Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

Why do the best-known examples of evolutionary change involve the alteration of one kind of animal into another very similar one, like the evolution of a bigger beak in a bird? Wouldn't it be much more interesting to understand how beaks originated? Most people would agree, but until recently we didn't know much about such origins. That is now changing, with the growth of the interdisciplinary field evo-devo, which deals with the relationship between how embryos develop in the short term and how they (and the adults they grow into) evolve in the long term. One of the key questions is: can the origins of structures such as beaks, eyes, and shells be explained within a Darwinian framework? The answer seems to be yes, but only by expanding that framework. This book discusses the required expansion, and the current state of play regarding our understanding of evolutionary and developmental origins.

Big cats such as lions, tigers, leopards, and jaguars fascinate us like few other creatures. They are enduring symbols of natural majesty and power. Yet despite the magnetic appeal of the big cats, their origins and evolutionary history remain poorly understood-and human activity threatens to put an end to the big cats' glory. On the Prowl is a fully illustrated and approachable guide to the evolution of the big cats and what it portends for their conservation today. Mark Hallett and John M. Harris trace the origins of these iconic carnivores, venturing down the evolutionary pathways that produced the diversity of big cat species that have walked the earth. They place the evolution and paleobiology of these species in the context of ancient ecosystems and climates, explaining what made big cats such efficient predators and analyzing their competition with other animals. Hallett and Harris pay close attention to human impact, from the evidence of cave paintings and analysis of ancient extinctions up to present-day crises. Their engaging and carefully documented account is brought to life through Hallett's detailed, vivid illustrations, based on the most recent research by leading paleontologists. Offering a fresh look at the rise of these majestic animals, On the Prowl also makes a powerful case for renewed efforts to protect big cats and their habitats before it is too late.

Why are humans so fond of water? Why is our skin colour so variable? Why aren't we hairy like our close ape relatives? A savannah scenario of human evolution has been widely accepted primarily due to fossil evidence; and fossils do not offer insight into these questions. Other alternative evolutionary scenarios might, but these models have been rejected. This book explores a controversial idea - that human evolution was intimately associated with watery habitats as much or more than typical savannahs. Written from a medical point of view, the author presents evidence supporting a credible alternative explanation for how humans diverged from our primate ancestors. Anatomical and physiological evidence offer insight into hairlessness, different coloured skin, subcutaneous fat, large brains, a marine-type kidney, a unique heat regulation system and speech. This evidence suggests that humans may well have evolved, not just as savannah mammals, as is generally believed, but with more affinity for aquatic habitats - rivers, streams, lakes and coasts. Key Features: Presents the evidence for a close association between riparian habitats and the origin of humans Reviews the "savannah ape" hypothesis for human origins Describes various anatomical adaptations that are associated with hypotheses of human evolution Explores characteristics from the head and neck such as skull and sinus structures, the larynx and ear structures and functions

'Species' are central to understanding the origin and dynamics of biological diversity; explaining why lineages split into multiple distinct species is one of the main goals of evolutionary biology. However the existence of species is often taken for granted, and precisely what is meant by species and whether they really exist as a pattern of nature has rarely been modelled or critically tested. This novel book presents a synthetic overview of the evolutionary biology of species, describing what species are, how they form, the consequences of species boundaries and diversity for evolution, and patterns of species accumulation over time. The central thesis is that species represent more than just a unit of taxonomy; they are a model of how diversity is structured as well as how groups of related organisms evolve. The author adopts an intentionally broad approach, stepping back from the details to consider what species constitute, both theoretically and empirically, and how we detect them, drawing on a wealth of examples from microbes to multicellular organisms.

In this work, Robert Wright examines a science that has emerged from the work of evolutionary biologists and social scientists. Taking the life and work of the evolutionist Charles Darwin as his context, Wright seeks to demonstrate how Darwin's ideas have stood the test of time and retells - from the perspective of evolutionary psychology - the stories of Darwin's marriage, family, life and career. From this paradigm, Wright draws conclusions about the structure of our most basic preoccupations - sex, ambition, politics, justice - aiming to throw light on the background of these fundamental instincts, and to show why they are so important to us. The work poses questions about not only the biological bases for morality, but also the biological bases for amorality.

Integrating both scientific and philosophical perspectives, this book provides an informed analysis of the challenges of formulating a universal theory of life. Among the issues discussed are crucial differences between definitions and scientific theories and, in the context of examples from the history of science, how successful general theories develop. The central problem discussed is two-fold: first, our understanding of life is still tacitly wedded to an antiquated Aristotelian framework for biology; and second, there are compelling reasons for considering that familiar Earth life, which descends from a last universal common ancestor, is unrepresentative. What is needed are examples of life as we don't know it. Potential sources are evaluated, including artificial life, extraterrestrial life, and a shadow biosphere right here on Earth, and a novel strategy for searching for unfamiliar life in the absence of a definition or general theory is developed. The book is a valuable resource for graduate students and researchers studying the nature, origins, and extent of life in the universe.

Over the past decade, ecologists have increasingly embraced phylogenetics, the study of evolutionary relationships among species. As a result, they have come to discover the field's power to illuminate present ecological patterns and processes. Ecologists are now investigating whether phylogenetic diversity is a better measure of ecosystem health than more traditional metrics like species diversity, whether it can predict the future structure and function of communities and ecosystems, and whether conservationists might prioritize it when formulating conservation plans. In Phylogenetic Ecology, Nathan G. Swenson synthesizes this nascent field's major conceptual, methodological, and empirical developments to provide students and practicing ecologists with a foundational overview. Along the way, he highlights those realms of phylogenetic ecology that will likely increase in relevance--such as the burgeoning subfield of phylogenomics--and shows how ecologists might lean on these new perspectives to inform their research programs.

The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change-related threats confronting humanity. While time is short, the danger is great, and we are largely unprepared, The Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can "anticipate to mitigate" emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.

A remarkable investigation into the hominoids of Flores Island, their place on the evolutionary spectrum-and whether or not they still survive. While doing fieldwork on the remote Indonesian island of Flores, anthropologist Gregory Forth came across people talking about half-apelike, half-humanlike creatures that once lived in a cave on the slopes of a nearby volcano. Over the years he continued to record what locals had to say about these mystery hominoids while searching for ways to explain them as imaginary symbols of the wild or other cultural representations. Then along came the 'hobbit'. In 2003, several skeletons of a small-statured early human species alongside stone tools and animal remains were excavated in a cave in western Flores. Named Homo floresiensis, this ancient hominin was initially believed to have lived until as recently as 12,000 years ago-possibly overlapping with the appearance of Homo sapiens on Flores. In view of this timing and the striking resemblance of floresiensis to the mystery creatures described by the islanders, Forth began to think about the creatures as possibly reflecting a real species, either now extinct but retained in 'cultural memory' or even still surviving. He began to investigate reports from the Lio region of the island where locals described 'ape-men' as still living. Dozens claimed to have even seen them. In Between Ape and Human, we follow Forth on the trail of this mystery hominoid, and the space they occupy in islanders' culture as both natural creatures and as supernatural beings. In a narrative filled with adventure, Lio culture and language, zoology and natural history, Forth comes to a startling and controversial conclusion. Unique, important, and thought-provoking, this book will appeal to anyone interested in human evolution, the survival of species (including our own) and how humans might relate to 'not-quite-human' animals. Between Ape and Human is essential reading for all those interested in cryptozoology, and it is the only firsthand investigation by a leading anthropologist into the possible survival of a primitive species of human into recent times-and its coexistence with modern humans.

Michael Ruse, a leading expert on Charles Darwin, presents a fictional dialogue among characters with sharply contrasting positions regarding the tensions between science and religious belief. Ruse's main characters-an atheist scientist, a skeptical historian and philosopher of science, a relatively liberal female Episcopalian priest, and a Southern Baptist pastor who denies evolution-passionately argue about pressing issues, in a context framed within a television show: "Science versus God- Who is Winning?" These characters represent the different positions concerning science and religion often held today: evolution versus creation, the implications of Christian beliefs upon technological advances in medicine, and the everlasting debate over free will. The second edition of this innovative text incorporates the influence of Eastern religions and philosophies on the debate on human origins, broadening the contextual reach of the dialogue into comparative philosophy and religious studies.

Darwin famously proposed that sexual competition and courtship is (or at least was) the driving force of "art" production not only in animals, but also in humans. The present book is the first to reveal that Darwin's hypothesis, rather than amounting to a full-blown antidote to the humanist tradition, is actually strongly informed both by classical rhetoric and by English and German philosophical aesthetics, thereby Darwin's theory far richer and more interesting for the understanding of poetry and song. The book also discusses how the three most discussed hypothetical functions of the human arts--competition for attention and (loving) acceptance, social cooperation, and self-enhancement--are not mutually exclusive, but can well be conceived of as different aspects of the same processes of producing and responding to the arts. Finally, reviewing the current state of archeological findings, the book advocates a new hypothesis on the multiple origins of the human arts, posing that they arose as new variants of human behavior, when three ancient and largely independent adaptions--sensory and sexual selection-driven biases regarding visual and auditory beauty, play behavior, and technology--joined forces with, and were transformed by, the human capacities for symbolic cognition and language.

