This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

This thesis focuses on the dynamics of autonomous Boolean networks, on the basis of Boolean logic functions in continuous time without external clocking. These networks are realized with integrated circuits on an electronic chip as a field programmable gate array (FPGA) with roughly 100,000 logic gates, offering an extremely flexible model system. It allows fast and cheap design cycles and large networks with arbitrary topologies and coupling delays. The author presents pioneering results on theoretical modeling, experimental realization, and selected applications. In this regard, three classes of novel dynamic behavior are investigated: (i) Chaotic Boolean networks are proposed as high-speed physical random number generators with high bit rates. (ii) Networks of periodic Boolean oscillators are home to long-living transient chimera states, i.e., novel patterns of coexisting domains of spatially coherent (synchronized) and incoherent (desynchronized) dynamics. (iii) Excitable networks exhibit cluster synchronization and can be used as fast artificial Boolean neurons whose spiking patterns can be controlled. This work presents the first experimental platform for large complex networks, which will facilitate exciting future developments.

This book provides an introduction to vector optimization with variable ordering structures, i.e., to optimization problems with a vector-valued objective function where the elements in the objective space are compared based on a variable ordering structure: instead of a partial ordering defined by a convex cone, we see a whole family of convex cones, one attached to each element of the objective space. The book starts by presenting several applications that have recently sparked new interest in these optimization problems, and goes on to discuss fundamentals and important results on a wide range of topics. The theory developed includes various optimality notions, linear and nonlinear scalarization functionals, optimality conditions of Fermat and Lagrange type, existence and duality results. The book closes with a collection of numerical approaches for solving these problems in practice.

The present volume contains invited talks of 11th biennial conference on "Emerging Mathematical Methods, Models and Algorithms for Science and Technology". The main message of the book is that mathematics has a great potential to analyse and understand the challenging problems of nanotechnology, biotechnology, medical science, oil industry and financial technology. The book highlights all the features and main theme discussed in the conference. All contributing authors are eminent academicians, scientists, researchers and scholars in their respective fields, hailing from around the world.

Produced by an award-winning translator of Henri Poincare, this book contains translations of several seminal articles by Poincare and discusses the experimental and theoretical investigations of electrons that form their context. In the 1950s, a dispute ignited about the origin of the theory of special relativity and thrust considerable notoriety on a paper written by Henri Poincare in 1905. Accordingly, Part I presents the relevant translations of Poincare's work showing that radiation carries momentum and the covariance of the equations of electrodynamics, the continuity equation for charge, and the spacetime interval. Part II then discusses investigations by Thomson, Becquerel, and Kaufmann of electrons in diverse contexts; contributions of Abraham, Lorentz and Poincare to a theory of electrons that includes Lorentz transformations and explains the dependence of mass on velocity; and finally, Poincare's exploration of the relativity principle, electron stability, and gravitation while rejecting absolute motion (ether) and an electromagnetic origin of mass. Part III contains the 1904 article by H. A. Lorentz presenting his transformations.This book will be a fascinating read to graduate-level students, physicists, and science historians who are interested in the development of electrodynamics and the classical, relativistic theory of electrons at the beginning of the 20th century.

This book focuses on a critical discussion of the status and prospects of current approaches in quantum mechanics and quantum field theory, in particular concerning gravity. It contains a carefully selected cross-section of lectures and discussions at the seventh conference "Progress and Visions in Quantum Theory in View of Gravity" which took place in fall 2018 at the Max Planck Institute for Mathematics in the Sciences in Leipzig. In contrast to usual proceeding volumes, instead of reporting on the most recent technical results, contributors were asked to discuss visions and new ideas in foundational physics, in particular concerning foundations of quantum field theory. A special focus has been put on the question of which physical principles of quantum (field) theory can be considered fundamental in view of gravity. The book is mainly addressed to mathematicians and physicists who are interested in fundamental questions of mathematical physics. It allows the reader to obtain a broad and up-to-date overview of a fascinating active research area.

