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The Baboon in Biomedical Research (Paperback, Softcover reprint of hardcover 1st ed. 2009)
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The Baboon in Biomedical Research (Paperback, Softcover reprint of hardcover 1st ed. 2009)
Series: Developments in Primatology: Progress and Prospects
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Nonhuman primates have played critical roles in biomedical
research, and they are among the few animals whose use in research
continues to increase. The scienti?c value of nonhuman primates
derives from their close phylogenetic proximity to man and their
consequent anatomic, physiologic, and genetic similarities to man.
Only nonhuman primates can provide adequate models for many complex
physiological and disease processes of humans. The baboon is a
relative newcomer to the repertoire of nonhuman primates used in
biomedical research. However, in less than 50 years since its ?rst
use in the U. S. , it has become one of the most popular laboratory
primate species. It is larger than the other widely used monkey
species, making it advantageous for many types of experiments and
technological developments. It is extraordinarily hardy and highly
fecund in captivity. It closely resembles humans in a variety of
physiological and disease processes, such as cholesterol
metabolism, early stages of atherosclerosis, and alcoholic liver
disease. Its chromosomes closely resemble those of humans, and many
genes of the two species lie in the same chromosomal order. Among
all primates, baboons are the most widely used models for the
genetics of susceptibility to complex diseases and they are the
?rst nonhuman primate for which a framework genetic linkage map was
established. In addition, the baboon genome is currently being
sequenced, and as a result the utility of this species for
biomedical research will be dramatically increased.
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