Model integration - the process by which different modelling efforts can be brought together to simulate the target system - is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.

A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.

The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

This volume collects various contributions from the 5th International Conference on Jets, Wakes and Separated Flows (ICJWSF2015) that took place in Stockholm during June 2015. Researchers from all around the world presented their latest results concerning fundamental and applied aspects of fluid dynamics. With its general character, the conference embraced many aspects of fluid dynamics, such as shear flows, multiphase flows and vortex flows, for instance. The structure of the present book reflects the variety of topics treated within the conference i.e. Jets, Wakes, Separated flows, Vehicle aerodynamics, Wall-bounded and confined flows, Noise, Turbomachinery flows, Multiphase and reacting flows, Vortex dynamics, Energy-related flows and a section dedicated to Numerical analyses.

This book highlights cutting-edge research in the field of network science, offering scientists, researchers and graduate students a unique opportunity to catch up on the latest advances in theory and a multitude of applications. It presents the peer-reviewed proceedings of the fifth International Workshop on Complex Networks & their Applications (COMPLEX NETWORKS 2016), which took place in Milan during the last week of November 2016. The carefully selected papers are divided into 11 sections reflecting the diversity and richness of research areas in the field. More specifically, the following topics are covered: Network models; Network measures; Community structure; Network dynamics; Diffusion, epidemics and spreading processes; Resilience and control; Network visualization; Social and political networks; Networks in finance and economics; Biological and ecological networks; and Network analysis.

This book presents state-of-the-art research on security and privacy- preserving for IoT and 5G networks and applications. The accepted book chapters covered many themes, including traceability and tamper detection in IoT enabled waste management networks, secure Healthcare IoT Systems, data transfer accomplished by trustworthy nodes in cognitive radio, DDoS Attack Detection in Vehicular Ad-hoc Network (VANET) for 5G Networks, Mobile Edge-Cloud Computing, biometric authentication systems for IoT applications, and many other applications It aspires to provide a relevant reference for students, researchers, engineers, and professionals working in this particular area or those interested in grasping its diverse facets and exploring the latest advances on security and privacy- preserving for IoT and 5G networks.

Structured Controllers for Uncertain Systems focuses on the development of easy-to-use design strategies for robust low-order or fixed-structure controllers (particularly the industrially ubiquitous PID controller). These strategies are based on a recently-developed stochastic optimization method termed the Heuristic Kalman Algorithm (HKA) the use of which results in a simplified methodology that enables the solution of the structured control problem without a profusion of user-defined parameters. An overview of the main stochastic methods employable in the context of continuous non-convex optimization problems is also provided and various optimization criteria for the design of a structured controller are considered; H infinity, H2, and mixed H2/Hinfinity each merits a chapter to itself. Time-domain-performance specifications can be easily incorporated in the design.

This book simultaneously presents the theory and the numerical treatment of elliptic boundary value problems, since an understanding of the theory is necessary for the numerical analysis of the discretisation. It first discusses the Laplace equation and its finite difference discretisation before addressing the general linear differential equation of second order. The variational formulation together with the necessary background from functional analysis provides the basis for the Galerkin and finite-element methods, which are explored in detail. A more advanced chapter leads the reader to the theory of regularity. Individual chapters are devoted to singularly perturbed as well as to elliptic eigenvalue problems. The book also presents the Stokes problem and its discretisation as an example of a saddle-point problem taking into account its relevance to applications in fluid dynamics.

