This book targets new advances in areas of treatment and drug delivery sciences for Malaria. This is the only published book which compiles the complete road map of malarial drug delivery systems along with an overview on the pathology, current state of malaria across the globe, new clinical trials, emerging drugs and evolving novel drug delivery platforms. A wide variety of novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and addresses a much-needed update to the existing malaria drug delivery research.

Chapters collected from "The Virtual Conference on Chemistry and its Applications (VCCA-2021) - Research and Innovations in Chemical Sciences: Paving the Way Forward". This conference was held in August 2021 and organized by the Computational Chemistry Group of the University of Mauritius. These peer-reviewed chapters offer insights into research on fundamental and applied chemistry with interdisciplinary subject matter.

This up-to-date reference book compiles the recent developments, innovations, and perspectives on second and third-generation bioplastics. It discusses the main commercialized bioplastics, such as polylactic acid (PLA) and polyhydroxyalkanoates (PHAs). Chapters include the use of alternative raw materials and innovations in bioplastic production processes to reduce costs and decrease environmental impacts. It covers bioplastic production from lignocellulosic biomass, sugars, or oils produced by microbes and municipal waste material. It also includes techno-economic aspects. The book is meant for researchers and industry experts in biotechnology, environmental sciences, and applied microbiology.

This third edition provides new and updated chapters detailing preparation of liposomes, physicochemical characterization of liposomes, lipid analysis, drug encapsulation, surface modification, stimuli response as well as cellular interaction, and biodistribution. Also included is an updated chapter on the history and evolution of the field of liposomology. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Liposomes: Methods and Protocols, Third Edition aims to serve as a reference for graduate students, post-doctoral researchers as well as established investigators utilizing lipid-based systems.

A collection of twenty cutting-edge essays on issues raised by biotechnology's increasing impact on humans and nature, The Meaning of Life in the 21st Century provides a forward-looking discussion by a wide array of prominent experts on where today's scientific discoveries are taking humankind. The theme is that there are expanded perspectives for retaining unique meanings of being human in the 21st century. This collection is the result of a 2005 conference organized by the Yoko Civilization Research Institute of Japan. Organized into themes by Dr. Don Hanlon Johnson, these essays present deeply informed, sometimes conflicting views of complex issues, which, in the contemporary world, are inescapably global, including: Science and religion in a pivotal age Science, experience, and values Stem cells, embryos, and the meaning of embodiment Enhancement and transformative practices Religion and ecology: a growing alliance Bringing a diversity of prominent thinkers from several continents to the scientific, sociopolitical, and religious issues at the forefront of contemporary challenges, this collection makes clear that the world is now a community which faces these issues together. This serious, thoughtful book, rich in dialogue, provides hope for new perspectives for developing a positive, sustainable future.

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

This detailed volume explores fibrous proteins widely present in different biological tissues or biological structural materials. The book begins by introducing the structure of representative fibrous proteins, including animal silks, collagen, elastin, resilin, and keratin, and it then continues by providing detailed experimental protocols for the synthesis, assembly, and characterization of natural, regenerated, and recombinant fibrous proteins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Fibrous Proteins: Design, Synthesis, and Assembly is an ideal guide for researchers aiming to master fibrous protein preparations with the aid of this broad and interdisciplinary perspective on understanding the structure-property-function relationships of natural and reconstituted fibrous proteins.

Johannes Klumpers Biotechnologies, such as genetic engineering, cloning and biodiversity, raise many legal and ethical concerns, so it is important that people understand these issues and feel able to express their opinions. This is why the European Commission has been, for a number of years, supporting actions to improve communication among scientists in these diverse areas. The project 'Women in Biotechnology' (WONBIT), financed under the 6th Framework programme of the European Commission, is an excellent example of what can be done to target opinion-formers such as scientists, economists and lawyers in bottom-up activities, and to encourage a debate on gender issues triggered by developments in the life sciences. WONBIT gave rise to a successful international conference highlighting the importance of adopting good practices and ethical considerations in parallel with the rapid pace of progress in biotechnology - from a woman's point of view. In particular, the conference addressed women in decision-making positions in b- technology with specific reference to scientific excellence, social competencies and management qualities as well as issues relating to environment, society and the younger generation. But it did not stop there: a key part of the conference was dedicated to stimulating public debate among non-specialists, which has led to a number of recommen- tions to policy-makers on better communication in biotechnology, on taking better account of the gender aspects of research, and on involving more women in the decision-making process that surrounds developments in biotechnology.

