This book details a model of consciousness supported by scientific experimental data from the human brain. It presents how the Corollary Discharge of Attention Movement (CODAM) neural network model allows for a scientific understanding of consciousness as well as provides a solution to the Mind-Body problem. The book provides readers with a general approach to consciousness that is powerful enough to lead to the inner self and its ramifications for the vast range of human experiences. It also offers an approach to the evolution of human consciousness and features chapters on mental disease (especially schizophrenia) and on meditative states (including drug-induced states of mind). Solving the Mind-Body Problem bridges the gap that exists between philosophers of mind and the neuroscience community, allowing the enormous weight of theorizing on the nature of mind to be brought to earth and put under the probing gaze of the scientific facts of life and mind.

Three major aspects that distinguish this book are that (1) it contains the most detailed analysis of the sexual reproduction (oogenesis, fertilization and embryonic incubation) in a particular phylum of the aquatic invertebrates (Bryozoa) ever made; this analysis is based on an exhaustive review of the literature on that topic published over the last 260 years, as well as extensive original histological, anatomical and morphological data obtained during studies of both extant and extinct species; (2) this broad analysis has made it possible to reconstruct the major patterns, stages and trends in the evolution of sexual reproduction in various bryozoan clades, showing numerous examples of parallelisms during transitions from broadcasting to embryonic incubation, from planktotrophic to non-feeding larvae and from lecithotrophy to placentation; corresponding shifts in oogenesis, fertilization and embryonic development are discussed in detail; and (3) the key evolutionary novelties acquired by Bryozoa are compared with similar innovations that have evolved in other groups of marine invertebrates, showing the general trends in the evolution of their sexual reproduction. Ecological background of these innovations is considered too. Altogether these aspects make the monograph an “Encyclopedia of bryozoan sexual reproduction,� offering an integral picture of the evolution of this complex phenomenon.

Assembles a collection of experts to provide a current account of different approaches (e.g., traditional, comparative and experimental) being applied to study mobility. Moreover, the book aims to stimulate new theoretical perspectives that adopt a holistic view of the interaction among intrinsic (i.e. skeletal) and extrinsic (i.e. environmental) factors that influence differential expression of mobility. Since the environment undoubtedly impacts mobility of a wide variety of animals, insights into human mobility, as a concept, can be improved by extending approaches to investigating comparable environmental influences on mobility in animals in general. The book teases apart environmental effects that transcend typical categories (e.g., coastal versus inland, mountainous versus level, arboreal versus terrestrial). Such an approach, when coupled with a new emphasis on mobility as types of activities rather than activity levels, offers a fresh, insightful perspective on mobility and how it might affect the musculoskeletal system.

This book represents a cutting-edge contribution giving an all-around perspective of eco-immunology today. Beside questions of the utmost importance for the whole community of immunologists, e.g, the intrinsic limits of immunological experiments performed at the bench on a limited number of selected models, the book covers several other facets of the eco-immunological approach, including host-parasite interactions, human aging and population immunology. Throughout the book the importance of population dynamics and evolutionary diversification of immune systems is frequently recalled, and makes the reader aware of the basic similarities and differences existing between humans and the models adopted for studying human immune system. The evidenced differences have been recently challenging the reliability of several established animal models and in the book it is discussed for the first time in analytical terms whether mice are reliable models of human inflammatory disorders.

This volume explains the key ideas, questions and methods involved in studying the hidden world of vibrational communication in animals. The authors dispel the notion that this form of communication is difficult to study and show how vibrational signaling is a key to social interactions in species that live in contact with a substrate, whether it be a grassy lawn, a rippling stream or a tropical forest canopy. This ancient and widespread form of social exchange is also remarkably understudied. A frontier in animal behavior, it offers unparalleled opportunities for discovery and for addressing general questions in communication and social evolution. In addition to reviews of advances made in the study of several animal taxa, this volume also explores topics such as vibrational communication networks, the interaction of acoustic and vibrational communication, the history of the field, the evolution of signal production and reception and establishing a common vocabulary.

