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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Antioxidants and Cardiovascular Disease (Paperback, Softcover reprint of the original 1st ed. 2000)
Loot Price: R2,872
Discovery Miles 28 720
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Antioxidants and Cardiovascular Disease (Paperback, Softcover reprint of the original 1st ed. 2000)
Series: Developments in Cardiovascular Medicine, 233
Expected to ship within 10 - 15 working days
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Generation of oxidants or reactive oxygen species is a natural
process of human biology. Mitochondrial respiration, phagocytic
activity and cyclooxygenase activation are all essential processes
of life, which also generate oxidative species. In humans, chronic
oxidative stress often coupled with deficiency of antioxidant
defenses is associated with the aging process and can lead to the
development of disorders such as cancer and arterial disease. Major
cardiovascular conditions in which oxidative damage has been
strongly implicated include atherosclerosis, myocardial ischemia
and reperfusion, coronary restenosis and congestive heart failure.
Compelling evidence points to oxidative stress as an important
trigger in the complex chain of events leading to atherosclerosis.
The expression of chemotactic factors and adhesion molecules is
modified by oxidative stress. Exposure to superoxide ions activates
the NF-kappa B regulatory complex and triggers the transcription of
several atherosclerosis related genes. These events lead to the
accumulation of macrophages in the arterial wall. Macrophages
avidly incorporate oxidized low-density lipoproteins (LDL) to form
foam cells. The activity of matrix metalloproteinases is also
regulated by oxidative stress. This activity appears to be closely
coupled with smooth muscle cell activation and migration. Matrix
metalloproteinases have also been implicated in the pathophysiology
of plaque rupture. Antioxidant supplementation including vitamin E
decreases susceptibility ofLDL to oxidation and retards the
progression of atherosclerosis in animal models.
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