A compilation of the proceedings of a conference held to honor Alvin M. Liberman for his outstanding contributions to research in speech perception, this volume deals with two closely related and controversial proposals for which Liberman and his colleagues at Haskins Laboratories have argued forcefully over the past 35 years. The first is that articulatory gestures are the units not only of speech production but also of speech perception; the second is that speech production and perception are not cognitive processes, but rather functions of a special mechanism. This book explores the implications of these proposals not only for speech production and speech perception, but for the neurophysiology of language, language acquisition, higher-level linguistic processing, the visual perception of phonetic gestures, the production and perception of sign language, the reading process, and learning to read. The contributors to this volume include linguists, psycholinguists, speech scientists, neurophysiologists, and ethologists. Liberman himself responds in the final chapter.

Presenting the work of researchers who are at the forefront of the study of memory mechanisms, this volume addresses a wide range of topics including: physiological and biophysical studies of synaptic plasticity, neural models of information storage and recall, functional and structural considerations of amnesia in brain-damaged patients, and behavioral studies of animal cognition and memory. The book's coverage of diverse approaches to memory mechanisms is intended to help dissolve the borders between behavioral psychology, cognitive neuropsychology, and neurophysiology.

Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is being progressively delineated. A complete picture of the neurochemical and neuroanatomical structure of the mammalian clock is emerging and the complex pattern of control mechanisms involving endogenous clock mechan isms and photic and nonphotic zeitgebers is being built up as a result of behavioral studies. Secondly, in parallel with these exciting developments in basic science, clinical applications are being convincingly demonstrated in the general fields of pharmacology and medicine as well as in specific areas, e.g., jet lag, shiftwork maladaption syndrome, blindness, and cardiovascular system. It is therefore an opportune time to review progress in the field of chronopharmacology and to introduce some of the exciting developments and prospects to a readership beyond the confines of the chronobiological cognoscenti. This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology."

The seventh "Oxford Conference" on Modeling and Control of Ventilation was held in the beautiful setting of Northem Ontario at the Grandview Inn in Hunstville. This meet- ing was called the Canadian Conference on Modeling and Control ofVentilation (CCMCV) to follow on LCMCV held in London, England, three years ago. The beautiful view over Fairy Lake greeted everyone in the moming and provided an ideal setting for many discus- sions about respiratory physiology and modeling. The Oxford Conferences began in 1971 when Dr. Richard Hercynski (a mathematical modeler with an interest in respiratory physiology) and Dr. Dan Cunningham (a respiratory physiologist with an interest in modeling) decided to organize a meeting "Modelling of a Biological Control System: Tbe Regulation of Breathing" in Oxford, England, in 1978. The meeting was a success, and it spawned aseries of meetings that have continued to today. A second conference was organized at Lake Arrowbead, Califomia, in 1982. After tbis, con- ferences were repeated at tbree-year intervals. My first Oxford Conference was at tbe abbey in Solignac, France, in 1985. Next, we met in tbe cabins overlooking Grand Lake, Colorado, in 1988. In 1991, we traveled to the training institute at the base ofMt. Fuji (or at least they tell us Mt. Fuji was out there--we never saw it because of a typhoon rolling through). Our last meeting was at Royal Holloway College (University of London) where we got to dine in a castle among artwork that required guards and an electronic security system.

MICHAEL S. GAZZANIGA The investigation of the human brain and mind involves a myriad of ap proaches. Cognitive neuroscience has grown out of the appreciation that these approaches have common goals that are separate from other goals in the neural sciences. By identifying cognition as the construct of interest, cognitive neuro science limits the scope of investigation to higher mental functions, while simultaneously tackling the greatest complexity of creation, the human mind. The chapters of this collection have their common thread in cognitive neuroscience. They attack the major cognitive processes using functional stud ies in humans. Indeed, functional measures of human sensation, perception, and cognition are the keystone of much of the neuroscience of cognitive sci ence, and event-related potentials (ERPs) represent a methodological "coming of age" in the study of the intricate temporal characteristics of cognition. Moreover, as the field of cognitive ERPs has matured, the very nature of physiology has undergone a significant revolution. It is no longer sufficient to describe the physiology of non-human primates; one must consider also the detailed knowledge of human brain function and cognition that is now available from functional studies in humans-including the electrophysiological studies in humans described here. Together with functional imaging of the human brain via positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), ERPs fill our quiver with the arrows required to pierce more than the single neuron, but the networks of cognition."

From a New York Times bestselling author, a guide to restoring good bacteria to your gut–and keeping our microbiomes happy and healthy.

Because of our highly processed diet, pesticides, and overuse of antibiotics, our guts are now missing so many of the good bacteria that we require to be healthy. As a result, many of us have lost control over our health, weight, mood, and even behavior.

