This book summarizes the work of several decades, culminating in a revolutionary model of recent human evolution. It challenges current consensus views fundamentally, presenting in its support a mass of evidence, much of which has never been assembled before. This evidence derives primarily from archaeology, paleoanthropology, genetics, clinical psychology, neurosciences, linguistics and cognitive sciences. No even remotely similar thesis of recent human origins has ever been published, but some of the key elements of this book have been published by the author in major refereed journals in the last two years. Its implications are far-reaching and profoundly affect the way we perceive ourselves as a species. This book about what it means to be human is heavily referenced, with a bibliography of many hundreds of scientific entries.

Professor Parsons uses the colonizing species as a case study in the dynamics of microevolution at work in living systems. The colonizing species, a lie, and potentially disruptive force in a 'naive' habitat, is studied primarily as an ecological phenotype and more generally as an ecological behavioural phenotype. Conventional life-history traits and components of fitness, can be incorporated into these phenotypes. Integrating genetic change, natural selection, and the interaction of the species with its environment and other living systems therein, the colonizing species is transformed into a sophisticated and complex source of data for understanding evolutionary biology. Throughout the book it is emphasized that using the organism as the unit of selection is the most direct way of understanding the nature of successful colonizing phenotypes, and, by using specific phenotypic criteria, the prediction of likely successful colonists can be made. Such criteria include tolerance of extreme environments, resource utilization, reproductive capacity, and relative abundance.

Nearly half of the known species of mammals alive today (more than 1600) are rodents or "gnawing mammals" (Nowak and Paradiso, 1983). The diversity of rodents is greater than that of any other order of mammals. Thus, it is not surprising that the fossil record of this order is extensive and fossil material of rodents from the Tertiary is known from all continents except Antarctica and Australia. The purpose of this book is to compile the published knowledge on fossil rodents from North America and present it in a way that is accessible to paleontologists and mammalogists interested in evolutionary studies of ro dents. The literature on fossil rodents is widely scattered between journals on paleontology and mammalogy and in-house publications of museums and universities. Currently, there is no single source that offers ready access to the literature on a specific family of rodents and its fossil history. This work is presented as a reference text that can be useful to specialists in rodents (fossil or recent) as weIl as mammalian paleontologists working on whole faunas. Because the diversity of rodents in the world is essentially limitless, any monograph that included all fossil rodents would similarly be limitless. Hence, this book is limited to the re cord of Tertiary rodents of North America. The several species of South American (caviomorph) rodents that invaded North America near the end of the Tertiary are also not included in this text."

Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the genomic, cellular and biochemical levels with human cells, which has propelled the species Dictyostelium discoideum to become a model system for biology and medicine in many laboratories. This book covers the latest advances in our knowledge of these extraordinary organisms with topics spanning from their evolutionary history, ecology and diversity to the recent discoveries regarding their cellular and molecular biology.

This book evolved through the efforts of several organizations and the dedication of many individuals. In 1987, we received arequest to propose a workshop topic for the Fifth International Theriological Congress (ITC) to be held in August 1989 in Rome, Italy. After looking up the meaning of the word "theriological" in the dictionary and discovering that it pertains to mammalian behavior, we decided a symposium on sensory abilities of whales and dOlphins would be an interesting topic. The ITC convenes only every five years and has the distinction of being very weIl attended by scientists from around the world. We thought that hosting a workshop in conjunction with the ITC would attract a variety of international scientists that rarely have the opportunity to interact. Fortunately for all involved, our prediction was correct. The first two days of the workshop, 23-24 August 1989, were held in conjunction with ITC and the nearly 1,000 attending scientists were able to view our posters and listen to lectures. The third day was limited to only ab out 65 invited scientists who were divided into topical working groups chaired by a rapporteur.

