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Cell cycle checkpoints control the fidelity and orderly progression
of eukaryotic cell division. By controlling the orderly progression
of critical cell cycle events such as DNA replication and
chromosome segregation and ensuring proper repair of damaged DNA,
cell cycle checkpoints function to ensure genome integrity.
Mechanisms of checkpoint controls are not only the research focus
of investigators interested in mechanisms that regulate the cell
cycle, but are also the interests of researchers studying cancer
development as it is increasingly clear that loss of cell cycle
checkpoints, which leads to genomic instability as a result, is a
hallmark of tumorigenesis. Cell Cycle Checkpoints: Methods and
Protocols provides detailed descriptions of methodologies currently
employed by researchers in the field, including those commonly used
in the mammalian, yeast, C. elegans, Drosophila, and Xenopus model
systems. Each chapter describes a specific technique or protocol,
such as a method to induce cell cycle checkpoints in a particular
model system, to synchronize a population of cells to allow
observations of cell cycle progression, to identify genes involved
in checkpoint regulation, and to study particular protein
components of cell cycle checkpoint pathways. Written in the highly
successful Methods in Molecular Biology (TM) series format,
chapters contain introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and notes on troubleshooting and
avoiding known pitfalls. Authoritative and easily accessible, Cell
Cycle Checkpoints: Methods and Protocols seeks to serve both
professionals and novices with its well-honed methodologies in an
effort to further our knowledge of this essential field.
Is it possible, given culturally incongruent perspectives, to
validate any common standards of behaviour? How can cultural
relativity be a genuine problem if cultures are porous and
inter-penetrable? Is it possible to implement human rights in
societies without incorporating the idea into their fabric of
culture? Is it possible for cultural communities to survive in the
contemporary world without rights protection? This book addresses
questions like these in the light of an inventive and original
understanding of culture.
Human resource management performs a different function and operates very differently in Asia than it does in the US and Europe. This volume demonstrates how human resource management is enacted in Asian countries, how it is changing in response to recent economic events, and how firms are linking indigenous and external human resource management learning. Examples are taken from firms in Japan, China, Korea and Thailand. Contributors with perspectives from both the East and the West show how multinational firms can incorporate Asian thinking and acting into a modern business strategy for successful human resource development in international ventures.
Climate Change and Mycotoxins highlights the importance of the
continuous study of climate change impacts on mycotoxigenic fungi
and their toxins in food and feed crops. Changing climate
conditions across every geographical zone greatly affect rainfall,
temperature and concentration of greenhouse gases leading to loss
in yield and quality of food crops. In outstanding contributions,
the authors compile current evidence on the influence of climate
change on mycotoxigenic fungi and mycotoxins in food crops pre- and
postharvest and during storage of food and animal feed. The
chemistry and biology of toxin production is revised and an outlook
on control and prevention of the toxin's impact on food and animal
feed is given. The editors recommend this book to mycologists,
mycotoxicologists, pathologists, epidemiologists, toxicologists,
physicians, veterinarians, nutritionists, the food and feed
industries, legislators, analytical chemists, microbiologists, or
students of these fields. * Unique compilation on the impact of
climate change on mycotoxins based on observed trends over the last
10 years. * Special focus on the implications for food and feed
safety. * Latest advances on prediction and prevention of mycotoxin
threats to human and animal health. About the Editors Luis M.
Botana Is a full Professor of Pharmacology at the University of
Santiago, from 2004-2012 director of the Department of Pharmacology
and former Fogarty Fellow at the School of Medicine of the Johns
Hopkins University. He has been director of the European Reference
Laboratory for Marine Toxins from 2004 to 2009. He is author of 25
international patents, over 300 scientific papers and editor of 10
international books. Maria J. Sainz Is an associate Professor of
Agriculture and Forage Production and Conservation at the
University of Santiago de Compostela. She has been a visiting
scientist at the Rothamsted Experimental Station and for ten years
head of the department of Plant Production. Her research interests
focus on fungal pathogen detection and diagnostics, mycorrhizal
fungi in crop protection and production, and mycotoxigenic fungi
and mycotoxins on forage crops and animal feed.
Addresses FDI from both a theoretical and practical perspective.
Very timely - the coronavirus pandemic has reinforced the needs for
investment promotion agencies to focus on aftercare. Contains 90+
content boxes (with case study examples from different countries
globally). First professional book to focus specifically on the
aftercare needed following FDI.
Addresses FDI from both a theoretical and practical perspective.
Very timely - the coronavirus pandemic has reinforced the needs for
investment promotion agencies to focus on aftercare. Contains 90+
content boxes (with case study examples from different countries
globally). First professional book to focus specifically on the
aftercare needed following FDI.
