The objective of this study was to optimize a periodontal drug delivery system containing antibacterial drugs having synergistic activity for the treatment of mixed periodontal infections. Periodontal pockets provide natural reservoir bathed by gingival crevicular fluid that is easily accessible for the insertion of a delivery device. Controlled release delivery of antimicrobials directly into periodontal pockets has received great interest and appears to hold a sound promise in periodontal therapy. Both topical drug delivery and controlled drug release have been termed as local drug delivery. It does not substitute the local instrumentation but acts as an adjunct to it. The periodic use of local drug delivery in minimizing bleeding, stabilizing attachment levels and thereby reducing probing depth, would allow better control and management of periodontal disease. Various drugs have been under investigation for more than 3 decades promising encouraging results. The rationales of using antibacterial drugs through local delivery into the periodontal pockets have been discussed.

The method has also been developed for dissolution of antidiabetic drugs. Initially the solubility was determined in different dissolution media. The dissolution study of drugs was performed in 7.8 pH phosphate buffer in which these two drugs shows highest solubility. The dissolution was performed in pH 2.0 medium. The dissolution study was performed using Paddle with sinkers at 75 rpm. The amount of drugs were estimated.

Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2)

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I, II, III, IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubili