Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.

A comprehensive account of the origins, evolution, and behavior of South and Central American primates New World Monkeys brings to life the beauty of evolution and biodiversity in action among South and Central American primates, who are now at risk. These tree-dwelling rainforest inhabitants display an unparalleled variety in size, shape, hands, feet, tails, brains, locomotion, feeding, social systems, forms of communication, and mating strategies. Primatologist Alfred Rosenberger, one of the foremost experts on these mammals, explains their fascinating adaptations and how they came about. New World Monkeys provides a dramatic picture of the sixteen living genera of New World monkeys and a fossil record that shows that their ancestors have lived in the same ecological niches for up to 20 million years-only to now find themselves imperiled by the extinction crisis. Rosenberger also challenges the argument that these primates originally came to South America from Africa by floating across the Atlantic on a raft of vegetation some 45 million years ago. He explains that they are more likely to have crossed via a land bridge that once connected Western Europe and Canada at a time when many tropical mammals transferred between the northern continents. Based on the most current findings, New World Monkeys offers the first synthesis of decades of fieldwork and laboratory and museum research conducted by hundreds of scientists.

Leading scholars take stock of Darwin's ideas about human evolution in the light of modern science In 1871, Charles Darwin published The Descent of Man, a companion to Origin of Species in which he attempted to explain human evolution, a topic he called "the highest and most interesting problem for the naturalist." A Most Interesting Problem brings together twelve world-class scholars and science communicators to investigate what Darwin got right-and what he got wrong-about the origin, history, and biological variation of humans. Edited by Jeremy DeSilva and with an introduction by acclaimed Darwin biographer Janet Browne, A Most Interesting Problem draws on the latest discoveries in fields such as genetics, paleontology, bioarchaeology, anthropology, and primatology. This compelling and accessible book tackles the very subjects Darwin explores in Descent, including the evidence for human evolution, our place in the family tree, the origins of civilization, human races, and sex differences. A Most Interesting Problem is a testament to how scientific ideas are tested and how evidence helps to structure our narratives about human origins, showing how some of Darwin's ideas have withstood more than a century of scrutiny while others have not. A Most Interesting Problem features contributions by Janet Browne, Jeremy DeSilva, Holly Dunsworth, Agustin Fuentes, Ann Gibbons, Yohannes Haile-Selassie, Brian Hare, John Hawks, Suzana Herculano-Houzel, Kristina Killgrove, Alice Roberts, and Michael J. Ryan.

"Biodiversity" refers to the variety of life. It is now agreed that there is a "biodiversity crisis", corresponding to extinction rates of species that may be 1000 times what is thought to be "normal". Biodiversity science has a higher profile than ever, with the new Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services involving more than 120 countries and 1000s of scientists. At the same time, the discipline is re-evaluating its foundations - including its philosophy and even core definitions. The value of biodiversity is being debated. In this context, the tree of life ("phylogeny") is emerging as an important way to look at biodiversity, with relevance cutting across current areas of concern - from the question of resilience within ecosystems, to conservation priorities for globally threatened species - while capturing the values of biodiversity that have been hard to quantify, including resilience and maintaining options for future generations. This increased appreciation of the importance of conserving "phylogenetic diversity", from microbial communities in the human gut to global threatened species, has inevitably resulted in an explosion of new indices, methods, and case studies. This book recognizes and responds to the timely opportunity for synthesis and sharing experiences in practical applications. The book recognizes that the challenge of finding a synthesis, and building shared concepts and a shared toolbox, requires both an appreciation of the past and a look into the future. Thus, the book is organized as a flow from history, concepts and philosophy, through to methods and tools, and followed by selected case studies. A positive vision and plan of action emerges from these chapters, that includes coping with inevitable uncertainties, effectively communicating the importance of this "evolutionary heritage" to the public and to policy-makers, and ultimately contributing to biodiversity conservation policy from local to global scales.

