The DNA, RNA, and Histone Methylomes (Hardcover, 1st ed. 2019)

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.

General

Imprint:	Springer Nature Switzerland AG
Country of origin:	Switzerland
Series:	RNA Technologies
Release date:	September 2019
First published:	2019
Editors:	Stefan Jurga • Jan Barciszewski
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	624
Edition:	1st ed. 2019
ISBN-13:	978-3-03-014791-4
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Professional & Technical > Biochemical engineering > Biotechnology > Genetic engineering
LSN:	3-03-014791-6
Barcode:	9783030147914

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