This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson's, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.

This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

"In this 2nd edition, Robinson and Reiter give us an updated blueprint for full integration of behavioral health and primary care in practice. They review the compelling rationale, but their real contribution is telling us exactly HOW to think about it and how to do it. This latest book is a must for anyone interested in population health and the nuts and bolts of full integration through using the Primary Care Behavioral Health Consultation model." Susan H McDaniel Ph.D., 2016 President, American Psychological Association Professor, University of Rochester Medical Center The best-selling guide to integrating behavioral health services into primary care is now updated, expanded and better than ever! Integration is exploding in growth, and it is moving inexorably toward the model outlined here. To keep pace, this revised text is a must for primary care clinicians and administrators. It is also essential reading for graduate classes in a variety of disciplines, including social work, psychology, and medicine. This updated edition includes: * A refined presentation of the Primary Care Behavioral Health (PCBH) model * The latest terms, trends and innovations in primary care * Comprehensive strategies and resource lists for hiring and training new Behavioral Health Consultants (BHC) * Step-by-step guidance for implementing the PCBH model * A plethora of evolved practice tools, including new Core Competency Tools for BHCs and primary care providers * Sample interventions for behaviorally influenced problems * The use of "Third Wave" behavior therapies in primary care * Detailed program evaluation instructions and tools * The latest on financing integrated care * An entire chapter on understanding and addressing the prescription drug abuse epidemic * Experienced guidance on ethical issues in the PCBH model * Improved patient education handouts With all of the changes in health care, the potential for the Primary Care Behavioral Health (PCBH) model to improve primary care-and the health of the population-is greater than ever. This book should be the first read for anyone interested in realizing the potential of integration.

Medical practitioners receive little, if any, formal training in the prevention, assessment and management of pressure ulcers and other chronic wounds. Pressure Ulcers in the Aging Population: A Guide for Clinicians is a resource primarily aimed at physicians interested in the fundamentals of wound care. This book is written for geriatricians, internists, general practitioners, residents and fellows who treat older patients and unlike other texts on the market addresses the specific issues of wound prevention and managment in older individuals. Pressure Ulcers in the Aging Population: A Guide for Clinicians emphasizes prevention, proper documentation and the team care process which are often overlooked in standard texts. Chapters are written by experts in their fields and include such evolving topics as deep tissue injury and the newer support surface technologies.

A comprehensive, evidence-based introduction to the area of lymphology, the book is directed mainly to the US audience and will appeal to an interdisciplinary field of health professionals. It describes the unique anatomy and physiology of the lymphatic system and the intimate relationship it shares with the venous system. It explores the differential diagnosis of the "swollen leg/arm", which is often the presenting problem to the health care professional. The necessity of history taking, physical examination and laboratory studies are noted. Treatment methods are described as an introduction and psychosocial and quality of life issues are explored in depth.

Psychological Aspects of Cancer: A Guide to Emotional and Psychological Consequences of Cancer, Their Causes and Their Management opens with two essays on the biological basis of emotion/mental-driven body processes and disease. The consequence of such considerations is that since thoughts and emotions can be modulated and changed by health care professionals, psychological counseling should be seen not only as a way to help patients cope, but possibly to influence the disease itself. A unique overview of a key area of cancer care, this important title then proceeds to offer a section on genetic predispositions to cancer and the psychological considerations involved in screening and pre-emptive therapies and decision-making in cancer therapy. A third section deals with the philosophical and religious underpinnings of psychological factors involved in coping with disease state stressors and the roles of hope in coping. The fourth section is an acknowledgement that patients with cancer live in a social context, which often includes a partner and/or caregiver. The fifth section includes several essays on aspects and modalities of care-giving that are designed to help patients coping with their cancer and its aftermath, which increasingly extends for years. An important title covering key aspects of one of the most troubling disorders of our time, Psychological Aspects of Cancer: A Guide to Emotional and Psychological Consequences of Cancer, Their Causes and Their Management will provide the busy practitioner with cutting edge knowledge as well as practical information that can translate into better care for patients with cancer.