Semiconductor quantum optics is on the verge of moving from the lab to real world applications. When stepping from basic research to new technologies, device engineers will need new simulation tools for the design and optimization of quantum light sources, which combine classical device physics with cavity quantum electrodynamics. This thesis aims to provide a holistic description of single-photon emitting diodes by bridging the gap between microscopic and macroscopic modeling approaches. The central result is a novel hybrid quantum-classical model system that self-consistently couples semi-classical carrier transport theory with open quantum many-body systems. This allows for a comprehensive description of quantum light emitting diodes on multiple scales: It enables the calculation of the quantum optical figures of merit together with the simulation of the spatially resolved current flow in complex, multi-dimensional semiconductor device geometries out of one box. The hybrid system is shown to be consistent with fundamental laws of (non-)equilibrium thermodynamics and is demonstrated by numerical simulations of realistic devices.

This proceedings volume gathers a selection of outstanding research papers presented at the third Conference on Isogeometric Analysis and Applications, held in Delft, The Netherlands, in April 2018. This conference series, previously held in Linz, Austria, in 2012 and Annweiler am Trifels, Germany, in 2014, has created an international forum for interaction between scientists and practitioners working in this rapidly developing field. Isogeometric analysis is a groundbreaking computational approach that aims to bridge the gap between numerical analysis and computational geometry modeling by integrating the finite element method and related numerical simulation techniques into the computer-aided design workflow, and vice versa. The methodology has matured over the last decade both in terms of our theoretical understanding, its mathematical foundation and the robustness and efficiency of its practical implementations. This development has enabled scientists and practitioners to tackle challenging new applications at the frontiers of research in science and engineering and attracted early adopters for this his novel computer-aided design and engineering technology in industry. The IGAA 2018 conference brought together experts on isogeometric analysis theory and application, share their insights into challenging industrial applications and to discuss the latest developments as well as the directions of future research and development that are required to make isogeometric analysis an established mainstream technology.

This is the first book presenting dynamic responses and failure of polymer composite structures as they interact with internal and/or external fluid media. It summarizes authoritative research carried out by the author in the past decade on various aspects of Fluid-Structure Interaction (FSI) to present important effects of FSI on composite structures. The topics include impact loading on composite structures with air-back, water-back, or containing water; FSI effects on frequencies, mode shapes, and modal curvatures; cyclic loading for fatigue failure with FSI; coupling of independent composite structures by fluid media; and moving composite structures in water. Numerical techniques for FSI are also presented. Research was conducted both experimentally and numerically to complement each other. The book offers a timely, comprehensive information to fluid-structure interaction of composite structures for students, researchers or practicing engineers.

Starting from fundamentals of classical stability theory, an overview is given of the transition phenomena in subsonic, wall-bounded shear flows. At first, the consideration focuses on elementary small-amplitude velocity perturbations of laminar shear layers, i.e. instability waves, in the simplest canonical configurations of a plane channel flow and a flat-plate boundary layer. Then the linear stability problem is expanded to include the effects of pressure gradients, flow curvature, boundary-layer separation, wall compliance, etc. related to applications. Beyond the amplification of instability waves is the non-modal growth of local stationary and non-stationary shear flow perturbations which are discussed as well. The volume continues with the key aspect of the transition process, that is, receptivity of convectively unstable shear layers to external perturbations, summarizing main paths of the excitation of laminar flow disturbances. The remainder of the book addresses the instability phenomena found at late stages of transition. These include secondary instabilities and nonlinear features of boundary-layer perturbations that lead to the final breakdown to turbulence. Thus, the reader is provided with a step-by-step approach that covers the milestones and recent advances in the laminar-turbulent transition. Special aspects of instability and transition are discussed through the book and are intended for research scientists, while the main target of the book is the student in the fundamentals of fluid mechanics. Computational guides, recommended exercises, and PowerPoint multimedia notes based on results of real scientific experiments supplement the monograph. These are especially helpful for the neophyte to obtain a solid foundation in hydrodynamic stability. To access the supplementary material go to extras.springer.com and type in the ISBN for this volume.

