Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the third volume of a continuing series.

This book is intended to give readers an appreciation of what the future holds, as cutting-edge technologies in synthetic biology and pathway engineering and advanced bioprocessing development pave the way for providing goods and services to benefit humankind that are based on the synergy of two biomasses - i.e. of what a renewable feedstock could yield and an infinite microbial biomass could provide in terms of enzymes and biocatalysts. This 13-chapter book, with an introductory treatise on the guiding principles of green chemistry and engineering metrics, brings together a broad range of research and innovation agendas and perspectives from industries, academia and government laboratories using renewable feedstocks that include macroalgae and lignins. In addition, social-economic aspects and the pillars of competitiveness in regional cluster development are explored as we transition from fossil-fuel-based economies to a circular bioeconomy, with chemurgy and green chemistry being implicit to the innovation movement. The bulk of the book covers specific applications including the bioproduction of amino sugars, dicarboxylic acids, omega-3 fatty acids, starch and fermentable sugars from lignocellulosic materials, and phenolics as building blocks for polymer synthesis. Enzymatic systems for accessing chiral and special-purpose chemicals, as well as the development of specialized enzymes from macroalgae for biofuel and biochemical production are also addressed. Research gaps, hurdles to overcome in various biological processes, and present achievements in the production of biofuels and biochemicals from lignocellulosic materials are discussed. Going beyond the conventional expectation of discussing the production of drop-in chemicals, the book instead emphasizes how the potential of new chemicals and materials can be harnessed through innovative thinking and research. As such, it provides an invaluable reference source for researchers and graduate students interested in Chemurgy and Green Chemistry, as well as for practitioners in the field of industrial biotechnology and biobased industry. Peter C.K. Lau is a Distinguished Professor at Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, and an Adjunct Professor at the Departments of Chemistry and Microbiology & Immunology, McGill University, Canada.

The origin of agroforestry practices-growing trees and shrubs with food and fruit crops and grasses is traditional and very old-but the science of agroforestry is new. Years of experience and experiments have shown that agroforestry as a land-use system is capable of yielding both food and wood and at the same time helps in conserving and rehabilitating the ecosystems. It has the capability to increase the overall productivity of land, maintain the nutrient balance in the soil, and above all, protect the nature. In the recent years, agroforestry has been recommended as a core subject in the curriculum of B. Sc. (Forestry) and B. Sc. (Agriculture) courses of agricultural universities. This book has been divided into ten chapters covering very comprehensive information on all aspects of agroforestry including history, concepts, systems classification, tree-crop interactions, planning and management, diagnosis and design, policy and projects, and propagation and management practices of multipurpose trees. This book is co-published with NIPA. Taylor and Francis does not sell or distribute its print and electronic editions in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

The importance and actuality of nanotechnology is unabated and will be for years to come. A main challenge is to understand the various properties of certain nanostructures, and how to generate structures with specific properties for use in actual applications in Electrical Engineering and Medicine.
One of the most important structures are nanowires, in particular superconducting ones. They are highly promising for future electronics, transporting current without resistance and at scales of a few nanometers. To fabricate wires to certain defined standards however, is a major challenge, and so is the investigation and understanding of these properties in the first place. A promising approach is to use carbon nanotubes as well as DNA structures as templates.
Many fundamental theoretical questions are still unanswered, e.g. related to the role of quantum fluctuations. This work is tackling them and provides a detailed analysis of the transport properties of such ultrathin wires. It presents an account of theoretical models, charge transport experiments, and also conveys the latest experimental findings regarding fabrication, measurements, and theoretical analysis. In particular, it is the only available resource for the approach of using DNA and carbon nanotubes for nanowire fabrication.
It is intended for graduate students and young researchers interested in nanoscale superconductivity. The readers are assumed to have knowledge of the basics of quantum mechanics and superconductivity.

This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.

Explores the utilization of marine surfactants for biological and biomedical applications Provides depth knowledge on marine surfactant preparations Discusses the development of personal care or cosmeceutical products using marine surfactants Examines various marine derived surfactants for treatment of cancer related diseases Reviews marine surfactants for environmental applications

Cognitive Computing for Internet of Medical Things (IoMT) offers a complete assessment of the present scenario, role, challenges, technologies, and impact of IoMT-enabled smart healthcare systems. It contains chapters discussing various biomedical applications under the umbrella of the IoMT. Key Features Exploits the different prospects of cognitive computing techniques for the IoMT and smart healthcare applications Addresses the significance of IoMT and cognitive computing in the evolution of intelligent medical systems for biomedical applications Describes the different computing techniques of cognitive intelligent systems from a practical point of view: solving common life problems Explores the technologies and tools to utilize IoMT for the transformation and growth of healthcare systems Focuses on the economic, social, and environmental impact of IoMT-enabled smart healthcare systems This book is primarily aimed at graduates, researchers and academicians working in the area of development of the application of the of the application of the IoT in smart healthcare. Industry professionals will also find this book helpful.