Using a series of case studies, the book demonstrates the power of dynamic analysis as applied to the fossil record. The book considers how we think about certain types of paleontological questions and shows how to answer them. The analytical tools presented here will have wide application to other fields of knowledge; as such the book represents a major contribution to the deployment of modern scientific method as it builds on author's previous book, Dynamic Paleontology. Students and seasoned professionals alike will find this book to be of great utility for refining their approach to their ongoing and future research projects.

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

This second edition integrates the more technical and mathematical aspects of bioinformatics with concrete examples of their application to current research problems in molecular, cellular and evolutionary biology. This broad, unified approach is made possible, in large part, by the very wide scope of Dr. Xia's own research experience. The integration of genomics, proteomics and transcriptomics into a single volume makes this book required reading for anyone entering the new and emerging fields of Systems Biology and Evolutionary Bioinformatics.

This book summarizes current advances in our understanding of how infectious disease represents an ecological interaction between a pathogenic microorganism and the host species in which that microbe causes illness. The contributing authors explain that pathogenic microorganisms often also have broader ecological connections, which can include a natural environmental presence; possible transmission by vehicles such as air, water, and food; and interactions with other host species, including vectors for which the microbe either may or may not be pathogenic. This field of science has been dubbed disease ecology, and the chapters that examine it have been grouped into three sections. The first section introduces both the role of biological community interactions and the impact of biodiversity on infectious disease. In turn, the second section considers those diseases directly affecting humans, with a focus on waterborne and foodborne illnesses, while also examining the critical aspect of microbial biofilms. Lastly, the third section presents the ecology of infectious diseases from the perspective of their impact on mammalian livestock and wildlife as well as on humans. Given its breadth of coverage, the volume offers a valuable resource for microbial ecologists and biomedical scientists alike.

Big cats such as lions, tigers, leopards, and jaguars fascinate us like few other creatures. They are enduring symbols of natural majesty and power. Yet despite the magnetic appeal of the big cats, their origins and evolutionary history remain poorly understood-and human activity threatens to put an end to the big cats' glory. On the Prowl is a fully illustrated and approachable guide to the evolution of the big cats and what it portends for their conservation today. Mark Hallett and John M. Harris trace the origins of these iconic carnivores, venturing down the evolutionary pathways that produced the diversity of big cat species that have walked the earth. They place the evolution and paleobiology of these species in the context of ancient ecosystems and climates, explaining what made big cats such efficient predators and analyzing their competition with other animals. Hallett and Harris pay close attention to human impact, from the evidence of cave paintings and analysis of ancient extinctions up to present-day crises. Their engaging and carefully documented account is brought to life through Hallett's detailed, vivid illustrations, based on the most recent research by leading paleontologists. Offering a fresh look at the rise of these majestic animals, On the Prowl also makes a powerful case for renewed efforts to protect big cats and their habitats before it is too late.

This book provides new insights into the universality of biological systems in animal reproduction and development by a comparative study of a variety of mechanisms in animals ranging from basal invertebrates to vertebrates, including mammals. Animals accomplish genetic diversity through meiosis and fertilization, and during embryogenesis animals must produce specialized cell types, including germ cells, in accordance with their individual body plan. This series of phenomena is essential to the continuity of life in the animal kingdom, and animals show various reproductive and developmental strategies. This volume, comprising four parts, reviews animal kingdom diversity, including reproductive strategies and germ cell differentiation mechanisms (Part 1), sex determination and differentiation (Part2), the mechanisms of fertilization (Part 3), and body axis formation (Part 4). Readers will find descriptions of the reproduction or development of 180 species, 13 phyla, 35 classes, 74 orders, 117 families, and 151 genera in this book. Of particular interest is the diversity of molecules and mechanisms used to achieve the same biological purpose in different animals. Undergraduates, graduate students, and professional scientists who want a deeper understanding of animal reproductive and developmental mechanisms will find this book to be of great value.

The social sciences share a mission to shed light on human nature and society. However, there is no widely accepted meta-theory; no foundation from which variables can be linked, causally sequenced, or ultimately explained. This book advances "life history evolution" as the missing meta-theory for the social sciences. Originally a biological theory for the variation between species, research on life history evolution now encompasses psychological and sociological variation within the human species that has long been the stock and trade of social scientific study. The eighteen chapters of this book review six disciplines, eighteen authors, and eighty-two volumes published between 1734 and 2015-re-reading the texts in the light of life history evolution.

