Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of existing applications in health and disease as well as potential future directions of microbiome modulations and subsequent translation to the global industry and market. This important reference provides the most current status of microbiome therapeutics as well as possible future perspectives through coverage of topics including the application of microbiome therapeutics; various additive, subtractive and modulatory approaches; microbiome composition of health and diseases, insights into live bio-therapeutics and the clinical data supporting their efficacy. Case studies are provided throughout the book to further define, describe and evaluate microbiome therapeutics success and failure.

The book will provide a fundamental understanding of engineering properties of agricultural produce and the knowledge of engineering properties are combined with agriculture. Each chapter in the book will be helpful for the students to understand the relationship between engineering properties of raw, semi-finished and processed food to obtain products with desired shelf-life and quality. This book discusses basic definitions, principles of engineering properties and their measurement methods with research findings. It will be helpful to the students for their self-study and to gain information how to analyze experimental data to generate practical information. It will also be helpful for students who deal with engineering properties in their research. Methods to measure these properties are also explained in details. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka. This title is co-published with New India Publishing Agency.

Adopt an effortless approach to avoid the hassles of complex concurrency and scaling patterns when building distributed applications in .NET Key Features Explore the Orleans cross-platform framework for building robust, scalable, and distributed applications Handle concurrency, fault tolerance, and resource management without complex programming patterns Work with essential components such as grains and silos to write scalable programs with ease Book DescriptionBuilding distributed applications in this modern era can be a tedious task as customers expect high availability, high performance, and improved resilience. With the help of this book, you'll discover how you can harness the power of Microsoft Orleans to build impressive distributed applications. Distributed .NET with Microsoft Orleans will demonstrate how to leverage Orleans to build highly scalable distributed applications step by step in the least possible time and with minimum effort. You'll explore some of the key concepts of Microsoft Orleans, including the Orleans programming model, runtime, virtual actors, hosting, and deployment. As you advance, you'll become well-versed with important Orleans assets such as grains, silos, timers, and persistence. Throughout the book, you'll create a distributed application by adding key components to the application as you progress through each chapter and explore them in detail. By the end of this book, you'll have developed the confidence and skills required to build distributed applications using Microsoft Orleans and deploy them in Microsoft Azure. What you will learn Get to grips with the different cloud architecture patterns that can be leveraged for building distributed applications Manage state and build a custom storage provider Explore Orleans key design patterns and understand when to reuse them Work with different classes that are created by code generators in the Orleans framework Write unit tests for Orleans grains and silos and create mocks for different parts of the system Overcome traditional challenges of latency and scalability while building distributed applications Who this book is forThis book is for .NET developers and software architects looking for a simplified guide for creating distributed applications, without worrying about complex programming patterns. Intermediate web developers who want to build highly scalable distributed applications will also find this book useful. A basic understanding of .NET Classic or .NET Core with C# and Azure will be helpful.

A comprehensive guide to every important component of C# and .NET 6 required to build robust enterprise web applications Key Features * Explore the advanced features of C# and .NET 6 to enhance your code and productivity * Follow clear and easy instructions for building an end-to-end enterprise application * Learn how to build scalable web applications and host them on the cloud Book Description Building production-ready enterprise applications can be a challenging task due to the overabundance of tools and their different versions that make app development complex. This book simplifies the process with an end-to-end road map for building enterprise applications from scratch using the latest features of .NET Core 6 and C# 10. Throughout the book, you'll work on creating an enterprise app, adding a key component to the app with each chapter, before ?nally getting it ready for testing and deployment. You'll learn concepts relating to advanced data structures, the Entity Framework Core, parallel programming, and dependency injection. As you progress, you'll cover various authentication and authorization schemes provided by .NET Core to make your apps and APIs secure. The book then shows you how the latest Microsoft Visual Studio and C# 10 help you simplify developer tasks and shares tips and tricks in Visual Studio to improve your productivity. You'll discover various testing techniques, such as unit testing and performance testing, as well as di?erent methods to deploy enterprise apps. By the end of this book, you'll be able to create enterprise apps using the powerful features of .NET 6 and deploy them to the cloud while working with various cloud components using Azure. What you will learn * Design enterprise apps by making the most of the latest features of .NET 6 * Discover di?erent layers of an app, such as the data layer, API layer, and web layer * Explore end-to-end architecture by implementing an enterprise web app using .NET and C# 10 and deploying it on Azure * Focus on the core concepts of web application development and implement them in .NET 6 * Integrate the new .NET 6 health and performance check APIs into your app * Explore MAUI and build an application targeting multiple platforms - Android, iOS, and Windows Who This Book Is For If you are a developer, architect, or senior programmer, this book will show you how to leverage the features of .NET 6 and the C# language, as well as help you grasp essential techniques to build your skills.