Due to the huge quantity and diverse nature of their metabolic pathways, fungi have great potential to be used for the production of different biofuels such as bioethanol, biobutanol, and biodiesel. This book presents recent advances, as well as challenges and promises, of fungal applications in biofuel production, subsequently discussing plant pathogenic fungi for bioethanol and biodiesel production, including their mechanisms of action. Additionally, this book reviews biofuel production using plant endophytic fungi, wood-rotting fungi, fungal biocontrol agents, and gut fungi, and it investigates highly efficient fungi for biofuel production and process design in fungal-based biofuel production systems. Finally, life cycle assessment of fungal-based biofuel production systems are discussed in this volume.

This book joins an international and interdisciplinary group of leading experts on the biomedical, energy and environmental applications of Metal-Organic Frameworks (MOFs). The resulting overview covers everything from the environmentally friendly and scale up synthesis of MOFs, their application in green energy generation and storage, and water purification to their use as drug delivery systems, biosensors, and their association with relevant macromolecules (genes, enzymes). This book is focused on the interest of MOFs in applications such as the leading -edge environmental (energy-related) and biomedical fields. The potential of MOFs in these areas is currently progressing at a fast pace, since the wide possibilities that MOFs offer in terms of composition, topology, incorporation of active species (in their porosity, on their external surface or within the framework), and post-synthetic modifications, among others. The aim here is to provide future research goals that emphasize relevant nuances to this class of materials as a whole.

This book presents improved numerical techniques and applied computer-aided simulations as a part of emerging trends in mechatronics in all areas related to complex fluids, with particular focus on using a combination of modeling, theory, and simulation to study systems that are complex due to the rheology of fluids (i.e., ceramic pastes, polymer solutions and melts, colloidal suspensions, emulsions, foams, micro-/nanofluids, etc.) and multiphysics phenomena in which the interactions of various effects (thermal, chemical, electric, magnetic, or mechanical) lead to complex dynamics. The areas of applications span materials processing, manufacturing, and biology.

This book consists of 10 Chapters in 4 Parts. The first Part is an introduction and contains Chapter 1 to introduce the book chapters to the audiences. The second Part consists of two chapters under the name, Impact of Climate Change on Crop Production and the Physiological and Biochemical Basis for Crops Tolerance. The Chapter 2 focus on critical periods of crop plants to stress conditions and the expected impacts of climate changes mainly on the productivity and quality of field crops. While, Chapter 3 highlights the foundations of crop tolerance to environmental stress and plant traits relevant to stress tolerance. It is devoted to explain and discuss mechanisms of adaptation to environmental stress conditions and addresses various plant traits related to stress environmental tolerance i.e. phenological, morpho-physiological and biochemical traits which could be used as selection criteria for crops improvement. The third Part consists of 5 Chapters under the theme "Improve Crop Adaptability and Stability to Climate Change and Modern Technology". Chapter 4 highlights the most important strategic food grain crop (wheat), Chapter 5 focuses the important staple food crop (rice), while Chapter 6 deals with one of the most important food legume crops (faba bean). Chapter 7 and 8 discuss two important oil crops (sesame and sunflower). However, Chapter 9 focuses on cotton as one of the most important fiber crops. The author addresses these crops under the following headings: genotype x environment interaction and its relation to climatic change on yield production, performance of genotypes in response to environmental changes, adaptability and yield stability to environmental conditions, additive main effects and multiplicative interaction model, gene action, genetic behavior and heritability for traits related to environmental stress tolerance, role of recent approaches, biotechnology and nanotechnology. This is besides how can measure sensitivity of genotypes to environmental stress, and finally the appropriate agricultural practices to mitigate environmental stress on crops under attention. The book ends with Chapter No. 10 where the author presents an update of the book topics, present the most important conclusions and recommendations from all chapters. This book has been prepared and supported by recent references and statistics with coloured tables and illustrations for audiences interested in crop science,environment, plant breeding, genetics and biotechnology, as well as postgraduate students and researchers in universities and research centres.