Provides exhaustive coverage of Biochar and its production and properties. Highlights use of biochar in pollution control and environment protection. Covers use of agricultural waste /waste biomass for dye decolorization and degradation. Explores synergistic approaches for contaminants removal for better insights into basic and advanced biotechnological applications. Describes how biochar treatment can be successfully applied for reuse of wastewater and contaminated soil eco-restoration and environment protection.

Describe new developments in non-opsin-based optogenetic tools Introduce cutting-edge methods for precise modulation of cell signaling Highlight applications of optogenetic regulation of cellular functions Cover contributions from an international team of leading experts

Presents the latest research in genetic engineering. Topics include agrobacterium -mediated horizontal gene transfer, detection of single nucleotide variations, the ribosome as a vehicle for antisense RNA, cloning and expression of large mammalian cDNAs, the use of genetically engineered cells in dr

This book offers a comprehensive treatment of the molecular design, characterization, and physical chemistry of soft interfaces. At the same time, the book aims to encourage the fabrication of functional materials including biomaterials. During the past few decades there has been steady growth in soft-interface science, and that growth has been especially rapid in the twenty-first century. The field is interdisciplinary because it involves chemistry, polymer science, materials science, physical chemistry, and biology. Based on the increasing interdisciplinary nature of undergraduate and graduate programs, the primary goal of this present work is to serve as a comprehensive resource for senior-level undergraduates and for graduate students, particularly in polymer chemistry, materials science, bioconjugate chemistry, bioengineering, and biomaterials. Additionally, with the growing interest in the fabrication of functional soft materials, this book provides essential fundamental information for researchers not only in academia but also in industry.

The biotechnology business in India with an increase from USD 500 million in 1997 and reaching an estimated USD I billion next year health related prod ucts accounting for 60%, agro and veterinary products together 15%, and con tract R&D, reagents, devices and supplies adding up to the remaining 25% of which the diagnostics share was about 10% of the total surely presented an encouraging picture even five years ago. While volumes have increased, the pat tern has not. According to a report, prepared by McKinsey & Co, India's Phar maceutical industry including domestic and export sales and contract services totals nearly USD 5 billion. Furthermore, the company optimistically projects the growth to a factor of five fold only if both the industry and the government are able to put in place achievable solutions that must take care of the formida ble obstacles preventing further growth. If this assessment is correct, then the established transformation made by IT growth should also provide the confi dence required by the high expectations for biotechnology which have arisen in the country in recent years. Some contributors to this are overenthusiastic these are bureaucrats, some retired scientists and of course the complacent politicians who have the least knowledge of what the new biotechnology is all about. However, there are clear indications of biotechnology growth demon strated by a few but rapidly expanding biotech companies such as Biocon Ltd, Shantha Biotech (P) Lid, Dr.

Drawing on contributions from more than thirty scholars and experts in the field, this book examines the role of business as an enabler, as an inhibitor, and ultimately as a co-actor in global sustainability transformations expected over the next few decades. The Role of Business in Global Sustainability Transformations employs several theoretical perspectives and provides abundant examples and cases to discuss a variety of emerging concepts, phenomena, and trends shaping business sustainability. Weaving through the chapters, the editors present core tensions and sources of inertia towards transformative change, and acknowledge that envisioning multiple solutions and pathways are possible and desirable. They advocate for the need to align visions, actions and time horizons between policy, society and business in addressing the interlinked socio-ecological challenges that our society currently faces. This book will be an important resource for scholars and professionals working in the field of sustainability and sustainable business, and a vital educational text for students interested in this discipline.

reviews a wide-range of genetically modified (GM) crops, to understand how they are produced, the impacts on the agricultural industry, and the potential for improving food security. examines how food security can be achieved through GM crops. provides an important synthesis of GM crops from their commercial value to the agricultural industry, as well as their potential for improving food security. will be of great interest to students and scholars of agricultural engineering, crop science, food biotechology, food security and those interested in food and agriculture and sustainable development more broadly.

This volume offers environmentally friendly technical solutions that can be implemented to solve problems throughout the value chain of the fossil fuel industry. This new book presents an up-to date view of hydrocarbon microbiology and biotechnology, presented by experts around the world with interest in how our expanding understanding of hydrocarbonoclast ecology and physiology can translate to better tools for bioremediation, oil recovery, bio-upgrading of unconventional crudes, the development of biorefining technologies, and the production of hydrogen and electricity from hydrocarbon wastes. The common theme across the chapters in this book is an interest in how developing hydrocarbon biotechnologies may reduce our impact on the global environment. Written by eminent scientists from both academia and industry, the book starts with a historical perspective on hydrocarbon chemistry and formation, petroleum microbiology, and biotechnology. This is followed by a review of recent research developments in bioremediation and other biotechnologies for hydrocarbons, the principal constituents of petroleum and natural gas.

