Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essentialdevelopmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term regenerative medicine was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general. Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cell cycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerativedisease, are recurring themes throughout the book. We are all now part of the regeneration revolution."

Physiology of Human Reproduction bietet Studenten einen pragnanten und zuganglichen UEberblick uber mehr 200 Themenkomplexe, von der grundlegenden Physiologie von Mannern und nicht schwangeren Frauen bis hin zu Befruchtung, Wachstum des Embryos und Foetus, Geburt, Laktation u.v.m. Im Text werden Kernbegriffe durchgangig hervorgehoben, um Informationen zu einem Themenbereich schnell zu finden. Dieses Lehrbuch hilft dem Leser, die menschliche Fortpflanzung besser zu verstehen und kann von Anfang bis Ende oder selektiv nach Themen durchgearbeitet werden. Dieser unverzichtbare Lernbegleiter zu Kursen in Anatomie und Physiologie - beschaftigt sich mit der Physiologie von Mannern, der Physiologie von nicht schwangeren Frauen sowie mit Schwangerschaft und Laktation und altersbedinges Veranderungen wie die Menopause. - diskutiert Themen wie Schwangerschaft, Geburtenkontrolle, das Fortpflanzungssystem im Kindesalter, in Adoleszenz und Pubertat. - beschreibt Anatomie, Physiologie und Phasen des menschlichen Sexualempfindens. - erklart genetischbedingte Erkrankungen und Stoerungen, wie Androgen-Insensitivitat und das Kallmann-Syndrom. Physiology of Human Reproduction ist ein Pflichtlehrbuch fur Studenten der Medizin- und Biowissenschaften, wie Medizin, Pflege, Biologie, Physiologie, Biomedizin, Kurse zu menschlicher Fortpflanzung und Schwangerschaft.

This book was written by many outstanding investigators who have spent decades to study different aspects of blood-tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood-brain barrier, the blood-retinal barrier, the gut barrier, the blood-biliary barrier, the blood-follicle barrier, the blood-epididymis barrier, the blood-testis barrier, the tight junction barrier in general as well as barriers in the female reproductive tract. Included are also chapters that focus on topics that are physiologically applicable to all blood-tissue barriers. Many of these chapters also include information on specific human diseases, such as pathological changes of the gut barrier that cause bowel disorders resulting from inflammation of the epithelial lining in the intestine, and infertility in men as a result of disruption of the blood-epididymal and/or blood-testis barriers; and on new therapeutic approaches (e.g., drug delivery across the blood-brain and the blood-retinal barriers).

This textbook explores the fundamental qualitative and quantitative aspects of human physiology. It approaches biological and physiological processes and phenomena from a quantitative perspective, revealing how physiological problems can be mathematically formulated starting from simple laws of physics. The book addresses a broad range of topics, including: the statics and dynamics of circulation; muscle and sarcomere force-length and force-velocity relations, together with their mechanisms and functional consequences; subdivisions and meaning of the heat produced by muscle; locomotion, statics and dynamics of respiration; diffusion of gases and acid base equilibrium; phonation; general functions of the kidney and of the different sections of the nephron; changes in clearance with a substance's plasmatic concentration; pH regulation and the kidney; Donnan's equilibrium and its consequences; and the Nernst equation. The book offers the ideal learning resource for students of human physiology courses in medicine and biomedicine, as well as biomedical engineering and biophysics graduate students. An elementary grasp of mathematics and physics is sufficient to understand the content.

Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as well as brain tuberculosis. Pulmonary medicine is represented by articles addressing a range of practical issues, including the diagnosis, symptoms, comorbidities, and treatment of obstructive sleep apnea, a syndrome whose incidence shows a persistent upward trend worldwide. Other articles address the pathogenesis of air pollution toxicity and allergy and sensory irritation in toxic exposure studies. An intriguing relation of atopic dermatitis to depression and serotoninergic system is debated. The book attempts to integrate research into clinical work and to implement findings to improve care and to decrease suffering from diseases. It is dedicated to the practicing professionals, researchers, and all engaged in health care.