Determining the precise timing for the evolutionary origin of groups of organisms has become increasingly important as scientists from diverse disciplines attempt to examine rates of anatomical or molecular evolution and correlate intrinsic biological events to extrinsic environmental events. Molecular clock analyses indicate that many major groups are twice as old, or more, than a literal reading of the fossil record attests, implying that the fossil record is incomplete. Few paleontologists agree that the fossil record is inadequate, arguing instead that our understanding of the molecular clock is far from ideal. Telling the Evolutionary Time: Molecular Clocks and the Fossil Record represents a discussion between molecular biologists and paleontologists, in which they investigate the significance of competing sources of data, explain the nature of molecular clocks and the fossil record, and strive to develop compromise models that incorporate contradictory opinions. These are presented as a series of case studies dealing with many of the most important groups of complex organisms, such as protists, land plants, flowering plants, complex animals, chordates, vertebrates, tetrapods, and modern birds. Bringing fresh insight and various perspectives to a complicated argument, this book assembles all sides of the debate into one comprehensive text. It is a significant volume for research scientists and advanced students across the field of evolutionary biology.

Charles Darwin's On the Origin of Species By Means of Natural Selection is both a key scientific work of research, still read by scientists, and a readable narrative that has had a cultural impact unmatched by any other scientific text. First published in 1859, it has continued to sell, to be reviewed and discussed, attacked and defended. The Origin is one of those books whose controversial reputation ensures that many who have never read it nevertheless have an opinion about it. Jim Endersby's major scholarly edition debunks some of the myths that surround Darwin's book, while providing a detailed examination of the contexts within which it was originally written, published and read. Endersby provides a very readable introduction to this classic text and a level of scholarly apparatus (explanatory notes, bibliography and appendixes) that is unmatched by any other edition.

The extended continental South American turtle record (Norian to Lujanian) allows us to follow the evolution of this reptile clade from its origins. Several significant stem turtle taxa such as: Palaeochersis talampayensis and Condorchelys antiqua provide information on the first steps of turtle evolution. Others such as: Chubutemys copelloi or Patagoniaemys gasparinae provide clues to the origin of the bizarre horned tortoises of the clade Meiolaniidae. The panpleurodiran species such as Notoemys laticentralis or Notoemys zapatocaensis shed light on the origin of modern pleurodiran turtles. This book explores aquatic and terrestrial cryptodiran turtles, South Gondwana pleurodiran turtles, North Gondwana pleurodiran turtles; Meiolaniforms and early differentiation of Mesozoic turtles.

This book provides a series of comprehensive views on various important aspects of vertebrate photoreceptors. The vertebrate retina is a tissue that provides unique experimental advantages to neuroscientists. Photoreceptor neurons are abundant in this tissue and they are readily identifiable and easily isolated. These features make them an outstanding model for studying neuronal mechanisms of signal transduction, adaptation, synaptic transmission, development, differentiation, diseases and regeneration. Thanks to recent advances in genetic analysis, it also is possible to link biochemical and physiological investigations to understand the molecular mechanisms of vertebrate photoreceptors within a functioning retina in a living animal. Photoreceptors are the most deeply studied sensory receptor cells, but readers will find that many important questions remain. We still do not know how photoreceptors, visual pigments and their signaling pathways evolved, how they were generated and how they are maintained. This book will make clear what is known and what is not known. The chapters are selected from fields of studies that have contributed to a broad understanding of the birth, development, structure, function and death of photoreceptor neurons. The underlying common word in all of the chapters that is used to describe these mechanisms is "molecule". Only with this word can we understand how these highly specific neurons function and survive. It is challenging for even the foremost researchers to cover all aspects of the subject. Understanding photoreceptors from several different points of view that share a molecular perspective will provide readers with a useful interdisciplinary perspective.