This book explores fascinating topics at the edge of life, guiding the reader all the way from the relation of life processes to the second law of thermodynamics and the abundance of complex organic compounds in the universe through to the latest advances in synthetic biology and metabolic engineering. The background to the book is the extraordinary scientific adventures that are being undertaken as progress is made toward the creation of an artificial cell and the control of life processes. This journey involves input from research areas as diverse as genetic engineering, physical chemistry, and information theory. Life is to be thought of not only as a chemical event but also as an information process, with the genome a repository of information gathered over time through evolution. Knowledge of the mechanisms affecting the increase in complexity associated with evolutionary paths is improving, and there appear to be analogies with the evolution of the technologies promoting the development of our society. The book will be of wide interest to students at all levels and to others with an interest in the subject.

The origin of life is one of the biggest unsolved scientific questions. This book deals with the formation and first steps of the chemical evolution of nucleic acids, including the chemical roots behind the origin of their components from the simplest sources in a geochemical context. Chemical evolution encompasses the chemical processes and interactions conducive to self-assembly and supramolecular organization, leading to an increase of complexity and the emergence of life. The book starts with a personal account of the pioneering work of Stanley Miller and Jeffrey Bada on the Chemistry of Origins of Life and how the development of organic chemistry beginning in the 19th century led to the emergence of the field of prebiotic chemistry, situated at the frontier between organic, geo- and biochemistry. It then continues reviewing in tutorial manner current central topics regarding the organization of nucleic acids: the origin of nucleobases and nucleosides, their phosphorylation and polymerization and ultimately, their self-assembly and supramolecular organization at the inception of life.

Principles of right and wrong guide the lives of almost all human beings, but we often see them as external to ourselves, outside our own control. In a revolutionary approach to the problems of moral philosophy, Philip Kitcher makes a provocative proposal: Instead of conceiving ethical commands as divine revelations or as the discoveries of brilliant thinkers, we should see our ethical practices as evolving over tens of thousands of years, as members of our species have worked out how to live together and prosper. Elaborating this radical new vision, Kitcher shows how the limited altruistic tendencies of our ancestors enabled a fragile social life, how our forebears learned to regulate their interactions with one another, and how human societies eventually grew into forms of previously unimaginable complexity. The most successful of the many millennia-old experiments in how to live, he contends, survive in our values today.

Drawing on natural science, social science, and philosophy to develop an approach he calls "pragmatic naturalism," Kitcher reveals the power of an evolving ethics built around a few core principles-including justice and cooperation-but leaving room for a diversity of communities and modes of self-expression. Ethics emerges as a beautifully human phenomenon-permanently unfinished, collectively refined and distorted generation by generation. Our human values, Kitcher shows, can be understood not as a final system but as a project-the ethical project-in which our species has engaged for most of its history, and which has been central to who we are.

Awarded second place in the 2018 AJN Book of the Year Award in the Advanced Practice Nursing category Awarded third place in the 2018 AJN Book of the Year Award in the Maternal-Child Health/Prenatal Nursing/Childbirth category Complex concepts made manageable! Build the foundation you need to understand the science of genetics and its growing role in the diagnosis and treatment of diseases and disorders. Confidently tackle the basics of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior. Everyday language makes these often-intimidating topics easy to understand, while clearly defined principles, logical explanations, illustrations, tables, and clinical examples ensure you master the material. See what students are saying online about the previous edition... Genetics simplified and easy to understand. "Genetics simplified and easy to understand. Wish I had this when learning DNA replication in Microbiology. Lot of good charts. I plan to keep even after the class because it's interesting and easy to understand." - Katalina Cade Great resource! "This is a complex subject and this book makes it so much easier to learn and understand! I love the "memory hints" it gives you throughout the book." - Kira Short

Darwin's greatest accomplishment was to show how life might be explained as the result of natural selection. But does Darwin's theory mean that life was unintended? William A. Dembski argues that it does not. In this book Dembski extends his theory of intelligent design. Building on his earlier work in The Design Inference (Cambridge, 1998), he defends that life must be the product of intelligent design. Critics of Dembski's work have argued that evolutionary algorithms show that life can be explained apart from intelligence. But by employing powerful recent results from the No Free Lunch Theory, Dembski addresses and decisively refutes such claims. As the leading proponent of intelligent design, Dembski reveals a designer capable of originating the complexity and specificity found throughout the cosmos. Scientists and theologians alike will find this book of interest as it brings the question of creation firmly into the realm of scientific debate.