The first volume of Evolutionary Bio/ogy was published eleven years ago. Since that time eleven volumes and one supplement have appeared. As stated in earlier prefaces, we are continuing the focus of this series on critical reviews, commentaries, original papers, and controversies in evolu tionary biology. lt is our aim to publish papers primarily of greater length than normally published by society journals and quarterlies. We therefore invite colleagues to submit chapters that fall within the focus and standards of Evolutionary Bio/ogy. The Editors vii Contents 1. Precambrian Evolution of Photosynthetic and Respiratory Organisms lohn M. 0/son Outline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Basic Assumptions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Photosynthetic Energy Conversion and Electron Transport . . . . . . . 6 Oxygen-Evolving Organisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Photosynthetic Bacteria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Photoassimilation and Cyclic Electron Flow . . . . . . . . . . . . . . 13 . . . . . Acetate Assimilation . . . . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . . . . . The Common Ancestor . . . . . . . . . . . . . . . . . . . . . . . . . . 17 . . . . . . . . . . . Chlorophyll. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . Quinone................................................ 19 Linear Electron Transport . . . . . . . . . . . . . . . . . . . . . . . 22 . . . . . . . . . Light-Harvesting Systems. . . . . . . . . . . . . . . . . . . . . . . . 22 . . . . . . . . . Evolution of Photosynthetic Bacteria . . . . . . . . . . . . . . . . . . 22 . . . . . . . Purpie and Green Bacteria . . . . . . . . . . . . . . . . . . . . . . . 23 . . . . . . . . . Evolution of Blue-Green Algae . . . . . . . . . . . . . . . . . . . . . . 24 . . . . . . . . Weak Electron Donors for the Protoalgae . . . . . . . . . . . . . . 25 . . . . . Evolution of Respiration . . . . . . . . . . . . . . . . . . . . . . . . . . 29 . . . . . . . . . . General Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 . . . . . . . . . . . . . . 2. Molecular Structure and Protein Variation within and among Populations Richard K. Koehn and Waller F. Eanes Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 . . . . . . . . . . . . . . Molecular Properlies and Structural Variation . . . . . . . . . . . . . 45 . . . . Amino Acid Composition and Quaternary Structure . . . . . . . . 46 . . Protomer Size and Quaternary Structure . . . . . . . . . . . . . . . 47 . . . . . ix X Contents Enzyme Polymorphism and Quaternary Structure . . . . . . . . . . . 50 . . . Enzyme Polymorphism and Subunit Size . . . . . . . . . . . . . . . . 53 . . . . . . Data and Analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 . . . . . . . . . . . Drosophila Enzyme Polymorphism . . . . . . . . . . . . . . . . . . 60 . . . . . . . Human Enzyme Polymorphism . . . . . . . . . . . . . . . . . . . . 63 . . . . . . . . Enzyme Polymorphism: Structure and Size . . . . . . . . . . . . . . . 67 . . . . .

In 1962 at the Burg Wartenstein Symposium on "Classification and Human Evolution," Emile Zuckerkandl used the term "molecular anthropology" to characterize the study of primate phylogeny and human evolution through the genetic information contained in proteins and polynucleotides. Since that time, our knowledge of molecular evolution in primates and other organisms has grown considerably. The present volume examines this knowledge especially as it relates to the phyletic position of Homo sapiens in the order Primates and to the trends which shaped the direction of human evolution. Participants from the disciplines of protein and nucleotide chemistry, genetics, statistics, paleon tology, and physical anthropology held cross-disciplinary discussions and argued some of the major issues of molecular anthropology and the data upon which these arguments rest. Chief among these were the molecular clock controversy in hominoid evolution; the molecular evidence on phylogenetic relationships among primates; the evolution of gene expression regulation in primates; the relationship of fossil and molecular data in the Anthropoidea and other pri mates; the interpretation of the adaptive significance of evolutionary changes; and, finally, the impact on mankind of studies in molecular anthropology. Most of the papers in this volume were presented in a preliminary form at Symposium No. 65 on "Progress in Molecular Anthropology" held at Burg Wartenstein, Austria, from July 25 to August 1, 1975. These papers were subsequently revised and some additional papers related to the theme of the symposium were also contributed to this volume."

Research in whale origins is now in an explosive phase, with a cascade of discoveries adding to our understanding of the evolutionary pattern and a suite of new techniques being applied to address new questions. The objective of this volume is to provide a snapshot of this explosion. The volume paints the scene with a broad brush. Taken together the chapters clearly indicate that cetacean origins is a field that is dynamic, multidisciplinary, and that the end of the explosive phase is not in sight.