Current demand in biomedical sciences emphasizes the understanding of basic mechanisms and problem solving rather than rigid empiricism and factual recall. Knowledge of the basic laws of mass and momentum transport as well as model development and validation, biomedical signal processing, biomechanics, and capstone design have indispensable roles in the engineering analysis of physiological processes. To this end, an introductory, multidisciplinary text is a must to provide the necessary foundation for beginning biomedical students. Assuming no more than a passing acquaintance with molecular biology, physiology, biochemistry, and signal processing, Biomedical Engineering Principles, Second Edition provides just such a solid, accessible grounding to this rapidly advancing field. Acknowledging the vast range of backgrounds and prior education from which the biomedical field draws, the organization of this book lends itself to a tailored course specific to the experience and interests of the student. Divided into four sections, the book begins with systems physiology, transport processes, cell physiology, and the cardiovascular system. Part I covers systems analysis, biological data, and modeling and simulation in experimental design, applying concepts of diffusion, and facilitated and active transport. Part II presents biomedical signal processing, reviewing frequency, periodic functions, and Fourier series as well as signal acquisition and processing techniques. Part III presents the practical applications of biomechanics, focusing on the mechanical and structural properties of bone, musculoskeletal, and connective tissue with respect to joint range, load bearing capacity, and electrical stimulation. The final part highlights capstone design, discussing design perspectives for living and nonliving systems, the role of the FDA, and the project timeline from inception to proof of concept. Cutting across many disciplines, Biomedical Engineering Principles, Second Edition offers illustrative examples as well as problems and discussion questions designed specifically for this book to provide a readily accessible, widely applicable introductory text.

Fish Vaccines: Health Management for Sustainable Aquaculture is a timely reference book that highlights the role of vaccination in the fast-growing aquaculture industry. It discusses topics such as vaccine formulation, vaccine delivery and enhancing the immune response of fish using nanoparticles. Information related to vaccine safety, ethical approval and regulations is also discussed, together with dissemination of vaccines to fish farms across the globe. This cutting-edge book presents novel strategies to meet the growing demand for vaccines in finfish aquaculture. The book is useful to students, academics, clinicians, and professionals in the field of fisheries sciences, aquaculture, and veterinary sciences.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eight volume of a continuing series.

This singular text aims to strengthen the scientific understanding of food product design and engineering, and to stimulate and accelerate the development of innovative, complex and highly structured products and suitable production processes. By gathering an interdisciplinary team of scientists from the research areas of food engineering, biophysics, applied soft matter, food technology and applied human nutrition, this book contributes to an integrated process and product design approach for creating innovative, multi-phase structured foods delivering functionality. Delivering functionality in foods: from structure design to product engineering serves as an important reference for food engineers, food technologists and nutritionists, covering all aspects of the design of food structures and their application in the development of functional food products. From the delivery of health-related functionalities to process and product engineering for delivery of multiple food properties, this work provides a comprehensive overview of the knowledge, processes and technologies required for the design of functional foods.

This textbook provides a thorough introduction and overview of the design and engineering of state-of-the-art prosthetics and assistive technologies. Innovations in prosthetics are increasingly made by cross-disciplinary thinking, and the author introduces the application of biomedical, mechanical, electrical, computer, and materials engineering principles to the design of artificial limbs. Coverage includes the fundamentals of biomechanics, biomechanical modeling and measurements, the basics of anatomy and physiology of limb defects, and the historical development of prosthetic design. This book stimulates the innovative thinking necessary for advancing limb restoration, and will be essential reading for students, as well as researchers, professional engineers, and prosthetists involved in the design and manufacture of artificial limbs. Learning enhanced by the exercises, including physical modeling with MATLAB and Simulink; Includes appendices with relevant equations and parameters for reference; Introduction to the design and engineering of prosthetics and assistive technologies.

This book presents abiotic stresses that cause crop damage in the range of 6-20%. Understanding the interaction of crop plants to the abiotic stresses caused by heat, cold, drought, flooding, submergence, salinity, acidity, etc., is important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomic-assisted breeding, and the recently emerging genome editing for developing resistant varieties in cereal crops is imperative for addressing FPNEE (food, health, nutrition, energy, and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing has facilitated precise information about the genes conferring resistance useful for gene discovery, allele mining, and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to abiotic stresses. The nine chapters each dedicated to a cereal crop in this volume are deliberate on different types of abiotic stresses and their effects on and interaction with crop plants; enumerate on the available genetic diversity with regard to abiotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; are brief on the classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; elucidate on the success stories of genetic engineering for developing abiotic stress-resistant crop varieties; discuss on molecular mapping of genes and QTLs underlying stress resistance and their marker-assisted introgression into elite varieties; enunciate on different emerging genomics-aided techniques including genomic selection, allele mining, gene discovery, and gene pyramiding for developing adaptive crop varieties with higher quantity and quality, and also elaborate some case studies on genome editing focusing on specific genes for generating abiotic stress-resistant crops.