The origin of energy-conserving organelles, the mitochondria of all aerobic eukaryotes and the plastids of plants and algae, is commonly thought to be the result of endosymbiosis, where a primitive eukaryote engulfed a respiring -proteobacterium or a phototrophic cyanobacterium, respectively. While present-day heterotrophic protists can serve as a model for the host in plastid endosymbiosis, the situation is more difficult with regard to (the preceding) mitochondrial origin: Two chapters describe these processes and theories and inherent controversies. However, the emphasis is placed on the evolution of phototrophic eukaryotes: Here, intermediate stages can be studied and the enormous diversity of algal species can be explained by multiple secondary and tertiary (eukaryote-eukaryote) endosymbioses superimposed to the single primary endosymbiotic event. Steps crucial for the establishment of a stable, mutualistic relationship between host and endosymbiont, as metabolic symbiosis, recruitment of suitable metabolite transporters, massive gene transfer to the nucleus, development of specific translocases for the re-import of endosymbiont proteins, etc. are discussed in individual chapters. Experts, dealing with biochemical, genetic and bioinformatic approaches provide insight into the state of the art of one of the central themes of biology. The book is written for graduate students, postdocs and scientists working in evolutionary biology, phycology, and phylogenetics.

More than two thirds of all living organisms described to date belong to the phylum Arthropoda. But their diversity, as measured in terms of species number, is also accompanied by an amazing disparity in terms of body form, developmental processes, and adaptations to every inhabitable place on Earth, from the deepest marine abysses to the earth surface and the air. The Arthropoda also include one of the most fashionable and extensively studied of all model organisms, the fruit-fly, whose name is not only linked forever to Mendelian and population genetics, but has more recently come back to centre stage as one of the most important and more extensively investigated models in developmental genetics. This approach has completely changed our appreciation of some of the most characteristic traits of arthropods as are the origin and evolution of segments, their regional and individual specialization, and the origin and evolution of the appendages. At approximately the same time as developmental genetics was eventually turning into the major agent in the birth of evolutionary developmental biology (evo-devo), molecular phylogenetics was challenging the traditional views on arthropod phylogeny, including the relationships among the four major groups: insects, crustaceans, myriapods, and chelicerates. In the meantime, palaeontology was revealing an amazing number of extinct forms that on the one side have contributed to a radical revisitation of arthropod phylogeny, but on the other have provided evidence of a previously unexpected disparity of arthropod and arthropod-like forms that often challenge a clear-cut delimitation of the phylum.

The central insight of Darwin's Origin of Species is that evolution is an ecological phenomenon, arising from the activities of organisms in the 'struggle for life'. By contrast, the Modern Synthesis theory of evolution, which rose to prominence in the twentieth century, presents evolution as a fundamentally molecular phenomenon, occurring in populations of sub-organismal entities - genes. After nearly a century of success, the Modern Synthesis theory is now being challenged by empirical advances in the study of organismal development and inheritance. In this important study, D. M. Walsh shows that the principal defect of the Modern Synthesis resides in its rejection of Darwin's organismal perspective, and argues for 'situated Darwinism': an alternative, organism-centred conception of evolution that prioritises organisms as adaptive agents. His book will be of interest to scholars and advanced students of evolutionary biology and the philosophy of biology.

This book collects three outstanding examples of the work of Mexican biologist Alfonso Luis Herrera (1868-1943), a pioneer in experimental origins of life research. Two of the collected works appear here in English for the first time. Herrera's works represent the attempt to deal experimentally with the issue of an autotrophic origin of life, a possibility that was widely accepted prior to Alexander I. Oparin's ideas regarding the possibility of organic synthesis and the origin of life in an early Earth environment. An active promoter of Darwinian ideas in Latin America, Herrera was also among the first 20th century researchers to attempt to "create life in a test tube." This collection shows the remarkable prescience of researchers in Mexico with regards to laboratory approaches to the problem of the origin of life. It also includes a modern commentary by researchers actively engaged in research in prebiotic evolution and the origins of life, and deeply concerned with the historical development of ideas in these fields. The list includes H. James Cleaves, Antonio Lazcano, Alicia Negron-Gonzalez and Juli Pereto, who discuss in detail the relevance of Herrera's ideas to modern theory and their historical context. The book will expose modern readers and researchers to currents of thinking that have been lost, largely to time and language inaccessibility, of a seminal early theoretical biologist.