As in the previous volume on the topic, the authors close the gap between abstract mathematical approaches, such as applied methods of modern algebra and analysis, fundamental and computational mechanics, nonautonomous and stochastic dynamical systems, on the one hand and practical applications in nonlinear mechanics, optimization, decision making theory and control theory on the other. Readers will also benefit from the presentation of modern mathematical modeling methods for the numerical solution of complicated engineering problems in biochemistry, geophysics, biology and climatology. This compilation will be of interest to mathematicians and engineers working at the interface of these fields. It presents selected works of the joint seminar series of Lomonosov Moscow State University and the Institute for Applied System Analysis at National Technical University of Ukraine "Kyiv Polytechnic Institute". The authors come from Brazil, Germany, France, Mexico, Spain, Poland, Russia, Ukraine and the USA.

Mathematical Geoscience is an expository textbook which aims to provide a comprehensive overview of a number of different subjects within the Earth and environmental sciences. Uniquely, it treats its subjects from the perspective of mathematical modelling with a level of sophistication that is appropriate to their proper investigation. The material ranges from the introductory level, where it can be used in undergraduate or graduate courses, to research questions of current interest. The chapters end with notes and references, which provide an entry point into the literature, as well as allowing discursive pointers to further research avenues. The introductory chapter provides a condensed synopsis of applied mathematical techniques of analysis, as used in modern applied mathematical modelling. There follows a succession of chapters on climate, ocean and atmosphere dynamics, rivers, dunes, landscape formation, groundwater flow, mantle convection, magma transport, glaciers and ice sheets, and sub-glacial floods. This book introduces a whole range of important geoscientific topics in one single volume and serves as an entry point for a rapidly expanding area of genuine interdisciplinary research. By addressing the interplay between mathematics and the real world, this book will appeal to graduate students, lecturers and researchers in the fields of applied mathematics, the environmental sciences and engineering.

Brownian dynamics serve as mathematical models for the diffusive motion of microscopic particles of various shapes in gaseous, liquid, or solid environments. The renewed interest in Brownian dynamics is due primarily to their key role in molecular and cellular biophysics: diffusion of ions and molecules is the driver of all life. Brownian dynamics simulations are the numerical realizations of stochastic differential equations that model the functions of biological micro devices such as protein ionic channels of biological membranes, cardiac myocytes, neuronal synapses, and many more. Stochastic differential equations are ubiquitous models in computational physics, chemistry, biophysics, computer science, communications theory, mathematical finance theory, and many other disciplines. Brownian dynamics simulations of the random motion of particles, be it molecules or stock prices, give rise to mathematical problems that neither the kinetic theory of Maxwell and Boltzmann, nor Einstein's and Langevin's theories of Brownian motion could predict.This book takes the readers on a journey that starts with the rigorous definition of mathematical Brownian motion, and ends with the explicit solution of a series of complex problems that have immediate applications. It is aimed at applied mathematicians, physicists, theoretical chemists, and physiologists who are interested in modeling, analysis, and simulation of micro devices of microbiology. The book contains exercises and worked out examples throughout.

This book contains selected and expanded contributions presented at the 15th Conference on Acoustics and Vibration of Mechanical Structures held in Timisoara, Romania, May 30-31, 2019. The conference focused on a broad range of topics related to acoustics and vibration, such as analytical approaches to nonlinear noise and vibration problems, environmental and occupational noise, structural vibration, biomechanics and bioacoustics, as well as experimental approaches to vibration problems in industrial processes. The different contributions also address the analytical, numerical and experimental techniques applicable to analyze linear and non-linear noise and vibration problems (including strong nonlinearity) and they are primarily intended to emphasize the actual trends and state-of-the-art developments in the above mentioned topics. The book is meant for academics, researchers and professionals, as well as PhD students concerned with various fields of acoustics and vibration of mechanical structures.

