"Evolution by Tumor Neofunctionalization" explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution.

Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution.

This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology.
Covers the role that tumors might play in evolution.Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more

We live in a world surrounded by remarkable cultural achievements of human kind. Almost every day we hear of new innovations in technology, in medicine and in the arts which remind us that humans are capable of remarkable creativity. But what is human creativity? The modern world provides a tiny fraction of cultural diversity and the evidence for human creativity, far more can be seen by looking back into prehistory. The book examines how our understanding of human creativity can be extended by exploring this phenomenon during human evolution and prehistory.
The book offers unique perspectives on the nature of human creativity from archaeologists who are concerned with long term patterns of cultural change and have access to quite different types of human behaviour than that which exists today. It asks whether humans are the only creative species, or whether our extinct relatives such as Homo habilis and the Neanderthals also displayed creative thinking. It explores what we can learn about the nature of human creativity from cultural developments during prehistory, such as changes in the manner in which the dead were buried, monuments constructed, and the natural world exploited. In doing so, new light is thrown on these cultural developments and the behaviour of our prehistoric ancestors.
By examining the nature of creativity during human evolution and prehistory these archaeologists, supported by contributions from psychology, computer science and social anthropology, show that human creativity is a far more diverse and complex phenomena than simply flashes of genius by isolated individuals. Indeed they show that unless perspectives from prehistory are taken into account, our understanding of human creativity will be limited and incomplete.

Taking up the historical evolution of Darwin and his theories and the cultural responses they have inspired, Reflecting on Darwin poses the following questions: 'How are the apparatuses in the mid-nineteenth century and at the turn of the twenty-first century interconnected with bio-scientific paradigms in art, literature, culture and science?' 'How are naturalism, determinism and Darwinism - the eugenics of the nineteenth century and the genetic coding of the twentieth century - positioned, embodied and staged in various media configurations and media genres?' and 'How have particular media apparatuses formed, displaced or stabilized the various concepts of humankind in the framework of evolutionary theory?' Ranging from the early circulation of Darwin's ideas to the present, this interdisciplinary collection pays particular attention to Darwin's postmillennial reception. Beginning with an overview of the historical development of contemporary ecological and ethical fears, Reflecting on Darwin then turns to Darwin's influence on contemporary media, neo-Victorian literature and culture, science fiction literature and film, and contemporary theory. In examining the plurality of ways in which Darwin has been rewritten and reappropriated, this unique volume both mirrors and inspects the complexity of recent debates in Victorian and neo-Victorian studies.

Plant-herbivore interactions are a central topic in evolutionary ecology. Historically, their study has been a cornerstone for coevolutionary theory. Starting from classic ecological studies at the phenotypic level, it has since expanded to molecular and genomic approaches. After a historical perspective, the book's subsequent chapters cover a wide range of topics: from populations to ecosystems; plant- and herbivore-focused studies; in natural and in man-modified ecosystems; and both micro- and macro-evolutionary levels. All chapters include valuable background information and empirical evidence. Given its scope, the book will be of interest to both students and researchers, and will hopefully stimulate further research in this exciting field of evolutionary biology.

Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner 's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkh user MTBM book series.

The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences.

The most trusted and best-selling textbook on the diverse forms and fascinating lives of vertebrate animals. Covering crucial topics from morphology and behavior to ecology and zoogeography, Donald Linzey's popular textbook, Vertebrate Biology, has long been recognized as the most comprehensive and readable resource on vertebrates for students and educators. Thoroughly updated with the latest research, this new edition discusses taxa and topics such as * systematics and evolution * zoogeography, ecology, morphology, and reproduction * early chordates * fish, amphibians, reptiles (inclusive of birds), and mammals * population dynamics * movement and migration * behavior * study methods * extinction processes * conservation and management For the first time, 32 pages of color images bring these fascinating organisms to life. In addition, 5 entirely new chapters have been added to the book, which cover * restoration of endangered species * regulatory legislation affecting vertebrates * wildlife conservation in a modern world * climate change * contemporary wildlife management Complete with review questions, updated references, appendixes, and a glossary of well over 300 terms, Vertebrate Biology is the ideal text for courses in zoology, vertebrate biology, vertebrate natural history, and general biology. Donald W. Linzey carefully builds theme upon theme, concept upon concept, as he walks students through a plethora of topics. Arranged logically to follow the most widely adopted course structure, this text will leave students with a full understanding of the unique structure, function, and living patterns of all vertebrates.

