Created to support students and teachers through the OCR Core Maths (MEI) courses and designed to create confident mathematicians able to apply their learning to a wide range of situations. // Written in conjunction with the MEI team to ensure the best possible support for the course. // Covers all components from both specifications: Introduction to quantitative reasoning , Critical maths and Statistical problem solving. // Innovative approach places learning in context throughout and focusses on learning through practice with a large number of questions, exercises, activities and exam-style questions. // Real-world examples are used to give students opportunities to apply their learning to different settings including everyday life and the workplace.

APPLIED BIOSTATISTICS FOR THE HEALTH SCIENCES In this newly revised edition of Applied Biostatistics for the Health Sciences, accomplished statistician Dr. Richard Rossi delivers a robust and easy-to-understand exploration of statistics in the context of applied health science and biostatistics. The book covers sample design, logistic regression, experimental design, survival analysis, basic statistical computation, and many more topics with a strong focus on the correct use and interpretation of statistics. The author also explains how to assess the quality of observed data, how to collect quality data, and the use of confidence intervals in conjunction with hypothesis and significance tests. A thorough introduction to biostatistics, including explanations of fundamental concepts like populations, samples, statistics, biomedical studies, and data set examples A comprehensive exploration of population descriptions, including qualitative and quantitative variables, multivariate data, measures of dispersion, and probability Practical discussions of random sampling, summarizing random samples, and the measurement of the reliability of statistics In-depth examinations of confidence intervals, statistical hypothesis testing, simple and multiple linear regression, and experimental design Perfect for health science and biostatistics students and professors at the upper undergraduate and graduate levels, Applied Biostatistics for the Health Sciences is also a must-read reference for practitioners and professionals in the fields of pharmacy, biochemistry, nursing, health care informatics, and the applied health sciences.

This second edition of the International Handbook of Mathematics Teacher Education builds on and extends the topics/ideas in the first edition while maintaining the themes for each of the volumes. Collectively, the authors look back beyond and within the last 10 years to establish the state-of-the-art and continuing and new trends in mathematics teacher and mathematics teacher educator education, and look forward regarding possible avenues for teachers, teacher educators, researchers, and policy makers to consider to enhance and/or further investigate mathematics teacher and teacher educator learning and practice, in particular. The volume editors provide introductions to each volume that highlight the subthemes used to group related chapters, which offer meaningful lenses to see important connections within and across chapters. Readers can also use these subthemes to make connections across the four volumes, which, although presented separately, include topics that have relevance across them since they are all situated in the common focus regarding mathematics teachers. Volume 2, Tools and Processes in Mathematics Teacher Education, describes and analyze various promising tools and processes, from different perspectives, aimed at facilitating the mathematics teacher learning and development. It provides insights of how mathematics teacher educators think about and approach their work with teachers. Thus, as the second volume in the series, it broadens our understanding of the mathematics teacher and their learning and teaching.

This book is entirely devoted to discrete time and provides a detailed introduction to the construction of the rigorous mathematical tools required for the evaluation of options in financial markets. Both theoretical and practical aspects are explored through multiple examples and exercises, for which complete solutions are provided. Particular attention is paid to the Cox, Ross and Rubinstein model in discrete time. The book offers a combination of mathematical teaching and numerous exercises for wide appeal. It is a useful reference for students at the master's or doctoral level who are specializing in applied mathematics or finance as well as teachers, researchers in the field of economics or actuarial science, or professionals working in the various financial sectors. Martingales and Financial Mathematics in Discrete Time is also for anyone who may be interested in a rigorous and accessible mathematical construction of the tools and concepts used in financial mathematics, or in the application of the martingale theory in finance

The Digital Twin Paradigm for Smarter Systems and Environments: The Industry Use Cases, Volume 117, the latest volume in the Advances in Computers series, presents detailed coverage of new advancements in computer hardware, software, theory, design and applications. Chapters vividly illustrate how the emerging discipline of digital twin is strategically contributing to various digital transformation initiatives. Specific chapters cover Demystifying the Digital Twin Paradigm, Digital Twin Technology for "Smarter Manufacturing", The Fog Computing/ Edge Computing to leverage Digital Twin, The industry use cases for the Digital Twin idea, Enabling Digital Twin at the Edge, The Industrial Internet of Things (IIOT), and much more.

Advances in Computers, Volume 114, the latest volume in this innovative series published since 1960, presents detailed coverage of new advancements in computer hardware, software, theory, design and applications. Chapters in this updated release include A Comprehensive Survey of Issues in Solid State Drives, Revisiting VM performance and optimization challenges for big data, Towards Realizing Self-Protecting Healthcare Information Systems: Design and Security Challenges, and SSIM and ML based QoE enhancement approach in SDN context.

In diesem Werk werden Moeglichkeiten der Wirkstoffverabreichung dargestellt, wobei physikalische und pharmakokinetische Modelle zur Erzielung der gewunschten Profile und Ansatze herangezogen werden. Nach einem UEberblick uber die Wirkstoffaufnahme und die physiologischen Modelle werden in den Kapiteln uber die oralen Verabreichungswege (die haufigste Form der Verabreichung) die PBPK und verschiedene moegliche Darreichungsformen beschrieben. Bei der systemischen transdermalen Verabreichung ist es notwendig, die Pharmakokinetik der Formulierung und des Wirkstoffs zu verstehen, um die Formulierung von der ersten Konzeption uber die gesamte Entwicklung darauf auszurichten. In weiteren Kapiteln werden die biologischen und praktischen Ansatze bei der pulmonalen und mukosalen Verabreichung besprochen. Fur den Fall der Notfallversorgung betrachten die Autoren die Beziehung zwischen parenteralen Infusionsprofilen und PK/PD. In den letzten Kapiteln werden aktuelle Trends dargestellt, darunter virtuelle Experimente zur Verdeutlichung von Mechanismen sowie moderne Ansatze in der Wirkstoffverabreichung und personalisierten Medizin. Das Werk Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics eignet sich nicht nur perfekt fur Wissenschaftler, Forscher in der Industrie, Doktoranden und Postdoktoranden in den Bereichen der Pharmawissenschaft und Pharmatechnik, sondern verdient auch einen Platz in den Bucherregalen von Experten, die sich mit Formulierungen, Pharmakokinetik und klinischer Pharmakologie beschaftigen.