Brain Mapping: A Comprehensive Reference offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content - basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

In the past few years, the application of proteomics to examine the molecular mechanisms underlying (mal-)functioning of the nervous system and brain disorders has risen steeply, which in many cases has yielded novel insights. As neuroproteomics is a new research field involving the use of a number of high-end analytical instruments and technologies, both promises and pitfalls may not be well appreciated by the researchers, and the design of a proper proteomics experiment may not be obvious. "Neuroproteomics" brings together a collection of detailed protocols written by experienced professionals in the field in order to cover aspects of various dimensions of this new technology, together with some established methods that have supporting roles in the workflow of neuroproteomics. Written for the popular "Neuromethods" series, the chapters in this book contain step-by-step, easy to follow instruction along with practical tips and key implementation advice essential for successful implementation of the techniques.

Authoritative and cutting-edge, "Neuroproteomics" will be of great assistance to all researchers seeking to design and execute their own proteomics experiments in an optimal way and continue moving forward this exciting area of study.

Clinical Exercise Physiology, Fifth Edition With HKPropel Access, is a comprehensive guide to the clinical aspects of exercise physiology, investigating 24 chronic diseases and conditions and addressing a variety of populations. The text has been a mainstay in the field since its inception in 2003 and is an ideal resource for students preparing for clinical exercise certifications, including those offered by the American College of Sports Medicine (ACSM-CEP), American Council on Exercise (Medical Exercise Specialist), Canadian Society for Exercise Physiology (CSEP-CEP), and Exercise & Sports Science Australia (ESSA-AEP). Clinical Exercise Physiology, Fifth Edition, employs a logical progression of content to provide greater coverage and depth of diseases than is typically found in most clinical exercise physiology textbooks. It examines the effects of exercise on 24 chronic conditions, with each chapter covering the epidemiology, pathophysiology, clinical considerations, drug and surgical therapies, and exercise testing and prescription issues for the chronic condition. Other chapters are devoted to examining exercise-related issues for four special populations. Each chapter in this fifth edition is revised and updated to include the latest research, clinical guidelines, and position statements from professional organizations. In addition, it incorporates the following new elements: An upgrade to a full-color layout, for a more engaging learning experience and enhanced presentation of data New Clinical Exercise Bottom Line sidebars that highlight key information a clinical exercise physiologist needs when working with clinical populations A new chapter on clinical exercise programming that offers detailed recommendations for clinical populations A completely rewritten chapter on spinal cord injury and updates throughout each chapter to reflect the most up-to-date guidelines and position statements Expanded coverage of clinical exercise physiology certification options In addition to practical application sidebars throughout the text, the fifth edition also has related online tools to support student learning. Delivered through HKPropel, more than 60 case studies are presented in a SOAP note format so students can explore clinical evaluations, looking closely at subjective and objective data, assessments, and plans. Discussion questions and interactive key term flash cards foster better understanding and retention, while chapter quizzes can be assigned by instructors through the platform to assess student comprehension. Endorsed by the Clinical Exercise Physiology Association (CEPA), the Canadian Society for Exercise Physiology (CSEP), the British Association of Sport and Exercise Sciences (BASES), and Exercise & Sports Science Australia (ESSA), Clinical Exercise Physiology, Fifth Edition, offers a contemporary review of the variety of diseases and conditions that students and professionals may encounter in the field. New and veteran clinical exercise physiologists, as well as those preparing for clinical exercise certification exams, will appreciate the in-depth coverage of the clinical populations that benefit from physical activity. Note: A code for accessing HKPropel is included with this ebook.

