Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Across rural America there are disruptive leaders who are finding the courage to ignite their small local communities with creativity, ingenuity, scrappiness, and collaboration despite political, racial, or religious differences. By combining skills, experience, and culture heritage, they are successfully igniting their own creative economies. Many of these communities are providing products and services to much larger urban areas and are thriving in international trade. In addition, they have capitalized their own unique cultural heritage and have developed a bustling tourism industry. All have developed events, public art, fine arts, music, theater, and technology to create a modern new local enlightenment. Developing Creative Economy Through Disruptive Leadership: Emerging Research and Opportunities is a collection of innovative research that explores strategies for reinventing and rebuilding creative economies. While highlighting topics such as entrepreneurism, social media, and branding, the research within this book is based on the interviews and analysis of fifteen state agencies that are a mixture of rural, semi-urban, and urban, and are all quite different in culture and diversity. This publication is ideally designed for community leaders, government officials, policymakers, entrepreneurs, educators, researchers, academicians, and students.

will appeal to researchers, instructors, and applied practitioners interested in human-animal interactions extends our understanding of the contexts in which humans and animals interact shares considerations for applied programming and implementation including how to create virtual human-animal content the book is anchored in seminal and just-published findings from the field of human-animal interactions shares new quantitative and qualitative findings attesting to the efficacy of virtual human-animal interactions

will appeal to researchers, instructors, and applied practitioners interested in human-animal interactions extends our understanding of the contexts in which humans and animals interact shares considerations for applied programming and implementation including how to create virtual human-animal content the book is anchored in seminal and just-published findings from the field of human-animal interactions shares new quantitative and qualitative findings attesting to the efficacy of virtual human-animal interactions

An original retelling of a classic Taoist tale. Once upon a time, there was a tiny grain of sand. Its life was rather boring, until one day it made a wish. Suddenly the grain of sand found out what it might be like to be something else – but is the grass always greener? This rendition of a classic fable tackles an age-old question: how can you be happy with your lot in a world full of temptation? With bold, contemporary illustrations and a rhythmic and witty text, this book is funny, lively and wise.

It's been two decades since the fall of apartheid, a quarter century since the liberation of Eastern European states, five decades since the death of American "Jim Crow," and seventy-plus years since the beginning of the emancipation of the African states. Freedom has advanced, yet there are some Black people in South Africa, the United States, and other parts around the globe who question if it has advanced far enough and are embittered.

I am a Black woman born to the racist apartheid regime of South Africa. My family suffered the slights of apartheid--petty and grand-as well as the poverty, degradation, street violence, lack of opportunity, and other ills of the system. In telling my story, as well as the stories of some of my friends and teachers, I share my perspective on the issues I have grappled with-including choice, identity, forgiveness, and humanity--with those who are wrestling with similar issues in the United States, my adopted home country, and in South Africa, the country of my birth. Deprivation and marginalization are, after all, as hurtful and debilitating in inner city Baltimore as they are in Soweto, and making a deliberate decision to move forward in the face of either, or both, is always powerful, no matter what your address or particular circumstances.

Lindi was born in Soweto to anti-apartheid activist forebears. Her dad was murdered and her paternal granddad exiled as part of the struggle. Lindi's maternal granddad fought for the dignity of the oppressed, while her female forebears taught her the importance of making good lifestyle choices. Lindi earned four degrees from the University of the Witwatersrand and Boston University, is qualified as an attorney in South Africa, and is a finance professional at Amazon's headquarters in Seattle.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

This second edition of the Transesophageal Echocardiography Multimedia Manual is a comprehensive resource and essential guide to the rapidly expanding field of perioperative transesophageal echocardiography (TEE), encompassing newer cardiac surgery techniques, more diverse surgical procedures, and use in the intensive care unit. With over 900 figures, this well-illustrated manual and its accompanying videos and self-test questions demonstrate new developments and challenges for the anesthesiologist, cardiologist, cardiac surgeon, critical care physician, and those interested in perioperative TEE. The accompanying downloads present two-dimensional examples in their original video format accompanied by sketches, three-dimensional orientation, Doppler-related information, and hemodynamic, radiologic, and anatomical correlation to assist the user visualize the dynamic process of transesophageal echocardiography. New to this edition! Now in full-color with over 800 pages of content, including six new chapters covering new minimally invasive cardiac surgical techniques, non-cardiac surgery, and complementary imaging techniques such as three-dimensional echocardiography plus updates to all existing chapters Over 900 high-resolution images to illustrate the advancement of echocardiography technology Companion downloads showcase over 1000 videos of 2-dimensional examples accompanied by 3-dimension orientation providing an interpretation of results, plus over 140 self-test questions Expert perspectives from over 85 renowned and experienced anesthesiologists, cardiologists, cardiac surgeons, and critical care physicians from five countries

Peruse the postcard-like pages to discover cultural treasures, amazing architecture and key landmarks of magnificent cities around the globe, including New York, Rome, London, Sydney, Montreal, Athens, Nairobi, Mumbai, Tokyo, Istanbul and many more. As well as iconic buildings - The Empire State Building, the Eiffel Tower, The Sydney Opera House, La Sagrada Familia - Metropolis delves into food and culture, sport and tradition. Benoit Tardif's stunning, graphic artwork makes this a truly colourful celebration of the cities of our multicoloured, multi-cultural world.

