This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

This book presents the fundamentals of modern tensor calculus for students in engineering and applied physics, emphasizing those aspects that are crucial for applying tensor calculus safely in Euclidian space and for grasping the very essence of the smooth manifold concept. After introducing the subject, it provides a brief exposition on point set topology to familiarize readers with the subject, especially with those topics required in later chapters. It then describes the finite dimensional real vector space and its dual, focusing on the usefulness of the latter for encoding duality concepts in physics. Moreover, it introduces tensors as objects that encode linear mappings and discusses affine and Euclidean spaces. Tensor analysis is explored first in Euclidean space, starting from a generalization of the concept of differentiability and proceeding towards concepts such as directional derivative, covariant derivative and integration based on differential forms. The final chapter addresses the role of smooth manifolds in modeling spaces other than Euclidean space, particularly the concepts of smooth atlas and tangent space, which are crucial to understanding the topic. Two of the most important concepts, namely the tangent bundle and the Lie derivative, are subsequently worked out.

This book explores Probabilistic Cellular Automata (PCA) from the perspectives of statistical mechanics, probability theory, computational biology and computer science. PCA are extensions of the well-known Cellular Automata models of complex systems, characterized by random updating rules. Thanks to their probabilistic component, PCA offer flexible computing tools for complex numerical constructions, and realistic simulation tools for phenomena driven by interactions among a large number of neighboring structures. PCA are currently being used in various fields, ranging from pure probability to the social sciences and including a wealth of scientific and technological applications. This situation has produced a highly diversified pool of theoreticians, developers and practitioners whose interaction is highly desirable but can be hampered by differences in jargon and focus. This book - just as the workshop on which it is based - is an attempt to overcome these difference and foster interest among newcomers and interaction between practitioners from different fields. It is not intended as a treatise, but rather as a gentle introduction to the role and relevance of PCA technology, illustrated with a number of applications in probability, statistical mechanics, computer science, the natural sciences and dynamical systems. As such, it will be of interest to students and non-specialists looking to enter the field and to explore its challenges and open issues.

Periodically Correlated Solutions to a Class of Stochastic Difference Equations.- On Nonlinear SDE'S whose Densities Evolve in a Finite-Dimensional Family.- Composition of Skeletons and Support Theorems.- Invariant Measure for a Wave Equation on a Riemannian Manifold.- Ergodic Distributed Control for Parameter Dependent Stochastic Semilinear Systems.- Dirichlet Forms, Caccioppoli Sets and the Skorohod Equation Masatoshi Fukushima.- Rate of Convergence of Moments of Spall's SPSA Method.- General Setting for Stochastic Processes Associated with Quantum Fields.- On a Class of Semilinear Stochastic Partial Differential Equations.- Parallel Numerical Solution of a Class of Volterra Integro-Differential Equations.- On the Laws of the Oseledets Spaces of Linear Stochastic Differential Equations.- On Stationarity of Additive Bilinear State-space Representation of Time Series.- On Convergence of Approximations of Ito-Volterra Equations.- Non-isotropic Ornstein-Uhlenbeck Process and White Noise Analysis.- Stochastic Processes with Independent Increments on a Lie Group and their Selfsimilar Properties.- Optimal Damping of Forced Oscillations Discrete-time Systems by Output Feedback.- Forecast of Levy's Brownian Motion as the Observation Domain Undergoes Deformation.- A Maximal Inequality for the Skorohod Integral.- On the Kinematics of Stochastic Mechanics.- Stochastic Equations in Formal Mappings.- On Fisher's Information Matrix of an ARMA Process.- Statistical Analysis of Nonlinear and NonGaussian Time Series.- Bilinear Stochastic Systems with Long Range Dependence in Continuous Time.- On Support Theorems for Stochastic Nonlinear Partial Differential Equations.- Excitation and Performance in Continuous-time Stochastic Adaptive LQ-control.- Invariant Measures for Diffusion Processes in Conuclear Spaces.- Degree Theory on Wiener Space and an Application to a Class of SPDEs.- On the Interacting Measure-Valued Branching Processes.

