The objective of this research work was to formulate and evaluate the floating drug delivery system containing Albendazole, an anthelmintic drug, using different polymers and to optimize the best formulation. Different excipients were tested for their compatibility with Albendazole by the FTIR studies. Present study has demonstrated the successful utilization of technique of FT IR to assesst he compatibility of Albendazole with the excipients used in the development of floating drug delivery system of Albendazole. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Albendazole which were then used in the preparation of Albendazole floating tablets. Albendazole tablets were prepared by wet granulation technique using HPMC, HPMC K4M and chitosan as polymers, stearic acid, citric acid, lactose and gas generating agent such as sodium bicarbonate were taken as independent variables. It was then evaluated by using USP-II (Paddle) apparatus containing 0.1 N HCl as a dissolution media. The release mechanisms of Albendazole from floating tablet were evaluated by the n value of Krosmeyer Peppas model.

This study was to investigate the effect of formulation variables like Microcrystalline cellulose (MCC), Lactose, Dicalcium phosphate dihydrate (DCPD), Starch 1500, Pearlitol 200sd etc. which are widely used tabeleting excipients. These diluents were used individually and in combination with MCC. Binders like Hydroxypropyl cellulose (HPC-sL), Polyvinylpyrrrolidone-K 30, were used to study their effect on pellet properties. The pellets prepared were analyzed for the properties like their shape (aspect ratio), size distribution, smoothness, bulk density, tapped density, car index, hausner ratio, Loss on drying and yield.

Metformin matrix and gastro retentive tablets formulations were prepared with different compositions. Finally, one optimized formula for each, matrix and gastro retentive, were selected and studied in detail. The effect of formulation variables namely, process of manufacturing, different excipients, different polymers, and concentration of polymer were studied. Metformin release was inversely proportional to the polymer concentration. Drug release from the developed formulations was independent of pH of the release medium but dependent on the agitational intensity, hardness of tablet, and surface area of tablet. Metformin release from both developed matrix and gastro retentive formulations follows first order. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.

Amlodipine used as an anti-hypertensive and in the treatment of angina. FDT of amlodipine besylate were prepared using different superdisintegrants by direct compression method. Mannitol was used as a diluent. Aspartame and Acesulfame Potassium were used for unpleasant taste masked from the amlodipine by cosifting and serial of blending with other excipients. The mixed final blend was then compressed into tablets. The formulations were evaluated for weight variation, hardness, friability, wetting time, disintegrating time, dissolution, taste evaluation study and in vitro dispersion time.

In this study, controlled release matrix tablets containing cephelexin were prepared using HPMC15 cps and Eudragit L100 in different concentration by Direct compression method. Tablets were evaluated for physical properties, Hardness, friability, weight variation and In vitro dissolution study was carried on USP II apparetus (peddle type). The best formulations selected based on above parameters were subjected for Extend release study with use of different ratio of polymer as Eudragit and HPMC .The tablets with Eudragit were found to release drug for longer duration of time as compared to formulations containing HPMC. The drug release from the tablets was sufficiently sustained.