Awarded second place in the 2018 AJN Book of the Year Award in the Advanced Practice Nursing category Awarded third place in the 2018 AJN Book of the Year Award in the Maternal-Child Health/Prenatal Nursing/Childbirth category Complex concepts made manageable! Build the foundation you need to understand the science of genetics and its growing role in the diagnosis and treatment of diseases and disorders. Confidently tackle the basics of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior. Everyday language makes these often-intimidating topics easy to understand, while clearly defined principles, logical explanations, illustrations, tables, and clinical examples ensure you master the material. See what students are saying online about the previous edition... Genetics simplified and easy to understand. "Genetics simplified and easy to understand. Wish I had this when learning DNA replication in Microbiology. Lot of good charts. I plan to keep even after the class because it's interesting and easy to understand." - Katalina Cade Great resource! "This is a complex subject and this book makes it so much easier to learn and understand! I love the "memory hints" it gives you throughout the book." - Kira Short

"Are they needed? To be sure. The Darwinian industry, industrious though it is, has failed to provide texts of more than a handful of Darwin's books. If you want to know what Darwin said about barnacles (still an essential reference to cirripedists, apart from any historical importance) you are forced to search shelves, or wait while someone does it for you; some have been in print for a century; various reprints have appeared and since vanished." -Eric Korn, Times Literary Supplement Charles Robert Darwin (1809-1882) has been widely recognized since his own time as one of the most influential writers in the history of Western thought. His books were widely read by specialists and the general public, and his influence had been extended by almost continuous public debate over the past 150 years. New York University Press's new paperback edition makes it possible to review Darwin's public literary output as a whole, plus his scientific journal articles, his private notebooks, and his correspondence. This is complete edition contains all of Darwin's published books, featuring definitive texts recording original pagination with Darwin's indexes retained. The set also features a general introduction and index, and introductions to each volume.

At a time of unprecedented expansion in the life sciences, evolution is the one theory that transcends all of biology. Any observation of a living system must ultimately be interpreted in the context of its evolution. Evolutionary change is the consequence of mutation and natural selection, which are two concepts that can be described by mathematical equations."Evolutionary Dynamics" is concerned with these equations of life. In this book, Martin Nowak draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves. His work introduces readers to the powerful yet simple laws that govern the evolution of living systems, no matter how complicated they might seem.

Evolution has become a mathematical theory, Nowak suggests, and any idea of an evolutionary process or mechanism should be studied in the context of the mathematical equations of evolutionary dynamics. His book presents a range of analytical tools that can be used to this end: fitness landscapes, mutation matrices, genomic sequence space, random drift, quasispecies, replicators, the Prisoner's Dilemma, games in finite and infinite populations, evolutionary graph theory, games on grids, evolutionary kaleidoscopes, fractals, and spatial chaos. Nowak then shows how evolutionary dynamics applies to critical real-world problems, including the progression of viral diseases such as AIDS, the virulence of infectious agents, the unpredictable mutations that lead to cancer, the evolution of altruism, and even the evolution of human language. His book makes a clear and compelling case for understanding every living system--and everything that arises as a consequence of livingsystems--in terms of evolutionary dynamics.

A fully updated edition of one of the most original accounts of evolution ever written, featuring new fractal diagrams, six new 'tales' and the latest scientific developments. THE ANCESTOR'S TALE is a dazzling, four-billion-year pilgrimage to the origins of life: Richard Dawkins and Yan Wong take us on an exhilarating reverse journey through evolution, from present-day humans back to the microbial beginnings of life. It is a journey happily interrupted by meetings of fellow modern animals (as well as plants, fungi and bacteria) similarly tracing their evolutionary path back through history. As each evolutionary pilgrim tells their tale, Dawkins and Wong shed light on topics such as speciation, sexual selection and extinction. Written with unparalleled wit, clarity and intelligence; taking in new scientific discoveries of the past decade; and including new 'tales', illustrations and fractal diagrams, THE ANCESTOR'S TALE shows us how remarkable we are, how astonishing our history, and how intimate our relationship with the rest of the living world.