The shift of weather patterns has affected the incidence and prevalence of infectious diseases, including mycoses. Mycoses have remained neglected due to a lack of training and recognition within the medical community. Nonetheless, these diseases remain common worldwide while frequently being underdiagnosed. Climate change affects the distribution of fungal communities, provoking outbreaks in locations where these mycoses were absent or in low frequencies. Moreover, the reports of clinical cases related to new fungal pathogens have increased due to the description of new fungal species or due to the ability of some species to shift to new hosts. Thus, this book, The Impact of Climate Change on Fungal Diseases, is a contribution to the knowledge of a global environmental phenomenon and its relation to these diseases, and it serves as a guide for health professionals to dive deep into the repercussions of climate change and how they can implement measures for the prevention and control of fungal infections.

This book covers state-of-the-art development in microfluidics-enabled soft manufacturing (MESM), ranging from fundamentals to applications. The book addresses the long-standing challenge in the manufacture of simultaneously achieving both precise control over nano-/micro-scale structures and large-scale fabrication of materials for pragmatic use, with microfluidics-enabled soft manufacture to fill the gap between the widely-varied length scales involved. It offers a comprehensive insight into the microfluidic generation of fluid systems as liquid templates, such as droplets, bubbles, jets, emulsions, and foams, which are categorized into individual templates, one-dimensional arrays, and two-/three-dimensional assemblies for the modular fabrication of microparticles, microfibers, and porous materials, respectively. MESM enriches the compositional and structural diversity of engineered materials for well-tailored properties and functionalities, markedly broadening the application horizons across interdisciplinary fields, including engineering, environment, physics, chemistry, biology, and medicine. This book aims to systematize this emerging yet versatile and powerful technology, with the hope of aiding the realization of its full potential. Microfluidics-Enabled Soft Manufacture will be an invaluable reference for graduate students, postgraduates, researchers, and practitioners/professionals working in micro and nanofabrication, materials science, surface science, fluid dynamics, and engineering.

"RFK Jr. exposes the decades of lies."--Luc Montagnier, Nobel laureate From the New York Times, Wall Street Journal, USA Today, Publishers Weekly bestselling author of The Real Anthony Fauci comes an explosive exposé of the cover-up behind the true origins of COVID-19. "Gain-of-function" experiments are often conducted to deliberately develop highly virulent, easily transmissible pathogens for the stated purpose of developing preemptive vaccines for animal viruses before they jump to humans. More insidious is the "dual use" nature of this research, specifically directed toward bioweapons development. The Wuhan Cover-Up pulls back the curtain on how the US government's increase in biosecurity spending after the 2001 terror attacks--facilitated by Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID)--set in motion a plan to transform the NIAID into a de facto Defense Department agency. While Dr. Fauci zealously funded and pursued gain-of-function research, concern grew among some scientists and government officials about the potential for accidental or deliberate release of weaponized viruses from labs that might trigger worldwide pandemics. A moratorium was placed on this research, but true to form, Dr. Fauci found ways to continue unperturbed--outsourcing some of the most controversial experiments offshore to China and providing federal funding to Wuhan Institute of Virology's (WIV's) leading researchers for gain-of-function studies in partnership with the Chinese military and the Chinese Communist Party. Robert F. Kennedy Jr., whose meticulously researched and rigorously sourced analysis, leads readers on a staggering journey to learn about: the key enablers and henchmen pushing for gain-of-function research the economic motives behind gain-of-function research successfully engineered "chimeric viruses" that can infect and kill humans the coordinated effort to silence speculation of COVID-19's laboratory genesis the complicity of scientific journals to hide the origins of COVID-19 the role of the Wuhan Institute of Virology in China's biowarfare/biodefense program the relationships between US health, military, and intelligence bureaucracies and scientists and their Chinese counterparts the roles of Bill Gates and Sir Jeremy Farrar in helping to orchestrate China's global cover-up The Wuhan Cover-Up unveils a global conspiracy of epic proportion and lethal consequence.

This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.

A behind-the-scenes look at the most lucrative discipline within biotechnology
Bioinformatics represents a new area of opportunity for investors and industry participants. Companies are spending billions on the potentially lucrative products that will come from bioinformatics. This book looks at what companies like Merck, Glaxo SmithKline Beecham, and Celera, and hospitals are doing to maneuver themselves to leadership positions in this area. Filled with in-depth insights and surprising revelations, Digital Code of Life examines the personalities who have brought bioinformatics to life and explores the commercial applications and investment opportunities of the most lucrative discipline within genomics.
Glyn Moody (London, UK) has published numerous articles in Wired magazine. He is the author of the critically acclaimed book Rebel Code.