This volume presents the state-of-the-art in selected topics across modern nuclear physics, covering fields of central importance to research and illustrating their connection to many different areas of physics. It describes recent progress in the study of superheavy and exotic nuclei, which is pushing our knowledge to ever heavier elements and neutron-richer isotopes. Extending nuclear physics to systems that are many times denser than even the core of an atomic nucleus, one enters the realm of the physics of neutron stars and possibly quark stars, a topic that is intensively investigated with many ground-based and outer-space research missions as well as numerous theoretical works. By colliding two nuclei at very high ultra-relativistic energies one can create a fireball of extremely hot matter, reminiscent of the universe very shortly after the big bang, leading to a phase of melted hadrons and free quarks and gluons, the so-called quark-gluon plasma. These studies tie up with effects of crucial importance in other fields. During the collision of heavy ions, electric fields of extreme strength are produced, potentially destabilizing the vacuum of the atomic physics system, subsequently leading to the decay of the vacuum state and the emission of positrons. In neutron stars the ultra-dense matter might support extremely high magnetic fields, far beyond anything that can be produced in the laboratory, significantly affecting the stellar properties. At very high densities general relativity predicts the stellar collapse to a black hole. However, a number of current theoretical activities, modifying Einstein's theory, point to possible alternative scenarios, where this collapse might be avoided. These and related topics are addressed in this book in a series of highly readable chapters. In addition, the book includes fundamental analyses of the practicalities involved in transiting to an electricity supply mainly based on renewable energies, investigating this scenario less from an engineering and more from a physics point of view. While the topics comprise a large scope of activities, the contributions also show an extensive overlap in the methodology and in the analytical and numerical tools involved in tackling these diverse research fields that are the forefront of modern science.

The book is devoted to several topical questions in modern mathematical and theoretical physics, astrophysics, geophysics, and cosmology that remain unsolved within the framework of the standard approaches. To them, one can attribute unexplained properties of the magnetic fields of stars and planets, puzzles of the Earth's atmosphere, the phenomenon of ball lightning, the problem of a qualitative description for nuclear forces and their well-known property of saturation, enigmatic properties of spiral galaxies, the problem of the cosmological singularity, mysteries of the dark matter and dark energy, amongst others. To find theoretical ways for understanding such phenomena, new nonlinear generalizations of the classical field theories and advanced methods to solve nonlinear equations arising in them are studied and presented in this book.

The book conveys modern techniques and the latest state-of-the-art with regard to the most fundamental aspects of computational contact mechanics. However, since contact can readily be interpreted as a special type of interface problem, it seems advisable not to isolate contact mechanics, but rather to address it in the context of a broader class of problems denoted as computational interface mechanics. The book gives a clear understanding of the underlying physics of interfaces, and a comprehensive insight into the current state-of-the-art and selected cutting-edge research directions in the computational treatment of interface effects. It focuses on the modeling of friction, wear, lubrication, cohesive interfaces, grain boundaries, phase boundaries, fracture, thermo-mechanics and particulate contact (e.g. granular media). Also the most important computational aspects are addressed, including discretization techniques for finite deformations, solution algorithms for single- and multi-processor computing environments, multi-scale approaches, discrete element models and multi-physics problems including contact and interface constraints. Among the computational techniques covered in this book are finite element (FEM) and boundary element (BEM) methods, atomistic models, molecular dynamics (MD), discrete element methods (DEM), coupling approaches for multi-scale simulations, and tools for an efficient automated FEM code generation.

This book shows how mathematics, computer science and science can be usefully and seamlessly intertwined. It begins with a general model of cognitive processes in a network of computational nodes, such as neurons, using a variety of tools from mathematics, computational science and neurobiology. It then moves on to solve the diffusion model from a low-level random walk point of view. It also demonstrates how this idea can be used in a new approach to solving the cable equation, in order to better understand the neural computation approximations. It introduces specialized data for emotional content, which allows a brain model to be built using MatLab tools, and also highlights a simple model of cognitive dysfunction.

This book presents the various types of coherent states introduced and studied in the physics and mathematics literature and describes their properties together with application to quantum physics problems. It is intended to serve as a compendium on coherent states and their applications for physicists and mathematicians, stretching from the basic mathematical structures of generalized coherent states in the sense of Perelomov via the semiclassical evolution of coherent states to various specific examples of coherent states (hydrogen atom, quantum oscillator, ...).