This book brings together a rich selection of studies in mathematical modeling and computational intelligence, with application in several fields of engineering, like automation, biomedical, chemical, civil, electrical, electronic, geophysical and mechanical engineering, on a multidisciplinary approach. Authors from five countries and 16 different research centers contribute with their expertise in both the fundamentals and real problems applications based upon their strong background on modeling and computational intelligence. The reader will find a wide variety of applications, mathematical and computational tools and original results, all presented with rigorous mathematical procedures. This work is intended for use in graduate courses of engineering, applied mathematics and applied computation where tools as mathematical and computational modeling, numerical methods and computational intelligence are applied to the solution of real problems.

This book demonstrates how mathematical methods and techniques can be used in synergy and create a new way of looking at complex systems. It becomes clear nowadays that the standard (graph-based) network approach, in which observable events and transportation hubs are represented by nodes and relations between them are represented by edges, fails to describe the important properties of complex systems, capture the dependence between their scales, and anticipate their future developments. Therefore, authors in this book discuss the new generalized theories capable to describe a complex nexus of dependences in multi-level complex systems and to effectively engineer their important functions. The collection of works devoted to the memory of Professor Valentin Afraimovich introduces new concepts, methods, and applications in nonlinear dynamical systems covering physical problems and mathematical modelling relevant to molecular biology, genetics, neurosciences, artificial intelligence as well as classic problems in physics, machine learning, brain and urban dynamics. The book can be read by mathematicians, physicists, complex systems scientists, IT specialists, civil engineers, data scientists, urban planners, and even musicians (with some mathematical background).

This textbook presents in a concise and self-contained way the advanced fundamental mathematical structures in quantum theory. It is based on lectures prepared for a 6 months course for MSc students. The reader is introduced to the beautiful interconnection between logic, lattice theory, general probability theory, and general spectral theory including the basic theory of von Neumann algebras and of the algebraic formulation, naturally arising in the study of the mathematical machinery of quantum theories. Some general results concerning hidden-variable interpretations of QM such as Gleason's and the Kochen-Specker theorems and the related notions of realism and non-contextuality are carefully discussed. This is done also in relation with the famous Bell (BCHSH) inequality concerning local causality. Written in a didactic style, this book includes many examples and solved exercises. The work is organized as follows. Chapter 1 reviews some elementary facts and properties of quantum systems. Chapter 2 and 3 present the main results of spectral analysis in complex Hilbert spaces. Chapter 4 introduces the point of view of the orthomodular lattices' theory. Quantum theory form this perspective turns out to the probability measure theory on the non-Boolean lattice of elementary observables and Gleason's theorem characterizes all these measures. Chapter 5 deals with some philosophical and interpretative aspects of quantum theory like hidden-variable formulations of QM. The Kochen-Specker theorem and its implications are analyzed also in relation BCHSH inequality, entanglement, realism, locality, and non-contextuality. Chapter 6 focuses on the algebra of observables also in the presence of superselection rules introducing the notion of von Neumann algebra. Chapter 7 offers the idea of (groups of) quantum symmetry, in particular, illustrated in terms of Wigner and Kadison theorems. Chapter 8 deals with the elementary ideas and results of the so called algebraic formulation of quantum theories in terms of both *-algebras and C*-algebras. This book should appeal to a dual readership: on one hand mathematicians that wish to acquire the tools that unlock the physical aspects of quantum theories; on the other physicists eager to solidify their understanding of the mathematical scaffolding of quantum theories.

This book presents the proceedings of the "5th International Interdisciplinary Chaos Symposium on Chaos and Complex Systems (CCS)." All Symposia in the series bring together scientists, engineers, economists and social scientists, creating a vivid forum for discussions on the latest insights and findings obtained in the areas of complexity, nonlinear dynamics and chaos theory, as well as their interdisciplinary applications. The scope of the latest Symposium was enriched with a variety of contemporary, interdisciplinary topics, including but not limited to: fundamental theory of nonlinear dynamics, networks, circuits, systems, biology, evolution and ecology, fractals and pattern formation, nonlinear time series analysis, neural networks, sociophysics and econophysics, complexity management and global systems.

This book focuses on the stability analysis of Markovian jump systems (MJSs) with various settings and discusses its applications in several different areas. It also presents general definitions of the necessary concepts and an overview of the recent developments in MJSs. Further, it addresses the general robust problem of Markovian jump linear systems (MJLSs), the asynchronous stability of a class of nonlinear systems, the robust adaptive control scheme for a class of nonlinear uncertain MJSs, the practical stability of MJSs and its applications as a modelling tool for networked control systems, Markovian-based control for wheeled mobile manipulators and the jump-linear-quadratic (JLQ) problem of a class of continuous-time MJLSs. It is a valuable resource for researchers and graduate students in the field of control theory and engineering.

