Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Advances in Organometallic Chemistry, Volume 77, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. It is ideal for a wide range of researchers involved in organometallic chemistry, with this updated release including chapters on Organometallic-like reactivity of group 10 metal-heteroatom sigma bonds, Organometallic interactions between metal nanoparticles and carbon-based molecules: a surface reactivity rationale, Group VI Allenylidene Complexes, and more.

Oil Palm Biomass for Composite Panels: Fundamentals, Processing, and Applications explains the preparation and utilization of oil palm biomass for advanced composite panel products. It introduces the fundamentals of oil palm biomass and wood-based panel products, including basic properties, durability, deterioration, and adhesives. It also includes in-depth information on processing and treatments organized by biomass type, covering oil palm trunk and lumber, veneer, empty fruit bunches (EFBs), oil palm fronds, and other sources. Additionally, this book focuses on specific composite panel applications, explaining the utilization of oil palm biomass in specific products. Finally, current policy, economic and environmental factors, and supply considerations are discussed. The information contained in Oil Palm Biomass for Composite Panels will be of interest to researchers, scientists and advanced students in bio-based materials, polymer science, composites, wood science, forestry, and biomass, as well as industrial scientists and product designers working with oil palm biomass, wood-based products, and sustainable materials.

Surface Modified Nanomaterials for Applications in Catalysis: Fundamentals, Methods and Applications provides an overview of the different state-of-the-art surface modification methods of nanomaterials and their commercial applications. The main objective of this book is to comprehensively cover the modification of nanomaterial and their fabrication, including different techniques and discussions of present and emerging commercial applications. The book addresses fundamental chemistry concepts as applied to the modification of nanomaterials for applications in energy, catalysis, water remediation, sensors, and more. Characterization and fabrication methodologies are reviewed, along with the challenges of up-scaling of processes for commercial applications. This book is suitable for academics and practitioners working in materials science, engineering, nanotechnology, green chemistry and chemical engineering.

Advances in Inorganic Chemistry, Volume 79, the latest release in an esteemed series that highlights new advances in the field of inorganic chemistry, presents new and interesting topics authored by an international field of experts.

Separations of Water Pollutants with Nanotechnology, the latest volume in the Separation Science and Technology series, offers new solutions for remediating water pollution utilizing nanomaterials with separation methods. Current water purification methods are unsuitable, inconvenient or expensive, so there is a need for new and better processes and techniques. Nanomaterials can purify water by removing pollutants such as heavy metals, pathogens, organic compounds, inorganic compounds, pharmaceuticals, and chemicals of emerging concern. These can effectively replace membrane-based methods if the right expertise is developed-this book helps separation scientists do just that. Existing water treatment problems can be solved by applying a nanotechnology-based processes: antimicrobial nanotechnology, zero-valent iron nanoparticles, nanoadsorbents, nano-enhanced membranes, nanometal oxides, and nano photocatalysts. The current literature places emphasis on materials chemistry rather than the separation methods used for water purification. This new volume presents a collection of chapters that deal with remediation based on separation chemistry.

Isolated Pyranones: Multifaceted Building Blocks for Molecular Diversity covers the latest findings on synthesis and chemical reactivity of highly functionalized pyran-2-ones and pyran-4-ones, their reduced analogs and compounds derived from them through chemical reactions, and their applications in drug discovery and material sciences. It covers the mechanisms of the reaction and step by step formation of final products. Numerous pyranones from natural and synthetic origins, as well as their derived products, have shown diverse pharmacological activities and some are in clinical use. The applications of these compounds are not limited to drug development and imaging agents, and they are also used in material science as organic semiconductors, liquid crystals, organic light emitting diodes (OLEDs), organic catalysts, solid state lasers, photovoltaic and photoconductive devices. The book is ideal for organic, bioorganic, physical, material and natural product chemists working to generate diverse molecular entities through ring transformation reactions of pyranones, and those working in material science to generate new chemical entities.

Elastomer Blends and Composites: Principles, Characterization, Advances, and Applications presents the latest developments in natural rubber and synthetic rubber-based blends and nanocomposites, with a focus on current trends, future directions and state-of-the-art applications. The book introduces the fundamentals of natural rubber and synthetic rubbers, outlining synthesis, structure, properties, challenges and potential applications. This is followed by detailed coverage of compounding and formulations, manufacturing methods, and preparation of elastomer-based blends, composites, and nanocomposites. The next section of the book focuses on properties and characterization, examining elasticity, spectroscopy, barrier properties, and rheological, morphological, mechanical, thermal, and viscoelastic behavior, and more. This is a highly valuable resource for researchers and advanced students in rubber (or elastomer) science, polymer blends, composites, polymer science, and materials science and engineering, as well as engineers, technologists, and scientists working with rubber-based materials for advanced applications.

The Alkaloids, Volume 88, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on the Biology of quinoline and quinazoline alkaloids, Synthesis of pyrimidine-containing alkaloids, and much more.

