von K. D. Bock Gestatten Sie, daB ich einleitend Sinn und Zweck dieses Kolloquiums kurz umreiBe. Risikofaktoren sind, vorbehaltlich einer genaueren, vielleicht auch etwas abweichenden Definition, die Herr Epstein in seinem einfuhrenden Referat geben wird, Haupt-oder Teilursachen von Krankheiten oder Krankheitskomplikationen. Sie zeichnen sich durch einige Besonderheiten aus, die es rechtfertigen, sie von der ku- rativen Medizin abzugrenzen und sie auch als Spezialfall der Praven- tivmedizin zu betrachten. Man kann zwei Arten von Risikofaktoren unterscheiden. Zum einen sind Risikofaktoren angeborene oder erworbene biologische Norm- abweichungen oder exogene Einwirkungen, die bei (noch) gesunden Individuen auftreten. Die Eigenschaft, noch nicht krank zu sein, hat der Risikofaktorentrager gemeinsam mit Personen, die z. B. einer Schutzimpfung unterzogen werden. Jedoch unterscheidet er sich von daB ihn das Risiko erstens permanent und zweitens diesen dadurch, immer auch personlich bedroht, wahrend z. B. bei einer Massen- schutzimpfung der einzelne vielleicht uberhaupt nicht oder nur zeit- weise dem Risiko einer Infektion ausgesetzt ist. Zum anderen wird aber auch eine bereits manifeste Krankheit als Risiko/aktor bezeich- net, wenn sie bestimmte Komplikationen allein-oder mitverursacht, z. B. die arterielle Hypertonie die Hirnblutung. Der Risikofaktorentrager erkrankt trotzdem nicht in jedem Faile und auch dann meist nach unterschiedlich langer Dauer der Einwirkung des Risikos. Insofern enthalt das Risikofaktorenkonzept ein progno- stisches Element, das nur in statistischer Form (mehr oder weniger genau) erfaBbar ist, jiir den konkreten Einze/fall aber keine Aussage zu- laj1t. Diese wichtige Tatsache wird in der praktischen Anwendung oft nicht berucksichtigt.

This Open Access book is a guide to good, responsible research at each step of the process of research discovery, so that a researcher at the beginning of a scientific career has a clear pathway to doing good research and producing reliable results.The textbook will give context to the practices described in the European Code of Conduct for Research Integrity, guided by the fundamental principles or research integrity – reliability, honesty, respect, and accountability. Although we base the book on the European Code, the principles are the same in the global research community, such as those outlined in Fostering Integrity in Research from the US National Academies; Engineering and Medicine. The chapters in the book follow good research practices, give practical advice and address basic principles. In this way, the book is applicable to different research fields. It directs readers to various sources for further and updated information, particularly drawing from the resources available at The Embassy of Good Science, the European platform for research integrity and ethics.

The announcement last spring that a lab in Scotland had successfully cloned a mammal captured the attention of the media and the imagination of the public. This culmination of decades of research has profound scientific and ethical implications. If applied to other species, cloning could further genetic engineering and greatly improve animal husbandry. Now that a sheep has been cloned, are humans next? Governments reacted swiftly with bans on funding for human cloning research. Churches united in calling for a complete ban on the cloning of higher animals. Critics immediately alluded to Mary Shelley's "Frankenstein" and the myth of Icarus. Has scientific sophistication outpaced our social and moral development? Can we "save" our society from this possible evil by banning any attempts to expand the knowledge? Does cloning really differ in spirit from the selective breeding that humankind has performed for centuries? "Cloning: For and Against" comprises 30 articles by scientists, ethicists, religious leaders and legal experts who explore the benefits and costs of cloning. Topics include: playing God: is cloning against human nature?; is cloning the salvation for endangered species?; no need for marriage: the separation of reproduction from human relationships; can you xerox a soul? and other theological issues; Brave New World: what's possible and what isn't; clones in medicine; and a million Michael Jacksons: eugenic/dysgenic and cultural consequences of human cloning.