Two hundred million years ago the earth consisted of a single vast continent, Pangea, surrounded by a great planetary sea. Continental drift tore apart Pangaea, and for millennia the hemispheres were separate, evolving almost entirely different suites of plants and animals. Columbus's arrival in the Americas brought together these long-separate worlds. Many historians believe that this collision of ecosystems and cultures - the Columbian Exchange - was the most consequential event in human history since the Neolithic Revolution. And it was the most consequential event in biological history since the extinction of the dinosaurs. Beginning with the world of microbes and moving up the species ladder to mankind, Mann rivetingly describes the profound effect this exchanging of species had on the culture of both continents.

This book is about morphogenesis as the genesis of forms. It is not restricted to plants growing from seed or animals developing from an embryo (although these do supply the most abundant examples) but also addresses kindred processes, from inorganic to social to biomorphic technology. It is about our morphogenetic universe: unplanned, unfair and frustratingly complicated but benevolent in allowing us to emerge, survive, and inquire into its laws.

The letters, most of which are published for the first time, include all that have been preserved from Darwin's correspondence with family, undergraduate friends as well as others in Shropshire and Staffordshire. voyage.

From one of America's best-known biologists, a revolutionary new way of thinking about evolution that shows "why, in light of our origins, humans are still special" (Edward J. Larson, Pulitzer Prize-winning author of Evolution). Once we had a special place in the hierarchy of life on Earth--a place confirmed by the literature and traditions of every human tribe. But then the theory of evolution arrived to shake the tree of human understanding to its roots. To many of the most passionate advocates for Darwin's theory, we are just one species among multitudes, no more significant than any other. Even our minds are not our own, they tell us, but living machines programmed for nothing but survival and reproduction. In The Human Instinct, Brown University biologist Kenneth R. Miller "confronts both lay and professional misconceptions about evolution" (Publishers Weekly, starred review), showing that while evolution explains how our bodies and brains were shaped, that heritage does not limit or predetermine human behavior. In fact, Miller argues in this "highly recommended" (Forbes) work that it is only thanks to evolution that we have the power to shape our destiny. Equal parts natural science and philosophy, The Human Instinct makes an "absorbing, lucid, and engaging...case that it was evolution that gave us our humanity" (Ursula Goodenough, professor of biology at Washington University in St. Louis).

"The facts of variability, of the struggle for existence, of adaptation to conditions, were notorious enough; but none of us had suspected that the road to the heart of the species problem lay through them, until Darwin and Wallace dispelled the darkness."T H Huxley (1887)Darwin is one of the most famous scientists in history. But he was not alone. Comparatively forgotten, Wallace independently discovered evolution by natural selection in Southeast Asia. This book is based on the most thorough research ever conducted on Wallace's voyage. Closely connected, but worlds apart, Darwin and Wallace's stories hold many surprises. Did Darwin really keep his theory a secret for twenty years? Did he plagiarise Wallace? Were their theories really the same? How did Wallace hit on the solution, and on which island? This book reveals for the first time the true story of Darwin, Wallace and the discovery that would change our understanding of life on Earth forever.