The main concern of the book is analysis of biological processes, the final stage of which is mathematical modeling, i.e. quantitative presentation of the processes in rigorous mathematical terms. It is designated for non-mathematicians. Mathematical models can be compared with experimental data thus verifying the validity of the models and finally of the initial assumptions and verbal descriptions of the processes. The models (usually in the form of mathematical equations) are achieved painlessly via the schemes summarising verbal description of what is known concerning the processes. To solve the equations computer software is used. The step-by-step analysis leads to quite sophisticated models some of them being original. The book helps the reader to develop more general approach to the problems. It may be useful for experienced readers as well.

This book presents recent developments in nonlinear dynamics and physics with an emphasis on complex systems. The contributors provide recent theoretic developments and new techniques to solve nonlinear dynamical systems and help readers understand complexity, stochasticity, and regularity in nonlinear dynamical systems. This book covers integro-differential equation solvability, Poincare recurrences in ergodic systems, orientable horseshoe structure, analytical routes of periodic motions to chaos, grazing on impulsive differential equations, from chaos to order in coupled oscillators, and differential-invariant solutions for automorphic systems, inequality under uncertainty.

This thesis deals with the dynamics of state-of-the-art nanophotonic semiconductor structures, providing essential information on fundamental aspects of nonlinear dynamical systems on the one hand, and technological applications in modern telecommunication on the other. Three different complex laser structures are considered in detail: (i) a quantum-dot-based semiconductor laser under optical injection from a master laser, (ii) a quantum-dot laser with optical feedback from an external resonator, and (iii) a passively mode-locked quantum-well semiconductor laser with saturable absorber under optical feedback from an external resonator. Using a broad spectrum of methods, both numerical and analytical, this work achieves new fundamental insights into the interplay of microscopically based nonlinear laser dynamics and optical perturbations by delayed feedback and injection.

This book presents simple design paradigms related to lightweight design, that are derived from an in-depth and theoretically sound analysis based on Pareto theory. It uses numerous examples, including torsion and inflated tubes, to fully explain the theories discussed. Lightweight Construction Principles begins by defining terms in relation to engineering design and optimal design of complex mechanical systems. It then discusses the analytical derivation of the Pareto-optimal set, before applying analytical formulae to optimal design of bent beams. The book moves through numerous case studies of different beam and tube construction including beams subject to bending, thin walled tubes under torsion and truss structures. This book will be of interest to researchers and graduate students in the field of structural optimisation and multi-objective optimization, as well as to practitioners such as design engineers.

The first volume of the proceedings of the 7th conference on "Finite Volumes for Complex Applications" (Berlin, June 2014) covers topics that include convergence and stability analysis, as well as investigations of these methods from the point of view of compatibility with physical principles. It collects together the focused invited papers, as well as the reviewed contributions from internationally leading researchers in the field of analysis of finite volume and related methods. Altogether, a rather comprehensive overview is given of the state of the art in the field.

The finite volume method in its various forms is a space discretization technique for partial differential equations based on the fundamental physical principle of conservation. Recent decades have brought significant success in the theoretical understanding of the method. Many finite volume methods preserve further qualitative or asymptotic properties, including maximum principles, dissipativity, monotone decay of free energy, and asymptotic stability. Due to these properties, finite volume methods belong to the wider class of compatible discretization methods, which preserve qualitative properties of continuous problems at the discrete level. This structural approach to the discretization of partial differential equations becomes particularly important for multiphysics and multiscale applications.

Researchers, PhD and masters level students in numerical analysis, scientific computing and related fields such as partial differential equations will find this volume useful, as will engineers working in numerical modeling and simulations."

This book covers a wide spectrum of systems such as linear and nonlinear multivariable systems as well as control problems such as disturbance, uncertainty and time-delays. The purpose of this book is to provide researchers and practitioners a manual for the design and application of advanced discrete-time controllers. The book presents six different control approaches depending on the type of system and control problem. The first and second approaches are based on Sliding Mode control (SMC) theory and are intended for linear systems with exogenous disturbances. The third and fourth approaches are based on adaptive control theory and are aimed at linear/nonlinear systems with periodically varying parametric uncertainty or systems with input delay. The fifth approach is based on Iterative learning control (ILC) theory and is aimed at uncertain linear/nonlinear systems with repeatable tasks and the final approach is based on fuzzy logic control (FLC) and is intended for highly uncertain systems with heuristic control knowledge. Detailed numerical examples are provided in each chapter to illustrate the design procedure for each control method. A number of practical control applications are also presented to show the problem solving process and effectiveness with the advanced discrete-time control approaches introduced in this book.