With cutting-edge research, Dr. Davis connects the dots between gut health and modern ailments such as SIBO (small intestinal bacterial overgrowth), a silent and profound epidemic, which affects one out of three people and is responsible for an astounding range of human health conditions.

Super Gut shows us how to fix your microbiome once and for all. It includes more than forty recipes, a diet plan, and resources so you can pinpoint your gut issues, correct them, and maintain your long-term health and well-being.

Biomechanics of the Gastrointestinal Tract is an up-to-date book for researchers on the study of the mechanical properties and the motor system of the gastrointestinal tract. A well-illustrated book, it provides a comprehensive overview to relevant tissue geometry, morphology and biomechanical theory. Separate chapters cover smooth muscle and nerve function including the application to animal and human studies of motility, symptoms and pain, determination of the true resting state, history-dependent properties, and tissue remodelling in disease. Several methods and diagnostic applications such as determination of in vivo length-tension diagrams and multimodal pain testing are completely new but will undoubtedly be used by many in the future. New non-invasive imaging techniques based on ultrasound, MR- and CT-scanning in combination with balloon distension are emerging as the techniques for future in vivo studies.

Explore the science behind over 50 pilates exercises to master each movement with confidence and control. DK brings you a ground-breaking health book that will help you revitalise your workouts and perfect your Pilates practice, by understanding the muscle action, breathwork and techniques required, every step of the way. Did you know that performing Pilates can strengthen your core, improve flexibility and posture, and help to reduce stress and anxiety at the same time? Backed by scientific research, learn how Pilates exercises benefit every system in the body. Science of Pilates reveals the facts with annotated artworks that show the mechanics, the angles, how your blood flow and respiration are affected, the key muscle and joint actions working below the surface of each exercise, safe alignment, and much more! Go on a journey of self-discovery to explore: - Specially commissioned CGI artworks depict all the main Pilates exercises with variations that add or reduce challenge. - Artworks detail the mechanics of each exercise, correct body posture, the muscles involved and how they engage to perform movements. - Illustrations featuring colour-coding to highlight how the muscles, ligaments, and joints engage, stretch, and relax to perform each exercise. - Pilates programmes tailored to different abilities and aims. - Suggested practices with a progressive increase in challenge over weeks and months. - Easy-to-follow infographics help explain the hard science behind why Pilates training is so effective and what beneficial physical adaptations it can bring. Set out to unearth the facts behind the pseudo-science fads, The Science of Pilates is an approachable, entertaining and easy-to read fitness guide for those seeking self-development backed up by solid scientific evidence. The popular question and answer format brings an immediacy to the information provided, and the highly visually illustrations truly bring the science to life in a contemporary and accessible way. At DK, we believe in the power of discovery. So why stop there? If you like Science of Pilates, then why not try Science of Yoga to help you better understand yoga anatomy in order to perfect your practice and poses, or Science of Strength Training to support you in your journey to build you strongest body. Complete the collection today!

First Published in 1988. Routledge is an imprint of Taylor & Francis, an informa company.

In this volume of Reviews of Physiology there are three outstanding contributions, the first on Selenium-containing proteins in mammals and other forms of life, and the second on constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0 and the third on Chloroplast quest: a journey from the cytosol into the chloroplast and beyond.

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

First published in 1987. Routledge is an imprint of Taylor & Francis, an informa company.

Fatigue is a condition spanning the breadth of human functioning in health and disease and is a central concern in sport and exercise. Even so we are yet to fully understand its causes. One reason for this lack of understanding is that we seldom consider fatigue from an evolutionary perspective - as an adaptation that provided reproductive success. This ground-breaking book outlines the evidence that fatigue is a result of adaptations distinctive to humans. It argues that humans developed adaptations which led to enhanced fatigue resistance compared with other mammals and discusses the implications in the context of exercise, health and performance. Highly illustrated throughout, it covers topics such as defining and measuring fatigue, the emotional aspect of fatigue, how thermoregulation affects the human capacity to resist fatigue, and fatigue in disease. Human Fatigue is essential reading for all exercise scientists as well as graduate and undergraduate students in the broad field of physiology and exercise physiology.

Diagnosis and Treatment of Spinal Cord Injury will enhance readers' understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers' understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the importance of endothelium-dependent responses, triggered by the intellectual curiosity of one of the pioneers of vascular physiology and pharmacology, is now recognized not only by basic scientists, but also by all concerned with the cardiovascular diseases. The purpose of this monograph is to provide them with a reference work, so that they know where to start."

The seven papers of this volume present a glimpse into current research on soft tissue mechanics as well as some future directions. The seven papers concern tissues within the cardiovascular system: three focus on arteries, three on the heart, and one on biaxial testing of planar tissues such as heart valves. Given that cardiovascular disease continues to be the leading cause of death in the developed world, the importance of such research is clear.