There are two main reasons for pursuing research in the Sports Sciences. Firstly, by studying responses to exercise, we learn about the normal function of the tissues and or gans whose function allows exercise to be performed. The genetic endowment of elite ath letes is a major factor in their success, and they represent one end of the continuum of human performance capability: the study of elite athletes also demonstrates the limits of human adaptation because nowhere else is the body subjected to such levels of intensive exercise on a regular basis. The second reason for studying Sports Science is the intrinsic interest and value of the subject itself. Elite performers set levels to which others can as pire, but even among spectators, sport is an important part oflife and society. of top sport and elite performers, there is also another reason Apart from the study for medical and scientific interest in sport. There is no longer any doubt that lack ofphysi cal activity is a major risk factor for many of the diseases that affect people in all coun tries: such diseases include coronary heart disease, obesity, hypertension, and diabetes. An increased level of recreational physical activity is now an accepted part of the prescription for treatment and prevention of many illnesses, including those with psychological as well as physical causes. An understanding of the normal response to exercise, as well as of the role of exercise in disease prevention, is therefore vital."

The Formation of the Heart and its Regulation reviews in considerable detail the major events in heart development and their control via genes, cell-cell interactions, growth factors and other contributing elements. In addition, there is an extensive and useful overview of the field of heart development taken as a whole. The book will appeal to all students and researchers working on cardiovascular development and to pediatric cardiologists.

H; J. Apell: Structure -Function Relationship in P-Type ATPases - A Biophysical Approach; H. Koepsell, B. Schmitt, and V. Goboulev: Organic Cation Transporters; W.G. Wier and K.G. Morgan: Alpha 1- Adrenergic Signaling Mechanisms in Mammalian Resistance Arteries; G. Ahnert-Hilger, M. Holtje, I. Pahner, S. Winter and I.

This new book provides an accessible review of the field of lung biology and disease aimed at the graduate or medical student and biomedical researcher. The book starts by considering the anatomy and ultrastructure of the lung and the tracheal and bronchial system, the control of respiration as well as the fundamentals of pulmonary physiology, gas exchange and circulation. This is followed by discussion of the regulation of acid-base balance, high altitude physiology and pathophysiology as well as exercise and the pulmonary system. Chapters follow on the immunology of the lung, lung injury, asthma and emphysema, granulomatous lung disease, inhalation of toxic substances as well as diseases of the small airways. The final chapter considers current research into lung transplantation.

Almost every aspect of energy and nutrient metabolism is altered by hormonal and other physiological changes during pregnancy and lactation. While it is evident that hormonal adjustments affect nutrient requirements, these are rarely considered when nutrient recommen dations are made for pregnant or lactating women, and often neglected during evaluation of nutritional status. In addition, changes in nutrient metabolism during the stages of pregnancy and oflactation are usually considered separately, while in reality events during pregnancy can have a major influence on nutritional status and nutrient requirements during lactation. The purpose of this volume is to describe changes in the metabolism of important nutrients during pregnancy and lactation, including the physiological basis for these changes and their implications for nutrient requirements and assessment. Authors have considered such issues as inter-relationships between endocrine changes and nutrient metabolism at the tissue, cellular and molecular level; alterations in nutrient binding proteins; the efficiency of nutrient absorp tion and retention; and the impact on maternal as well as fetal nutritional status. Another unique aspect of this book is the focus on pregnancy and lactation as a continuum."

This is the first textbook solely dedicated to the study of exocrine glands and cells throughout the human body. Students will gain a broad overview of the whole exocrine system, it's structural features and learn to understand it's integral parts in almost all bodily functions. Taking a systemic approach, the author guides readers through the different organ sites, shapes, methods of secretion and their secretory products. Starting with the glands of the integument, which is covering the outside of the body, the chapters proceed to also discuss the urinary tract, respiratory, digestive and reproductive systems. Various levels of complexity, from single goblet cells to the major organs, are thoroughly explained. A basic knowledge in histology is advantageous, for the numerous and rich illustrations. With its inviting writing style, this textbook is a perfect learning tool for students in Physiology and Medicine - particularly considering Dentistry, Dermatology, Gastroenterology and Pulmonology.