"The facts of variability, of the struggle for existence, of adaptation to conditions, were notorious enough; but none of us had suspected that the road to the heart of the species problem lay through them, until Darwin and Wallace dispelled the darkness."T H Huxley (1887)Darwin is one of the most famous scientists in history. But he was not alone. Comparatively forgotten, Wallace independently discovered evolution by natural selection in Southeast Asia. This book is based on the most thorough research ever conducted on Wallace's voyage. Closely connected, but worlds apart, Darwin and Wallace's stories hold many surprises. Did Darwin really keep his theory a secret for twenty years? Did he plagiarise Wallace? Were their theories really the same? How did Wallace hit on the solution, and on which island? This book reveals for the first time the true story of Darwin, Wallace and the discovery that would change our understanding of life on Earth forever.

Chronic inflammation is one of the major pathological bases manifesting the development of gastric cancers, hepatitis and hepatocellular carcinoma, cervical cancer, ulcerative colitis and colorectal cancer [1]. Microbial infections, viral infections and autoimmune responses can lead to chronic inflammation-associated cancer formation. Human herpesviruses, such as human cytomegalovirus (HCMV) and Kaposi sarcoma herpesvirus (KSHV) are known to be associated with tumorigenesis and tumor progression. HCMV infection potentiates malignancies of colon cancer and malignant glioma [2,3]. KSHV was initially discovered from Kaposi's sarcoma lesion of an AIDS patient [4]. It was subsequently discovered that KSHV contributed to the pathogenesis of KS, primary effusion lymphoma [5] and lymphoproliferative disorder multicentric Castleman's disease. Emerging evidence shows that herpesvirus infection interferes or inhibits host cell immune defense and maintains a tumor-promoting microenvironment by expressing virulent homologues of host cell proteins that disturb normal cell cycle progression and leads to apoptosis of the host cells. For example, cellular growth and transformation are induced by viral-encoded homologues of cytokines, chemokines or chemokine receptors [6]. The constitutive expression of viral chemokine GPCRs triggers prolonged activation of G protein signaling and eventually becomes the major inputs for chronic leukocyte infiltration and cancer development. GPCRs can serve as proto-oncogenes since overexpression of various wild type GPCRs can transform cells in the presence of their specific ligands. Mutations on GPCRs may result in constitutive signaling and oncogenesis [7]. Naturally occurring mutations in GPCRs have been identified in human tumors [8,9].

The current volume includes articles on the conceptual relationship of ontogeny, phylogeny, and classification; correlation studies of spatial patterns of genetic variation; and the evolution of flower display and reward. about a previous volume: 'Excellent; we should all press for its maintenance in our institution's libraries.' Biologist

This book explores the evolutionary and cognitive foundations of human communication, focusing on narrative as its distinctive dimension. Within a framework of continuity with both the communication of our hominin predecessors and that of non-human animals, the book is about a twofold proposal. It includes the idea that (human and animal) communication has an intrinsically persuasive nature along with the hypothesis that humans developed narrative forms of communication in order to enhance their persuasive abilities. In this view, narrative persuasion becomes the feature that distinguishes human communication from animal communication. The study of the transition from animal communication to language addresses both the selective pressures that led communication for persuasive purposes to take a narrative form and the cognitive architectures and expressive systems that enabled our ancestors to cope with the selective pressures of persuasive/narrative-based communication. Language evolution is interdisciplinary, even from the specific perspective of evolutionary pragmatics chosen here. Therefore, this book is intended for researchers working in fields such as cognitive sciences, philosophy, evolutionary biology, cognitive psychology, and primatology. It also represents a valuable resource for advanced students in cognitive sciences, linguistics, and philosophy.

The three greatest scientific mysteries, which remain poorly understood, are the origin of the universe, the origin of life and the development of consciousness. This book describes the processes preceding the Big Bang, the creation of matter, the concentration of that matter into stars and planets, the development of simple life forms and the theory of evolution that has given higher life forms, including mankind.There are many popular and excellent science books that present various aspects of science. However, this book follows a narrow scientific pathway from the Big Bang to mankind, and depicts the causal relationship between each step and the next. The science covered will be enough to satisfy most readers. Many important areas of science are dealt with, and these include cosmology, particle physics, atomic physics, galaxy and star formation, planet formation and aspects of evolution. The necessary science is described in a narrative form that general-interest readers should understand, without the use of equations or formulae.This 2nd edition includes several updates on the subjects that form the pillars of this book. They are: cosmology and astronomy, the features and formation of the solar system, the origin of life, and genetics and evolution. This book will appeal to readers with an interest in biology and those curious about the origins of the universe.