The Fifth International Biomineralization Symposium was held in May 1986 at The University of Texas at Arlington, Arlington, Texas. The chosen theme was the origin, evolution and modern aspects of biomineralization in plants and animals. Thus, the symposium was designed to bring together experts in ocean and atmospheric chemistry, geochemistry, paleontology, biology, medicine and related fields to share accumulated knowledge and to broaden research horizons. The contents of this volume reflect the diversified interests and views of contributors from these fields. Topics range from contrasting views of the origin of ocean chemistry, the cause or causes for the biomineralization among plants and animals, the evolution of style and structure of biomineralization, and the role of inorganic and organic compounds in biomineraliza tion. It was clear from those gathered in Arlington that the efforts of all researchers in any aspect of biomineralization can be strengthened and extended by greater exposure to the work of others in allied fields. At the time of this printing, several collaborative efforts have grown from interest and contacts developed during the symposium. Rex E. Crick viii ACKNOWLEDGEMENTS The symposium would not have occurred with the financial support of The Organized Research Fund of The University of Texas at Arlington and The Sea Grant Program administered by Texas A & M University. The staff of the Department of Geology of The University of Texas at Arlington were largely responsible for providing a pleasant atmosphere for learning."

With contributions from a team of leading experts, this volume provides a comprehensive survey of recent achievements in our scientific understanding of evolution. The questions it asks concern the beginnings of the universe, the origin of life and the chances of its arising at all, the role of contingency, and the search for universal features in the plethora of evolutionary phenomena. Rather than oversimplified or premature answers, the chapters provide a clear picture of how these essential problems are being tackled, enabling the reader to understand current thinking and open questions. The tools employed stem from a range of disciplines including mathematics, physics, biochemistry and cell biology. Self-organization as an overarching concept is demonstrated in the most diverse areas: from galaxy formation in the universe to spindle and aster formation in the cell. Chemical master equations, population dynamics, and evolutionary game theory are presented as suitable frameworks for understanding the universal mechanisms and organizational principles observed in a wide range of living units, ranging from cells to societies. This book will provide engaging reading and food for thought for all those seeking a deeper understanding of the science of evolution.

This book, originally published in 2004, is concerned with the links between human evolution and infectious disease. It has long been recognised that an important factor in human evolution has been the struggle against infectious disease and, more recently, it was revealed that complex genetic polymorphisms are the direct result of that struggle. As molecular biological techniques become more sophisticated, a number of breakthroughs in the area of host-pathogen evolution led to an increased interest in this field. From the historical beginnings of J. B. S. Haldane's original hypothesis to more recent research, this book strives to evaluate infectious diseases from an evolutionary perspective. It provides a survey of information regarding host-pathogen evolution related to major infectious diseases and parasitic infections, including malaria, influenza and leishmaniasis. Written by leading authorities in the field, and edited by a former pupil of Haldane, Infectious Disease and Host-Pathogen Evolution will be valuable for those working in related areas of microbiology, parasitology, immunology and infectious disease medicine, as well as genetics, evolutionary biology and epidemiology.

The study of primate locomotion is a unique discipline that by its nature is interdis ciplinary, drawing on and integrating research from ethology, ecology, comparative anat omy, physiology, biomechanics, paleontology, etc. When combined and focused on particular problems this diversity of approaches permits unparalleled insight into critical aspects of our evolutionary past and into a major component of the behavioral repertoire of all animals. Unfortunately, because of the structure of academia, integration of these different approaches is a rare phenomenon. For instance, papers on primate behavior tend to be published in separate specialist journals and read by subgroups of anthropologists and zoologists, thus precluding critical syntheses. In the spring of 1995 we overcame this compartmentalization by organizing a con ference that brought together experts with many different perspectives on primate locomo tion to address the current state of the field and to consider where we go from here. The conference, Primate Locomotion-1995, took place thirty years after the pioneering confer ence on the same topic that was convened by the late Warren G. Kinzey at Davis in 1965."

Marine Invertebrate Evolution in the Galapagos Islands MATTHEW J. JAMES 1. Perspective of This Volume . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Directions for Future Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Plan of This Volume . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1. Perspective of This Volume Charles Darwin brought the Galapagos Islands to the attention of zoologists, botanists, and geologists following the six-week visit of H. M. S. Beagle to the islands in 1835. Since then published research on the biota of the islands, partic ularly in multiauthored volumes, has focused on terrestrial plants and animals. The present volume is designed specifically to provide a summary of work on the marine invertebrate fauna. One deviation from that objective was the inclusion of a chapter on land snails, which proved to be a good choice because the phylum Mollusca is now covered more thoroughly in this volume than in any single previous scholarly work on the Galapagos. The academic bottom line with this book is to elucidate the evolutionary responses of shallow water, benthic marine invertebrates to the unique set of insular conditions that exist in the Galapagos Islands. The route taken to that objective has many paths including taxonomic revision, determining biogeo graphic affinities, and examining the ecological requirements of species. The information presented here is for some groups from the islands the first stage in a thorough process that can eventually lead to an understanding of the phylogenetic relationships of these species."

