In the rapidly-evolving landscape of neurosciences, it is no
easy task to select a limited array of topics to present in a text
such as this. The current volume takes as its purpose to provide a
representative survey of the current science of brain repair for
those seeking to establish a foundation in the field or to
replenish a prior knowledge base that may have lapsed in its
currency. It also hopes to offer insights into what remains elusive
to our collective investigations, defining the frontiers of brain
repair for those that are currently immersed in the exciting
intersection of biological advances and neuroscientific
In Chapter 1 the fundamentals of imaging transplanted cells is
discussed with emphasis on animal models as well as the horizon for
clinical trials. Then, detailed methods on the culture of neural
stem cells is reviewed as a foundation for approaching therapeutic
goals. Chapter 3 presents the broad scope of animal models that
serve as the foundation for developmental and pre-clinical
investigation, with mention of recent genetically engineered mouse
models that represent the best models for studying disease
development and treatment. Chapter 4 provides background on the
delivery techniques to animals and patients that are available,
providing vital information on the subtleties of technique
necessary for optimal cellular grafting. Chapters 5 and 6 discuss
new and evolving information on the origins of brain tumors and the
indelible role of stromal and microenvironmental influences on
oncogenesis and tumor progression. Subsequently, the utility of
neural stem cells as cellular vehicles to deliver chemotherapeutics
to broad neuropathology is reviewed. In Chapter 8 the scope of
treating brain tumors is expanded beyond stem cells, to present the
best biological interventions to improve upon current treatment
options for brain malignancy. The last two chapters present a
comprehensive review on stem cell and gene therapy options for
treating cerebrovascular and neurovascular pathology.
In amassing this collection, my intention has been to provide
the reader with a broad introduction into molecular imaging, stem
cell biology, cell therapy, animal models, central nervous system
malignancies, stroke, and neurodegeneration. My hope is that
Frontiers of Brain Repair will be the intellectual soil from which
a deeply rooted and well-nourished vintage of neuroscience will
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