Traumatic brain injury (TBI) is a major cause of disability worldwide. Each year 1.7 million new TBIs occur in the United States, and it is also considered a signature injury of the Iraq and Afghanistan conflicts. Despite the relatively high incidence-within both civilian and military populations-the diagnosis and treatment, particularly of mild TBI/concussion, remains an inexact science. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation is a concise guide designed for neurologists, primary care, and sports physicians and other medical providers, psychologists and neuropsychologists, and athletic trainers who may evaluate and care for patients with TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies. A superb contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation offers a well-designed, well-written, useful resource for all providers who treat patients with TBI.

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

This book offers thorough coverage of emergencies in dermatology, from the basics of critical care for dermatologic emergencies, to neonatal and pediatric emergencies, infectious emergencies, drug eruptions and HIV-AIDS-related emergencies, among many others.

As the values of integrative medicine continues to grow, alternative points of view and treatments are increasing in acceptance and prevalence. Homeopathic medicine is considered an important root to this approach. However, contributions of homeopathically qualified doctors have long been overlooked. A Century of Homeopaths is a detailed account of the many homeopaths who have contributed to medical progress since 1840. The accomplishments of over 100 homeopaths form the organizing structure of the book - many of whom have been lost to history. The text describes the ways in which homeopaths have influenced medical practice, research and public health, as well as the seminal effect of homeopaths in the emergence of today's medical specialties and in social reform, thus providing insights to healthcare professionals, researchers, students and medical historians.

Hailed by professional journals and esteemed by primary care physicians, Bronchial Asthma: A Guide for Practical Understanding and Treatment, Sixth Edition, has been fully updated to help physicians face the challenge of diagnosis and management in every variety of patient subpopulation.

The updated second edition of Cutaneous Manifestations of Infection in the Immunocompromised Host is an invaluable reference for physicians and ancillary medical professionals involved in the care of patients with impaired immune systems due to cancer, chemotherapy, systemic steroids and other immunosuppressive drugs, HIV/AIDS or organ transplantation. This volume will help you recognize skin lesions and diagnose their infectious cause. Textbook features include: * Over 350 color images demonstrating pathognomonic, atypical, rare and routine skin lesions * Tables for differential diagnosis of different skin lesions in the immunocompromised host * Complete coverage of infectious pathogens with the patterns of infection and the likely causes in different clinical settings (HIV/AIDS versus solid organ transplantation versus neutropenia post-chemotherapy versus bone marrow recovery post hematopoietic stem cell transplantation ) * New chapter discussing the role of viruses causing malignancies with cutaneous signs in the immunocompromised patient Written by dermatologists, the new edition is an indispensable diagnostic tool intended for use by all clinicians who care for immunocompromised patients.

Colorectal Cancer Screening and Computerized Tomographic Colonography: A Comprehensive Overview is an authoritative volume on CT colonography. Structured in a manner that will allow the reader to understand the practical and larger public health issues surrounding both CT colonography and CRC screening in general, the text is designed to reach a broad audience of specialist clinicians and primary care physicians. The book provides an overview of the disease and risk factors of colorectal cancer, as well as the history and development of CTC as both a colorectal imaging and screening modality. The text also reviews the controversies, potential pitfalls, and exciting new directions and capabilities inherent in the practice of CTC. Filled with high quality images and authored by experts in the field, Colorectal Cancer Screening and Computerized Tomographic Colonography: A Comprehensive Overview is the definitive reference for clinicians interested in computerized tomographic colonography and CRC screening.

This compact pictorial atlas highlights variations in the appearance of healthy skin, hair, and nails in children of all colors, as well as their appearance when affected by skin diseases. Illustrated using clinical photographs, microscopy and dermoscopy.