This volume brings together information about recent discoveries and current theories concerning the origin and early evolution of anthropoid primates monkeys, apes, and humans. Although Anthropoidea is one of the most dis tinctive groups of living primates, and the origin of the group is a frequent topic of discussion in the anthropological and paleontological literature, the topic of anthropoid origins has rarely been the foeus of direct discussion in primate evolution. Rather, diseussion of anthropoid origins appears as a ma jor side issue in volumes dealing with the origin of platyrrhines (Ciochon and Chiarelli, 1980), in discussions about the phylogenetic position of Tarsius, in descriptions of early anthropoid fossils, and in descriptions and revisions of various fossil prosimians. As a result, the literature on anthropoid origins has a long history of argument by advocacy, in which scholars with different views have expounded individual theories based on a small bit of evidence at hand, often with little consideration of alternative views and other types of evidence that have been used in their support. This type of scholarship struck us as a relatively unproductive approach to a critical issue in primate evolution.

Our purposes in this preface are, first, to reiterate our view of Current Ornithology's role; second, to describe briefly the contents of this vol ume; and third, to acknowledge the generous help of our Editorial Board and of the reviewers we have consulted about the contents of Volumes 13 and 14. As far as we know, Current Ornithology is the only English-lan guage publication currently devoted exclusively to extensive reviews and syntheses of topics pertaining to all aspects of the biology of birds. Its chapters deal with subjects falling under such diverse rubrics as ecology, evolution, behavior, phylogeny, behavioral ecology, anatomy and physiology, and conservation biology, but all focus primarily on birds. Its authors, whether members of the National Academy or young investigators just beginning their careers, are leading authorities on their subjects, and its referees are selected for their knowledge and expertise in the topics covered by the chapters they are asked to review.

Social scientists can learn a lot from evolutionary biology - from systematics and principles of evolutionary ecology to theories of social interaction including competition, conflict and cooperation, as well as niche construction, complexity, eco-evo-devo, and the role of the individual in evolutionary processes. Darwinian sociocultural evolutionary theory applies the logic of Darwinism to social-learning based cultural and social change. With a multidisciplinary approach for graduate biologists, philosophers, sociologists, anthropologists, social psychologists, archaeologists, linguists, economists, political scientists and science and technology specialists, the author presents this model of evolution drawing on a number of sophisticated aspects of biological evolutionary theory. The approach brings together a broad and inclusive theoretical framework for understanding the social sciences which addresses many of the dilemmas at their forefront - the relationship between history and necessity, conflict and cooperation, the ideal and the material and the problems of agency, subjectivity and the nature of social structure. Please visit Marion Blute's blog at http: //bluteblog.com

Originally published in 1993, this second edition of a successful textbook describes and explains in a refreshingly clear way the origin and evolution of plants as revealed by the fossil record and summarises paleobotanical information relevant to our understanding of the relationships between the major plant groups, extant and extinct. As in the first edition, the text is profusely illustrated with line illustrations and half-tones. For those students with little knowledge of plant structure and morphology there is a brief resume of those features of extant plants that will be needed to gain a better understanding of the fossil record. Summarising charts are also used to help students visualise the interpretative material.

