One Hundred Years of Chromosome Research: What Remains to be Learned, offers the reader a critical analysis of the observations and experiments that shaped the last 100 years of chromosome research, as well as the ideas which prevailed during this period.
Emphasis is placed on what remains to be learned, particularly in light of reality of the sequencing of DNA which leaves the previous era of chromosome research as a prehistoric event. It is at this turning point, that well formulated questions can be asked about many of the chromosome's properties, which remain to be unveiled.

The author, Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund Unviersity, Sweden, previously Head of the Institute of Molecular Cytogenetics, Lund University.

How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Mullerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

Understanding animal andrology is fundamental to optimising genetic breeding traits in domestic and wild animals. This book provides extensive coverage of male reproductive biology, discussing the essentials of sperm production, harvest and preservation before covering the applications to a range of animals including cattle, horses, pigs, small ruminants, camelids, cats and dogs, poultry and exotic species. It also examines the laboratory procedures that provide the basis of general fertility research.

The study of alternative reproductive tactics (the behavioural strategies used by individuals to increase their reproductive success) is an evolutionary puzzle, and one of great interest to researchers. For instance, why do some males guard both nest and eggs, while others sneak into nests while pairs are spawning and fertilise those eggs? The field offers a special opportunity to study the evolution and functional causes of phenotypic variation, which is a general problem in the field of evolutionary biology. By integrating both mechanistic (psychological) and evolutionary (behavioural ecology) perspectives and by covering a great diversity of species, Alternative Reproductive Tactics addresses this integrated topic of longstanding interest, bringing together a multitude of otherwise scattered information in an accessible form that is ideal for graduate students and researchers.

Cooperative breeding refers to a social system in which individuals other than the parents provide care for the offspring. Since individuals delay breeding and invest in the offspring of others, cooperative breeding poses a challenge to a Darwinian explanation of the evolution of social behaviour. The contributors to this book explore the evolutionary, ecological, behavioural and physiological basis of cooperative breeding in mammals. The book contains a collection of chapters by the leading researchers in the field, and it is dedicated exclusively to the study of mammalian cooperative breeding. It will appeal to zoologists, ecologists, evolutionary biologists, and to those interested in animal behaviour.

Neurobiological Effects of Sex Steroid Hormones describes the neurobiological basis for the understanding of how sex steroid hormones, oestrogen and testosterone, interact with parts of the brain. The contributors have all made significant advances in the understanding of how these steroids regulate neural function, and how this activity is translated into reproductive behaviours necessary for the propagation of the species. This book covers a broad range of topics, extending from the molecular and cellular processes, through the action of steroids on neurotransmission, all the way to defining the brain circuitry involved in both male and female behaviour. This volume presents a snapshot of the rapidly advancing field of reproductive neuroendocrinology by the investigators who are most intimately involved with the discoveries.

Building on the successful structure of the first edition, the second edition of Reproductive Technologies in Farm Animals has been totally updated and revised to provide an up to date account of the key techniques employed in manipulating reproduction in farm animals, including beef and dairy cattle, pigs, sheep, goats, buffaloes, camelids, horses and poultry. A classic introductory text to the subject, the book is based on a comprehensive review of the current literature. It: - outlines different agricultural systems and explores the ethical implications of modern farming methods; - details the many new developments, including the commercial application of sexed semen and large-scale application of in vitro produced cattle embryos; - provides a valuable synopsis of current and future reproductive technologies, such as cloning and the production of transgenic animals. This text remains key reading for students in animal science, agriculture, veterinary medicine and biology, and veterinary practitioners and farmers who wish to keep updated on developments in techniques that may be useful in their daily practice.