Handbook of MARINE CRAFT HYDRODYNAMICS AND MOTION CONTROL The latest tools for analysis and design of advanced GNC systems Handbook of Marine Craft Hydrodynamics and Motion Control is an extensive study of the latest research in hydrodynamics, guidance, navigation, and control systems for marine craft. The text establishes how the implementation of mathematical models and modern control theory can be used for simulation and verification of control systems, decision-support systems, and situational awareness systems. Coverage includes hydrodynamic models for marine craft, models for wind, waves and ocean currents, dynamics and stability of marine craft, advanced guidance principles, sensor fusion, and inertial navigation. This important book includes the latest tools for analysis and design of advanced GNC systems and presents new material on unmanned underwater vehicles, surface craft, and autonomous vehicles. References and examples are included to enable engineers to analyze existing projects before making their own designs, as well as MATLAB scripts for hands-on software development and testing. Highlights of this Second Edition include: Topical case studies and worked examples demonstrating how you can apply modeling and control design techniques to your own designs A Github repository with MATLAB scripts (MSS toolbox) compatible with the latest software releases from Mathworks New content on mathematical modeling, including models for ships and underwater vehicles, hydrostatics, and control forces and moments New methods for guidance and navigation, including line-of-sight (LOS) guidance laws for path following, sensory systems, model-based navigation systems, and inertial navigation systems This fully revised Second Edition includes innovative research in hydrodynamics and GNC systems for marine craft, from ships to autonomous vehicles operating on the surface and under water. Handbook of Marine Craft Hydrodynamics and Motion Control is a must-have for students and engineers working with unmanned systems, field robots, autonomous vehicles, and ships. MSS toolbox: https: //github.com/cybergalactic/mss Lecture notes: https: //www.fossen.biz/wiley Author's home page: https: //www.fossen.biz

This book, published in honor of Professor Laurent Praly on the occasion of his 65th birthday, explores the responses of some leading international authorities to new challenges in nonlinear and adaptive control. The mitigation of the effects of uncertainty and nonlinearity - ubiquitous features of real-world engineering and natural systems - on closed-loop stability and robustness being of crucial importance, the contributions report the latest research into overcoming these difficulties in: autonomous systems; reset control systems; multiple-input-multiple-output nonlinear systems; input delays; partial differential equations; population games; and data-driven control. Trends in Nonlinear and Adaptive Control presents research inspired by and related to Professor Praly's lifetime of contributions to control theory and is a valuable addition to the literature of advanced control.

This textbook teaches students techniques for the design of advanced digital systems using System-on-Chip (SoC) Field Programmable Gate Arrays (FPGAs). The author demonstrates design of custom hardware components for the FPGA fabric using VHDL, with implementation of custom hardware-software interfaces. Readers gain hands-on experience by writing programs and Linux device drivers in C to interact with custom hardware. This textbook enables laboratory experience in the design of custom digital systems using SoC FPGAs, emphasizing computational tasks such as digital signal processing, audio, or video processing.

This monograph examines the stability of various coupled systems with local Kelvin-Voigt damping. The development of this area is thoroughly reviewed along with the authors' contributions. New results are featured on the fundamental properties of solutions of linear transmission evolution PDEs involving Kelvin-Voigt damping, with special emphasis on the asymptotic behavior of these solutions. The vibrations of transmission problems are highlighted as well, making this a valuable resource for those studying this active area of research. The book begins with a brief description of the abstract theory of linear evolution equations with a particular focus on semigroup theory. Different types of stability are also introduced along with their connection to resolvent estimates. After this foundation is established, different models are presented for uni-dimensional and multi-dimensional linear transmission evolution partial differential equations with Kelvin-Voigt damping. Stabilization of Kelvin-Voigt Damped Systems will be a useful reference for researchers in mechanics, particularly those interested in the study of control theory of PDEs.

While the possible depletion of energy sources has been emphasized in most literatures, this book aims to show that the increase of entropy in the biosphere, resulting since the dawn of industrial era, is a cause for urgent concern.As the entropy release puts a limit on sustainable growth, and the CO2 atmospheric content is a reliable indicator of global entropy release that threatens the biospheric balance, a change of paradigm is necessary with the need to switch from an economy of exploitation to an economy of entropy.

This book provides an integrated framework for natural and artificial cognition by highlighting the fundamental role played by the cognitive architecture in the dialectics with the surrounding environment and consequently in the definition of a particular meaningful world. This book is also about embodied and non-embodied artificial systems, cognitive architectures that are human constructs, meant to be able to populate the human world, capable of identifying different life contexts and replicating human patterns of behavior capable of acting according to human values and conventions, systems that perform tasks in a human-like way. By identifying the essential phenomena at the core of all forms of cognition, the book addresses the topic of design of artificial cognitive architectures in the domains of robotics and artificial life. Moving from mere bio-inspired design methodology it aims to open a pathway to semiotically determined design.

Provides a comprehensive introduction to multi-robot systems planning and task allocation; Explores multi robot aerial planning, flight planning, orienteering and coverage, and deployment, patrolling, and foraging; Includes real-world case studies; Treats different aspects of cooperation in multi-agent systems.