Carbon (C), Nitrogen (N) and Phosphorus (P) are three of the most important elements used to build living beings, and their uptake from the environment is consequently essential for all organisms. Photosynthesis is the process in which plants absorb atmospheric C as they grow and convert it to biomass. However, plants acquire N and P only when these are available in the soil solution, which makes these elements the most limiting nutrients in plant growth and productivity in most ecosystems. When plant residues and roots decompose, the C, N and P they contain is transformed primarily into soil organic matter (SOM) or C and N can release to the atmosphere. Recent interest on the global C, N and P cycles has focused attention on the different proportion of terrestrial C, N and P stored in different ecosystem pools. Cuatro Cienegas represents an exceptional place, since the plants are not the base of the food web, they are the microbial community, that recycle the elements essential for life. In this book we describe how this is an analog of early Earth.

What does God's creation of humanity through the process of evolution mean for human flourishing? The emerging field of evolutionary psychology remains controversial, perhaps especially among Christians. Yet according to Justin Barrett and Pamela Ebstyne King it can be a powerful tool for understanding human nature and our distinctively human purpose. Thriving with Stone Age Minds provides an introduction to evolutionary psychology, explaining key concepts like hyper-sociality, information gathering, and self-control. Combining insights from evolutionary psychology with resources from the Bible and Christian theology, Barrett and King focus fresh attention on the question, What is human flourishing? When we understand how humans still bear the marks of our evolutionary past, new light shines on some of the most puzzling features of our minds, relationships, and behaviors. One key insight of evolutionary psychology is how humans both adapt to and then alter our environments, or "niches." In fact, we change our world faster than our minds can adapt-and then gaps in our "fitness" emerge. In effect, humans are now attempting to thrive in modern contexts with Stone Age minds. By integrating scientific evidence with wisdom from theological anthropology, we can learn to close up nature-niche gaps and thrive, becoming more what God has created us to be. BioLogos Books on Science and Christianity invite us to see the harmony between the sciences and biblical faith on issues including cosmology, biology, paleontology, evolution, human origins, the environment, and more.

Why are humans so fond of water? Why is our skin colour so variable? Why aren't we hairy like our close ape relatives? A savannah scenario of human evolution has been widely accepted primarily due to fossil evidence; and fossils do not offer insight into these questions. Other alternative evolutionary scenarios might, but these models have been rejected. This book explores a controversial idea - that human evolution was intimately associated with watery habitats as much or more than typical savannahs. Written from a medical point of view, the author presents evidence supporting a credible alternative explanation for how humans diverged from our primate ancestors. Anatomical and physiological evidence offer insight into hairlessness, different coloured skin, subcutaneous fat, large brains, a marine-type kidney, a unique heat regulation system and speech. This evidence suggests that humans may well have evolved, not just as savannah mammals, as is generally believed, but with more affinity for aquatic habitats - rivers, streams, lakes and coasts. Key Features: Presents the evidence for a close association between riparian habitats and the origin of humans Reviews the "savannah ape" hypothesis for human origins Describes various anatomical adaptations that are associated with hypotheses of human evolution Explores characteristics from the head and neck such as skull and sinus structures, the larynx and ear structures and functions

This volume is part of the definitive edition of letters written by and to Charles Darwin, the most celebrated naturalist of the nineteenth century. Notes and appendixes put these fascinating and wide-ranging letters in context, making the letters accessible to both scholars and general readers. Darwin depended on correspondence to collect data from all over the world, and to discuss his emerging ideas with scientific colleagues, many of whom he never met in person. The letters are published chronologically. Darwin died in April 1882, but was active in science almost up until the end, raising new research questions and responding to letters about his last book, on earthworms. The volume also contains a supplement of nearly 400 letters written between 1831 and 1880, many of which have never been published before.