Reproduction is a fundamental feature of life, it is the way life persists across the ages. This book offers new, wider vistas on this fundamental biological phenomenon, exploring how it works through the whole tree of life. It explores facets such as asexual reproduction, parthenogenesis, sex determination and reproductive investment, with a taxonomic coverage extended over all the main groups - animals, plants including 'algae', fungi, protists and bacteria. It collates into one volume perspectives from varied disciplines - including zoology, botany, microbiology, genetics, cell biology, developmental biology, evolutionary biology, animal and plant physiology, and ethology - integrating information into a common language. Crucially, the book aims to identify the commonalties among reproductive phenomena, while demonstrating the diversity even amongst closely related taxa. Its integrated approach makes this a valuable reference book for students and researchers, as well as an effective entry point for deeper study on specific topics.

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products' chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies.

This volume, and its companion volume on the oocyte, provide an authoritative and wide-ranging account of the gametes, and their reproductive role and function in humans. Acknowledged authorities from around the world provide a detailed and timely account of the spermatozoon. The volume starts with an evolutionary perspective before focusing on the molecular and cellular biology of the sperm cell, and its structure and function. The development and maturation of sperm are described, as is their movement and transport in the male and female genital tract. Practical issues such as sperm storage and assisted contraception are fully covered. The causes of male infertility are also an important theme. The volume concludes with a thought-provoking chapter on ethical considerations. The volume will be an essential source of information for all clinicians and scientists with an interest in human reproduction.

This volume, and its companion volume on the spermatozoon, provide an authoritative and wide ranging account of the gametes and their reproductive role and function in humans. Acknowledged authorities from around the world contribute a detailed and timely account of the oocyte. The volume starts with an evolutionary perspective before focusing on the molecular and cellular biology of the oocyte and its structure and function. The development and maturation of the oocyte is fully dealt with to include the endocrine and paracrine regulation of ovarian function. Practical issues such as oocyte storage and ovarian stimulation are also fully covered. The causes of female infertility are also an important theme. The volume concludes with a thought provoking chapter on ethical considerations. The volume will be an essential source of information for all clinicians and scientists with an interest in human reproduction.

This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.

This book presents a completely novel approach to the understanding of ageing, which many believe is an unsolved problem in biology. It explains why ageing exists in animals, and reviews our understanding of it at the biological level. This includes a discussion of the origins and evolution of ageing. The book is not a review of research on ageing, but instead draws on material from a wide range of disciplines, including the very extensive biomedical information about age-related diseases in humans. Understanding Ageing argues that much research needs to be done on the cellular and molecular aspects of ageing, if the origins of these diseases are to be understood, and their prevention made possible. This thought-provoking book will appeal to all students and researchers who are interested in ageing, whether they are working in the clinical or basic research sphere.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

The habitats of most species have been fragmented by human actions, isolating small populations that consequently develop genetic problems. Millions of small, isolated, fragmented populations are likely suffering from inbreeding depression and loss of genetic diversity, greatly increasing their risk of extinction. Crossing between populations is required to reverse these effects, but managers rarely do so. A key reason for such inaction is that managers are often advised to manage populations in isolation whenever molecular genetic methods indicate genetic differences among them. Following this advice will often doom small populations to extinction when the habitat fragmentation and genetic differences were caused by human activities. A paradigm shift is required whereby evidence of genetic differentiation among populations is a trigger to ask whether any populations are suffering genetic problems, and if so, whether they can be rescued by augmenting gene flow. Consequently, there is now an urgent need for an authoritative practical guide to facilitate this paradigm shift in genetic management of fragmented populations.

Marsupials differ from most other mammals in their method of reproduction, in that they have chosen, in an evolutionary sense, to develop lactation rather than placentation for the nurture of their young. The neonate is therefore born with a mixture of advanced and embryonic characters, and yet is readily accessible within the pouch, providing a unique system for the study of the ontogeny of various physiological and endocrinological parameters. Marsupials are therefore ideal animals for research into mammalian reproductive physiology. The results of this exciting new research are summarized in this book by two of the foremost workers in the field. Individual chapters analyse the genetic and hormonal control of sexual differentiation, male and female reproductive structures and their functions, the role of the corpus luteum in the oestrous cycle and pregnancy, the hormonal control of embryonic diapause and the role of the marsupial placenta in the development of the embryo. This book is more than just a straightforward review of marsupial reproduction for its detailed analyses and broad comparative coverage will attract mammalogists and reproductive physiologists with a wide range of research interests.

