Cell-cell adhesion is fundamental for the development and
homeostasis of animal tissues and organs. Adherens junctions (AJs)
are the best understood cell-cell adhesion complexes. In this
volume, a group of internationally recognized experts reviews AJ
biology over a wide range of organization; from atoms to molecules,
to protein complexes, molecular networks, cells, tissues, and
overall animal development. AJs have also been an integral part of
animal evolution, and play central roles in cancer development,
pathogen infection and other diseases. This book addresses major
questions encompassing AJ biology. * How did AJs evolve? * How do
cadherins and catenins interact to assemble AJs and mediate
adhesion? * How do AJs interface with other cellular machinery to
couple adhesion with the whole cell? * How do AJs affect cell
behaviour and multicellular development? * How can abnormal AJ
activity lead to disease?
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