This book presents mathematical models of mob control with threshold (conformity) collective decision-making of the agents. Based on the results of analysis of the interconnection between the micro- and macromodels of active network structures, it considers the static (deterministic, stochastic and game-theoretic) and dynamic (discrete- and continuous-time) models of mob control, and highlights models of informational confrontation. Many of the results are applicable not only to mob control problems, but also to control problems arising in social groups, online social networks, etc. Aimed at researchers and practitioners, it is also a valuable resource for undergraduate and postgraduate students as well as doctoral candidates specializing in the field of collective behavior modeling.

State-space models as an important mathematical tool has been widely used in many different fields. This edited collection explores recent theoretical developments of the models and their applications in economics and finance. The book includes nonlinear andnon-Gaussian time series models, regime-switching and hidden Markov models, continuous- or discrete-time state processes, and models of equally-spaced or irregularly-spaced (discrete or continuous) observations.The contributed chapters are divided into four parts. The first part is on Particle Filtering and Parameter Learning in Nonlinear State-Space Models.The second part focuseson the application of Linear State-Space Models in Macroeconomics and Finance.The third part deals with Hidden Markov Models, Regime Switching and Mathematical Finance and the fourth part is on Nonlinear State-Space Models for High Frequency Financial Data. The book will appeal to graduate students and researchers studying state-space modeling in economics, statistics, and mathematics, as well as to finance professionals."

This volume contains a selection of contributions that were presented at the Modeling and Optimization: Theory and Applications Conference (MOPTA) held at Lehigh University in Bethlehem, Pennsylvania, USA on July 30-August 1, 2012. The conference brought together a diverse group of researchers and practitioners, working on both theoretical and practical aspects of continuous or discrete optimization. Topics presented included algorithms for solving convex, network, mixed-integer, nonlinear, and global optimization problems, and addressed the application of optimization techniques in finance, logistics, health, and other important fields. The contributions contained in this volume represent a sample of these topics and applications and illustrate the broad diversity of ideas discussed at the meeting.

The book conveys modern techniques and the latest state-of-the-art with regard to the most fundamental aspects of computational contact mechanics. However, since contact can readily be interpreted as a special type of interface problem, it seems advisable not to isolate contact mechanics, but rather to address it in the context of a broader class of problems denoted as computational interface mechanics. The book gives a clear understanding of the underlying physics of interfaces, and a comprehensive insight into the current state-of-the-art and selected cutting-edge research directions in the computational treatment of interface effects. It focuses on the modeling of friction, wear, lubrication, cohesive interfaces, grain boundaries, phase boundaries, fracture, thermo-mechanics and particulate contact (e.g. granular media). Also the most important computational aspects are addressed, including discretization techniques for finite deformations, solution algorithms for single- and multi-processor computing environments, multi-scale approaches, discrete element models and multi-physics problems including contact and interface constraints. Among the computational techniques covered in this book are finite element (FEM) and boundary element (BEM) methods, atomistic models, molecular dynamics (MD), discrete element methods (DEM), coupling approaches for multi-scale simulations, and tools for an efficient automated FEM code generation.

The book focuses on Social Collective Intelligence, a term used to denote a class of socio-technical systems that combine, in a coordinated way, the strengths of humans, machines and collectives in terms of competences, knowledge and problem solving capabilities with the communication, computing and storage capabilities of advanced ICT. Social Collective Intelligence opens a number of challenges for researchers in both computer science and social sciences; at the same time it provides an innovative approach to solve challenges in diverse application domains, ranging from health to education and organization of work. The book will provide a cohesive and holistic treatment of Social Collective Intelligence, including challenges emerging in various disciplines (computer science, sociology, ethics) and opportunities for innovating in various application areas. By going through the book the reader will gauge insight and knowledge into the challenges and opportunities provided by this new, exciting, field of investigation. Benefits for scientists will be in terms of accessing a comprehensive treatment of the open research challenges in a multidisciplinary perspective. Benefits for practitioners and applied researchers will be in terms of access to novel approaches to tackle relevant problems in their field. Benefits for policy-makers and public bodies representatives will be in terms of understanding how technological advances can support them in supporting the progress of society and economy.

