This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.

This book covers a broad range of topics from the interdisciplinary research field of ultrafast intense laser science, focusing on atoms and molecules interacting with intense laser fields, laser-induced filamentation, high-order harmonics generation, and high power lasers and their applications. This sixteenth volume features contributions from world-renowned researchers, introducing the latest reports on probing molecular chirality with intense laser fields, and the most recent developments in the Shanghai Superintense Ultrafast Laser Facility project. The PUILS series delivers up-to-date reviews of progress in this emerging interdisciplinary research field, spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each of their own subfields of ultrafast intense laser science. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, especially graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries.

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

With nanotechnology being a relatively new field, the questions regarding safety and ethics are steadily increasing with the development of the research. This book aims to give an overview on the ethics associated with employing nanoscience for products with everyday applications. The risks as well as the regulations are discussed, and an outlook for the future of nanoscience on a manufacturer's scale and for the society is provided. Ethics in nanotechnology is a valuable resource for, philosophers, academicians and scientist, as well as all other industry professionals and researchers who interact with emerging social and philosophical ethical issues on routine bases. It is especially for deep learners who are enthusiastic to apprehend the challenges related to nanotechnology and ethics in philosophical and social education. This book presents an overview of new and emerging nanotechnologies and their societal and ethical implications. It is meant for students, academics, scientists, engineers, policy makers, ethicist, philosophers and all stakeholders involved in the development and use of nanotechnology.

This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Foerster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.

Chemistry is a conceptual subject and, in order to explain many of the concepts, teachers use models to describe the microscopic world and relate it to the macroscopic properties of matter. This can lead to problems, as a student's every-day experiences of the world and use of language can contradict the ideas put forward in chemical science. These titles have been designed to help tackle this issue of misconceptions. Part 1 deals with the theory, by including information on some of the key alternative conceptions that have been uncovered by research; ideas about a variety of teaching approaches that may prevent students acquiring some common alternative conceptions; and general ideas for assisting students with the development of appropriate scientific conceptions. Part 2 provides strategies for dealing with some of the misconceptions that students have, by including ready to use classroom resources including copies of probes that can be used to identify ideas held by students; some specific exercises aimed at challenging some of the alternative ideas; and classroom activities that will help students to construct the chemical concepts required by the curriculum. Used together, these two books will provide a good theoretical underpinning of the fundamentals of chemistry. Trialled in schools throughout the UK, they are suitable for teaching ages 11-18.

For one-semester courses in General, Organic, and Biological Chemistry A friendly, engaging text that reveals connections between chemistry, health, and the environment Chemistry: An Introduction to General, Organic, and Biological Chemistry, 13th Edition is the ideal resource for anyone interested in learning about allied health. Assuming no prior knowledge of chemistry, author Karen Timberlake engages readers with her friendly presentation style, revealing connections between the structure and behavior of matter and its role in health and the environment. Aiming to provide a better learning experience, the text highlights the relevance of chemistry through real-world examples. Activities and applications throughout the program couple chemistry concepts with health and environmental career applications to help readers understand why the content matters. The text also fosters development of problem-solving skills, while helping readers visualize and understand concepts through its engaging figures, sample problems, and concept maps. The 13th Edition expands on Karen Timberlake's main tenets: relevance, a clinical focus, educational research, and learning design. New applications added to questions and problem sets emphasize the material's relevance, while updated chapter openers with follow-up stories help readers form a basis for making decisions about issues concerning health and the environment. New problem-solving tools in this edition, including Try it First and Connect, urge readers to think critically about problem-solving while learning best practices. Also available with Mastering Chemistry. Mastering (TM) Chemistry is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students with powerful content. Instructors ensure students arrive ready to learn by assigning educationally effective content and encourage critical thinking and retention with in-class resources such as Learning Catalytics (TM). Students can further master concepts through homework assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions. Note: You are purchasing a standalone product; Mastering (TM) Chemistry does not come packaged with this content. Students, if interested in purchasing this title with Mastering Chemistry, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and Mastering Chemistry, search for: 0134416791 / 9780134416793 Chemistry: An Introduction to General, Organic, and Biological Chemistry Plus Mastering Chemistry with eText -- Access Card Package, 13/e Package consists of: 0134421353 / 9780134421353 Chemistry: An Introduction to General, Organic, and Biological Chemistry 0134473124 / 9780134473123 Mastering Chemistry with Pearson eText -- ValuePack Access Card -- for Chemistry: An Introduction to General, Organic, and Biological Chemistry

This volume looks at modern approaches to catalysis and reviews the extensive literature. Chapters highlight application of 2D materials in biomass conversion catalysis, plasmonic photocatalysis, catalytic demonstration of mesoporosity in the hierarchical zeolite and the effect of surface phase oxides on supported metals and catalysis. Looking to the future a chapter on ab initio machine learning for accelerating catalytic materials discovery is included. Appealing broadly to researchers in academia and industry, these illustrative chapters bridge the gap from academic studies in the laboratory to practical applications in industry not only for catalysis field but also for environmental protection. Other chapters with an industrial perspective include heterogeneous and homogeneous catalytic routes for vinyl acetate synthesis, catalysis for production of jet fuel from renewable sources by HDO/HDC and microwave-assisted catalysis for fuel conversion. Chemical reactions in ball mills is also explored. The book will be of great benefit to any researcher wanting a succinct reference on developments in this area now and looking to the future.

Suitable for both concept- and context-led approaches, this Revision Guide is Edexcel's own resource for the 2008 Edexcel GCE Chemistry specification. Written by experienced examiners, it features guidance from the people who write and mark exam papers and draws on real exam data from Edexcel's ResultsPlus service. 'ResultsPlus' Examiner feedback draws on examiner expertise and real past exam data to help students avoid common pitfalls and build better answers. Exam-style questions - including the multiple-choice style - offer plenty of practice ahead of the exam. Worked examples provide step-by-step guidance on how totackle exam questions. Guidance on Practical Assessment helps students to write better AS visit/case study and practical reports. Thinking tasks, quick questions and checklistsenable students to track their own progress and revise more effectively.

Natural phenolics are powerful bioactive compounds, but their use as antioxidant agents in lipid-based foodstuffs and cosmetics is limited due to their hydrophilic traits. A promising technique to overcome low solubility of phenolics is to increase their hydrophobicity by grafting with lipophilic moiety to form lipid-enriched phenolics (lipo-phenolics). Another way to enhance the amphiphilic traits of phenolics is by lipophilization with phospholipids in a suitable solvent to form phenolics-enriched phospholipids (pheno-phospholipids). Both functionalized phenolics (phenolipids) exhibit high bioavailability and antioxidative potential. Functional phenolics-enriched phospholipids (pheno-phospholipids) play an important role in enhancing the functional properties of both phenolic compounds and phospholipids in food for their use in nutrition and health. Phenolipids have also found applications on an industrial scale, likely due to low costs, the availability of starting material and safety. Recent advances in the field of lipophilization allow accessing molecules with high potency and targeted action covering a wide spectrum of bioactivities. Owing to their cost and availability, phenolipids find applications in niche sectors such as cosmetics and pharmaceutics as well as in the novel food. This book reports on the chemistry, preparation, and functionality of lipid-enriched phenolics (lipo-phenolics), broadening their applications in food, pharmaceuticals and cosmetics. The strategies of the lipophilization of phenolics, the effect of modification on the biological properties and potential applications of the resulting lipo-phenolics are reviewed. The text also discusses the preparation, physicochemical characteristics and functional properties of phenolipids and phytosomes, including the latest developments and their current industrial status.