During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated "orphan rec- tors," such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors-including those for thyroid hormone, estrogens, androgens, and progesterone-were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.

Develop a healthier connection between worker and work with this practical introduction The United States Bureau of Labor Statistics estimates that 34% of all workdays lost each year are the result of work-related musculoskeletal disorders (WMSDs). These disorders result from a mismatch between a worker, their working conditions, and the task they perform. Improperly designed tasks or equipment, insufficient downtime between shifts or tasks, or even simple sitting position can all produce WMSDs. The key insights into preventing these disorders are produced by ergonomics, the scientific study of human bodies as they relate to objects, systems, and environments, especially work environments. Occupational Ergonomics: A Practical Approach aims to supply an ergonomic toolkit for creating healthier relationships between workers' bodies and their work. Beginning with a set of foundational ergonomic principles, it then details multiple assessment techniques in ways easily adapted to specific workplace situations. This balance of theory and practice has made Occupational Ergonomics an essential reference concerning human beings and the work they do. Readers of the second edition will also find: Up-to-date ergonomic research reflecting the latest clinical and workplace data. Entirely new chapters on Work Physiology, Total Worker Health, Return on Investment, and more. Major revisions to chapters on Elements of an Ergonomic Program, Workstation Design, Work-Related MSDs, How to Conduct an Assessments, and Office Ergonomics Detailed and updated case studies applying ergonomic assessment techniques to common workplace scenarios. Occupational Ergonomics is a must for workplace safety managers, safety coordinators, ergonomics program coordinators, facilities managers, and any professionals concerned with the work environment, and worker health and safety.

Plant secondary metabolites are plant-based natural products that display a variety of pharmacological effects. This book discusses the invaluable bioactivity and multifaceted potential of these compounds. The book describes the physico-chemical and biochemical aspects of the plant secondary metabolites along with the chemistry, therapeutics and future perspectives of these plant secondary metabolites. Moreover, the book also discusses about various sources of plant secondary metabolites, and the metabolite determination through various analytical techniques. It further describes the potential applications of plant secondary metabolites as anticancer and chemo preventive agents, their role as cosmetic ingredients and activity in skin cancer therapy. Further chapters emphasize upon the plethora of roles of plant secondary metabolites, including those as antivirals, anti-bacterial, anti-inflammatory drugs, cardioprotective agents etc. The book culminates with chapters on the impact of certain plant secondary metabolites in plant defence and human healthcare. This book is meant for researchers and students in the field of pharmacology and plant sciences. Moreover, this book is also useful for industry experts especially working in the field of herbal therapeutics.

This body of work represents the first volume of a book series covering the field of tissue engineering. Tissue engineering, which refers to a category of therapeutic or diagnostic products and processes which are based upon a combination of living cells and biomaterials, was defined as a field only a few years ago (1988). Tissue engineering is an inherently interdisciplinary field, combining bioengineering, life sciences and clinical sciences. The definition of this area of work as the field of tissue engineering brought together scientists from multiple backgrounds who already were working toward the achievement of similar goals. Why a book series exclusively devoted to tissue engineering? The field of tissue engineering is heterogeneous. The cells involved in tissue engineering can be autologous, allogeneic or xenogeneic. The biomaterials utilized can be either naturally occurring, synthetic or a combination of both. The appli cation of the technology can be either for acute or permanent purposes. An attempt to cover the field of tissue engineering in a single volume, with the degree of detail necessary for individuals with different scientific back grounds and disciplines, would be a difficult task to accomplish, particularly when this field is just emerging and changing rapidly. Therefore, addressing different technologies within the field of tissue engineering, in a comprehen sive manner, is the main mission of this series of volumes. A stellar group of scientists has been brought together to form the editorial board of the series."

Simulating for a crisis is far more than creating a simulation of a crisis situation. In order for a simulation to be useful during a crisis, it should be created within the space of a few days to allow decision makers to use it as quickly as possible. Furthermore, during a crisis the aim is not to optimize just one factor, but to balance various, interdependent aspects of life. In the COVID-19 crisis, decisions had to be made concerning e.g. whether to close schools and restaurants, and the (economic) consequences of a 3 or 4-week lock-down had to be considered. As such, rather than one simulation focusing on a very limited aspect, a framework allowing the simulation of several different scenarios focusing on different aspects of the crisis was required. Moreover, the results of the simulations needed to be easily understandable and explainable: if a simulation indicates that closing schools has no effect, this can only be used if the decision makers can explain why this is the case. This book describes how a simulation framework was created for the COVID-19 crisis, and demonstrates how it was used to simulate a wide range of scenarios that were relevant for decision makers at the time. It also discusses the usefulness of the approach, and explains the decisions that had to be made along the way as well as the trade-offs. Lastly, the book examines the lessons learned and the directions for the further development of social simulation frameworks to make them better suited to crisis situations, and to foster a more resilient society.