This volume describes features of autonomy and integrates them into the recent discussion of factors in evolution. In recent years ideas about major transitions in evolution are undergoing a revolutionary change. They include questions about the origin of evolutionary innovation, their genetic and epigenetic background, the role of the phenotype and of changes in ontogenetic pathways. In the present book, it is argued that it is likewise necessary to question the properties of these innovations and what was qualitatively generated during the macroevolutionary transitions. The author states that a recurring central aspect of macroevolutionary innovations is an increase in individual organismal autonomy whereby it is emancipated from the environment with changes in its capacity for flexibility, self-regulation and self-control of behavior. The first chapters define the concept of autonomy and examine its history and its epistemological context. Later chapters demonstrate how changes in autonomy took place during the major evolutionary transitions and investigate the generation of organs and physiological systems. They synthesize material from various disciplines including zoology, comparative physiology, morphology, molecular biology, neurobiology and ethology. It is argued that the concept is also relevant for understanding the relation of the biological evolution of man to his cultural abilities. Finally the relation of autonomy to adaptation, niche construction, phenotypic plasticity and other factors and patterns in evolution is discussed. The text has a clear perspective from the context of systems biology, arguing that the generation of biological autonomy must be interpreted within an integrative systems approach.

This is the first textbook of Virtual Anthropology, the new science that combines elements from fields as diverse as anthropology, medicine, statistics, computing, scientific visualization, and industrial design. The book is intended for students in any of these or nearby fields within biology, medicine, or engineering and for teachers, journalists, and all others who will enjoy the many examples from our real biological world. After a general introduction to the field and an overview, the book is organized around six themes conveyed in more than 300 pages of text accompanied by hundreds of carefully annotated images: medical imaging and 3D digitising techniques, electronic preparation of individual specimens, analysis of complex forms in space one or many at a time, reconstruction of forms that are partly missing or damaged, production of real objects from virtual models, and, finally, thoughts about data accessibility and sharing and the implications of all this for the future of anthropology. The authors' emphasis is not on technical details but rather on step-by-step explanations of the wealth of examples included here, from brain evolution to surgical planning, always in light of the relevance of these approaches to science and to society. All readers are encouraged to try out the techniques on their own using the tools and data included in the Online Extra Materials resource.

The present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as chloroplasts, plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles.  

Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.

Non-mammalian synapsids were the dominant terrestrial vertebrates from the Late Carboniferous to the Middle Triassic and play a key role in understanding the origin and evolution of mammals. Despite these facts and the outstanding fossil record of the group, early synapsids remain obscure. This book showcases the full breadth of contemporary research on non-mammalian synapsids, ranging from taxonomy and phylogenetics to functional morphology, biogeography, paleoecology, and patterns of diversity. It also underscores the importance and potential of studying non-mammalian synapsid paleobiology in its own right, not just in the context of mammalian evolution.

How do desires and fears motivate human sociability? What effect do these motivators have on reproductive, social and political behaviour? And, crucially, how might we understand them separate from preconceived notions of design or higher morality? Taking these questions as a focus, this book examines human evolution with the emphasis on sexual selection and the evolution of a number of human psychological processes. Exploring evolutionary, sexual and maturational processes, along with primate, fossil and geological evidence, Vannelli argues that human nature can be conceptualised as species-typical desires and fears, derived from sexual selection during human evolution, and that these are major motivators of behaviour. Presenting additional evidence from the anthropology of band societies, along with material from group behaviour, Vannelli highlights the importance of pair-bonding, friendship, alliance behaviour, vengeance seeking and interpersonal politics in social behaviour, providing a unique interdisciplinary framework for understanding human nature and the evolution of human sociability.

There is long-standing disagreement among systematists about how to divide biodiversity into species. Over twenty different species concepts are used to group organisms, according to criteria as diverse as morphological or molecular similarity, interbreeding and genealogical relationships. This, combined with the implications of evolutionary biology, raises the worry that either there is no single kind of species, or that species are not real. This book surveys the history of thinking about species from Aristotle to modern systematics in order to understand the origin of the problem, and advocates a solution based on the idea of the division of conceptual labor, whereby species concepts function in different ways - theoretically and operationally. It also considers related topics such as individuality and the metaphysics of evolution, and how scientific terms get their meaning. This important addition to the current debate will be essential for philosophers and historians of science, and for biologists.