When was the human threshold crossed? What is the evidence for evolving humans and their emerging humanity? This volume explores in a global overview the archaeology of the Middle Pleistocene, 800,000 to 130,000 years ago when evidence for innovative cultural behaviour appeared. The evidence shows that the threshold was crossed slowly, by a variety of human ancestors, and was not confined to one part of the Old World. Crossing the Human Threshold examines the changing evidence during this period for the use of place, landscape and technology. It focuses on the emergence of persistent places, and associated developments in tool use, hunting strategies and the control of fire, represented across the Old World by deeply stratified cave sites. These include the most important sites for the archaeology of human origins in the Levant, South Africa, Asia and Europe, presented here as evidence for innovation in landscape-thinking during the Middle Pleistocene. The volume also examines persistence at open locales through a cutting-edge review of the archaeology of Northern France and England. Crossing the Human Threshold is for the worldwide community of students and researchers studying early hominins and human evolution. It presents new archaeological data. It frames the evidence within current debates to understand the differences and similarities between ourselves and our ancient ancestors.

"Are they needed? To be sure. The Darwinian industry, industrious though it is, has failed to provide texts of more than a handful of Darwin's books. If you want to know what Darwin said about barnacles (still an essential reference to cirripedists, apart from any historical importance) you are forced to search shelves, or wait while someone does it for you; some have been in print for a century; various reprints have appeared and since vanished." -Eric Korn, Times Literary Supplement Charles Robert Darwin (1809-1882) has been widely recognized since his own time as one of the most influential writers in the history of Western thought. His books were widely read by specialists and the general public, and his influence had been extended by almost continuous public debate over the past 150 years. New York University Press's new paperback edition makes it possible to review Darwin's public literary output as a whole, plus his scientific journal articles, his private notebooks, and his correspondence. This is complete edition contains all of Darwin's published books, featuring definitive texts recording original pagination with Darwin's indexes retained. The set also features a general introduction and index, and introductions to each volume.

"Are they needed? To be sure. The Darwinian industry, industrious though it is, has failed to provide texts of more than a handful of Darwin's books. If you want to know what Darwin said about barnacles (still an essential reference to cirripedists, apart from any historical importance) you are forced to search shelves, or wait while someone does it for you; some have been in print for a century; various reprints have appeared and since vanished." -Eric Korn, Times Literary Supplement Charles Robert Darwin (1809-1882) has been widely recognized since his own time as one of the most influential writers in the history of Western thought. His books were widely read by specialists and the general public, and his influence had been extended by almost continuous public debate over the past 150 years. New York University Press's new paperback edition makes it possible to review Darwin's public literary output as a whole, plus his scientific journal articles, his private notebooks, and his correspondence. This is complete edition contains all of Darwin's published books, featuring definitive texts recording original pagination with Darwin's indexes retained. The set also features a general introduction and index, and introductions to each volume.

The Metaphysical Society was founded in 1869 at the instigation of James Knowles (editor of the Contemporary Review and then of the Nineteenth Century) with a view to 'collect, arrange, and diffuse Knowledge (whether objective or subjective) of mental and moral phenomena' (first resolution of the society in April 1869). The Society was a private dining and debate club that gathered together a latter-day clerisy. Building on the tradition of the Cambridge Apostles, they elected talented members from across the Victorian intellectual spectrum: Bishops, one Cardinal, philosophers, men of science, literary figures, and politicians. The Society included in its 62 members prominent figures such as T. H. Huxley, William Gladstone, Walter Bagehot, Henry Edward Manning, John Ruskin, and Alfred Lord Tennyson. The Metaphysical Society (1869-1880) moves beyond Alan Willard Brown's 1947 pioneering study of the Metaphysical Society by offering a more detailed analysis of its inner dynamics and its larger impact outside the dining room at the Grosvenor Hotel. The contributors shed light on many of the colourful figures that joined the Society as well as the alliances that they formed with fellow members. The collection also examines the major concepts that informed the papers presented at Society meetings. By discussing groups, important individuals, and underlying concepts, the volume contributes to a rich, new picture of Victorian intellectual life during the 1870's, a period when intellectuals were wondering how, and what, to believe in a time of social change, spiritual crisis, and scientific progress.

