Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, internationally recognized experts review AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. - How did AJs evolve? - How do cadherins and catenins interact to assemble AJs and mediate adhesion? - How do AJs interface with other cellular machinery to couple adhesion with the whole cell? - How do AJs affect cell behaviour and multicellular development? - How can abnormal AJ activity lead to disease? Valuable for both newcomers and experts in the field, this book offers a comprehensive resource for the research laboratory and a teaching tool for advanced undergraduate and graduate courses in cell and developmental biology.

Much more than just a tale of sailing against mountainous seas, but a book with every aspect of sailing and motor boating, in many parts of the world. It illustrates how times have changed to the extent the stories are never to be repeated. Providing a more permanent record, it tells how in post-war Britain, we developed a system of teaching and testing recreational users of marine craft of every description. This has now been copied in almost every country with recreational waterborne sports, including a UK approved sailing school in the USA. If all that sounds a mighty bit boring, be assured it has ten most unusual stories with excitement, including projects in China and Nigeria. There are tales of law-breaking villains afloat, and you won't want to put the book down. Looking for a present for a sea-loving friend? Look no further.

Cornelius Cardew is an enigma. Depending on which sources one consults he is either an influential and iconic figure of British musical culture or a marginal curiosity, a footnote to a misguided musical phenomenon. He is both praised for his uncompromising commitment to world-changing politics, and mocked for being blindly caught up in a maelstrom of naA-ve political folly. His works are both widely lauded as landmark achievements of the British avant-garde and ridiculed as an archaic and irrelevant footnote to the established musical culture. Even the events of his death are shrouded in mystery and lack a sense of closure. As long ago as 1967, Morton Feldman cited Cardew as an influential figure, central to the future of modern music-making. The extent to which Cardew has been a central figure and a force for new ideas in music forms the backbone to this book. Harris demonstrates that Cardew was an original thinker, a charismatic leader, an able facilitator, and a committed activist. He argues that Cardew exerted considerable influence on numerous individuals and groups, but also demonstrates how the composer's significance has been variously underestimated, undermined and misrepresented. Cardew's diverse body of work and activity is here given coherence by its sharing in the values and principles that underpinned the composer's world view. The apparently disparate and contradictory episodes of Cardew's career are shown to be fused by a cohesive 'Cardew aesthetic' that permeates the man, his politics and his music.

Cornelius Cardew is an enigma. Depending on which sources one consults he is either an influential and iconic figure of British musical culture or a marginal curiosity, a footnote to a misguided musical phenomenon. He is both praised for his uncompromising commitment to world-changing politics, and mocked for being blindly caught up in a maelstrom of naA-ve political folly. His works are both widely lauded as landmark achievements of the British avant-garde and ridiculed as an archaic and irrelevant footnote to the established musical culture. Even the events of his death are shrouded in mystery and lack a sense of closure. As long ago as 1967, Morton Feldman cited Cardew as an influential figure, central to the future of modern music-making. The extent to which Cardew has been a central figure and a force for new ideas in music forms the backbone to this book. Harris demonstrates that Cardew was an original thinker, a charismatic leader, an able facilitator, and a committed activist. He argues that Cardew exerted considerable influence on numerous individuals and groups, but also demonstrates how the composer's significance has been variously underestimated, undermined and misrepresented. Cardew's diverse body of work and activity is here given coherence by its sharing in the values and principles that underpinned the composer's world view. The apparently disparate and contradictory episodes of Cardew's career are shown to be fused by a cohesive 'Cardew aesthetic' that permeates the man, his politics and his music.

When Jack Knight is forced to pick up the Starman's Cosmic Rod, he finds himself flung into a life he never wanted for himself...but it just might be his destiny! Watch Starman go up against The Mist, The Shade, and even Captain Marvel! Starman Compendium One collects: Starman #0-42, Starman 80-Page Giant #1, Starman Annual #1, Starman Annual #2, Starman Secret Files #1, Showcase '95 #12, Showcase '96 #4, Showcase '96 #5, The Power of Shazam! #35, The Power of Shazam! #36, and The Shade #1-4.

This book is designed to help coordinators and teachers of mathematics in primary schools to plan and develop an appropriate, differentiated scheme of mental mathematics activity to support numeracy and other mathematical work throughout the primary years.

Moving beyond simplistic notions of recall and memorizing, the authors explore: the multi-dimensional range of mental mathematics, the various representations and images that assist learning and the development of language to promote the discussion of mathematical ideas. For non-specialist mathematicians and students in training the book provides a resource bank of ideas to help pupils to become efficient 'in-head' workers, as promoted in the National Numeracy Strategy. Each chapter discusses the context and theory underlying particular aspects of work before setting out a range of suggested activities for each year group.

First Published in 2000. Routledge is an imprint of Taylor and Francis, an informa company.

Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. * How did AJs evolve? * How do cadherins and catenins interact to assemble AJs and mediate adhesion? * How do AJs interface with other cellular machinery to couple adhesion with the whole cell? * How do AJs affect cell behaviour and multicellular development? * How can abnormal AJ activity lead to disease?

Science fiction thrills collide with explosive political drama in this critically acclaimed tale from renowned writer Brian K. Vaughan and legendary artist Tony Harris--assembled in a single hardcover volume!

When a strange accident gives Mitchell Hundred the ability to control machinery, he uses his newfound powers to become the world’s first superhero. But the thrill of risking his life simply to help maintain the status quo eventually wears thin, leading Mitch to retire from masked crime-fighting in order to run for mayor of New York City. And that’s when the real weirdness begins!

Collects the Eisner Award-winning series Ex Machina #1-50 and Ex Machina Special #1-4.

Unlike many textbooks or popular science books, A Simple Guide to Popular Physics has truly been crafted for the uninitiated or those spooked by the subject's complexity. Harris's inviting guide promises to give "absolute beginners" from "teens to centenarians" a basic grounding in particle physics, quantum physics, and cosmology-all without making readers do math. With the goal of introducing the basics and encouraging readers to explore more deeply afterwards, Harris notes "Like the fish we have no notion of what is beyond the boundaries of our knowledge, but unlike the fish, we know there is something." He starts by presenting those boundaries, the fundamentals of classic physics (Newton's law, states of matter, types of energy), with crisp clarity before laying out an accessible explanation of Einstein's theory of relativity, the structure of the atom, the mysteries of quantum mechanics and cosmology. Readers will not need to search online for key terms or explanations of concepts that have been glossed over. Instead, one by one, with patience and good humor, Harris introduces each of these building blocks of our universe, taking a little time to invite readers to contemplate the momentousness of the information, as in the chapter titled nothing less than "What Is Reality?" . The watchword, here, is clarity, which Harris offers throughout, with professional illustrations and illuminating accounts of experiments and breakthroughs, offering a solid foundation for understanding and future reading Inviting and illuminating, this introduction to physics truly targets the reader who is entirely new to the subject.

""One feature of this book that sets it apart from others is the care that is taken to clarify the authors' interpretation of the phrase 'teaching for understanding'. Each component of this interpretation - connections, representations, reasoning, communication and misconceptions - is then successfully incorporated as a theme in the subsequent chapters that develop important mathematical topics."
Ian Thompson, Visiting Professor at Edge Hill University and Northumbria University, UK"

This important book aims to support and develop teachers' understanding of the key primary mathematics topics. It takes an innovative approach by defining exactly what is meant by 'understanding' and uses this model to examine and explain various mathematical topics.

The authors emphasize the importance of the different representations that can be used for mathematical concepts and inform the reasoning process. By focusing on understanding, the book also draws attention to common misconceptions that teachers may encounter in the classroom.

Key features: Specific focus on 'understanding' to offer new insights in to how to teach the topics Case studies to demonstrate how to communicate mathematical topics in the classroom End of chapter questions to stimulate discussion The authors integrate research and theory throughout, to highlight core issues. This theoretical background is also linked directly to classroom practice and informs suggestions for how topics can be communicated in the classroom. This offers valuable guidance to trainee teachers on how to teach the topics and presents experienced teachers with the opportunity to develop their subject and pedagogical knowledge.

Zeegpaw is the tale of a puppy who has it all, then one day the lot is taken away from him and he has to battle for his life against the might of the evil cat, Inkpen and the might of his Inkpire. If you add a criminal rat called Stendl, an old dog called Heilmut and two spies called One and Two, you have a ripping adventure story with allegorical qualities.

Zeegpaw, the dog with more luck than any animal on the face of the land is back! Once again, Inkpen, the evil feline is trying to kill him and works on a fiendish plot to send the lovable canine to the dangerous Outlands where he must battle Mother Rat, the gangster with a liking for all that is bad, and The Children of the Vine, a group of cats who specialise in Dumort, the ancient art of cat duelling.

This is a detective thriller, packed with action and suspense, for the young, both boys and girls, the young at heart, and those who wish they still were. Care has been taken to ensure the non-nautical reader won't feel all at sea, so to give these shipmates a hand, the sometimes unusual phraseology is explained. But the author does want you to really feel you are climbing the ratlines, hauling yourself up by your cold hands grasping the greasy rigging, whilst you look up at the mast head swaying across the dark threatening clouds, before climbing onto the yardarm to bundle up the sail. It's also possible that some might think the idea of Knights Templar being involved is just a bit fanciful. Be assured there are still some afloat today. In this case, four teenage pupils from the Knights Templar School in the west of England (yes, it does exist!) outwit a criminal gang, the police and the customs, but delight the intelligence agencies.