In Bonk, the best-selling author of Stiff turns her outrageous curiosity and insight on the most alluring scientific subject of all: sex. Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline.
Calcium-Sensing Receptor is the nineteenth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

D. Kamimura, K. Ishihara, T. Hirano: IL-6 Signal Transduction and its Physiological Roles: The Signal Orchestration Model

M. Tanaka and A. Miyajima: Oncostatin M, a Multifunctional Cytokine

G.-J. van de Geijn, L.H.J. Aarts, S.J. Erkeland, J. Prasher, and I.P. Touw: Granulocyte Colony-Stimulating Factor and its Receptor in Normal Hematopoietic Cell Development and Myeloid Disease

T. Hanada, I. Kinjyo, K. Inagaki-Ohara and A. Yoshimura: Negative Regulation of Cytokine Signaling by CES/SOCS Family Proteins and Their Roles in Inflammatory Diseases

J. Kalesnikoff, L.M. Sly, M.R. Hughes, T. B chse, M.J. Rauh, L.-P. Cao, V. Lam, A. Mui, M. Huber, and G. Krystal: The Role of SHIP in Cytokine-Induced Signaling

Discover all there is to know about human anatomy in DK's latest concise visual guide to the human body. Fully updated to reflect the latest medical information, The Concise Human Body Book is illustrated throughout with colourful and comprehensive diagrams, photographs, scans, and 3D artworks, which take you right into the cells and fibres that are responsible for keeping your body ticking. The Concise Human Body Book provides full coverage of the body, function by function, system by system. In the opening chapter, colourful medical scans, illustrations, and easy-to-understand diagrams show you how the different parts of the body work together to produce a living whole. Eleven main body systems - including the skeletal system, cardiovascular system, and respiratory system - are then covered in intricate detail in the following chapters, with each section ending on common diseases and disorders that can affect that system. From bones and muscles to systems and processes, this in-depth, pocket-sized guide to the body's physical structure, chemical workings, and potential problems is the must-have reference manual for trainee medical professionals, students, or anyone interested in finding out more about how the human body works.

This volume is concerned with the enzymes of the nervous system. Cerebral enzymes form the basis of the functional brain. They are needed for the control of the energetics of the nervous system, whether it be their release or their direction; for the elaboration of transmitters and for their destruction; for the synthesis, transport, and breakdown of all metabolites of the nervous system. They are indispensable for the control of the multitude of factors that govern our thinking and our behavior. They make it possible for us to comprehend what is taking place around us and perhaps to understand what may be in store for us. Enzymes are the stuff of life, and no living cell can be without them. They are the results of many millions of years of evolution, from the time when biological membranes first came into being and were folded to produce the first cells within which the earliest enzymes were wrought. Countless changes have taken place within them, so that, now, only those enzymes exist that play specific roles in the functions of the living cells of today. Those in the nervous system possess a mUltiple role: in the creation, maintenance, and ultimate breakdown of the component cells and in enabling consciousness, perception, memory, and thought to become possible. But though life may go on forever, the enzymes that make life possible will undergo the many changes involved in the evolutionary process.

Iodine is an essential micronutrient and an integral component of the thyroid hormones, which are required for normal growth and development. The iodine deficiency disorders (IDD) encompass a spectrum of adverse health effects including goiter, cretinism, hypothyroidism, growth retardation, and increased pregnancy loss and infant mortality. This volume summarizes the current understanding of the effects of iodine deficiency as well as iodine excess. It also discusses best practices for salt iodization, the mainstay of global IDD prevention efforts, and other forms of food fortification. The effectiveness of iodine supplementation for vulnerable populations, an evolving strategy in many regions, is also described. Low level environmental exposure to chemicals such as perchlorate and thiocyanate, which competitively block thyroidal iodine uptake, appears to be ubiquitous worldwide. There has been recent concern that such environmental exposures might pose a health hazard by inducing or aggravating underlying thyroid dysfunction. This up-to-date volume explores both the effects of iodine deficiency as well as the best strategies for IDD prevention.

This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers' understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special "clinical correlates" sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.