'From your brain to your fingertips, you emerge from her book entertained and with a deeper understanding of yourself' Richard Dawkins 'A masterful account of why our bodies are the way they are . . . this book really shines . . . Roberts's lightness of touch is joyous, and celebratory' Observer 'Witty, personal and above all informed by passion and deep knowledge, this is the story of you, not just from conception onwards but from the millions of years of evolution that have shaped the way we are today' Adam Rutherford ***SHORTLISTED FOR THE WELLCOME BOOK PRIZE*** Alice Roberts takes you on the most incredible journey, revealing your path from a single cell to a complex embryo to a living, breathing, thinking person. It's a story that connects us with our distant ancestors and an extraordinary, unlikely chain of events that shaped human development and left a mark on all of us. Alice Roberts uses the latest research to uncover the evolutionary history hidden in all of us, from the secrets found only in our embryos and genes - including why as embroyos we have what look like gills - to those visible in your anatomy. This is a tale of discovery, exploring why and how we have developed as we have. This is your story, told as never before.

Both natural and cultural selection played an important role in shaping human evolution. Since cultural change can itself be regarded as evolutionary, a process of gene-culture coevolution is operative. The study of human evolution - in past, present and future - is therefore not restricted to biology. An inclusive comprehension of human evolution relies on integrating insights about cultural, economic and technological evolution with relevant elements of evolutionary biology. In addition, proximate causes and effects of cultures need to be added to the picture - issues which are at the forefront of social sciences like anthropology, economics, geography and innovation studies. This book highlights discussions on the many topics to which such generalised evolutionary thought has been applied: the arts, the brain, climate change, cooking, criminality, environmental problems, futurism, gender issues, group processes, humour, industrial dynamics, institutions, languages, medicine, music, psychology, public policy, religion, sex, sociality and sports.

"Are they needed? To be sure. The Darwinian industry, industrious though it is, has failed to provide texts of more than a handful of Darwin's books. If you want to know what Darwin said about barnacles (still an essential reference to cirripedists, apart from any historical importance) you are forced to search shelves, or wait while someone does it for you; some have been in print for a century; various reprints have appeared and since vanished." -Eric Korn, Times Literary Supplement Charles Robert Darwin (1809-1882) has been widely recognized since his own time as one of the most influential writers in the history of Western thought. His books were widely read by specialists and the general public, and his influence had been extended by almost continuous public debate over the past 150 years. New York University Press's new paperback edition makes it possible to review Darwin's public literary output as a whole, plus his scientific journal articles, his private notebooks, and his correspondence. This is complete edition contains all of Darwin's published books, featuring definitive texts recording original pagination with Darwin's indexes retained. The set also features a general introduction and index, and introductions to each volume.

"Are they needed? To be sure. The Darwinian industry, industrious though it is, has failed to provide texts of more than a handful of Darwin's books. If you want to know what Darwin said about barnacles (still an essential reference to cirripedists, apart from any historical importance) you are forced to search shelves, or wait while someone does it for you; some have been in print for a century; various reprints have appeared and since vanished." -Eric Korn, Times Literary Supplement Charles Robert Darwin (1809-1882) has been widely recognized since his own time as one of the most influential writers in the history of Western thought. His books were widely read by specialists and the general public, and his influence had been extended by almost continuous public debate over the past 150 years. New York University Press's new paperback edition makes it possible to review Darwin's public literary output as a whole, plus his scientific journal articles, his private notebooks, and his correspondence. This is complete edition contains all of Darwin's published books, featuring definitive texts recording original pagination with Darwin's indexes retained. The set also features a general introduction and index, and introductions to each volume.

Determining the precise timing for the evolutionary origin of groups of organisms has become increasingly important as scientists from diverse disciplines attempt to examine rates of anatomical or molecular evolution and correlate intrinsic biological events to extrinsic environmental events. Molecular clock analyses indicate that many major groups are twice as old, or more, than a literal reading of the fossil record attests, implying that the fossil record is incomplete. Few paleontologists agree that the fossil record is inadequate, arguing instead that our understanding of the molecular clock is far from ideal. Telling the Evolutionary Time: Molecular Clocks and the Fossil Record represents a discussion between molecular biologists and paleontologists, in which they investigate the significance of competing sources of data, explain the nature of molecular clocks and the fossil record, and strive to develop compromise models that incorporate contradictory opinions. These are presented as a series of case studies dealing with many of the most important groups of complex organisms, such as protists, land plants, flowering plants, complex animals, chordates, vertebrates, tetrapods, and modern birds. Bringing fresh insight and various perspectives to a complicated argument, this book assembles all sides of the debate into one comprehensive text. It is a significant volume for research scientists and advanced students across the field of evolutionary biology.