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

This book puts together all aspects of valorization of vegetable and fruit wastes (VFWs) into different biocommodities and platform chemicals using fermentation and non-fermentation processes. VFWs are a special group of solid waste (biomass) that needs to be characterized to understand the nature of applications as raw materials and to propose an appropriate methodology for bioprocessing into value-added commodities. VFWs provide favorable conditions for the growth of microorganisms, and this opens up great opportunities for their use in fermentation processes. For example, VFWs can be used as a solid support, carbon, and nutrient source in fermentation for the production of a variety of value-added biocommodities such as enzymes, single-cell proteins, bioadsorbents, phenolic bioactive compounds, aroma and flavor compounds, and platform chemicals like lactic acid, bioethanol, and biobutanol. Researchers and academics in the area of environmental science and engineering, chemical engineering, biotechnology, life science, and food science and technology, undergraduate and graduate students, industry professionals, and policymakers will find this publication useful. Bioprocessing of agro-wastes is a recent technology for developing novel bioproducts. This book will also be of interest to the general public as a reference for all those interested in waste management.

This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing.

My professional interest in antimicrobial agents and contamination control goes back 50 years to my tour as a microbiologist in a field hospital in Europe during World War II. With no experience and relying solely on a military handbook, I prepared thermometer trays with jars of blue bichloride of mercury and pink isopropyl alcohol. A preliminary typhoid diagnosis of one of our cooks resulted in the need for lab testing. His stool specimen and its subsequent disposal was my problem. My handbook said bum it. So burn it T did, in a five-gallon can with gasoline. Flames shot up almost six feet, and my next mistake was to extinguish them with carbon tetrachloride. This resulted in the production of lethal phosgene gas. The hospital had a near disaster. I could say that at that moment I vowed to write a how-to book so that such stupidities could be avoided. Nevertheless, when I was offered the opportunity to edit this book I thought back on the need for a real, practical treatment of my subject. This book, then, is a practical handbook for technical service personnel and scientists who are not necessarily specialists in microbiology. It provides information on suitable antimicrobial agents appropriate to their particular problem-solving needs and information on the microbial groups contributing to the specific problem, their ecologies, and strategies for controlling their access to the area or material of interest.

This volume presents a complete statistical analysis of data from the clinical trials of the wide variety of types of prostheses used in skeletal repair. The contributions are written by professionals in medicine, dentistry and engineering and cover all the information regarding the lifetime survivablility of each type of implant. The biomolecular and biomechanical factors responsible for the relative clinical success are described in the 16 chapters. This text should be useful reading for orthopaedic surgeons, dental implantologists and ENT surgeons, as well as senior graduate and postgraduate biomaterial, medical and dental students.

This handbook is an edited and updated version of the final report of the IEA Bioenergy sponsored Pyrolysis Activity - PYRA - that officially finished in 1998 and accomplished many valuable contributions to the science and technology of fast pyrolysis. It is intended that this handbook will provide a useful guide both to newcomers to the subject area as well as those already involved in research, development and implementation. The IEA Bioenergy Pyrolysis Task is continuing this work as a collaborative project with the European Commission network on fast pyrolysis of biomass which is now known as PyNe. The European Network was first formed in 1995 as an EC sponsored project in the AIR Programme (AIR3-CT94-1857). At the end of the three-year lives of the Networks in 1997, both sponsoring organisations recognised the benefits from their integration. This led to the present PyNe Network, which is co-sponsored by the European Commission FAIR Programme (FAIR-CT97-3409) and IEA Bioenergy, and which itself is sponsoring the publication of this book as a contribution to the technology.

This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.

NMR has become the most diverse spectroscopic tool available to date in biomedical research. It is now routinely used to study biomolecular structure and dynamics particularly as a result of recent developments of a cascade of highly sophisticated multidimensional NMR pulse sequences, and of advances in genetic engineering to produce biomolecules, uniformly or selectively enriched with 13C, 15N and 2H.

Features of this book:

- Provides an up-to-date treatment of NMR techniques and their application to problems of biomedical interest

- Most refined multidimensional pulse sequences including the basic aspects are covered by leading NMR spectroscopists.

The book will be useful to NMR spectroscopists, biochemists, and to molecular biologists interested in the use of NMR techniques for solving biological problems.

The field of industrial microbiology involves a thorough knowledge of the microbial physiology behind the processes in the large-scale, profit-oriented production of microbe-related goods which are the subject of the field. In recent times a paradigm shift has occurred, and a molecular understanding of the various processes by which plants, animals and microorganisms are manipulated is now central to industrial microbiology. Thus the various applications of industrial microbiology are covered broadly, with emphasis on the physiological and genomic principles behind these applications. Relevance of the new elements such as bioinformatics, genomics, proteomics, site-directed mutation and metabolic engineering, which have necessitated the paradigm shift in industrial microbiology are discussed.