Advances in Carbohydrate Chemistry and Biochemistry, Volume 77, the latest release in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on Temporary Ether Protecting Groups at the Anomeric Center in Complex Carbohydrate Synthesis and Mucopolysaccharidosis Type II (Hunter Syndrome): Clinical and Biochemical Aspects of the Disease and Approaches to its Diagnosis and Treatment.

Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0-3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored.

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

Advances in Physical Organic Chemistry, Volume 54, presents the latest reviews of recent work in physical organic chemistry. The book provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 57, is a continuous series of books covering all aspects of rare earth science, including chemistry, life sciences, materials science and physics. The book's main emphasis is on rare earth elements [Sc, Y, and the lanthanides (La through Lu], but whenever relevant, information is also included on the closely related actinide elements.

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 63, the latest release in this continuous series that covers all aspects of rare earth science, including chemistry, life sciences, materials science and physics, presents interesting chapters on a variety of topics, with this release including sections on Lanthanide calixarene complexes and their applications, Recent developments in lanthanide-based single-molecule magnets, Rare earth permanent magnets, and the Importance of Ligand Design in Lanthanide Azamacrocyclic Complexes Relevant to Biomedical Applications.

Green Chemistry and Water Remediation: Research and Applications explores how integrating the principles of green chemistry into remediation research and practice can have a great impact from multiple directions. This volume reviews both common sources of chemical pollution and how using green chemistry as the basis for new or improved remediation techniques can ensure that remediation itself is conducted in a sustainable way. By outlining the main types of chemical pollutants in water and sustainable ways to address them, the authors hope to help chemists identify key areas and encourage them to integrate green chemistry into the design of new processes and products. In addition, the books highlights and encourages the use of the growing range of green remediation approaches available to experts, helping researchers, planners and managers make informed decisions in their selection of remediation techniques.

Handbook on Miniaturization in Analytical Chemistry: Application of Nanotechnology provides a source of authoritative fundamentals, interdisciplinary knowledge and primary literature for researchers who want to fully understand how nano-technologies work. Covering all stages of analysis, from sample preparation to separation and detection, the book discusses the design and manufacturing technology of miniaturization and includes an entire section on safety risks, ethical, legal and social issues (ELSI), the economics of nanotechnologies, and a discussion on sustainability with respect to nano- and lab-on-chip technologies. This guide for students and researchers working on applications of nanotechnology in modern systems for analysis gives readers everything they need to know to bring their current practices up-to-date.

Annual Reports on NMR Spectroscopy, has established itself as a premier resource for both specialists and non-specialists who are looking to become familiar with new techniques and applications pertaining to NMR spectroscopy.

Analysis of Cannabis, Volume 91, contains a wide variety of information on the analysis of cannabis and hemp, including cannabinoids, terpenes, volatile solvents and metals. Specific chapters in this new release include the Comprehensive Analytical Testing of Cannabis and Hemp, Machine Learning Methods for Inferring Chemotype Profiles in Cannabis Sativa, Recent Analytical Methodologies and Strategic Pharmacological Applications of Cannabinoids, Analysis of Cannabinoids in Plants, Marijuana Products and Biological Tissues, LC-based (UV and MS) Analysis of Cannabinoids, Testing Cannabis Samples for Heavy Metal Contamination using Microwave Assisted Digestion and ICP-MS Techniques, Applications of GC-MS Techniques for Cannabis Analysis, and much more.

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

The Effect of Radiation on Properties of Polymers examines the effects of radiation on plastics and elastomers. Polymers are required in products or parts for a range of cutting-edge applications that are exposed to radiation, in areas such as space, medicine, and radiation processing. This book focuses on the effects of radiation exposure within that environment, providing in-depth data coverage organized by category of polymer. Aspects such as radiation impact on mechanical and thermal properties, including glass transition and heat deflection temperatures, are described, demonstrating how changes in these properties affect the performance of plastic or elastomer parts. The effect of radiation on electrical properties is also included. Supporting introductory chapters explain the key concepts of radiation, including the physical, mechanical, and thermal properties of plastics and elastomers. This is a vital resource for plastics engineers, product designers, and R&D professionals, working on products or parts for radioactive environments, as well as engineers and scientists in the medical, nuclear, and radiation processing industries. The book also supports researchers and scientists in plastics engineering, polymer processing and properties, polymer and coatings chemistry, materials science, and radiation.

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds.

The study of gases, clusters, liquids, and solids as units or systems, eventually focuses on the properties of these systems as governed by interactions between atoms, molecules, and radicals that are not covalently bonded to one another. The stereo/spatial properties of molecular species themselves are similarly controlled, with such interactions found throughout biological, polymeric, and cluster systems and are a central feature of chemical reactions. Nevertheless, these interactions are poorly described and characterized, with efforts to do so, usually based on a particular quantum or even classical mechanical procedure, obscuring the fundamental nature of the interactions in the process. Intra- and Intermolecular Interactions Between Noncovalently Bonded Species addresses this issue directly, defining the nature of the interactions and discussing how they should and should not be described. It reviews both theoretical developments and experimental procedures in order to explore interactions between nonbonded entities in such a fundamental manner as to elucidate their nature and origins. Drawing attention to the extensive experience of its editor and team of expert authors, Intra- and Intermolecular Interactions Between Noncovalently Bonded Species is an indispensable guide to the foundational knowledge, latest advances, most pressing challenges, and future directions for all those whose work is influenced by these interactions.