Cell cycle checkpoints control the fidelity and orderly progression
of eukaryotic cell division. By controlling the orderly progression
of critical cell cycle events such as DNA replication and
chromosome segregation and ensuring proper repair of damaged DNA,
cell cycle checkpoints function to ensure genome integrity.
Mechanisms of checkpoint controls are not only the research focus
of investigators interested in mechanisms that regulate the cell
cycle, but are also the interests of researchers studying cancer
development as it is increasingly clear that loss of cell cycle
checkpoints, which leads to genomic instability as a result, is a
hallmark of tumorigenesis. Cell Cycle Checkpoints: Methods and
Protocols provides detailed descriptions of methodologies currently
employed by researchers in the field, including those commonly used
in the mammalian, yeast, C. elegans, Drosophila, and Xenopus model
systems. Each chapter describes a specific technique or protocol,
such as a method to induce cell cycle checkpoints in a particular
model system, to synchronize a population of cells to allow
observations of cell cycle progression, to identify genes involved
in checkpoint regulation, and to study particular protein
components of cell cycle checkpoint pathways. Written in the highly
successful Methods in Molecular Biology (TM) series format,
chapters contain introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and notes on troubleshooting and
avoiding known pitfalls. Authoritative and easily accessible, Cell
Cycle Checkpoints: Methods and Protocols seeks to serve both
professionals and novices with its well-honed methodologies in an
effort to further our knowledge of this essential field.
Is it possible, given culturally incongruent perspectives, to
validate any common standards of behaviour? Is cultural relativity
be a problem when cultures are porous? Can we implement human
rights without incorporating the idea into the fabric of culture?
This book addresses such questions with an inventive and original
understanding of culture.
Human resource management performs a different function and
operates very differently in Asia to its practice in the US and
Europe. This volume demonstrates how human resource management is
enacted in Asian countries, how it is changing in response to
recent economic events, and how firms are linking indigenous and
external human resource management learning. Examples are taken
from firms in Japan, China, Korea and Thailand, and these domestic
approaches are then considered in the context of joint ventures. As
well as providing a detailed analysis of Asian human resource
management, contributors with perspectives from both the East and
the West show how multinational firms can incorporate Asian
thinking and acting into a modern business strategy for successful
human resource development in international ventures.
This SpringerBrief explores unconventional functions of eight
different transcription factors and concludes with a discussion
of their biological significance and impact, including
effects on processes within the cell nucleaus during development
and in adult organisms. Chapter One
details unconventional functions of the transcription
factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB.Â
Surprisingly, all of these transcription factors can be found in
association with heterochromatin as well as euchromatin, and in
some cases unconventional functions have been demonstrated for
these heterochromatin-associated factors. Chapter Two focuses
on the unconventional functions of STAT and HP1 and discusses
their roles in the promotion of longevity, and in protection
from cancer and DNA damage. Chapter Three explores the
biological significance of the findings presented in the first two
chapters and considers how global changes in the epigenome
brought about by factors such as STAT and HP1 might affect
processes within the cell nucleus during development and in adult
organisms. This succinct yet thorough SpringerBrief is
essential for researchers studying epigenetics, and to
instructors of the subject. It should also appeal to people
interested in the control of gene transcription and other processes
in the cell nucleus, and to those interested in development.
With all the complex issues of acceptance or rejection of a
transplanted organ, immunology is a key subject for all
transplantation clinicians. During recent years, there has been an
explosion of research and knowledge in this area. Produced in
association with the American Society of Transplantation, and
written by experts within the field, Transplant Immunology provides
a comprehensive overview of the topic in relation to clinical
transplantation. Starting with the basic functionality of the
immune system, it then moves on to cover the very latest
developments in immunosuppressive drugs and protocols, as well as a
look at all emerging technologies in the field. Key chapters
include: * Transplant-related complications * Immune responses to
transplants * Emerging issues in transplantation * Biomarkers of
Allograft rejection and tolerance * T cells and the principles of
immune responses In full colour throughout, over 100 outstanding
diagrams support the text, all figures being fully downloadable via
the book's companion website. The result is an essential tool for
all those responsible for managing patients awaiting and undergoing
organ transplantation, including transplant surgeons and
clinicians, immunologists and researchers.
For six years, Harmony Ink has been privileged to showcase the very
best up-and-coming writers of LGBTQ+ fiction. We are once again
awed and inspired by the talent, creativity, and heart displayed by
these authors, all fourteen to twenty-one years old. Selected from
dozens of entrants, these young people are the winners of the
Harmony Ink Young Author Challenge, and they represent the entire
spectrum as well as a variety of fictional genres. They are the
future voices of our community, and they invite you to take a
journey into their rich and imaginative worlds.
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