There are notable common features of the seven papers. First, most of the proposed constitutive relations are motivated directly by data on the underlying microstructure, and especially the orientations of a structurally important protein (collagen) that forms as undulated cross-linked fibers. Another feature of most of the papers is the consideration of the fact that both arteries and the heart contain muscle and that there is a need to quantify the so-called active (contractile) response in addition to the passive (non-contractile) response. Such relations must not only be structurally motivated, they must ultimately include the kinetics of calcium transport in the muscle. Constitutive relations for active behavior are discussed in the majority of the papers. The growth and remodeling of cardiovascular tissues is another common feature of the papers. Over the last twenty years, separate advances in biochemistry, cell biology, genetic engineering, and biomechanics have focused attention on the ubiquitous role of growth and remodeling of tissues. This volume should be of interest to cardiovascular researchers in particular, and to bioengineers and biomechanics soft tissue researchers in general.

First published in 1986. Routledge is an imprint of Taylor & Francis, an informa company.

This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.

Venous Ulcers, Second Edition, provides a comprehensive synthesis of evidence-based recommendations and the highest level of expertise from a leading group of doctors, which is a fundamental constituent for the appropriate management of nonhealing venous wounds in everyday practice. This book offers a fertile environment for a complete understanding of genetics and molecular and biochemical mechanisms that lead to the development and progression of venous ulcers, which is essential for elucidating the underlying pathophysiology and can be utilized for developing novel therapies and accessing previously inaccessible areas of research. Socioeconomic impact, impact on health-related quality of life, the clinical course of the disease, and diagnostic algorithms are elaborated in detail. All currently available treatment modalities are explained in a clinically applicable approach with particular emphasis on operative technique, technical feasibility, success rates (both clinical and technical), and side effects. Lastly, this book elaborates on special diagnostic considerations and management of the most complex patients, often requiring the highest level of expertise for successful treatment.

Nearly everything making up what we call the "environment" of a plant has an infuence on the way it grows. Sunlight, te- perature, moisture contents of soil and atmosphere and vib- tions are all obvious examples of environmental components, and transient variations in their amount or intensity lead the plant to manifest more or less immediate responses. Small changes in carbon dioxide level in the atmosphere can even have effects, but these take a longer time to be registered - at least those that are visible, albeit at the microscopic level. Plants meet the challenges of the environment by means of acclimation. In this respect, plants are notable for the pl- ticity of their development. However, where morphological or physiological plasticity is no longer an option, the responses would be by means of adaptations as a result of genetic - lection or genetic "assimilation" (Waddington 1957). Thus, a feature that was once a facultative transient response to an environmental perturbation becomes a constitutive charac- ristic of plant structure or function. It is in this way that the environment continually molds the way in which plants de- lop, and also defnes the areas upon planet Earth where they will thrive.

First published in 1985. Routledge is an imprint of Taylor & Francis, an informa company.

The prefrontal cortex is known to play important roles for performing a variety of higher cognitive functions. Among regions of the prefrontal cortex, the dorsolateral prefrontal cortex plays the most important roles for these functions. This book focuses on functions of the dorsolateral prefrontal cortex, summarizes research results obtained mainly by non-human primate studies, and describes neural mechanisms of executive functions that the dorsolateral prefrontal cortex participates. First, to understand the feature of the dorsolateral prefrontal cortex and how its function has been understood, anatomical and functional features of the dorsolateral prefrontal cortex and historical overview of prefrontal functions are described. To understand functions of the prefrontal cortex and neural mechanisms of executive functions, working memory is an important concept and sustained activation during the memory period of working memory tasks is known as a neural mechanism of working memory. Therefore, this book describes features of sustained memory-related activity based on neurophysiological results obtained in the prefrontal cortex and how memory-related activity contributes to executive functions including control of attention, inhibitory control, task management, and planning. And further, this book describes how the dorsolateral prefrontal cortex contributes to neural mechanisms for sensory and motor processing, memory control in multi-task performance, decision-making, metacognition, and top-down control. Thus, this book provides important information regarding neural mechanisms of dorsolateral prefrontal functions to neuroscientists and helps to plan further investigation to understand prefrontal functions in primates and human subjects.

First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics. The timing of this volume is long overdue and is the first comprehensive coverage of leptin physiology in the field.

Primer on the Autonomic Nervous System, Fourth Edition provides a concise and accessible overview of autonomic neuroscience for students, scientists, and clinicians. The book's 142 chapters draw on the expertise of more than 215 basic scientists and clinicians who discuss key information on how the autonomic nervous system controls the body, particularly in response to stress. This new edition also focuses on the translational crossover between basic and clinical research. In addition to comprehensively covering all aspects of autonomic physiology and pathology, topics such as psychopharmacology decoding and modulating nerve function are also explored.