William LaFleur (1936-2010), an eminent scholar of Japanese studies, left behind a substantial number of influential publications, as well as several unpublished works. The most significant of these examines debates concerning the practice of organ transplantation in Japan and the United States, and is published here for the first time. This provocative book challenges the North American medical and bioethical consensus that considers the transplantation of organs from brain dead donors as an unalloyed good. It joins a growing chorus of voices that question the assumption that brain death can be equated facilely with death. It provides a deep investigation of debates in Japan, introducing numerous Japanese bioethicists whose work has never been treated in English. It also provides a history of similar debates in the United States, problematizing the commonly held view that the American public was quick and eager to accept the redefinition of death. A work of intellectual and social history, this book also directly engages with questions that grow ever more relevant as the technologies we develop to extend life continue to advance. While the benefits of these technologies are obvious, their costs are often more difficult to articulate. Calling attention to the risks associated with our current biotech trajectory, LaFleur stakes out a highly original position that does not fall neatly onto either side of contemporary US ideological divides.

Winner of the NCTE George Orwell Award for Distinguished Contribution to Honesty and Clarity in Public Language Although Roe v. Wade identified abortion as a constitutional right in1973, it still bears stigma-a proverbial scarlet A. Millions of Americans have participated in or benefited from an abortion, but few want to reveal that they have done so. Approximately one in five pregnancies in the US ends in abortion. Why is something so common, which has been legal so long, still a source of shame and secrecy? Why is it so regularly debated by politicians, and so seldom divulged from friend to friend? This book explores the personal stigma that prevents many from sharing their abortion experiences with friends and family in private conversation, and the structural stigma that keeps it that way. In public discussion, both proponents and opponents of abortion's legality tend to focus on extraordinary cases. This tendency keeps the national debate polarized and contentious, and keeps our focus on the cases that occur the least. Professor Katie Watson focuses instead on the cases that happen the most, which she calls "ordinary abortion." Scarlet A gives the reflective reader a more accurate impression of what the majority of American abortion practice really looks like. It explains how our silence around private experience has distorted public opinion, and how including both ordinary abortion and abortion ethics could make our public exchanges more fruitful. In Scarlet A, Watson wisely and respectfully navigates one of the most divisive topics in contemporary life. This book explains the law of abortion, challenges the toxic politics that make it a public football and private secret, offers tools for more productive private exchanges, and leads the way to a more robust public discussion of abortion ethics. Scarlet A combines storytelling and statistics to bring the story of ordinary abortion out of the shadows, painting a rich, rarely seen picture of how patients and doctors currently think and act, and ultimately inviting readers to tell their own stories and draw their own conclusions. The paperback edition includes a new preface by the author addressing recent cultural developments in abortion discourse and new legal threats to reproductive rights, and updated statistics throughout.

This book provides an overview of the US laws that affect clinical practice for healthcare professionals with no legal background. Divided into thirteen sections, each chapter starts with a summary of the chapter's content and relevant legal concepts in bullet points before discussing the topics in detail. An application section is provided in many chapters to clarify essential issues by reflecting on clinically relevant case law or clinical vignette(s). Filling a crucial gap in the literature, this comprehensive guide gives healthcare professionals an understanding or a starting point to legal aspects of healthcare.

What rational justification is there for conceiving of all living things as possessing inherent worth? In "Respect for Nature," Paul Taylor draws on biology, moral philosophy, and environmental science to defend a biocentric environmental ethic in which all life has value. Without making claims for the moral rights of plants and animals, he offers a reasoned alternative to the prevailing anthropocentric view--that the natural environment and its wildlife are valued only as objects for human use or enjoyment. "Respect for Nature" provides both a full account of the biological conditions for life--human or otherwise--and a comprehensive view of the complex relationship between human beings and the whole of nature.

This classic book remains a valuable resource for philosophers, biologists, and environmentalists alike--along with all those who care about the future of life on Earth. A new foreword by Dale Jamieson looks at how the original 1986 edition of "Respect for Nature" has shaped the study of environmental ethics, and shows why the work remains relevant to debates today.

Since its first publication in 1996, Ethics and Epidemiology has been an invaluable resource for practicing public health professionals and MPH students around the world. This third edition presents an international perspective of prominent epidemiologists, ethicists, and legal scholars to address important ethical developments in epidemiology and related public health fields from the last decade, including the rise of public health ethics and the complex inter-relations between professional ethics in epidemiology, public health ethics, and research ethics. Ethics and Epidemiology, Third Edition is organized topically and divided into four parts covering "Foundations," "Key Values and Principles," "Methods," and "Issues." New or updated chapters include ethical issues in public health practice, ethical issues in genetic epidemiology, and ethical issues in international health research and epidemiology. Now updated with timely global examples, Ethics and Epidemiology, Third Edition provides an in-depth account to the theoretical and practical moral problems confronting public health students and professionals and offers guidance for how justified moral conclusions can be reached.

Bioethics in Our World: A Reader explores issues related to public health, psychiatry, genetics, and more, and examines the moral worth of actions within these fields. The anthology features collected cases that examine various topics and encourage readers to consider the ethical dilemmas they may face in their futures as clinicians, researchers, and citizens. The book is organized into seven units. The first unit presents the theories of utilitarianism, deontology, virtue ethics, and care ethics. Additional units cover topics that are salient to understanding the nature of bioethics and the world in which bioethics exists. These units address ethical issues in research; the history of eugenics and its relationship to eugenic practices today; and reproductive rights and technologies. Readers learn about experiences faced by patients, researchers, and healthcare professionals with regard to race, gender, age, and ability, and how these experiences are the result of a history of bias and stereotyping. Euthanasia and physician-assisted suicide, stem cell research, gene-editing technology, and medicalization are explored. Timely, thought-provoking, and essential, Bioethics in Our World is an exemplary text for courses in public health, psychiatry, genetics, medical research, or any other course that explores bioethics.

If our bodies could do more things, would our lives be better? Genome editing is a rapidly developing technology that can modify human genes. It can cure heritable diseases, but we could even make certain genetic "improvements" to healthy people. Should we change human embryos genetically to achieve such goals? Bringing together a leading molecular biologist and a Christian ethicist this book responds to the need for solid information and helpful orientation for a pressing moral issue. They explain relevant technical issues without the jargon, clarify the most important philosophical and religious arguments and bring empirical insights to the question of what helps us lead meaningful lives.

In a world where incredible medical technologies are possible ... does "can do" mean "should do"? Why the Church Needs Bioethics helps you understand and constructively engage bioethical challenges with the resources of Christian wisdom and ministry. Three rich and true-to-life case studies illustrate the urgency of such bioethical issues as reproductive and genetic technologies, abortion, forgoing treatment, assisted suicide, stem cell research, and human enhancement technologies. Leading Christian voices bring biblical and theological perspective to bear on the incredible medical technologies available today; mobilize useful insights from health care, law, and business; and demonstrate the powerful ways the church can make a difference through counseling, pastoral care, intercultural ministry, preaching, and education. This book equips students, church and lay leaders, and people in health-related fields with the knowledge to make faithful bioethical decisions and to help foster a world where human beings are shown respect as people created in the image of God. Contributors to Why the Church Needs Bioethics include leading Bible and theology scholars, such as D. A. Carson and Kevin Vanhoozer; leaders in the areas of preaching (Greg Scharf) and ethics (Scott Rae); and 15 other experts in the fields of biblical-theological studies, ministry, communication, business, law, healthcare, and bioethics.

We all assume we know what life is, but the more scientists learn about the living world - from protocells to brains, from zygotes to pandemic viruses - the harder they find it to define exactly what it is and what it isn't. What is life? In this riveting and thought-provoking book, Carl Zimmer explores the question by journeying to the edges of life in every direction, from viruses to computer intelligence, from its origins on earth to the search for extra-terrestrial life and the strange experiments that have attempted to recreate life from scratch in the lab. The question is not only a scientific issue; it hangs over some of society's most charged conflicts - whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead. Whether he is handling pythons or searching for hibernating bats, Zimmer investigates life in its most unfamiliar forms. He tries his own hand at evolving life in a test tube with unnerving results, explores our cultural obsession with Dr. Frankestein's monster and how Coleridge came to believe the whole universe was alive. The result is an entirely gripping exploration of one of the most crucial questions of all: the meaning of life.