The three greatest scientific mysteries, which remain poorly understood, are the origin of the universe, the origin of life and the development of consciousness. This book describes the processes preceding the Big Bang, the creation of matter, the concentration of that matter into stars and planets, the development of simple life forms and the theory of evolution that has given higher life forms, including mankind.There are many popular and excellent science books that present various aspects of science. However, this book follows a narrow scientific pathway from the Big Bang to mankind, and depicts the causal relationship between each step and the next. The science covered will be enough to satisfy most readers. Many important areas of science are dealt with, and these include cosmology, particle physics, atomic physics, galaxy and star formation, planet formation and aspects of evolution. The necessary science is described in a narrative form that general-interest readers should understand, without the use of equations or formulae.This 2nd edition includes several updates on the subjects that form the pillars of this book. They are: cosmology and astronomy, the features and formation of the solar system, the origin of life, and genetics and evolution. This book will appeal to readers with an interest in biology and those curious about the origins of the universe.

The Oxford Handbook of Philosophy of Biology is an exciting collection of new essays written especially to give the reader an introduction to one of the most vibrant areas of scholarship today, and at the same time to move the subject forward dramatically. Written in a clear and rigorous style it will give the more experienced scholar much to think about and will also be of great value to the new student of the subject. The handbook covers the history of the topic, then moves into important analyses of contemporary evolutionary thinking, and continues with discussions of genetics and the moral and epistemological foundations of our understanding of heredity. The book goes on to cover ecology, behavior and morality, and does not neglect religion or feminist issues. Finally, it takes up matters to do with language and metaphor.
The authors range from the senior and experienced to new and exciting young scholars. The Oxford Handbook of Philosophy of Biology is a collection that will be of interest to philosophers of science, to philosophers generally, as well as biologists of all kinds. There is no better way to learn about this dynamic field than through the essays in this volume.

This book compares the three most prominent representatives of evolutionary algorithms - genetic algorithms, evolution strategies, and evolutionary programming - computational methods at the border between computer science and evolutionary biology. The algorithms are explained within a common formal framework, thereby clarifying the similarities and differences of these methods. The author also presents new results regarding the role of mutation and selection in genetic algorithms and uses a meta-evolutionary approach to confirm some of the theoretical results.

In The Resurgence of Evolutionary Biology Terry Hoy charts the intersection between political theory and the intellectual debate over human evolution. The book deals with the contemporary interpretation of Darwinism as an apology for racism, imperialism, and capitalism. Hoy argues that this perspective underlies the contemporary debates between proponents of both genetic and environmental determinants of behavior. In response to several leading thinkers in the field--principally Edward Wilson, Stephen Gould and R. C. Lewontin--Hoy presents the neo-Darwinian synthesis of Edwin Mayr as a mediation between these two schools of thought. This concise work is essential reading for scholars of political theory and philosophy, and anyone interested in seeking to understand the rise and fall--and rise again--of Darwinism and the contemporary political relevance of Aristotelian-Darwinian naturalism.

From one of the world's leading natural scientists and the acclaimed author of "Trilobite , Life: A Natural History of Four Billion Years of Life on Earth" and "Dry Storeroom No. 1 "comes a fascinating chronicle of life's history told not through the fossil record but through the stories of organisms that have survived, almost unchanged, throughout time. Evolution, it seems, has not completely obliterated its tracks as more advanced organisms have evolved; the history of life on earth is far older--and odder--than many of us realize.
Scattered across the globe, these remarkable plants and animals continue to mark seminal events in geological time. From a moonlit beach in Delaware, where the hardy horseshoe crab shuffles its way to a frenzy of mass mating just as it did 450 million years ago, to the dense rainforests of New Zealand, where the elusive, unprepossessing velvet worm has burrowed deep into rotting timber since before the breakup of the ancient supercontinent, to a stretch of Australian coastline with stromatolite formations that bear witness to the Precambrian dawn, the existence of these survivors offers us a tantalizing glimpse of pivotal points in evolutionary history. These are not "living fossils" but rather a handful of tenacious creatures of days long gone.
Written in buoyant, sparkling prose, "Horseshoe Crabs and Velvet Worms" is a marvelously captivating exploration of the world's old-timers combining the very best of science writing with an explorer's sense of adventure and wonder.