For the past 50 years, the advancements of technology have equipped architects with unique tools that have enabled the development of new computer-mediated design methods, fabrication techniques, and architectural expressions. Simultaneously, in contemporary architecture new frameworks emerged that have radically redefined the traditional conceptions of design, of the built environment, and of the role of architects. Cybernetic Architectures argues that such frameworks have been constructed in direct reference to cybernetic thinking, a thought model that emerged concurrently with the origins of informatics and that embodies the main assumptions, values, and ideals underlying the development of computer science. The book explains how the evolution of the computational perspective in architecture has been parallel to the construction of design issues in reference to the central ideas fostered by the cybernetic model. It unpacks and explains this crucial relationship, in the work of digital architects, between the use of information technology in design and the conception of architectural problems around an informational ontology. This book will appeal to architecture students and scholars interested in understanding the recent transformations in the architectural landscape related to the advent of computer-based design paradigms.

This monograph examines in detail models of neural systems described by delay-differential equations. Each element of the medium (neuron) is an oscillator that generates, in standalone mode, short impulses also known as spikes. The book discusses models of synaptic interaction between neurons, which lead to complex oscillatory modes in the system. In addition, it presents a solution to the problem of choosing the parameters of interaction in order to obtain attractors with predetermined structure. These attractors are represented as images encoded in the form of autowaves (wave memory). The target audience primarily comprises researchers and experts in the field, but it will also be beneficial for graduate students.

The aim of the School on Rheology of Complex fluids is to bring together young researchers and teachers from educational and R&D institutions, and expose them to the basic concepts and research techniques used in the study of rheological behavior of complex fluids. The lectures will be delivered by well-recognized experts. The book contents will be based on the lecture notes of the school.

By incorporating biologically-inspired functions into ICT, various types of new-generation information and communication systems can be created. Just some example of areas already benefiting from such design inspiration are network architectures, information processing, molecular communication, and complex network modeling for solving real world-problems. This book provides the theoretical basis for understanding these developments and explains their practical applications. Highlighted inserts appears throughout to help readers to understand the very latest topics in these emerging research fields. The book ends with a more philosophical discussion on how new ICT solutions can be found by looking at analogous systems in biology. This new way of thinking may help researchers and practitioners to apply innovative ideas in developing next-generation technologies.

Computer-Controlled Systems with Delay is a systematic study of the problems of analysis and synthesis for multidimensional sampled-data (SD) systems with delay. It is based on the frequency polynomial method, in which the concept of a parametric transfer matrix (PTM) plays a key role. Until now, no alternative general methods have been available to solve the above problems. The text is divided into three parts: background information from the theory of polynomial and rational matrices, helps the reader to acquire the basic understanding necessary to use the main content of the book without addressing additional sources; methods for the mathematical description of multidimensional SD systems with delay, based on the concept of the PTM; and optimization methods for multidimensional SD systems with delay, including H2 and L2 optimization as well as H2 optimization for colored input signals. The monograph is completed by three appendices. An algorithm for constructing the set of pathological sampling periods for a continuous SISO object with delay is provided first. MATLAB (R)-toolbox algorithms representing methods described in the book and application examples for selected optimization problems are given in the second. A solution to the problem of guaranteeing the required performance in a class of stochastic disturbances for SD systems with delay is considered in the third. Computer-Controlled Systems with Delay is intended for engineers, scientists and teachers working in modern control theory. It will also benefit post-graduate students taking courses in related disciplines. The book continues the description of the authors' research results on developing methods for SD systems theory which are based on the PTM concept and published in the monographs Computer Controlled Systems and Multivariable Computer-controlled Systems.

Bayesian Inference of State Space Models: Kalman Filtering and Beyond offers a comprehensive introduction to Bayesian estimation and forecasting for state space models. The celebrated Kalman filter, with its numerous extensions, takes centre stage in the book. Univariate and multivariate models, linear Gaussian, non-linear and non-Gaussian models are discussed with applications to signal processing, environmetrics, economics and systems engineering. Over the past years there has been a growing literature on Bayesian inference of state space models, focusing on multivariate models as well as on non-linear and non-Gaussian models. The availability of time series data in many fields of science and industry on the one hand, and the development of low-cost computational capabilities on the other, have resulted in a wealth of statistical methods aimed at parameter estimation and forecasting. This book brings together many of these methods, presenting an accessible and comprehensive introduction to state space models. A number of data sets from different disciplines are used to illustrate the methods and show how they are applied in practice. The R package BTSA, created for the book, includes many of the algorithms and examples presented. The book is essentially self-contained and includes a chapter summarising the prerequisites in undergraduate linear algebra, probability and statistics. An up-to-date and complete account of state space methods, illustrated by real-life data sets and R code, this textbook will appeal to a wide range of students and scientists, notably in the disciplines of statistics, systems engineering, signal processing, data science, finance and econometrics. With numerous exercises in each chapter, and prerequisite knowledge conveniently recalled, it is suitable for upper undergraduate and graduate courses.