What is animal welfare? Why has it proved so difficult to find a definition that everyone can agree on? This concise and accessible guide is for anyone who is interested in animals and who has wondered how we can assess their welfare scientifically. It defines animal welfare as 'health and animals having what they want', a definition that can be easily understood by scientists and non-scientists alike, expresses in simple words what underlies many existing definitions, and shows what evidence we need to collect to improve animal welfare in practice. Above all, it puts the animal's own point of view at the heart of an assessment of its welfare. But, can we really understand what animals want? A consistent theme running through the book is that not only is it possible to establish what animals want, but that this information is vital in helping us to make sense of the long and often confusing list of welfare measures that are now in use such as 'stress' and 'feel good hormones', expressive sounds and gestures, natural behaviour, cognitive bias, and stereotypies. Defining welfare as 'health and what animals want' allows us to distinguish between measures that are simply what an animal does when it is alert, aroused, or active and those measures that genuinely allow us to distinguish between situations the animals themselves see as positive or negative. Sentience (conscious feelings of pleasure, pain, and suffering) is for many people the essence of what is meant by welfare, but studying consciousness is notoriously difficult, particularly in non-human species. These difficulties are discussed in the context of our current - and as yet incomplete - knowledge of human and animal consciousness. Finally, the book highlights some key ideas in the relationship between animal welfare science and animal ethics and shows how closely the well-being of humans is linked to that of other animals. The Science of Animal Welfare is an ideal companion for undergraduate and graduate students taking courses in animal behaviour and welfare, as well as for professional researchers, practitioners and animal welfare consultants. At the same time, it is easily understandable to non-scientists and anyone without prior knowledge but with an interest in animals and the rapidly evolving science of animal welfare.

"Oocyte Physiology and Development in Domestic Animals" reviews the most recent advances in the research of physiological and biochemical mechanisms underlying oocyte growth and development, providing readers with the fundamental understanding of these key processes and summarizing this important field of research. The book covers multiple molecular and physiological mechanisms including initiation of oocyte growth during folliculogenesis and in vitro follicle culture to support oocyte competence, that are critical to health and quality. Physiological process ranging from gene expression to metabolism will be covered with an eye toward using these factors to uncover biomarkers that will further advance the field. In addition, the text looks at the effects of in vitro maturation environments on oocyte quality and developmental outcome.

Essential Ornithology provides the reader with a concise but comprehensive introduction to the biology of birds, one of the most widely studied taxonomic groups. The book begins by considering the dinosaur origins of birds and their subsequent evolution. Development, anatomy, and physiology are then discussed followed by chapters devoted to avian reproduction, migration, ecology, and conservation. Sections dealing with aspects of bird/human relationships and bird conservation give the book an applied context. This new edition has been thoroughly updated, providing new information from rapidly-developing fields including the avian fossil record, urban and agricultural ecology, responses to climate change, invasive species biology, technologies to track movement, avian disease, and the role of citizen scientists. There is also a greater focus on North American ornithology. Drawing extensively upon the wider scientific literature, this engaging text places the results of classical studies of avian biology alongside the most recent scientific breakthroughs. Useful case studies are presented in a concise and engaging style with the student reader foremost in mind. Key points are highlighted and suggestions for guided reading and key references are included throughout. Essential Ornithology is a companion textbook for advanced undergraduate and graduate students taking courses in avian science, as well as a useful reference for professional researchers and consultants. Amateur ornithologists will also find this book offers a scientifically rigorous and accessible overview for a more general readership.

