Antioxidants and Cardiovascular Disease (Paperback, Softcover reprint of the original 1st ed. 2000)

Generation of oxidants or reactive oxygen species is a natural process of human biology. Mitochondrial respiration, phagocytic activity and cyclooxygenase activation are all essential processes of life, which also generate oxidative species. In humans, chronic oxidative stress often coupled with deficiency of antioxidant defenses is associated with the aging process and can lead to the development of disorders such as cancer and arterial disease. Major cardiovascular conditions in which oxidative damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis and congestive heart failure. Compelling evidence points to oxidative stress as an important trigger in the complex chain of events leading to atherosclerosis. The expression of chemotactic factors and adhesion molecules is modified by oxidative stress. Exposure to superoxide ions activates the NF-kappa B regulatory complex and triggers the transcription of several atherosclerosis related genes. These events lead to the accumulation of macrophages in the arterial wall. Macrophages avidly incorporate oxidized low-density lipoproteins (LDL) to form foam cells. The activity of matrix metalloproteinases is also regulated by oxidative stress. This activity appears to be closely coupled with smooth muscle cell activation and migration. Matrix metalloproteinases have also been implicated in the pathophysiology of plaque rupture. Antioxidant supplementation including vitamin E decreases susceptibility ofLDL to oxidation and retards the progression of atherosclerosis in animal models.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Developments in Cardiovascular Medicine, 233
Release date:	October 2012
First published:	2000
Editors:	J. C. Tardif • Martial G. Bourassa
Dimensions:	240 x 160 x 15mm (L x W x T)
Format:	Paperback
Pages:	258
Edition:	Softcover reprint of the original 1st ed. 2000
ISBN-13:	978-9401058810
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Medicine > General issues > Public health & preventive medicine > Epidemiology & medical statistics Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	9401058814
Barcode:	9789401058810

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