This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces.
The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few.
- Covers all areas of applications of biosensors
- No other book on biosensors describes the kinetics of binding
- Provides numerous examples of where biosensors may be used

Biofilms -- Science and Technology covers the main topics of biofilm formation and activity, from basic science to applied aspects in engineering and medicine. The book presents a masterly discussion of microbial adhesion, the metabolism of microorganisms in biofilms, modelling of mass transfer and biological reaction within biofilms, as well as the behaviour of these microbial communities in industry (waste water treatment, heat exchanger biofouling, membranes, food processing) and in medicine (teeth, implants, prosthetic devices). Laboratory techniques and industrial monitoring methods are also presented. The book is directed at readers at the postgraduate level and is organised as a textbook, containing 11 chapters, a glossary, and a detailed subject index.

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

This book is about different Enzymes from various sources that play an important role in the degradation of an array of pollutants with simultaneous generation of value-added products. This is an "Edited Book" which deals a comprehensive knowledge on the role of different microorganisms/their enzymes in the degradation of pollutants, wastewater treatment with simultaneous production of value added products. It also deals the current state, perspectives and various challenges associated with the microbial/enzymatic degradation of environmental pollutants. This book will provide a profound knowledge on the importance of microorganisms/their enzymes in the degradation of pollutants like pesticides, antibiotics, toxic/hazardous chemicals, endocrine disrupting chemicals/compounds with production of value-added products like bioplastics for the sustainable development of society. It covers various existing wastewater treatment approaches using microorganisms alone and /or in combination of other methods with their merits, demerits and future prospects.

Rabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal.  This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume I presents an overview of concepts critical to the study of rabies in the region, including evolutionary aspects, reservoir ecology and control, elimination efforts, vaccine development, and disease hallmarks and progression. It also analyzes the long-term cultural, social, and economic impacts of the disease in the Americas. 

Here, the author has compiled data on about 550 oil-bearing plant species with respect to their content of unsaponifiable matters and oils. This unique information resource offers important information for research and development of food products such as neutraceuticals as well as cosmetics. Unsaponifiable matters have varying effects: Conservation and stability (e.g. lignans, tocopherols, tocotrienols), anti-inflammatory properties (triterpene alcohols), cholesterol-lowering (sterols), well tolerated occlusive effect on the skin (squalene). Information is provided in a clear and systematic fashion, including data on relevant chemical families and pertinent chemical structures. Also included is a thesaurus of English, Latin and French plant species names as well as 655 references to the scientific literature.

The Pumps and Pipes collaboration and conference brings together energy, medicine, and higher education in a unique shared effort, exploring ideas and research common to these important fields and stimulating discussion and sharing technologies that can further the reach and goals of each individual area. The Proceedings explores the common attributes of oil and gas technology, computational sciences and cardiovascular medicine and probe the areas where there is room to cross-fertilize and develop research and commercial programs.

Recent innovations in agriculture and food technologies have brought benefits to many countries, particularly in developing regions, but information about the extent of these has often been sparse. This research review examines the best papers on the subject to form a comprehensive, global perspective on the impacts of agricultural biotechnology around the world. With an emphasis on the economic, environmental, health and food security aspects of agbiotech, Biotechnology, Agriculture and Development will prove to be an invaluable resource for academics, students and researchers alike.

This volume explores the latest techniques and methods used for performing up-to-date glycosylation research. The chapters in this book are organized into four parts. Part One looks at the latest analytical and bioinformatics technologies that enable the characterization of glycosylation complexity. Part Two details the importance of synthetic chemistry and glycoengineering in the fields of bioprocessing and biotherapeutic development. Part Three discusses systems biology and computational technologies used by scientists to analyze glycosylation events in the cell. Part Four focuses on how cellular glycosylation biomarkers can be identified and used to characterize human clinical datasets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Glycosylation: Methods and Protocols is a valuable resource for any scientist or researcher interested in learning more about this exciting and developing field.

Basics of proteins and proteomics techniques In-depth understanding of mass-spectrometry and quantitative proteomics An overview of interactomics and its application for translational research. Advancement in the field of proteomics and challenges in clinical applications.