Heterocyclic Mesomeric Betaines and Mesoionic Compounds, Volume 137 in the Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Heterocyclic Mesomeric Betaines, Type A Mesoionic Compounds (1980-2020), Type B Mesoionic Compounds (1980-2020), Recent Developments in the Chemistry of Heteroporphyrins, Carbaporphyrins and Related Systems, Heterocyclic Zwitterions Based on Coupled Polymethines, Meso-ionic Compounds reproduced from Adv. Heterocycl. Chem. 1976, 19, 1-122., and Meso-ionic Heterocycles (1976-1980) reproduced from Tetrahedron, 1982, 38, 2965-3011.

Databook of Blowing and Auxiliary Agents, Second Edition includes the most current information on foaming technology, guiding users on the proper selection of formulation, which is highly dependent on the mechanisms of action of blowing agents and foaming agents, as well as dispersion and solubility. The book includes properties of 23 groups of blowing agents and the typical range of technical performance for each group, including general properties, physical-chemical properties, health and safety, environmental impact, and applications in different products and polymers. All information is illustrated by chemical reactions and diagrams. Chapters in the book look at foaming mechanisms with the use of solid blowing agents, which are decomposed to the gaseous products by application of heat, production of gaseous products by chemical reaction, and foaming by gases and evaporating liquids.

Atlas of Material Damage, Third Edition provides a systematic analysis of modes of damage and morphology of damaged material and compares the experiences of different industries to provide insights into the most frequently encountered failures, reasons for these failures, and potential improvements to prevent future failure. The book covers defect formation, material damage, and how structure of materials impacts designed function. The effects of composition, processing conditions, and singular and combined actions of different degradants on industrial products are discussed at length. Technological steps required to obtain specifically designed morphology for specific performance are outlined, and numerous examples of how this special morphology can be achieved and deployed in electronics, plastics, pharmaceuticals, aerospace, automotive, medical, dental and a range of other fields and applications is also covered.

Applications of Polymers and Plastics in Medical Devices: Design, Manufacture, and Performance is a comprehensive guide to plastic materials for medical devices, covering fundamentals, materials, applications and regulatory requirements. Sections cover the role of plastics in medical devices, socioeconomic factors, the classification of medical devices. The performance of, medical grades and suppliers of polymer materials, which are categorized by performance level are also explored, along with manufacturing processes for device components, including extrusion, casting, injection molding and assembly processes. The book then covers applications in detail, examining each device and the role that polymers and plastics play in its construction and function. This is an essential resource for engineers, R&D, and other professionals working on plastics for medical devices and those in the plastics industry, medical device manufacturing, pharmaceuticals, packaging and biotechnology. In an academic setting, this book is of interest to researchers and advanced students in medical plastics, plastics engineering, polymer science, mechanical engineering, chemical engineering, biomedical engineering and materials science.

Properties and Functionalization of Graphene: Computational Chemistry Approaches, Volume 21 shows how computational chemistry can be used to explore molecular interactions when modeling and manipulating graphene's properties for varied applications. Sections compare results and experimental evidence, cover the experimental techniques employed in the functionalization of graphene and associated challenges, and delve into the properties of functionalized graphene. Under the guidance of its expert editor, this book shares insights from a global team of specialists, making it an authoritative, practical guide for all those studying, developing or applying graphene across a whole range of fields.

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry.

Annual Reports on NMR Spectroscopy, Volume 105, the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy includes a variety of updated chapters covering Recent advances in dynamic nuclear polarization-enhanced NMR spectroscopy for organic polymers and Functional and structural characterization of membrane-binding proteins using NMR.

Studies in Natural Products Chemistry, Volume 72 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts on fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, hence the importance of this book.

Sustainable Polylactide-Based Blends provides a critical overview of the state-of-the-art in polylactide (PLA)-based blends, addressing the latest advances, innovative processing techniques and fundamental issues that persist in the field. Sections cover the fundamentals of sustainable polymeric materials, polylactide and polymer blends, current and upcoming processing technologies, structure and morphology characterization techniques for PLA and PLA-based blends, and the processing, morphology development, and properties of polylactide-based blends. Final chapters focus on current and future applications, market potential, key challenges and future outlooks. Throughout the book, theoretical modeling of immiscible polymer blends helps to establish structure-property relationships in various PLA-based polymer blends. With in-depth coverage of fundamentals and processing techniques, the book aims to support the selection of each processing method, along with an understanding of surface chemistry to achieve improved compatibility between phases.

Molecular Modeling of the Sensitivities of Energetic Materials, Volume 22 introduces experimental aspects, explores the relationships between sensitivity, molecular structure and crystal structure, discusses insights from numerical simulations, and highlights applications of these approaches to the design of new materials. Providing practical guidelines for implementing predictive models and their application to the search for new compounds, this book is an authoritative guide to an exciting field of research that warrants a computer-aided approach for the investigation and design of safe and powerful explosives or propellants. Much recent effort has been put into modeling sensitivities, with most work focusing on impact sensitivity and leading to a lot of experimental data in this area. Models must therefore be developed to allow evaluation of significant properties from the structure of constitutive molecules.