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Cell-cell adhesion is fundamental for the development and
homeostasis of animal tissues and organs. Adherens junctions (AJs)
are the best understood cell-cell adhesion complexes. In this
volume, internationally recognized experts review AJ biology over a
wide range of organization; from atoms to molecules, to protein
complexes, molecular networks, cells, tissues, and overall animal
development. AJs have also been an integral part of animal
evolution, and play central roles in cancer development, pathogen
infection and other diseases. This book addresses major questions
encompassing AJ biology. - How did AJs evolve? - How do cadherins
and catenins interact to assemble AJs and mediate adhesion? - How
do AJs interface with other cellular machinery to couple adhesion
with the whole cell? - How do AJs affect cell behaviour and
multicellular development? - How can abnormal AJ activity lead to
disease? Valuable for both newcomers and experts in the field, this
book offers a comprehensive resource for the research laboratory
and a teaching tool for advanced undergraduate and graduate courses
in cell and developmental biology.
Much more than just a tale of sailing against mountainous seas, but
a book with every aspect of sailing and motor boating, in many
parts of the world. It illustrates how times have changed to the
extent the stories are never to be repeated. Providing a more
permanent record, it tells how in post-war Britain, we developed a
system of teaching and testing recreational users of marine craft
of every description. This has now been copied in almost every
country with recreational waterborne sports, including a UK
approved sailing school in the USA. If all that sounds a mighty bit
boring, be assured it has ten most unusual stories with excitement,
including projects in China and Nigeria. There are tales of
law-breaking villains afloat, and you won't want to put the book
down. Looking for a present for a sea-loving friend? Look no
further.
When Jack Knight is forced to pick up the Starman's Cosmic Rod, he
finds himself flung into a life he never wanted for himself...but
it just might be his destiny! Watch Starman go up against The Mist,
The Shade, and even Captain Marvel! Starman Compendium One
collects: Starman #0-42, Starman 80-Page Giant #1, Starman Annual
#1, Starman Annual #2, Starman Secret Files #1, Showcase '95 #12,
Showcase '96 #4, Showcase '96 #5, The Power of Shazam! #35, The
Power of Shazam! #36, and The Shade #1-4.
Cornelius Cardew is an enigma. Depending on which sources one
consults he is either an influential and iconic figure of British
musical culture or a marginal curiosity, a footnote to a misguided
musical phenomenon. He is both praised for his uncompromising
commitment to world-changing politics, and mocked for being blindly
caught up in a maelstrom of naA-ve political folly. His works are
both widely lauded as landmark achievements of the British
avant-garde and ridiculed as an archaic and irrelevant footnote to
the established musical culture. Even the events of his death are
shrouded in mystery and lack a sense of closure. As long ago as
1967, Morton Feldman cited Cardew as an influential figure, central
to the future of modern music-making. The extent to which Cardew
has been a central figure and a force for new ideas in music forms
the backbone to this book. Harris demonstrates that Cardew was an
original thinker, a charismatic leader, an able facilitator, and a
committed activist. He argues that Cardew exerted considerable
influence on numerous individuals and groups, but also demonstrates
how the composer's significance has been variously underestimated,
undermined and misrepresented. Cardew's diverse body of work and
activity is here given coherence by its sharing in the values and
principles that underpinned the composer's world view. The
apparently disparate and contradictory episodes of Cardew's career
are shown to be fused by a cohesive 'Cardew aesthetic' that
permeates the man, his politics and his music.
Cornelius Cardew is an enigma. Depending on which sources one
consults he is either an influential and iconic figure of British
musical culture or a marginal curiosity, a footnote to a misguided
musical phenomenon. He is both praised for his uncompromising
commitment to world-changing politics, and mocked for being blindly
caught up in a maelstrom of naA-ve political folly. His works are
both widely lauded as landmark achievements of the British
avant-garde and ridiculed as an archaic and irrelevant footnote to
the established musical culture. Even the events of his death are
shrouded in mystery and lack a sense of closure. As long ago as
1967, Morton Feldman cited Cardew as an influential figure, central
to the future of modern music-making. The extent to which Cardew
has been a central figure and a force for new ideas in music forms
the backbone to this book. Harris demonstrates that Cardew was an
original thinker, a charismatic leader, an able facilitator, and a
committed activist. He argues that Cardew exerted considerable
influence on numerous individuals and groups, but also demonstrates
how the composer's significance has been variously underestimated,
undermined and misrepresented. Cardew's diverse body of work and
activity is here given coherence by its sharing in the values and
principles that underpinned the composer's world view. The
apparently disparate and contradictory episodes of Cardew's career
are shown to be fused by a cohesive 'Cardew aesthetic' that
permeates the man, his politics and his music.
This book is designed to help coordinators and teachers of
mathematics in primary schools to plan and develop an appropriate,
differentiated scheme of mental mathematics activity to support
numeracy and other mathematical work throughout the primary years.
Moving beyond simplistic notions of recall and memorizing, the
authors explore: the multi-dimensional range of mental mathematics,
the various representations and images that assist learning and the
development of language to promote the discussion of mathematical
ideas. For non-specialist mathematicians and students in training
the book provides a resource bank of ideas to help pupils to become
efficient 'in-head' workers, as promoted in the National Numeracy
Strategy. Each chapter discusses the context and theory underlying
particular aspects of work before setting out a range of suggested
activities for each year group.
First Published in 2000. Routledge is an imprint of Taylor and
Francis, an informa company.