Since the publication of the first Atlas of Mammalian Chromosomes in 1967 the continuous compilation of mammalian karyotypes has become a useful instrument in cytologic and taxonomic studies. Technical advances in preparing mitotic cells from nonmammalian vertebrates have since allowed a better comparison of taxa in fishes, amphibia, reptiles, and birds. In these fields the literature is also widely scat tered; and it has become difficult to survey such information, published as well as unpublished, by nonspecialists. These were among the reasons for the new endeavor of compiling a chromosome atlas for nonmammalian vertebrates. An annual publication is planned with presentation of between 10 and 15 karyotypes from each class. In this second volume, 52 species are presented. For convenience in future colation, the numbering system employs class abbreviations, viz., P-Pisces, Am-Amphibia, R-Reptilia, and Av-Aves. Within each class, the numbers are necessarily consecutive. In general the karyotypes are laid out following the format employed in An Atlas of Mammalian Chromosomes. Whenever possible both sexes are represented, even though sexual chromosomal dimorphism is not (currently) evident. When the sex chromosomes are known, they are so indicated by conventional nomenclature (XX/XY or ZW /ZZ). In the karyotypes of birds the so-called microchromosomes are grouped together at the end without an attempt at complete enumeration, which is presently impossible. They are usually considered as acrocentrics, but a few are distinctly biarmed."

The function of scientific research is promoting the understanding of the world around us. In theory, anyway, the more we learn, the more potential we have of making our lives better. Thus, we have seen research in electronics provide us with computers, research in chemistry provide us with all manner of synthetics, and research in agriculture provide us with more food. Periodically, scientific research uncovers something that makes some of us uncomfortable. The discovery of the link between smoking and lung cancer and heart disease was not received well by the tobacco industry, and the link between global climate change and fossil fuel use has not been well received by the petroleum industry, to cite just two examples. Usually the response of those whose world has been disrupted by science is denial, often followed by attack on or ridicule of the science that has challenged them. In the long term, however, science usually turns out to be correct.

The habitats of most species have been fragmented by human actions, isolating small populations that consequently develop genetic problems. Millions of small, isolated, fragmented populations are likely suffering from inbreeding depression and loss of genetic diversity, greatly increasing their risk of extinction. Crossing between populations is required to reverse these effects, but managers rarely do so. A key reason for such inaction is that managers are often advised to manage populations in isolation whenever molecular genetic methods indicate genetic differences among them. Following this advice will often doom small populations to extinction when the habitat fragmentation and genetic differences were caused by human activities. A paradigm shift is required whereby evidence of genetic differentiation among populations is a trigger to ask whether any populations are suffering genetic problems, and if so, whether they can be rescued by augmenting gene flow. Consequently, there is now an urgent need for an authoritative practical guide to facilitate this paradigm shift in genetic management of fragmented populations.

This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.

When Charles Darwin first proposed Sexual Selection Theory, he suggested two mechanisms: competition among males and choice by females. Although their importance is long established and extremely well understood, their mirror images have remained largely underappreciated; males also choose, and females also compete. The combination of male mate choice (MMC) and female competition (FC) may be one of the most overlooked yet important and intriguing phenomena in modern sexual selection theory. This novel text reviews our current understanding of MMC and FC, highlighting the important connections between them. It places both concepts in the context of related fields such as female choice, mating systems, and sexual selection theory more broadly. A truly holistic approach is provided which takes all the relevant elements into consideration, especially the relative roles of MMC and FC, female ornamentation, their evolutionary consequences, and their genetic basis. Considering male mate choice and female competition in this way as effectively two sides of the same coin creates a powerful paradigm for a more complete understanding of sexual selection. Male Choice, Female Competition, and Female Ornaments in Sexual Selection will be suitable for both graduate students and researchers interested in sexual selection from an evolutionary, psychological, and anthropological perspective. It will also appeal to a broader audience of behavioural ecologists and evolutionary psychologists.