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.

Chronic oxidative stress is associated with the aging process and often leads to the development of disorders such as cancer and arterial disease. Cardiovascular conditions in which oxidation damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive heart failure. Antioxidants and Cardiovascular Disease, Second Edition covers three major topics: 1) the first seven chapters review the oxidative modifcation hypothesis and its close relationship to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the next four chapters describe the different compounds, nutrients and supplements with antioxidant properties and their mechanisms of action; 3) and finallly, the last ten chapters discuss the potential benefits of antioxidants in overall cardiovascular prevention, including hypertension, diabetes mellitus, dyslipidemias, and in the treatment and prevention of specific conditions such as chronic coronary artery disease, restenosis after percutaneous coronary intervention, and chronic heart failure. Antioxidants and Cardiovascular Disease, Second Edition is written by recognized experts in the fields of atherosclerosis, heart failure and antioxidants. It should be of interest to medical students and fellows, researchers, and practicing physicians. There has been rapid progress in our knowledge in this field during the last two to three years. Thus the current reedition appears timely. For instance, this second edition captures several recently reported and published clinical trials as welll as new information on diabetic and hypertensive cardiovascular disease.

Generation of oxidants or reactive oxygen species is a natural process of human biology. Mitochondrial respiration, phagocytic activity and cyclooxygenase activation are all essential processes of life, which also generate oxidative species. In humans, chronic oxidative stress often coupled with deficiency of antioxidant defenses is associated with the aging process and can lead to the development of disorders such as cancer and arterial disease. Major cardiovascular conditions in which oxidative damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis and congestive heart failure. Compelling evidence points to oxidative stress as an important trigger in the complex chain of events leading to atherosclerosis. The expression of chemotactic factors and adhesion molecules is modified by oxidative stress. Exposure to superoxide ions activates the NF-kappa B regulatory complex and triggers the transcription of several atherosclerosis related genes. These events lead to the accumulation of macrophages in the arterial wall. Macrophages avidly incorporate oxidized low-density lipoproteins (LDL) to form foam cells. The activity of matrix metalloproteinases is also regulated by oxidative stress. This activity appears to be closely coupled with smooth muscle cell activation and migration. Matrix metalloproteinases have also been implicated in the pathophysiology of plaque rupture. Antioxidant supplementation including vitamin E decreases susceptibility ofLDL to oxidation and retards the progression of atherosclerosis in animal models.

Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Chronic oxidative stress is associated with the aging process and often leads to the development of disorders such as cancer and arterial disease. Cardiovascular conditions in which oxidation damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive heart failure.

Antioxidants and Cardiovascular Disease, Second Edition covers three major topics: 1) the first seven chapters review the oxidative modifcation hypothesis and its close relationship to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the next four chapters describe the different compounds, nutrients and supplements with antioxidant properties and their mechanisms of action; 3) and finallly, the last ten chapters discuss the potential benefits of antioxidants in overall cardiovascular prevention, including hypertension, diabetes mellitus, dyslipidemias, and in the treatment and prevention of specific conditions such as chronic coronary artery disease, restenosis after percutaneous coronary intervention, and chronic heart failure.

Antioxidants and Cardiovascular Disease, Second Edition is written by recognized experts in the fields of atherosclerosis, heart failure and antioxidants. It should be of interest to medical students and fellows, researchers, and practicing physicians.

There has been rapid progress in our knowledge in this field during the last two to three years. Thus the current reedition appears timely. For instance, this second edition captures several recently reported and published clinical trials as welll as new information on diabetic and hypertensive cardiovascular disease.

Kids are under a lot of pressure to fit in. Sometimes bowing to this pressure forces them to betray their own ideas of what is right and wrong. Alexandra and Jenny have been best friends for a long time, but when Alexandra is dazzled by a glamorous new girl at school, she's willing to do almost anything to be the cool girl's friend, including first shunning Jenny and then revealing Jenny's biggest, most important secret. Seeing the hurt she has caused and realizing how bad it feels to lose her best friend, Alexandra then seeks a way to regain the relationship that means far more to her than being invited to sit with the popular girls. Ultimately, she and Jenny write down the rules that will cement their friendship forever. OUR FRIENDSHIP RULES is both a lyrical story of forgiveness and a guidebook on relationships. Author Peggy Moss employs her training as a mediator and communication expert to provide a simple, sweet but instructive tale of how to get along. The evocative collage-paintings of Alissa Imre Geis further illustrate the many layers of personality. Her Alexandra will amaze you with her artistic eye, and her Jenny will make you smile with her practical sensibility as you see these best friends reconnect with the help of their friendship rules. Fountas & Pinnell Level O

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism.