Emphasizes recent advances in biotechnologies that will help in tackling emerging global health challenges Provides detailed information on how to harness indigenous bio-resources including microorganisms and plants for health care delivery Introduces new frontiers in the area of molecular diagnostics and DNA forensic science and bioinformatics with case studies, recent advances in medical insect biotechnology, molecular genetics of pest towards the exploitation of arthropod midgut components to develop interventions against infectious diseases Reviews bioactive molecules derived from commonly used and underutilized medicinal plants that could be used to develop novel drugs for improved healthcare delivery Discuss current approaches in medical and biopharmaceutical biotechnology, deployment of inexpensive genomics-based vector surveillance for effective disease outbreak prediction and control of mosquito-borne viruses

Emphasizes recent advances in biotechnology that could ameliorate the high level global food insecurity through the deployment of the technology in Nigeria. Provides detailed information on how to domesticate biotechnology and boost training of the biotechnology workforce in the universities and research institutes Introduces new frontiers in the area of organizing informal biotechnology capacity building courses and professional certification Reviews biosafety and bioethical guidelines that could enhance adoption of biotechnology in alignment with national priorities and research agenda Discuss current biotechnology policy advocacy, enlightenment and public engagement with stakeholders and Policy makers

Emphasizes recent advances in metagenomics and microbiomes and their emerging applications in medicine, agriculture, industry and environment Provides detailed information on prebiotics and probiotics for enhanced human health Introduces microbiomes as the next frontiers in medicine, agriculture, industry and environment Reviews microbiota transplantation, health implications and the way forward Discuss microbiome - epigenetic-host interactions essential for the physiological functions of the body in health and disease

This classroom-tested textbook will assist dental students with their academic research activities and help them to be competitive in today's fast-growing research environment. It is designed as a core text for dental school classes such as Research Methodology and Scientific and Technical Writing, as well as Responsible Conduct of Research (RCR) training, but will also be a valuable resource for students and researchers in related fields, such as the medical sciences and biomedical engineering. The authors start the book by explaining key concepts and common approaches in dental research, both in basic science and clinical dentistry. They then familiarize readers with evidence-based research in dentistry and how to write a systematic review, explain the process of designing and presenting a proposal, discuss reporting results both in scientific and clinical research, and cover ethics in research, highlighting the significance of adherence to ethics both in animal as well as human studies.

This book aims at exposing its readers to some of the most significant advances in assistive technologies. Assistive technologies develop devices to assist vulnerable people, including elderly people, people with cognitive disabilities such as memory problems or dementia, and people with functional disabilities such as those needing support in toileting, moving around, eating, bathing, dressing, grooming, and taking personal care. The ever-increasing life expectancy and world population, along with the emergence of new diseases and the regrettable continuation of armed conflicts, press for development and availability of assistive technologies that offer people in need the opportunity to live secure and controlled lives with more active participation in society and at a reduced assistive cost. This task can be accomplished only with more advanced devices than traditional-powered wheelchairs or eating/drinking devices, including prosthetics, exoskeletons, visual and hearing aids, cognitive aids, and devices enhanced with artificial intelligence. The book consists of an editorial note and an additional twelve (12) chapters, all of which have been written by authors who work on the corresponding chapter theme and are recognized for their significant research contributions. In more detail, the chapters in the book are organized into four parts, namely (i) Advances in Assistive Technologies in Healthcare, (ii) Advances in Assistive Technologies in Medical Diagnosis, (iii) Advances in Assistive Technologies in Mobility and Navigation, and (iv) Advances in Privacy and Explainability in Assistive Technologies. This research book is directed towards professors, researchers, scientists, engineers, and students in assistive technologies. It is also directed towards readers who come from other disciplines and is interested in becoming versed in some of the most recent assistive technologies. An extensive list of bibliographic references at the end of each chapter guides its readers to probe further into the application areas of interest to them.

Exploring the mechanical features of biological cells, including their architecture and stability, this textbook is a pedagogical introduction to the interdisciplinary fields of cell mechanics and soft matter physics from both experimental and theoretical perspectives. This second edition has been greatly updated and expanded, with new chapters on complex filaments, the cell division cycle, the mechanisms of control and organization in the cell, and fluctuation phenomena. The textbook is now in full color which enhances the diagrams and allows the inclusion of new microscopy images. With around 280 end-of-chapter exercises exploring further applications, this textbook is ideal for advanced undergraduate and graduate students in physics and biomedical engineering. A website hosted by the author contains extra support material, diagrams and lecture notes, and is available at www.cambridge.org/Boal.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.

This monograph introduces current genome editing technologies-clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)-and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases-including CRISPR, TALEN, and ZFN-allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.

This book highlights important aspects of food biotechnology. It is very thoughtfully divided into five sections. The first section introduces the readers to food biotechnology and discusses functional foods, use of plant and animal biotechnology in improving food quality. The second section deals with food microbiology and includes topics such as application of microbial surfactants, use of probiotics, beneficial microorganisms used in food industry etc. The third section describes important macro and micromolecules in foods. It includes chapters on food enzymes, gluten free formulations, use of biopolymers, biofortification of food and other important topics. The next section discusses novel technologies such as use of nanotechnology in food industry, reverse micelle techniques, genome editing in food crops etc. The book culminates with a section on food quality and management. It describes important topics about biosafety and regulatory issues in food biotechnology. This book is meant for students, researchers and course instructors in food science, food technology and biotechnology. It is also useful for industry experts in the area of food technology.

The first and only book on Spray-freeze-drying" which is a relatively recent drying technique, that provides the signature advantages of spray-drying and freeze-drying, while overcoming the limitations of both. Provides examples and case studies of nuances and intricacies associated with each stage of the spray-freeze-drying process Contains 200+ illustrations and tabulations Highlights the applications of spray-freeze-drying in the production of food products including soluble coffee, dairy powders, probiotics, and flavors.

This book analyzes the possibilities for effective global governance of science in Europe, India and China. Authors from the three regions join forces to explore how ethical concerns over new technologies can be incorporated into global science and technology policies. The first chapter introduces the topic, offering a global perspective on embedding ethics in science and technology policy. Chapter Two compares the institutionalization of ethical debates in science, technology and innovation policy in three important regions: Europe, India and China. The third chapter explores public perceptions of science and technology in these same three regions. Chapter Four discusses public engagement in the governance of science and technology, and Chapter Five reviews science and technology governance and European values. The sixth chapter describes and analyzes values demonstrated in the constitution of the People's Republic of China. Chapter Seven describes emerging evidence from India on the uses of science and technology for socio-economic development, and the quest for inclusive growth. In Chapter Eight, the authors propose a comparative framework for studying global ethics in science and technology. The following three chapters offer case studies and analysis of three emerging industries in India, China and Europe: new food technologies, nanotechnology and synthetic biology. Chapter 12 gathers all these threads for a comprehensive discussion on incorporating ethics into science and technology policy. The analysis is undertaken against the backdrop of different value systems and varying levels of public perception of risks and benefits. The book introduces a common analytical framework for the comparative discussion of ethics at the international level. The authors offer policy recommendations for effective collaboration among the three regions, to promote responsible governance in science and technology and a common analytical perspective in ethics.

Past efforts to colonize the environment and domesticate living species, coupled with scientific research, have resulted in the possession (but not always the real control) by humans of any available terrestrial space. However, oceans, which represent up to two thirds of the surface of the planet, had not been really approached until the middle of this century. As oceanographic science develops, the picture of a rich, diverse, complex and also, in many respects, specific marine life, is coming into view. In a broad sense, marine biotechnologies can be understood as the various means or techniques of managing marine living systems for the benefit of mankind. The first goal we have is for marine life to provide biomass for food. However, today it is not certain that a significant increase of total world fisheries' catches will be possible in the future. There are several ways to address this. First, we need to generate better, more complete, or different uses of the biomass actually fished. This is mainly a matter of upgrading fish and fish wastes. Second, we need to artificially grow the living species. This falls within the scope of cell cultivation and of aquaculture. Both approaches have to be appreciated si multaneously in terms of biology, ecology, and economy. In both approaches, profit improvements are linked to the introduction of biotechnological methods and to the use of biotechnological processes."

Covers recent progress on green catalysts derived from biomass Explores biomass conversion to different resources Introduces utilization of bio-waste in environmental aspects Discusses biomass applications in different types of energy Proposes microbial waste biomass as a resource of renewable energy

There have been many great advances in the field of biomedical imaging in recent years, with supramolecular chemistry playing a key role in the evolution of modern imaging techniques. Non-covalent supramolecular interactions are fundamental to countless biological processes, from host-guest binding to the stabilisation of complex structures. Supramolecular chemistry techniques can be employed to create probes that can be targeted to either exploit or disrupt these interactions, giving the potential for both diagnostic and therapeutic effects. Furthermore, in techniques such as contrast enhanced MRI, controlling the interactions between solvent molecules and the imaging agent is crucial to the development of the technique. With rapid growth in the synthesis and study of molecular imaging agents, the understanding of their associated techniques has sometimes lagged behind. Supramolecular Chemistry in Biomedical Imaging will fill this gap by clarifying the state of current understanding and the nature of the underlying problems inherent to addressing problems in biology. It will cover both the techniques used in imaging and the molecular and supramolecular systems used to exploit them. This publication targets academics coming to the field from mainstream supramolecular chemistry, research graduates and undergraduates interested in supramolecular chemistry, synthesis or imaging agents and imaging techniques for biomedical applications.

Nanotechnology is the application of science to control matter at the molecular level. It has become one of the most promising applied technologies in all areas of science. Nanoparticles have multi-functional properties and have created very interesting applications in various fields such as medicine, nutrition, bioenergy, agriculture and the environment. But the biogenic syntheses of monodispersed nanoparticles with specific sizes and shapes have been a challenge in biomaterial science. Nanoparticles are of great interest due to their extremely small size and large surface-to-volume ratio, which lead to both chemical and physical differences in their properties (e.g., mechanical properties, biological and sterical properties, catalytic activity, thermal and electrical conductivity, optical absorption and melting point) compared to bulk of the same chemical composition. Recently, however, synthesizing metal nanoparticles using green technology via microorganisms, plants, viruses, and so on, has been extensively studied and has become recognized as a green and efficient way for further exploiting biological systems as convenient nanofactories. Thus the biological synthesis of nanoparticles is increasingly regarded as a rapid, ecofriendly, and easily scaled-up technology. Today researchers are developing new techniques and materials using nanotechnology that may be suitable for plants to boost their native functions. Recently, biological nanoparticles were found to be more pharmacologically active than physico-chemically synthesized nanoparticles. Various applications of biosynthesized nanoparticles have been discovered, especially in the field of biomedical research, such as applications to specific delivery of drugs, use for tumor detection, angiogenesis, genetic disease and genetic disorder diagnosis, photoimaging, and photothermal therapy. Further, iron oxide nanoparticles have been applied to cancer therapy, hyperthermia, drug delivery, tissue repair, cell labeling, targeting and immunoassays, detoxification of biological fluids, magnetic resonance imaging, and magnetically responsive drug delivery therapy. Nanoparticle synthesis for plant byproducts for biomedical applications has vast potential. This book offers researchers in plant science and biomedicine the latest research and opportunity to develop new tools for the synthesis of environmentally friendly and cost-effective nanoparticles for applications in biomedicine as well as other various fields.

This book covers the very important principle of nanobiotechnology as applied in the petroleum industry and how it can be used for Oil recovery Microbial enhanced oil recovery Petroleum refinery, such as, for example, desulfurization, denitrogenation, demetallization, biotransformation, and bio-upgrading Bioremediation of oil polluted soil and water Mitigation of microbial corrosion and bio-fouling Toxicity of nano-materials and its obstacles upon application Nanobiotechnology in petroleum industry and the 17 goals of sustainable development.

