text, images, and a video library of procedures. Choose the best options for your patients using evidence that supports the optimal surgical intervention for each case. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image gallery and a video library demonstrating nuances of key techniques. Apply a multi-disciplinary approach through coverage that reflects the changing nature of the specialty with chapters written by neurosurgeons and orthopaedists. Quickly review the most important elements of diagnosis through "Tips from the masters." Easily find the information you need with a consistent, case-based format that clearly presents evidence and techniques. Best Evidence for Spine Surgery is the perfect resource for any surgeon interested in learning about the best evidence on cases for which there is debate regarding the surgical management. Information presented includes a thorough review of literature, technique, and cases as presented by preeminent spine surgeons. Information is presented from a balanced panel of orthopaedic and neurological surgeons, to articulate a collaborative approach that has been the natural evolution in the academic setting. This title presents a representative case and the evidence for the optimal surgical intervention for that case, within a format that makes the most important elements accessible and appealing.

Embarking on the first clinical rotation in a hospital is a daunting experience for clinicians, as textbook knowledge does not necessarily correlate with the know-how that is necessary "in the trenches" at the hospital. Whether you are a nurse tending to a central venous line or an intern inserting that line, Code Blue is an indispensable addition to your arsenal of emergency care knowledge. Put this handbook in your lab coat pocket and place the following information at your fingertips: Basics on body systems, diseases, and drugs Critical information for emergent procedures at the patient's bedside Information on treating cardiopulmonary emergencies Pearls and pitfalls for a wide range of conditions Needed supplies Important post-procedure checks Notes and orders, laboratory values, and equations you will refer to every day