This volume examines the latest scientific and technological developments likely to shape our post-human future. Using a multidisciplinary approach, the author argues that we stand at the precipice of an evolutionary change caused by genetic engineering and anatomically embedded digital and informational technologies. The author delves into current scientific initiatives that will lead to the emergence of super smart individuals with unique creative capacities. He draws on technology, psychology and philosophy to consider humans-as-they-are relative to autonomy, creativity, and their place in a future shared with 'post humans.' The author discusses the current state of bioethics and technology law, both which policymakers, beset by a torrent of revolutionary advances in bioengineering, are attempting to steer. Significantly, Carvalko addresses why we must both preserve the narratives that brought us to this moment and continue to express our humanity through, music, art, and literature, to ensure that, as a uniquely creative species, we don't simply vanish in the ether of an evolution brought about by our own technology.

Although the 'Israeli case' of bioethics has been well documented, this book offers a novel understanding of Israeli bioethics that is a milestone in the comparative literature of bioethics. Bringing together a range of experts, the book's interdisciplinary structure employs a contemporary, sociopolitical-oriented approach to bioethics issues, with an emphasis on empirical analysis, that will appeal not only to scholars of bioethics, but also to students of law, medicine, humanities, and social sciences around the world. Its focus on the development of bioethics in Israel makes it especially relevant to scholars of Israeli society - both in and out of Israel - as well as medical practitioners and health policymakers in Israel.

Neil Messer brings together a range of theoretical and practical questions raised by current research on the human brain: questions about both the 'ethics of neuroscience' and the 'neuroscience of ethics'. While some of these are familiar to theologians, others have been more or less ignored hitherto, and the field of neuroethics as a whole has received little theological attention. Drawing on both theological ethics and the science-and-theology field, Messer discusses cognitive-scientific and neuroscientific studies of religion, arguing that they do not give grounds to dismiss theological perspectives on the human self. He examines a representative range of topics across the whole field of neuroethics, including consciousness, the self and the value of human life; the neuroscience of morality; determinism, freewill and moral responsibility; and the ethics of cognitive enhancement.

For decades, the field of bioethics has shaped the way we think about ethical problems in science, technology, and medicine. But its traditional emphasis on individual interests such as doctor-patient relationships, informed consent, and personal autonomy is minimally helpful in confronting the social and political challenges posed by new human biotechnologies such as assisted reproduction, human genetic modification, and DNA forensics. Beyond Bioethics addresses these provocative issues from an emerging standpoint that is attentive to race, gender, class, disability, privacy, and notions of democracy-a "new biopolitics." This authoritative volume provides an overview for those grappling with the profound dilemmas posed by these developments. It brings together the work of cutting-edge thinkers from diverse fields of study and public engagement, all of them committed to this new perspective grounded in social justice and public interest values.

From the cloning of Dolly the sheep a decade ago to more recent advances in embryonic stem cell research, new genetic technologies have often spurred polemical, ill-informed debates. Perhaps nowhere is this more evident than in the field of reproductive genetics, where difficult bioethical issues are distilled into sound bites and far-fetched claims for easy public consumption. The underlying complexities of reprogenetic research and practice are often drowned out by the noise.

In this thoughtful and informed collection, Lori P. Knowles and Gregory E. Kaebnick bring together bioethicists from the United States, Canada, and the United Kingdom to examine the ethical and policy quandaries created by new genetic technologies. Featuring an overview of the field's history (including lessons to be learned from eugenics), comparisons of international and domestic governmental regulations, and discussions of how the market and public opinion affect research, this book considers both the risks and the benefits of combining genetic and reproductive technologies.