Wheat, which is the second most important cereal crop in the world, is being grown in a wide range of climates over an area of about 228 945 thou sand ha with a production of about 535 842 MT in the world. Bread wheat (Triticum aestivum L. ) accounts for 80% of the wheat consumption, howe ver, it is attacked by a large number of pests and pathogens; rusts and smuts cause enormous damage to the crop and reduce the yield drastically in some areas. The major breeding objectives for wheat include grain yield, earliness, resistance to lodging and diseases, spikelet fertility, cold tolerance, leaf duration and net assimilation rate, fertilizer utilization, coleoptile length, nutritional value, organoleptic qualities, and the improvement of charac ters such as color and milling yield. The breeding of wheat by traditional methods has been practiced for centuries, however, it has only now come to a stage where these methods are insufficient to make any further breakthrough or to cope with the world's demand. Although numerous varieties are released every year around the world, they do not last long, and long-term objectives cannot be realized unless more genetic variability is generated. Moreover, the intro duction of exotic genetic stocks and their cultivation over large areas results in the depletion and loss of the native germplasm pool."

The book provides an overview of current trends in biotechnology and medicinal plant sciences. The work includes detailed chapters on various advance biotechnological tools involved in production of phytoactive compounds of medicinal significance. Some recent and novel research studies on therapeutic applications of different medicinal plants from various geographical regions of the world have also been included. These studies report the antimicrobial activity of various natural plant products against various pathogenic microbial strains. Informative chapters on recent emerging applications of plant products such as source for nutraceuticals and vaccines have been integrated to cover latest advances in the field. This book also explores the conservation aspect of medicinal plants. Thus, chapters having comprehensively complied "in vitro" conservation protocols for various commercially important rare, threatened and endangered medicinal plants were provided in the present book.

Nanomaterials in the Battle Against Pathogens and Disease Vectors presents an overview of the use of nanotechnology to mitigate pathogens of concern, and is the first book to discuss applications of nanotechnology in the fight against all three major domains of disease-causing pathogens. Bacteria, viruses, and parasites constitute the list of emerging and re-emerging pathogens of high priority. Nanotechnology has proven to be a groundbreaking success in the elimination, targeted toxicity, precise immunogenicity, diagnosis, and imaging of these major pathogens and disease vectors. This text discusses basic concepts and advanced applications for bacteria, viruses, and parasites. It describes the use of metallic and non-metallic nanoparticles and nanotoxicity, as well as presents future applications of nanotechnology in biological applications. This work is ideal for engineers and scientists across the interdisciplinary fields of materials science, biomedical engineering, biotechnology, and others concerned with mitigating the risk and effect of pathogens.

This book describes the way that pharmaceutical projects and programs are currently managed, and offers views from many highly experienced practitioners from within the industry on future directions for drug program management. The book integrates portfolio, program, and project management processes as fundamental for effective and efficient drug product development. Contributing expert authors provide their view of how the projectization approach can be taken forward by the drug industry over the coming years.

Legumes include many very important crop plants that contribute very critical protein to the diets of both humans and animals around the world. Their unique ability to fix atmospheric nitrogen in association with Rhizobia enriches soil fertility, and establishes the importance of their niche in agriculture. Divided into two volumes, this work presents an up-to-date analysis of in vitro and recombinant DNA technologies for the improvement of grain, forage and tree legumes.
Volume 10A examines the current status and future prospects of challenges of the following: in vitro morphogenesis; biotic and abiotic stress tolerance; genomics; nitrogen fixation and utilization; nutritional improvement, and biodiversity of wild and tribal legumes.
Volume 10B presents the current state and future prospects of in vitro regeneration and genetic transformation expression and stability of transgenes modification of traits in almost all the important legumes, for example: soybean; peanut; pea; french bean; chick pea; pigeon pea; cowpea; mung bean; black gram; azuki bean; lentil; Lathyrus; lupinus; Lotus spp; Medicago spp; Trifolium spp; Winged bean; Guar; and tree legumes for their improvement. Written by international experts, these volumes will be of great value to researchers, as well as graduate students and all those requiring an advanced level overview of the subject area.