After a short introduction to the fundamentals, this book provides a detailed account of major advances in applying fractional calculus to dynamical systems. Fractional order dynamical systems currently continue to gain further importance in many areas of science and engineering. As with many other approaches to mathematical modeling, the first issue to be addressed is the need to couple a definition of the fractional differentiation or integration operator with the types of dynamical systems that are analyzed. As such, for the fundamentals the focus is on basic aspects of fractional calculus, in particular stability analysis, which is required to tackle synchronization in coupled fractional order systems, to understand the essence of estimators for related integer order systems, and to keep track of the interplay between synchronization and parameter observation. This serves as the common basis for the more advanced topics and applications presented in the subsequent chapters, which include an introduction to the 'Immersion and Invariance' (I&I) methodology, the masterslave synchronization scheme for partially known nonlinear fractional order systems, Fractional Algebraic Observability (FAO) and Fractional Generalized quasi-Synchronization (FGqS) to name but a few. This book is intended not only for applied mathematicians and theoretical physicists, but also for anyone in applied science dealing with complex nonlinear systems.

AI for Digital Warfare explores how the weaponising of artificial intelligence can and will change how warfare is being conducted, and what impact it will have on the corporate world. With artificial intelligence tools becoming increasingly advanced, and in many cases more humanlike, their potential in psychological warfare is being recognised, which means digital warfare can move beyond just shutting down IT systems into more all-encompassing hybrid war strategies.

Simulation and molding are efficient techniques that can aid the city and regional planners and engineers in optimizing the operation of urban systems such as traffic light control, highway toll automation, consensus building, public safety, and environmental protection. When modeling transportation systems such as freeway systems, arterial or downtown grid systems, the city planner and engineer is concerned with capturing the varied interactions between drivers, automobiles, and the infrastructure. Modeling and simulation are used to effectively optimize the design and operation of all of these urban systems. It is possible that in an urban simulation community workshop, citizens can work interactively in front of computers and be able using the click of the mouse to walk up to their own front porch, looking at the proposed shopping mall alternatives across the street from virtually any angle and proposed bridge or tunnel and see how it can reduce traffic congestion. Buildings can be scaled down or taken out, their orientation can be changed in order to check the view and orientation in order to have better site with efficient energy-conservation. The stone or brick material on a building can be replaced by colored concrete, or more trees and lampposts can be placed on the site. Such flexibility in simulation and animation allows creative ideas in the design and orientation of urban sites to be demonstrated to citizens and decision makers before final realization.

In recent years fractional calculus has played an important role in various fields such as mechanics, electricity, chemistry, biology, economics, modeling, identification, control theory and signal processing. The scope of this book is to present the state of the art in the study of fractional systems and the application of fractional differentiation. Furthermore, the manufacture of nanowires is important for the design of nanosensors and the development of high-yield thin films is vital in procuring clean solar energy.

This wide range of applications is of interest to engineers, physicists and mathematicians.

The aim of this Book is to give an overview, based on the results of nearly three decades of intensive research, of transient chaos. One belief that motivates us to write this book is that, transient chaos may not have been appreciated even within the nonlinear-science community, let alone other scientific disciplines.

Continuous System Simulation describes in detail how to build mathematical simulations of systems that change continuously over time. It covers: - numerical integration - simulation of stiff systems - simulation of marginally stable systems - simulation of noisy systems - model validation techniques - simulation verification - the inverse problem - dynamic nonlinear programming - simulation software - simulation hardware Intended for advanced undergraduates in electrical, computer, mechanical, and civil engineering, it is a highly computer-oriented text, introducing numerical methods and algorithms along with the applications and conceptual tools. Homework problems, suggestions for research projects, and open-ended questions conclude each chapter.