Become a professional .NET developer by learning expert techniques for building enterprise-grade applications Key Features Explore the advanced features of C# and .NET 5 to enhance your code and productivity Follow clear and easy instructions for building an end-to-end enterprise application Learn how to build scalable web applications and host them on the cloud Book Description.NET Core is one of the most popular programming platforms in the world for an increasingly large community of developers thanks to its excellent cross-platform support. This book will show you how to confidently use the features of .NET 5 with C# 9 to build robust enterprise applications. Throughout the book, you'll work on creating an enterprise app and adding a key component to the app with each chapter, before ?nally getting it ready for testing and deployment. You'll learn concepts relating to advanced data structures, the Entity Framework Core, parallel programming, and dependency injection. As you progress, you'll cover various authentication and authorization schemes provided by .NET Core to make your apps and APIs secure. Next, you'll build web apps using ASP.NET Core 5 and deploy them on the cloud while working with various cloud components using Azure. The book then shows you how to use the latest Microsoft Visual Studio 2019 and C# 9 to simplify developer tasks, and also explores tips and tricks in Visual Studio 2019 to improve your productivity. Later, you'll discover various testing techniques such as unit testing and performance testing as well as di?erent methods to deploy enterprise apps. By the end of this book, you'll be able to create enterprise apps using the powerful features of .NET 5 and deploy them on the cloud. What you will learn Design enterprise apps by making the most of the latest features of .NET 5 Discover di?erent layers of an app, such as the data layer, API layer, and web layer Explore end-to-end architecture, implement an enterprise web app using .NET and C# 9, and deploy the app on Azure Focus on the core concepts of web application development such as dependency injection, caching, logging, con?guration, and authentication, and implement them in .NET 5 Integrate the new .NET 5 health and performance check APIs with your app Understand how .NET 5 works and contribute to the .NET 5 platform Who this book is forIf you are a developer, architect, or senior programmer who wants to leverage the features of .NET 5 and the C# language, as well as grasp essential techniques to build your skills, then this C# .NET 5 book is for you. Beginner to intermediate-level knowledge of the .NET framework and C# programming is required to understand the concepts covered in this book more effectively.

Metformin matrix and gastro retentive tablets formulations were prepared with different compositions. Finally, one optimized formula for each, matrix and gastro retentive, were selected and studied in detail. The effect of formulation variables namely, process of manufacturing, different excipients, different polymers, and concentration of polymer were studied. Metformin release was inversely proportional to the polymer concentration. Drug release from the developed formulations was independent of pH of the release medium but dependent on the agitational intensity, hardness of tablet, and surface area of tablet. Metformin release from both developed matrix and gastro retentive formulations follows first order. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.

This study was to investigate the effect of formulation variables like Microcrystalline cellulose (MCC), Lactose, Dicalcium phosphate dihydrate (DCPD), Starch 1500, Pearlitol 200sd etc. which are widely used tabeleting excipients. These diluents were used individually and in combination with MCC. Binders like Hydroxypropyl cellulose (HPC-sL), Polyvinylpyrrrolidone-K 30, were used to study their effect on pellet properties. The pellets prepared were analyzed for the properties like their shape (aspect ratio), size distribution, smoothness, bulk density, tapped density, car index, hausner ratio, Loss on drying and yield.

Amlodipine used as an anti-hypertensive and in the treatment of angina. FDT of amlodipine besylate were prepared using different superdisintegrants by direct compression method. Mannitol was used as a diluent. Aspartame and Acesulfame Potassium were used for unpleasant taste masked from the amlodipine by cosifting and serial of blending with other excipients. The mixed final blend was then compressed into tablets. The formulations were evaluated for weight variation, hardness, friability, wetting time, disintegrating time, dissolution, taste evaluation study and in vitro dispersion time.

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Albendazole, an anthelmintic drug, using different polymers and to optimize the best formulation. Different excipients were tested for their compatibility with Albendazole by the FTIR studies. Present study has demonstrated the successful utilization of technique of FT IR to assesst he compatibility of Albendazole with the excipients used in the development of floating drug delivery system of Albendazole. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Albendazole which were then used in the preparation of Albendazole floating tablets. Albendazole tablets were prepared by wet granulation technique using HPMC, HPMC K4M and chitosan as polymers, stearic acid, citric acid, lactose and gas generating agent such as sodium bicarbonate were taken as independent variables. It was then evaluated by using USP-II (Paddle) apparatus containing 0.1 N HCl as a dissolution media. The release mechanisms of Albendazole from floating tablet were evaluated by the n value of Krosmeyer Peppas model.

Fixed Point Theory is a beautiful mixture of analysis (pure and applied), topology and geometry. Fixed point theorems give the conditions under which mappings (single or multivalued) have solutions. The fixed point theory in probabilistic metric spaces is useful in the study of existence of solutions of operator equations in probabilistic metric space and probabilistic functional analysis, which is a very dynamic area of mathematical research. The notion of a probabilistic metric space corresponds to the situations when we do not know exactly the distance between two points; we know only probabilities of possible values of this distance. This book contains six chapters. New fixed point theorems for contraction mappings, expansion mappings, probabilistic densifying mappings are obtained in Menger spaces. Also related fixed point theorems in Menger spaces and applications of fixed point theorems are studied. This book will help the researchers studying fixed point theory.

In this study, controlled release matrix tablets containing cephelexin were prepared using HPMC15 cps and Eudragit L100 in different concentration by Direct compression method. Tablets were evaluated for physical properties, Hardness, friability, weight variation and In vitro dissolution study was carried on USP II apparetus (peddle type). The best formulations selected based on above parameters were subjected for Extend release study with use of different ratio of polymer as Eudragit and HPMC .The tablets with Eudragit were found to release drug for longer duration of time as compared to formulations containing HPMC. The drug release from the tablets was sufficiently sustained.

In a majority-minority framework, study provides analysis of various models and approaches adopted by the ruling elite aiming at nation-building in post-colonial India. Author argues that Sikh ethno-nationalism was a reaction to/ or the product of flawed and erroneous approach at nation-forging that was pursued by the people in power. Neighbouring state Pakistan having hostile relations with India provided support to the Sikh ethnic uprisings for its own strategic gains but had no territorial ambitions as are in case of Kashmir. Moreover, Pakistan was not responsible for the origin of Sikh ethnic uprisings. It only tried to exploit the situation when it originated due to the domestic political milieu in India. Sikh diaspora also participated in its kindred-community's movement while internationalizing the issue of Khalistan, raising the question of human rights abuses along with providing diverse types of moral & material support. Thus, this book is useful for academicians, statesmen, researchers, students and general readers to understand the Indian ruling elite's approach at nation-building in general and Sikh ethno-nationalism in particular.