The body of any animal can be viewed as a society or ecosystem whose individual members are cells, reproducing by cell division and organized into collaborative assemblies or tissues. In this ecosystem, the cells are born, live and die under various forms of selection pressure such as territorial limitation, population size, source of nutrients provided, infectious agents, etc. The body is a highly organized society of cells whose main task is the maintenance of homeostasis of the whole organism. The failure of control mechanisms which make the cell the unit of society, marking the beginning of its asocial behaviour, is most frequently a malignant alteration. This process is not abrupt, nor is it based on a single event. It is, rather, a long-term process characterized mainly by mutation, competition and natural selection operating within the population of cells. The basic mechanisms controlling the cell sociability represent the first defence line against the altered cells, while the second line of defence is supposed to be made up of the immune system cells.Speaking in Darwinian terms, within the ecosystem of an organism, cells of the immune system operate as predators of the altered and mutated cells or cells infected by the intracellular parasites. The biological phenomena whose mechanisms are, at present, explored and largely understood, certainly had their own evolution. Searching for the origin and details of the evolution of advanced solutions as well as selection pressures that might justify their emergence and existence, we often fail to see that many such phenomena are, in fact, co-evolutionary by-products of evolutionary innovations. In other words, the evolutionary emergence of advanced solutions is sometimes, if not always, accompanied by certain by-products and by the co-evolution of compensatory mechanisms acting as a counterbalance to these. An example of the evolution of advanced solutions is the evolution of adoptive immunity, and co-evolution of auto-immunity and alloimmunity. Alongside the diversification of the mechanisms of adoptive immunity, auto-immunity and alloimmunity gain attributes of the evolutionary by-products and become sources of selection pressure.To that effect, alloimmunity could be a source of very strong selection pressure in mammals, simply because it is directly connected with the reproductive efficacy. At the same time, new forms of selection pressure that are connected with adoptive immunity gave rise to new mechanisms controlling killer machinery of the immune system. Finally, the last in a line of by-products in the processes of evolutionary modelling and re-modelling of vertebrate immune systems can be regarded as the failure of anti-tumor immunity. There is now much evidence that tumors can be immunogenic. Tumor cells very often express antigens in a form recognizable by the host immune system, but most frequently without consequences on tumor progression. This has been shown in many experimental models and different experimental conditions. Immediate mechanisms for the escape of tumors from the immune response are very similar to mechanisms for the escape of the fetoplacental unit (as allograft) from the maternal immune response. The similarity between these two mechanisms is so significant that any randomness must be banished.Mechanisms of anti-tumor immunity in mammals are probably substantially different from mechanisms of anti-tumor immunity in other classes of vertebrates. Moreover, the type of most frequent tumors in non-mammalian vertebrates is also significantly different. Finally, the incidence of malignant tumors in non-mammalian vertebrates is significantly lower than the incidence of malignant tumors in mammals. These facts indicate that the mammalian immune system during the anti-tumor immune response is tricked by the similarity between tumor cells and trophoblast or other placental cells. From this aspect, anti-tumor immunity failure in mammals can be defined as an immunoreproductive phenomenon, which is developed under the evolutionary pressure of auto-immunity and alloimmunity/reproductive effectiveness. It may be a specific evolutionary approach in the rendering of anti-tumor immunity failure in mammals, and a new possibility for anti-tumor immunotherapy.

Several years ago, we realized that the most prominent ideas that had been ex pressed about the origin and early evolution of the Metazoa seemed to have been developed chiefly by zoologists using evidence from modern species without reference to the fossil record. Paleontologists had, in fact, put forth their own ideas but the zoological and the paleontological evidence were about the problem, seldom considered together, especially by zoologists. We believed that the paleon tological documentation of the first Metazoa was too scattered, too obscure to Western readers, and much of it too recent to have been readily available to our colleagues in zoology. Whether or not that was entirely true, we thought that a single volume reviewing the fossil record of the earliest Metazoa would be useful to many in both paleontology and zoology, especially since so much new informa tion has been developed in the last few years. Some of this information has been summarized in general articles recently, but an overview of most of the field does not exist. We therefore organized this book in five parts so that the evidence could be placed in perspective and summarized and inferences made from it. Part I intro duces the previous hypotheses that have been proposed for the origin and early radiation of Metazoa. Part II consists of two summary chapters that set the sedi mentological, geochemical, and biological background to the known radiations of Metazoa.

The orangutan is the most highly endangered species of great ape. Orangutans are threatened by deforestation, poaching, the illegal pet trade, and the isolation and fragmen tation of dwindling wild populations. Their conservation is impeded by certain aspects of their ecology (e. g. , a rain forest habitat) and certain features of their life history (e. g. , an eight-to twelve-year interbirth interval). Added to the U. S. Endangered Species List in 1970, the orangutan is now clearly on the road to extinction. The number of wild orangutans in Borneo and Sumatra is currently estimated to have decreased to between 12,300 and 20,571 individuals. Only 2% of original orangutan habitat is protected and some of these areas are now being destroyed. Clearly, attention to ecology, demography, censusing, rehabilitation, and conservation is essential if the orangutan is to survive in the wild beyond the next century. The protection of orangutans is a complex, multifaceted problem, involving such pressing issues as human poverty, overpopulation, and the economic development of Southeast Asia. Although the orangutan has been placed in Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), more orangutans were sold illegally in Taiwan between 1990 and 1993 than are housed in all the world's zoos. In the past, scientific and public attention has centered on the African apes. For this reason, the sole Asian great ape, the orangutan, has been called the "neglected ape.