This book addresses the basics of interval/fuzzy set theory, artificial neural networks (ANN) and computational methods. It presents step-by-step modeling for application problems along with simulation and numerical solutions. In general, every science and engineering problem is inherently biased by uncertainty, and there is often a need to model, solve and interpret problems in the world of uncertainty. At the same time, exact information about models and parameters of practical applications is usually not known and precise values do not exist. This book discusses uncertainty in both data and models. It consists of seven chapters covering various aspects of fuzzy uncertainty in application problems, such as shallow water wave equations, static structural problems, robotics, radon diffusion in soil, risk of invasive alien species and air quality quantification. These problems are handled by means of advanced computational and fuzzy theory along with machine intelligence when the uncertainties involved are fuzzy. The proposed computational methods offer new fuzzy computing methods that help other areas of knowledge construction where inexact information is present.

This monograph explains the theory of quantum waveguides, that is, dynamics of quantum particles confined to regions in the form of tubes, layers, networks, etc. The focus is on relations between the confinement geometry on the one hand and the spectral and scattering properties of the corresponding quantum Hamiltonians on the other. Perturbations of such operators, in particular, by external fields are also considered. The volume provides a unique summary of twenty-five years of research activity in this area and indicates ways in which the theory can develop further. The book is fairly self-contained. While it requires some broader mathematical physics background, all the basic concepts are properly explained and proofs of most theorems are given in detail, so there is no need for additional sources. Without a parallel in the literature, the monograph by Exner and Kovarik guides the reader through this new and exciting field.

This book presents cutting-edge developments in the advanced mathematical theories utilized in computer graphics research - fluid simulation, realistic image synthesis, and texture, visualization and digital fabrication. A spin-off book from the International Symposium on Mathematical Progress in Expressive Image Synthesis in 2016 and 2017 (MEIS2016/2017) held in Fukuoka, Japan, it includes lecture notes and an expert introduction to the latest research presented at the symposium. The book offers an overview of the emerging interdisciplinary themes between computer graphics and driven mathematic theories, such as discrete differential geometry. Further, it highlights open problems in those themes, making it a valuable resource not only for researchers, but also for graduate students interested in computer graphics and mathematics.

This textbook teaches advanced undergraduate and first-year graduate students in Engineering and Applied Sciences to gather and analyze empirical observations (data) in order to aid in making design decisions. While science is about discovery, the primary paradigm of engineering and "applied science" is design. Scientists are in the discovery business and want, in general, to understand the natural world rather than to alter it. In contrast, engineers and applied scientists design products, processes, and solutions to problems. That said, statistics, as a discipline, is mostly oriented toward the discovery paradigm. Young engineers come out of their degree programs having taken courses such as "Statistics for Engineers and Scientists" without any clear idea as to how they can use statistical methods to help them design products or processes. Many seem to think that statistics is only useful for demonstrating that a device or process actually does what it was designed to do. Statistics courses emphasize creating predictive or classification models - predicting nature or classifying individuals, and statistics is often used to prove or disprove phenomena as opposed to aiding in the design of a product or process. In industry however, Chemical Engineers use designed experiments to optimize petroleum extraction; Manufacturing Engineers use experimental data to optimize machine operation; Industrial Engineers might use data to determine the optimal number of operators required in a manual assembly process. This text teaches engineering and applied science students to incorporate empirical investigation into such design processes. Much of the discussion in this book is about models, not whether the models truly represent reality but whether they adequately represent reality with respect to the problems at hand; many ideas focus on how to gather data in the most efficient way possible to construct adequate models. Includes chapters on subjects not often seen together in a single text (e.g., measurement systems, mixture experiments, logistic regression, Taguchi methods, simulation) Techniques and concepts introduced present a wide variety of design situations familiar to engineers and applied scientists and inspire incorporation of experimentation and empirical investigation into the design process. Software is integrally linked to statistical analyses with fully worked examples in each chapter; fully worked using several packages: SAS, R, JMP, Minitab, and MS Excel - also including discussion questions at the end of each chapter. The fundamental learning objective of this textbook is for the reader to understand how experimental data can be used to make design decisions and to be familiar with the most common types of experimental designs and analysis methods.