Biodesign in the Age of Artificial Intelligence: Deep Green investigates the potential of nature based technology for shaping the evolution of contemporary architecture and design. It takes on the now pervasive topic of design intelligence, extending its definition to encompass both biological and digital realms. As in their first title, Systemic Architecture: Operating Manual for the Self Organizing City, the authors engage the topic through the specific lens of their innovative design practice, ecoLogicStudio and their research at the University of Innsbruck and at the Bartlett, UCL. Part One of the book, entitled PhotoSynthetica (TM), illustrates design solutions that engage the urban microbiome and seek to achieve an immediate impact, while Part Two, entitled Deep Green, includes synthetic landscapes and operates within a much larger spatio-temporal frame, going beyond human perception and life span to envision design as a geographical and geological force. In the age of catastrophic climate change, such perceptual expansion helps to clarify that change cannot simply be stopped or rolled back. We must instead establish more positive dynamics of change within the living world. To this end, this book proposes to engage with design and architecture as an extended cognitive interface, a sentient being that is co-evolutionary and symbiotic with the living planet, contributing to its beauty and to our continued enjoyment of it.

This book explores the connections between migration and terrorism and extrapolates, with the help of current research and case studies, what the future may hold for both issues. Migration and Radicalization: Global Futures looks at how migrants and terrorists have both been treated as Others outside the body politic, how growing migrant flows borne of a rickety state system cause both natives and migrants to turn violent, and how terrorist radicalization and tensions between natives and migrants can be reduced. As he contemplates potential global futures in the light of migration and radicalization, Gabriel Rubin charts a course between contemporary migration and terrorism scholarship, exploring their interactions in a methodologically rigorous but theoretically bold investigation.

This book details the frontier technologies in the area of bovine reproduction. It describes the importance and significance of different technologies for improving reproduction efficiency in bovines. The book delineates the advancements in the technologies that are currently in use for faster multiplication of elite germ plasm including multiple ovulation and embryo transfer, ovum-pick-up, in vitro fertilization and embryo production, and semen sexing. Other emerging technologies, having potential for improving reproductive efficiency in bovines, including stem cells are also discussed with special reference to spermatogonial stem cells. Simple but effective tools having a great scope for day-to-day application in bovine farms for effective reproductive management like ultrasonography and thermal imaging are also covered in this book. The chapters on sperm transcriptomics, proteomics, metabolomics provide current developments in these areas and use of integrated approach for identification of fertility biomarkers. The chapters also describe technological advancements for early pregnancy diagnosis and offspring sex pre-selection in bovines. Additionally, this book discusses different sperm selection procedures including application of nanotechnology to obtain superior spermatozoa for assisted reproduction. Futuristic technologies including genomic selection and transgenesis are also discussed in detail. Finally, the book also elucidates a comprehensive description of challenges perceived with bovine reproduction and how effectively these technologies can help in improving fertility in bovines.

This book complies latest advancement in the field of environmental biotechnology. It focuses on topics that comprises industrial, environment and agricultural related issues to microbiological studies and exhibits correlation between biological world and dependence of humans on it. It is designed into three sections covering the role of environmental biotechnology in industry, environmental remediation, and agriculture. Ranging from micro-scale studies to macro, it covers up a huge domain of environmental biotechnology. Overall the book portrays the importance of modern biotechnology technologies in solving the problems in modern day life. The book is a ready reference for practicing students, researchers of biotechnology, environmental engineering, chemical engineering and other allied fields likewise.

Natural resources and associated biological diversity provide the basis of livelihood for human population, particularly in the rural areas and mountain regions across the globe. Asia is home to the world's highest mountain regions including the Himalayas, Karakorum and Hindukush. These regions are renowned around the globe because of their unique beauty, climate, and biocultural diversity. Because of geoclimatic conditions, the mountains of Asia are medicinal and food plant diversity hot spots. The indigenous communities residing in the valleys of these mountains have their own culture and traditions, and have a long history of interaction with the surrounding plant diversity. Local inhabitants of these mountains areas possess significant traditional knowledge of plant species used as food, medicine, and for cultural purposes. So far, many workers have reported traditional uses of plant species from different regions of Asia including some mountain areas; however, there is not one inclusive document on the ethnobotany of mountains in Asia. This book provides a comprehensive overview on ethno-ecological knowledge and cross cultural variation in the application of plant species among various communities residing in the mountains of Asia; cross cultural variation in traditional uses of plant species by the mountain communities; high value medicinal and food plant species; and threats and conservation status of plant species and traditional knowledge. This book should be useful to researchers of biodiversity and conservation, ethnobiologists, ethnoecologists, naturalists, phytochemists, pharmacists, policy makers, and all who have a devotion to nature.

Industrial Hemp: Food and Nutraceutical Applications is a comprehensive overview of different value chains for the industrial hemp industry. This excellent reference supports multi-disciplines and presents industrial hemp as a multi-purpose crop, with special attention paid to its food and nutraceutical applications. By combining and presenting multidisciplinary knowledge, readers will be introduced to recent progress in hemp production, processing, utilization and marketing. The book provides a systematic overview of alternative hemp applications, but also serves as a guide to the challenges needed for hemp revitalization to reach its fullness.