A concise review of the epidemiology, pathogenesis, and management of common respiratory conditions seen in a primary care setting. Using an illuminating case-based approach, Dr. Mintz assesses the key clinical questions that a primary care physician would ask and applies the most up-to-date research and guidelines to offer the practitioner evidence-based solutions. The author covers the range of knowledge needed to provide excellent care for patients with respiratory disease, from the basics of pulmonary function testing to understanding and caring for common respiratory illnesses, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and pneumonia. For each disorder, Dr. Mintz explains the key points regarding the epidemiology of the disease, its pathophysiology, the differential diagnosis and diagnosis, and its recommended treatment. A special PDA version of Disorders of the Respiratory Tract: Common Challenges in Primary Care is also available.

Diagnosing and managing type 2 diabetes presents an enormous challenge to the primary care provider confronted with multiple emerging scientific insights, therapeutic strategies and risk reduction principles. In Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition, Ronald A. Codario, M.D., FACP -- a well-known and highly respected authority on diabetes -- details the state-of-the-art in diagnosing, managing and attenuating risks in patients with this disease. Utilizing his extensive experience in private practice, medical education and clinical research for over 35 years, Dr. Codario explains in simple clinical terms, the current understanding of the pathophysiology of diabetes, the latest clinical trials, developing controversies, updates on new medications and an expanded section on Special Populations. With his unique, multiple board certifications in clinical hypertension, vascular medicine, internal medicine, vascular ultrasound and clinical lipidology, Dr. Codario provides practical guidelines for treatment with insulin and oral agents, lipid and hypertension control and comprehensive risk reduction strategies. Extensively reviewed are the metabolic syndrome, the role of exercise and nutrition, and key issues associated with herb and nutriceutical use. Illustrative case studies in diabetes management, an outstanding bibliography of suggested readings, and extensive chapter subheadings for quick reference make this book a practical, easy-to-read guide for dealing with this killer disease. Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition is the direct result of many years of listening, teaching, lecturing and empathizing with fellow primary care providers and their patients in the ongoing fight against diabetes. Like the internationally acclaimed first edition, this is a must read and invaluable guide for all primary care providers, students, caregivers and patients battling the ravages of this ever increasing epidemic.

Because of the wealth of new information generated by the scientific community during the last decade on the role of nutrition on cancer risk, this book provides a forum for presentation and discussion of recent scientific data and highlights a set of dietary recommendations. Bioactive Compounds and Cancer presents chapters that highlight laboratory and clinical findings on how selected nutrients function as signaling molecules and, as such, influence cellular behavior and cancer predisposition. This important compendium focuses on understanding the role of nutrition in cancer biology, the molecular action of bioactive food components and xenobiotics on cancer risk, the role of dietary components in cancer prevention and/or treatment, and nutrition education with the most up to date dietary recommendations that may reduce cancer risk. This volume will be of interest to specialized health professionals, clinicians, nurses, basic and clinical researchers, graduate students, and health officials of public and private organizations.

The Nutrition and Health series of books have had great success because each volume has the consistent overriding mission of providing health professionals with texts that are essential because each includes (1) a synthesis of the state of the science, (2) timely, in-depth reviews by the leading researchers in their respective ?elds, (3) extensive, up-to-date fully annotated ref- ence lists, (4) a detailed index, (5) relevant tables and ?gures, (6) identi?cation of paradigm shifts and the consequences, (7) virtually no overlap of information between chapters, but targeted, inter-chapter referrals, (8) suggestions of areas for future research, and (9) balanced, data-driven answers to patient as well as health professionals questions which are based upon the totality of evidence rather than the ?ndings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter and in the choice of chapter authors. The editor(s), whose training(s) is (are) both research and practice oriented, has(ve) the opportunity to develop a primary objective for their book, de?ne the scope and focus, and then invite the leading authorities to be part of their initiative. The authors are encouraged to provide an overview of the ?eld, discuss their own research, and relate the research ?ndings to potential human health consequences.

Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders serves as an indispensable resource for physicians interested in, and dealing with, this very complex and evolving branch of neurology. This comprehensive title provides an introduction to basic neuroimmunology and principles of immunotherapy and also serves as a thorough guide to immune-mediated disorders of the central and peripheral nervous system, as well as other systemic disorders with a significant neuroimmunologic component. The chapters are written by experts in their fields and include the most up to date scientific information. This volume is made to simplify complex immunological mechanisms and to focus on practical patient-related issues. Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders is an invaluable addition to the literature and will be of significant interest to neurologists, residents and fellows, internists, and general practitioners who treat patients with neurologic disorders and other systemic autoimmune diseases.

Dietary Components and Immune Function focuses on immune modulation, immune mediated disease resistance, immune changes due to AIDS, immune modulated cancer therapy, and autoimmune diseases as modified by dietary supplement, bioactive foods and supplements. The potential value of such approaches in maintaining wellness and preventing disease are addressed by examining their effects in vitro and in vivo on innate and adaptive immune responses. Emerging fields of science and important discoveries relating to early stages of new nutriceuticals in cancer prevention, prior to clinical trials are also covered. This volume represents a single source of material related to nutriceuticals and their constituents as they relate to cancer therapy and prevention. As such the book will be essential reading for nutritionists, pharmacologists, health care professionals, research scientists, cancer workers, pathologists, molecular or cellular biochemists, physicians, general practitioners as well as those interested in diet and nutrition in disease resistance via immune regulation.

Sleep Disordered Breathing in Children: A Comprehensive Clinical Guide to Evaluation and Treatment is a comprehensive, timely and up-to-date review of pediatric sleep disordered breathing (SDB) and offers a thorough focus on several key areas: namely, the normal development and maturation of the airway and breathing during sleep, the techniques that are in place for assessment of SDB in children, the clinical manifestations and characteristics of several pediatric populations at risk for SDB, the implications of SDB in various end-organ systems, and, finally, a critical review of the evidence on current therapeutic approaches. This unique and complete text is of welcome interest to all practicing physicians and healthcare professionals who evaluate children with sleep problems -- namely pulmonologists, pediatricians, sleep physicians, pediatric neurologists, pediatric otolaryngologists, and family practitioners, as well as clinical researchers, pediatric nurse practitioners and respiratory therapists. Written by a distinguished and international panel of authors who are renowned experts in their field and who offer an expanded view of the problems associated with SDB, Sleep Disordered Breathing in Children: A Comprehensive Clinical Guide to Evaluation and Treatment is an indispensible resource for all physicians who evaluate children for sleep-disordered breathing.

It has been 5 years since publication of the first edition of Dr. Attarian's Clinical Handbook of Insomnia which at the time was the first significant cl- ical textbook dedicated to insomnia, an often overlooked but important me- cal problem. The book was very well received. There has now been sufficient new information on the subject to warrant a second expanded edition of this very useful volume. Then, as now, the approach is to emphasize the frequent biological causes of insomnia rather than to attribute it primarily to underlying psychological and emotional factors. This new edition is an impressive major effort, having been expanded from 14 to 23 chapters including an extensive revision and updating of previous chapters with new references and the ad- tion of many new authors. An entirely new section of the book deals with insomnia in special populations including teenagers, pregnancy, menopause, and the geriatric population. Other new topics include insomnia as enco- tered in primary care practice, the role of circadian rhythms, the contribution of sleep related movement disorders to insomnia, insomnia in pain disorders, and the interesting entity of paradoxical insomnia, in which there is a large d- crepancy between the objective and subjective estimation of quantity of sleep. This collection within a single volume of practical information concerning a common but often neglected disorder remains a very useful addition to the armamentarium of the general or specialty physician who wishes to properly address insomnia in an informed and responsible manner.