Charles Darwin was a bumbling neophyte naturalist when he boarded the Beagle in 1831. Through the five years that followed, as the ship hugged the coastline of South America, Darwin found himself crawling through waist-deep mud, climbing towerlike trees in the rainforest, and scaling craggy Patagonian cliffs as he collected specimens and closely observed the relationship between the creatures he stalked and the astonishing, utterly unfamiliar landscapes where he found them. What happened to Darwin? That's the question Lyanda Lynn Haupt compellingly explores in a narrative that puts us inside the young Darwin's shoes - and brings nose to nose with dung beetles, ostriches, and all form of wild creatures. By mining Darwin's lesser-known works - diaries, correspondence, his ornithological journals, unruly little pocket notebooks - Haupt illuminates the process that shaped Darwin's vision of the workings of nature. Her book not only chronicles Darwin's transformation from uncertain amateur to genius but reminds us how and why, in our own world as well as Darwin's, attention to small things can make a big difference.

This is the story of a profound revolution in the way biologists explore life's history, understand its evolutionary processes, and reveal its diversity. It is about life's smallest entities, deepest diversity, and greatest cellular biomass: the microbiosphere. Jan Sapp introduces us to a new field of evolutionary biology and a new brand of molecular evolutionists who descend to the foundations of evolution on Earth to explore the origins of the genetic system and the primary life forms from which all others have emerged. In so doing, he examines-from Lamarck to the present-the means of pursuing the evolution of complexity, and of depicting the greatest differences among organisms.
The New Foundations of Evolution takes us into a world that classical evolutionists could never have imagined: a deep phylogeny based on three domains of life and multiple kingdoms, and created by mechanisms very unlike those considered by Darwin and his followers. Evolution by leaps seems to occur regularly in the microbial world where molecular evolutionists have shown the inheritance of acquired genes and genomes are major modes of evolutionary innovation.
Revisiting the history of microbiology for the first time from the perspective of evolutionary biology, Sapp shows why classical Darwinian conceptions centering on questions of the origin of species were forged without a microbial foundation, why classical microbiologists considered it impossible to know the course of evolution, and classical molecular biologists considered the evolution of the molecular genetic system to be beyond understanding. In telling this stirring story of scientific iconoclasm, this book elucidates how the new evolutionary biology arose, what methods and assumptions underpin it, and the fiery controversies that continue to shape biologists' understanding of the foundations of evolution today.

Thought in a Hostile World is an exploration of the evolution of cognition, especially human cognition, by one of today's foremost philosophers of biology and of mind. The central idea of the book is that thought is a response to threat. Competitors and enemies make life hard by their direct physical effects. But they also make life hard by eroding epistemic conditions. They lie. They hide themselves. They seem other than what they are. Sterelny uses this and related ideas to explore from an evolutionary perspective the relationship between folk psychology and an integrated scientific conception of human cognition. In the process, he examines how and why human minds have evolved. The book argues that humans are cognitively, socially, and sexually very unlike the other great apes, and that despite our relatively recent separation from their lineages, human social and cognitive evolution has been driven by unusual evolutionary mechanisms. In developing his own picture of the descent of the human mind, Sterelny further offers a critique of nativist, modular versions of evolutionary psychology. This volume will be of vital interest to scholars and students interested in cognitive science, philosophy of mind, and evolutionary psychology.