Science fiction thrills collide with explosive political drama in
this critically acclaimed tale from renowned writer Brian K.
Vaughan and legendary artist Tony Harris--assembled in a single
hardcover volume! When a strange accident gives Mitchell Hundred
the ability to control machinery, he uses his newfound powers to
become the world s first superhero. But the thrill of risking his
life simply to help maintain the status quo eventually wears thin,
leading Mitch to retire from masked crime-fighting in order to run
for mayor of New York City. And that s when the real weirdness
begins! Collects the Eisner Award-winning series Ex Machina #1-50
and Ex Machina Special #1-4.
Cell-cell adhesion is fundamental for the development and
homeostasis of animal tissues and organs. Adherens junctions (AJs)
are the best understood cell-cell adhesion complexes. In this
volume, a group of internationally recognized experts reviews AJ
biology over a wide range of organization; from atoms to molecules,
to protein complexes, molecular networks, cells, tissues, and
overall animal development. AJs have also been an integral part of
animal evolution, and play central roles in cancer development,
pathogen infection and other diseases. This book addresses major
questions encompassing AJ biology. * How did AJs evolve? * How do
cadherins and catenins interact to assemble AJs and mediate
adhesion? * How do AJs interface with other cellular machinery to
couple adhesion with the whole cell? * How do AJs affect cell
behaviour and multicellular development? * How can abnormal AJ
activity lead to disease?
""One feature of this book that sets it apart from others is the
care that is taken to clarify the authors' interpretation of the
phrase 'teaching for understanding'. Each component of this
interpretation - connections, representations, reasoning,
communication and misconceptions - is then successfully
incorporated as a theme in the subsequent chapters that develop
important mathematical topics."
Ian Thompson, Visiting Professor at Edge Hill University and
Northumbria University, UK"
This important book aims to support and develop teachers'
understanding of the key primary mathematics topics. It takes an
innovative approach by defining exactly what is meant by
'understanding' and uses this model to examine and explain various
mathematical topics.
The authors emphasize the importance of the different
representations that can be used for mathematical concepts and
inform the reasoning process. By focusing on understanding, the
book also draws attention to common misconceptions that teachers
may encounter in the classroom.
Key features: Specific focus on 'understanding' to offer new
insights in to how to teach the topics Case studies to demonstrate
how to communicate mathematical topics in the classroom End of
chapter questions to stimulate discussion The authors integrate
research and theory throughout, to highlight core issues. This
theoretical background is also linked directly to classroom
practice and informs suggestions for how topics can be communicated
in the classroom. This offers valuable guidance to trainee teachers
on how to teach the topics and presents experienced teachers with
the opportunity to develop their subject and pedagogical
knowledge.
Unlike many textbooks or popular science books, A Simple Guide to
Popular Physics has truly been crafted for the uninitiated or those
spooked by the subject's complexity. Harris's inviting guide
promises to give "absolute beginners" from "teens to centenarians"
a basic grounding in particle physics, quantum physics, and
cosmology-all without making readers do math. With the goal of
introducing the basics and encouraging readers to explore more
deeply afterwards, Harris notes "Like the fish we have no notion of
what is beyond the boundaries of our knowledge, but unlike the
fish, we know there is something." He starts by presenting those
boundaries, the fundamentals of classic physics (Newton's law,
states of matter, types of energy), with crisp clarity before
laying out an accessible explanation of Einstein's theory of
relativity, the structure of the atom, the mysteries of quantum
mechanics and cosmology. Readers will not need to search online for
key terms or explanations of concepts that have been glossed over.
Instead, one by one, with patience and good humor, Harris
introduces each of these building blocks of our universe, taking a
little time to invite readers to contemplate the momentousness of
the information, as in the chapter titled nothing less than "What
Is Reality?" . The watchword, here, is clarity, which Harris offers
throughout, with professional illustrations and illuminating
accounts of experiments and breakthroughs, offering a solid
foundation for understanding and future reading Inviting and
illuminating, this introduction to physics truly targets the reader
who is entirely new to the subject.
Zeegpaw, the dog with more luck than any animal on the face of the
land is back! Once again, Inkpen, the evil feline is trying to kill
him and works on a fiendish plot to send the lovable canine to the
dangerous Outlands where he must battle Mother Rat, the gangster
with a liking for all that is bad, and The Children of the Vine, a
group of cats who specialise in Dumort, the ancient art of cat
duelling.
Zeegpaw is the tale of a puppy who has it all, then one day the lot
is taken away from him and he has to battle for his life against
the might of the evil cat, Inkpen and the might of his Inkpire. If
you add a criminal rat called Stendl, an old dog called Heilmut and
two spies called One and Two, you have a ripping adventure story
with allegorical qualities.
This is a detective thriller, packed with action and suspense, for
the young, both boys and girls, the young at heart, and those who
wish they still were. Care has been taken to ensure the
non-nautical reader won't feel all at sea, so to give these
shipmates a hand, the sometimes unusual phraseology is explained.
But the author does want you to really feel you are climbing the
ratlines, hauling yourself up by your cold hands grasping the
greasy rigging, whilst you look up at the mast head swaying across
the dark threatening clouds, before climbing onto the yardarm to
bundle up the sail. It's also possible that some might think the
idea of Knights Templar being involved is just a bit fanciful. Be
assured there are still some afloat today. In this case, four
teenage pupils from the Knights Templar School in the west of
England (yes, it does exist!) outwit a criminal gang, the police
and the customs, but delight the intelligence agencies.
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