The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change-related threats confronting humanity. While time is short, the danger is great, and we are largely unprepared, The Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can "anticipate to mitigate" emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.

The Indispensable Excess of the Aesthetic: Evolution of Sensibility in Nature traces the evolution of sensibility from the most primal indications detectable at the level of cellular receptors and plant tendril sensitivity, animal creativity and play to cultural ramifications. Taking on Darwin's insistence against Wallace that animals do have a sense of beauty, and on recent evolutionary observations, this book compellingly argues that sensibility is a biological faculty that emerges together with life. It argues that there is appreciation and discernment of quality, order, and meaning by organisms in various species determined by their morphological adaptations and environmental conditions. Drawing upon Baumgarten's foundational definition of aesthetics as scientia cognitionis sensitivae, this book proposes a non-anthropocentric approach to aesthetics as well as the use of empirical evidence to sustain its claims updating aesthetic understanding with contemporary biosemiotic and evolutionary theory. The text leads us along three distinct but entwined areas: from the world of matter to that of living matter to the realm of cultivated living matter for exploring how and why sensibility could have evolved. It points out that aspects traditionally used to demarcate and characterize human aesthetics-such as appreciation of symmetry, proportion and color, as well as pleasure, valuation and empathy, sensory seduction, creativity, and skills for representation, even fiction-are present not only in humans but among a variety of plant and animal species.

This edited volume systematically reviews the evidence for early human presence in one of the most relevant geographic regions of Europe - the Balkans and Anatolia, an area that has been crucial in shaping the course of human evolution in Europe, but whose paleoanthropological record is poorly known. The primary aim of this book is to showcase new paleoanthropological (human paleontological and paleolithic) research conducted in the region. The volume is organized into three sections. The first one deals with the human fossil record from Greece, the Central Balkans, Croatia, Romania, Bulgaria and Turkey. The second section presents the paleolithic record of the same countries. In the third part, the authors provide a synthesis of current paleoenvironmental evidence for the Balkans. Chapters summarize and systematize the available human fossil evidence, examine their context, and place them within the framework of our understanding of human evolution in Europe and beyond, as well as present new analyses of existing human fossils. This book will be of interest to professionals, upper undergraduate and graduate students in paleoanthropology, human paleontology and paleolithic archaeology and in a variety of related fields, including human variation and adaptation, paleontology and biogeography. It will also be appropriate as a reference book for advanced undergraduate and graduate courses on human evolution and European paleoanthropology.

The present book aims to examine how sexual selection works in the human species. Almost all scholarly effort focuses on sexual selection in non-human species and extrapolates the findings to the human one. However, human mating has a unique pattern not found in any other species, namely parental influence over mate choice. Across preindustrial societies, the typical pattern of long-term mating is arranged marriage, where parents choose spouses for their children. By doing so, parents effectively become a sexual selection force. Traits that enhance an individual's chance to be selected as a son- or a daughter-in-law confer important reproductive advantages to those who are endowed with them, increasing in frequency in the population. The author has coined the term parental choice to describe the sexual selection force that arises from parental control over mating. He synthesizes extensive theoretical and empirical work in order to understand and model this force. The aim is to understand which factors give rise to parental choice and to combine these insights into constructing a more formal model. It also aims to further examine whether the predictions of the model fit the patterns of mating found across different types of human societies, and how the model can be used to understand the evolution of behavioral traits involved in mating. By synthesizing the various arguments put forward and published across the literature, the book offers a comprehensive argument and overview of an aspect of sexual selection unique to our species. Furthermore, the book revises and extends previously made arguments and models, while it provides useful insights on how the proposed revision of sexual selection theory can enable us to understand a wide range of human behavioral phenomena. It should be key reading for those interested in studying sexual selection in general and in the Homo sapiens species in particular.