The celebrated Parisi solution of the Sherrington-Kirkpatrick model for spin glasses is one of the most important achievements in the field of disordered systems. Over the last three decades, through the efforts of theoretical physicists and mathematicians, the essential aspects of the Parisi solution were clarified and proved mathematically. The core ideas of the theory that emerged are the subject of this book, including the recent solution of the Parisi ultrametricity conjecture and a conceptually simple proof of the Parisi formula for the free energy. The treatment is self-contained and should be accessible to graduate students with a background in probability theory, with no prior knowledge of spin glasses. The methods involved in the analysis of the Sherrington-Kirkpatrick model also serve as a good illustration of such classical topics in probability as the Gaussian interpolation and concentration of measure, Poisson processes, and representation results for exchangeable arrays.

This book draws together the most interesting recent results to emerge in mechanical engineering in Russia, providing a fascinating overview of the state of the art in the field in that country which will be of interest to a wide readership. A broad range of topics and issues in modern engineering are discussed, including dynamics of machines, materials engineering, structural strength and tribological behavior, transport technologies, machinery quality and innovations. The book comprises selected papers presented at the conference "Modern Engineering: Science and Education", held at the Saint Petersburg State Polytechnic University in 2016 with the support of the Russian Engineering Union. The authors are experts in various fields of engineering, and all of the papers have been carefully reviewed. The book will be of interest to mechanical engineers, lecturers in engineering disciplines and engineering graduates.

This book provides a comprehensive overview of the theoretical concepts and experimental applications of planar waveguides and other confined geometries, such as optical fibres. Covering a broad array of advanced topics, it begins with a sophisticated discussion of planar waveguide theory, and covers subjects including efficient production of planar waveguides, materials selection, nonlinear effects, and applications including species analytics down to single-molecule identification, and thermo-optical switching using planar waveguides. Written by specialists in the techniques and applications covered, this book will be a useful resource for advanced graduate students and researchers studying planar waveguides and optical fibers.

This book presents various computationally efficient component- and system-level design optimization methods for advanced electrical machines and drive systems. Readers will discover novel design optimization concepts developed by the authors and other researchers in the last decade, including application-oriented, multi-disciplinary, multi-objective, multi-level, deterministic, and robust design optimization methods. A multi-disciplinary analysis includes various aspects of materials, electromagnetics, thermotics, mechanics, power electronics, applied mathematics, manufacturing technology, and quality control and management. This book will benefit both researchers and engineers in the field of motor and drive design and manufacturing, thus enabling the effective development of the high-quality production of innovative, high-performance drive systems for challenging applications, such as green energy systems and electric vehicles.

Inverse limits provide a powerful tool for constructing complicated spaces from simple ones. Theyalso turn the study of a dynamical system consisting of a space and a self-map into a study of a (likely more complicated) space and a self-homeomorphism. In four chapters along with an appendix containing background material the authors develop the theory of inverse limits. The bookbegins with an introduction through inverse limits on 0,1] before moving to a general treatment of the subject. Special topics in continuum theory complete thebook. Although it is not a book on dynamics, the influence of dynamics can be seen throughout; for instance, it includes studies of inverse limits with maps from families of maps that are of interest to dynamicists such as the logistic and the tent families.

This book will serve as a useful reference to graduate students and researchers in continuum theory and dynamical systems. Researchers working in applied areas who are discovering inverse limits in their work will also benefit from this book. "

The last decades have seen the emergence of Complex Networks as the language with which a wide range of complex phenomena in fields as diverse as Physics, Computer Science, and Medicine (to name just a few) can be properly described and understood. This book provides a view of the state of the art in this dynamic field and covers topics ranging from network controllability, social structure, online behavior, recommendation systems, and network structure. This book includes the peer-reviewed list of works presented at the 7th Workshop on Complex Networks CompleNet 2016 which was hosted by the Universite de Bourgogne, France, from March 23-25, 2016. The 28 carefully reviewed and selected contributions in this book address many topics related to complex networks and have been organized in seven major groups: (1) Theory of Complex Networks, (2) Multilayer networks, (3) Controllability of networks, (4) Algorithms for networks, (5) Community detection, (6) Dynamics and spreading phenomena on networks, (7) Applications of Networks.