Thrips (fhysanoptera) are very small insects, widespread throughout the world with a preponderance of tropical species, many temperate ones, and even a few living in arctic regions. Of the approximately 5,000 species so far identified, only a few hundred are crop pests, causing serious damage or transmitting diseases to growing crops and harvestable produce in most countries. Their fringed wings confer a natural ability to disperse widely, blown by the wind. Their minute size and cryptic behavior make them difficult to detect either in the field or in fresh vegetation transported during international trade of vegetables, fruit and ornamental flowers. Many species have now spread from their original natural habitats and hosts to favorable new environments where they often reproduce rapidly to develop intense damaging infestations that are costly to control. Over the past decade there have been several spectacular examples of this. The western flower thrips has expanded its range from the North American continent to Europe, Australia and South Africa. Thrips palmi has spread from its presumed origin, the island of Sumatra, to the coast of Florida, and threatens to extend its distribution throughout North and South America. Pear thrips, a known orchard pest of Europe and the western United States and Canada has recently become a major defoliator of hardwood trees in Vermont and the neighboring states. Local outbreaks of other species are also becoming problems in field and glasshouse crops as the effectiveness of insecticides against them decline.

The order Rodentia is the most abundant and successful group of mammals, and it has been a focal point of attention for compar ative and evolutionary biologists for many years. In addition, rodents are the most commonly used experimental mammals for bio medical research, and they have played a central role in investi gations of the genetic and molecular mechanisms of speciation in mammals. During recent decades, a tremendous amount of new data from various aspects of the biology of living and fossil rodents has been accumulated by specialists from different disciplines, ranging from molecular biology to paleontology. Paradoxically, our understanding of the possible evolutionary relationships among different rodent families, as well as the possible affinities of rodents with other eutherian mammals, has not kept pace with this information "explosion. " This abundance of new biological data has not been incorporated into a broad synthesis of rodent phylo geny, in part because of the difficulty for any single student of rodent evolution to evaluate the phylogenetic significance of new findings from such diverse disciplines as paleontology, embryology, comparative anatomy, molecular biology, and cytogenetics. The origin and subsequent radiation of the order Rodentia were based primarily on the acquisition of a key character complex: specializations of the incisors, cheek teeth, and associated mus culoskeletal features of the jaws and skull for gnawing and chewing."

An extremely well-organized, conceptually clear, empirically informed, and carefully argued volume...What makes this contribution special is the invigorating infusion of a wealth of principles and knowledge derived from evolutionary biology, neurophysiology, and cognitive science...The chapters provide abundant material for animated discussion.'' --- Evolution and Human Behavior, September 1997 When engaging in laboratory and field studies, researchers have an extensive set of implicit assumptions that justifies their research. However, these assumptions are rarely made explicit either to the researchers themselves, to their colleagues, or to the public. In this fascinating volume, the author gives insight into these underlying beliefs that scientists have regarding moral and biological issues involved in human life-such as decisions that influence reproductive practices, the termination of life, and the pursuit of biomedical research. He then uses this descriptive base to develop an ethic based on rational liberalism. His arguments stem from the thinking of biologists, moral philosophers, cognitive scientists, and social and developmental psychologists.

Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms'geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.

This book takes a fresh look at the work, thoughts, and life of 1956 Nobel Prize winner William B. Shockley. It reconstructs Shockley's upbringing, his patriotic achievements during World War II, his contribution to semiconductor physics - culminating with the epoch-making invention of the transistor - and his views on the social issues of his time. The author's unparalleled access to Shockley's personal documents provides insight into a colorful, yet controversial, man, and also sheds light on the attitudes of other prominent scientists of that era. Shockley was not only an outstanding scientist in his own right but also a fiercely independent thinker in perpetual search of the truth. His contributions to the field known today as microelectronics are enormous and unmatched. This book explores the critical facets of Shockley's life, replete with never-before-published photos and excerpts from his private correspondence and personal notebooks. The book also delves into Shockley's views on genetics and human intelligence. It tells the story of a man beset by an unrelenting rationality, slandered by the popular media, and ultimately alienated by his peers. It discusses his controversial, although sometimes prescient, ideas regarding human genetics, putting these into the context of modern research findings. Today, William Shockley is perhaps just as enigmatic as his work and accomplishments. The author presents a convincing argument that Shockley still has much to say about the issues of our age, and many of his ideas deserve evaluation in the public forum.