Over the past decade, a group of prolific and innovative evolutionary biologists has sought to reinvent historical linguistics through the use of phylogenetic and phylogeographical analysis, treating cognates like genes and conceptualizing the spread of languages in terms of the diffusion of viruses. Using these techniques, researchers claim to have located the origin of the Indo-European language family in Neolithic Anatolia, challenging the near-consensus view that it emerged in the grasslands north of the Black Sea thousands of years later. But despite its widespread celebration in the global media, this new approach fails to withstand scrutiny. As languages do not evolve like biological species and do not spread like viruses, the model produces incoherent results, contradicted by the empirical record at every turn. This book asserts that the origin and spread of languages must be examined primarily through the time-tested techniques of linguistic analysis, rather than those of evolutionary biology.

A noted conflict-resolution expert explores dignity, its role in human conflict, and its power to improve relationships "This book is a must read for those who want to experience peace in their everyday lives and peace in the world around them. . . . If you want peace, be sure everyone's dignity is intact."-Archbishop Emeritus Desmond Tutu "Anyone who understands the importance of personal feelings and their fuel for conflict should consider Dignity as a powerful advisory and motivational guide."-Midwest Book Review Drawing on her extensive experience in international conflict resolution and on insights from evolutionary biology, psychology, and neuroscience, Donna Hicks explains what the elements of dignity are, how to recognize dignity violations, how to respond when we are not treated with dignity, how dignity can restore a broken relationship, why leaders must understand the concept of dignity, and more. By choosing dignity as a way of life, Hicks shows, we open the way to greater peace within ourselves and to a safer and more humane world for all. For the Tenth Anniversary Edition of Dignity, Hicks has written a new preface that reflects on her experience helping communities and individuals understand the power of dignity and how it can lead to a more peaceful world. Winner of the 2012 Educator's Award, given by the Delta Kappa Gamma Society International.

Originally published in 1932, this book presents a detailed discussion regarding the capacity of humans to influence the process of natural selection and thereby control its outcomes. The text was written by prominent British geneticist Charles Chamberlain Hurst (1870-1947). Illustrative figures and reference lists are also included. This book will be of value to anyone with an interest in perspectives on evolutionary development and the history of science.

This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body Particular attention is paid to novel regulatory molecules and signals as well as the heterogeneity of origin that have revealed a developmental overlap between skeletal and cardiac muscle. Different functional muscle groups are the product of the evolution of the vertebrate classes, making a phylogenetic comparison worthwhile for understanding the role of muscle stem cells and precursors in myogenesis. New insights into the hierarchy of transcription factors, particularly in the context of these different muscle groups have been gained from detailed investigations of the spatio-temporal and regulatory relationships derived from mouse and zebrafish genetics and avian microsurgery. Importantly, epigenetic mechanisms that have surfaced recently, in particular the role of MyomiRs, are also surveyed. With an eye to the human patient, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers due to common regulatory molecules. On the other hand, both processes differ considerably in quality and complexity of the processes employed. Interestingly, the heterogeneity in embryonic sources from which skeletal muscle groups in the vertebrate including the human body take origin is paralleled by differences in their susceptibility to particular muscle dystrophies as well as by the characteristics of the satellite cells involved in regeneration. The progress that has been made in the field of muscle stem cell biology, with special focus on the satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. Furthermore, an improved understanding of muscle stem cells seems only possible when we study the impact of the cell environment on efficient stem cell replacement therapies for muscular dystrophies, putting embryological findings from different vertebrate classes and stem cell approaches into context.

Originally published in 1935, this book was written to provide the general reader with a concise guide to genetics and human evolution. The text begins with a discussion of heredity and genes before moving through to an account of the relationship between evolutionary theory and human development. Illustrative figures are also included. This book will be of value to anyone with an interest in genetics and the history of science.