Concluding with a cautionary call for increased regulation, Reprogenetics introduces fact, history, and reason into a public discussion of complex and vexing issues.

Pressing ethical issues are at the foreground of newfound knowledge of how the brain works, how the brain fails, and how information about its functions and failures are addressed, recorded and shared. In Neuroethics: Anticipating the Future, a distinguished group of contributors tackle current critical questions and anticipate the issues on the horizon. What new balances should be struck between diagnosis and prediction, or invasive and non-invasive interventions, given the rapid advances in neuroscience? Are new criteria needed for the clinical definition of death for those eligible for organ donation? What educational, social and medical opportunities will new neuroscience discoveries bring to the children of tomorrow? As data from emerging technologies are made available on public databases, what frameworks will maximize benefits while ensuring privacy of health information? How is the environment shaping humans, and humans shaping the environment? These challenging questions and other future-looking neuroethical concerns are discussed in depth. Written by eminent scholars from diverse disciplines - neurology and neuroscience, ethics, law, public health, and philosophy - this new volume on neuroethics sets out the conditions for active consideration. It is essential reading for the fields of neuroethics, neurosciences and psychology, and an invaluable resource for physicians in neurology and neurosurgery, psychiatry, paediatrics, and rehabilitation medicine, academics in humanities and law, and health policy makers.

Sport is often thought of as simply "games," but it can in fact be much more. Sport can be responsible for guiding social justice movements, igniting city-wide riots, uniting countries, permanently injuring youth, revolutionizing views about race, gender and class, and producing several of the most successful global industries. Reports of ethical crises in athletics are constant fodder for popular attention, whether performance enhancing drugs in baseball, corruption in college athletics, the epidemic of brain damage among NFL players, and others too numerous to mention. As a proxy for social concerns, we naturally think of sport in inherently moral terms. Yet we can hardly define the term "sport," or agree on acceptable levels of sporting risk, or determine clear roles and responsibilities for fans, players, coaches, owners, media and health care personnel. Bringing together 27 of the most essential recent articles from philosophy, history, sociology, medicine, and law, this collection explores intersections of sports and ethics and brings attention to the immense role of sports in shaping and reflecting social values.

Medical innovation as it stands today is fundamentally unsustainable. There is a widening gap between what biomedical research promises and the impact that it is currently achieving, in terms of patient benefit and health system improvement. This book highlights the global problem of the ineffective translation of bioscience innovation into health system improvements and its consequences, analyses the underlying causative factors and provides powerful prescriptions for change to close the gap. It contrasts the progress in biomedicine with other areas of scientific and technological endeavour, such as information technology, in which there are faster and more reliable returns for society. The author's career has spanned pharmaceuticals, diagnostics and health informatics and he draws lessons from a host of case examples in which bottlenecks have prevented progress, such as in dementia and antibiotic-resistant infections, and from many in which these barriers have been overcome, such as HIV therapy and targeted cancer treatment. The new era of precision medicine holds the greatest promise of closing this 'innovation gap'. Along with techniques such as open innovation and adaptive development, powerful new genomics and digital health tools are poised to transform the productivity of life sciences. Bioscience-Lost in Translation? lays out a fresh and provocative strategy for advancing the innovation process, shaping the right policy environment and building an ecosystem to deliver the 21st century cures that are urgently needed.

This book is a set of recommendations from the Bioethics Commission in response to a request from President Obama to review the ethical issues associated with the conduct and implications of neuroscience research; and President Obama's request related to the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Specifically the President asked the Bioethics Commission to "identify proactively a set of core ethical standards both to guide neuroscience research and to address some of the ethical dilemmas that may be raised by the application of neuroscience research findings." This book focuses on the integration of ethics into neuroscience research across the life of a research endeavor; and on the analysis on three particularly controversial topics that illustrate the ethical tensions and societal implications of advancing neuroscience and technology: cognitive enhancement, consent capacity, and neuroscience and the legal system. The book seeks to clarify the scientific landscape, identify common ground, and recommend ethical paths forward.